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新入职护士心理护理临床实践体验的质性研究
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作者 崇月 朱晓萍 +1 位作者 李玉梅 王艳波 《上海护理》 2024年第7期21-25,共5页
目的通过质性研究的方法探讨新入职护士心理护理临床实践体验,为构建新入职护士心理护理临床培训方案提供实证参考。方法2022年9-12月,采用目的抽样法,选取来自上海市3所三级甲等医院的14名新入职护士进行半结构式深入访谈,采用主题分... 目的通过质性研究的方法探讨新入职护士心理护理临床实践体验,为构建新入职护士心理护理临床培训方案提供实证参考。方法2022年9-12月,采用目的抽样法,选取来自上海市3所三级甲等医院的14名新入职护士进行半结构式深入访谈,采用主题分析法对访谈资料进行整理分析。结果围绕新入职护士心理护理实践体验,提炼出3个主题:基于自身需求体会到心理护理的重要性、在患者照护过程中有意识地观察和实践心理护理、对于规范化培训阶段心理护理能力提升存在多方面的培训需求。结论新入职护士能较好意识到临床心理护理的重要性,能够逐渐将心理护理理念融入临床实践,但其自助能力与助人能力均有待提升。护理管理者可结合临床情境案例等,针对新入职护士开展相关培训,促进其心理护理实践技能的临床转化与迁移。 展开更多
关键词 新入职护士 规范化培训 心理护理 临床实践 质性研究
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Propagation of crust deformation anomalies related to the Menyuan M_(S) 6.9 earthquake
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作者 Anfu Niu chong yue +3 位作者 Zhengyi Yuan Jing Zhao Wei Yan Yuan Li 《Earthquake Research Advances》 CSCD 2023年第4期43-48,共6页
Decoding the variation laws of the deformation field before strong earthquakes has long been recognized as an essential issue in earthquake prediction research. In this paper, the temporal and spatial distribution cha... Decoding the variation laws of the deformation field before strong earthquakes has long been recognized as an essential issue in earthquake prediction research. In this paper, the temporal and spatial distribution characteristics of deformation anomalies in the northeastern margin of the Qinghai-Tibetan Plateau before and after the Menyuan M_(S)6.9 earthquake were studied by using the Fisher statistical test method. By analyzing the characteristics of these anomalies, we found that: 1) The deformation anomalies are mainly distributed in the marginal front area of the Qinghai-Tibetan Plateau, where short-term deformation anomalies are prone to occur due to a high gradient of gravity;2) The deformation anomalies along the northeastern margin of the Qinghai-Tibetan Plateau are characterized by spatial propagation, and the migration rate is about 2.4 km/d. The propagation pattern is counterclockwise, consistent with the migration direction of M_(S)≥ 6.0 earthquakes;3) The time and location of the Menyuan earthquake are related to the group migration of earthquakes with M_(S)≥ 6.0. Finally,based on the results of gravity field variation and the theory of crust stress wave, the law of deformation anomaly distribution was discussed. We suggest that both the deformation propagation along the northeastern margin of the Qinghai-Tibetan Plateau and the earthquake migration are possibly associated with the variation of the stress field caused by subsurface mass flow. 展开更多
关键词 Northeastern margin of Qinghai-Tibetan Plateau Menyuan M_(S)6.9 earthquake Deformation propagation Earthquake migration Gravity field
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肾癌转移关键基因的Top250基因集富集分析
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作者 徐珊 张海宝 +4 位作者 种岳 田娟华 穆丽君 贺大林 杜岳峰 《现代泌尿外科杂志》 CAS 2018年第8期620-625,共6页
目的筛选影响肾癌转移的关键基因,为肾癌治疗研究奠定科学依据。方法从基因表达综合数据库(GEO)下载基因表达谱(GSE47352),利用GEO2R在线分析提取肾癌转移患者和未转移患者显著表达差异的前250位基因,运用基因本体(GO)富集分析、京都基... 目的筛选影响肾癌转移的关键基因,为肾癌治疗研究奠定科学依据。方法从基因表达综合数据库(GEO)下载基因表达谱(GSE47352),利用GEO2R在线分析提取肾癌转移患者和未转移患者显著表达差异的前250位基因,运用基因本体(GO)富集分析、京都基因与基因组百科全书(KEGG)信号通路富集分析、PPI(蛋白质-蛋白质互作用)网络构建以及Venn分析方法,筛选影响肾癌转移的核心基因。结果通过对比富集分析,PPI以及Venn分析结果,我们发现肾癌转移患者和未转移患者显著变化是细胞应激、细胞粘附特性、血管生成以及细胞向外信息传递等生物学功能,其中粘连蛋白α4链(LAMA4)和JUN有可能是肾癌转移的核心基因。结论 JUN和LAMA4可能在肾癌转移中发挥着重要作用,是肾癌转移的核心基因,本研究后续将对JUN和LAMA4基因进行生物学功能验证。 展开更多
关键词 肾癌 基因表达综合数据库(GEO) 肿瘤转移 基因主体(GO) 关键基因
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新入职护士角色适应体验质性研究的Meta整合 被引量:2
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作者 崇月 王灿 王艳波 《循证护理》 2022年第18期2439-2446,共8页
目的:系统评价和整合新入职护士角色适应的真实体验。方法:计算机检索the Cochrane Library、MedLine、PubMed、Web of Science、中国知网(CNKI)、万方数据库、维普数据库及中国生物医学文献数据库中关于新入职护士角色适应体验的质性研... 目的:系统评价和整合新入职护士角色适应的真实体验。方法:计算机检索the Cochrane Library、MedLine、PubMed、Web of Science、中国知网(CNKI)、万方数据库、维普数据库及中国生物医学文献数据库中关于新入职护士角色适应体验的质性研究,检索时限均为建库至2021年5月。采用澳大利亚Joanna Briggs Institute(JBI)循证卫生保健中心2016版质性研究质量评价标准评价文献质量,采用汇集性整合方法对结果进行整合。结果:共纳入23篇文献,提炼出29个主题,归纳为10个类别,综合得出4个整合结果:新入职护士角色适应过程中面临的困境;新入职护士负性身心体验;新入职护士的需要;新入职护士角色适应与成长。结论:新入职护士在角色适应过程中会面临各种复杂困境,受到来自生理、心理等多方面冲击,应给予新护士帮助和支持,加强规范化培训,以促进其早日完成角色适应,胜任临床实践工作。 展开更多
关键词 新护士 角色 适应 工作体验 质性研究 Meta整合 循证护理
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c-FOXP3对肾透明细胞癌体外侵袭迁移的效应及机制研究
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作者 种岳 朱国栋 +3 位作者 张海宝 徐珊 王新阳 贺大林 《现代泌尿外科杂志》 CAS 2018年第9期699-704,共6页
目的探究c-FOXP3基因在肾透明细胞癌体外侵袭迁移中的效应,并分析其与临床预后之间的关系。方法查询The Cancer Genomic Atlas(TCGA)数据库探寻c-FOXP3与肾细胞癌临床预后之间的关系;利用Western blot技术测定常见的肾透明细胞癌细胞系... 目的探究c-FOXP3基因在肾透明细胞癌体外侵袭迁移中的效应,并分析其与临床预后之间的关系。方法查询The Cancer Genomic Atlas(TCGA)数据库探寻c-FOXP3与肾细胞癌临床预后之间的关系;利用Western blot技术测定常见的肾透明细胞癌细胞系中c-FOXP3的表达水平;采用慢病毒感染技术感染c-FOXP3高表达的肾癌细株786-O与ACHN建立FOXP3敲低的肾癌细胞模型;采用细胞划痕实验,分别观察c-FOXP3敲低的786-O、ACHN及对照组细胞迁移能力的差异;分别用Transwell小室检测c-FOXP3敲低的786-O和ACHN以及对照组细胞的体外迁移和侵袭能力;Western blot法检测癌细胞侵袭迁移相关指标,初步探索c-FOXP3对肾癌细胞侵袭、迁移效应的分子机制。结果 TCGA临床数据库显示c-FOXP3表达量与肾细胞癌患者的总生存率呈现较明显的负相关关系,c-FOXP3表达量越高的肾癌患者,总生存率越低。常见肾癌细胞系中,786-O和ACHN相对高表达c-FOXP3。细胞划痕实验和Transwell实验显示c-FOXP3敲低的786-O和ACHN体外侵袭、迁移能力均较对照组减弱。Western blot检测发现c-FOXP3敲低的786-O和ACHN细胞中N-cadherin和Vimentin表达水平均较对照组减低。结论 c-FOXP3基因可促进肾透明细胞癌的体外侵袭、迁移潜能,并与肾透明细胞癌患者的临床预后不良有关。 展开更多
关键词 肾透明细胞癌 c-FOXP3 迁移 侵袭 生存率
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Characteristics of the coseismic geomagnetic disturbances recorded during the 2008 M_w 7.9 Wenchuan Earthquake and two unexplained problems 被引量:6
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作者 YaLi Wang Tao Xie +5 位作者 YanRu An chong yue JiuYang Wang Chen Yu Li Yao Jun Lu 《Earth and Planetary Physics》 CSCD 2019年第5期435-443,共9页
Twenty-seven FHDZ-M15 combined geomagnetic observation systems(each of which is equipped with a fluxgate magnetometer and a proton magnetometer)had been installed in the China geomagnetic network before the 2008 Wench... Twenty-seven FHDZ-M15 combined geomagnetic observation systems(each of which is equipped with a fluxgate magnetometer and a proton magnetometer)had been installed in the China geomagnetic network before the 2008 Wenchuan earthquake,during which coseismic disturbances were recorded by 26 fluxgate magnetometer observatories.The geomagnetic disturbances have similar spatial and temporal patterns to seismic waves,except for various delays.Six proton magnetometer observatories recorded coseismic disturbances with very small amplitudes.In addition,fluxgate magnetometers registered largeamplitude disturbances that are likely to have included responses to seismic waves.However,two problems remain unresolved.First,why do these geomagnetic disturbances always arrive later than P waves?Second,why do the geomagnetic disturbances have spatial and temporal directivity similar to the main rupture direction of the earthquake?Solving these two problems may be crucial to find the mechanism responsible for generating these geomagnetic anomalies. 展开更多
关键词 WENCHUAN Earthquake co-seismic disturbance GEOMAGNETIC field FLUXGATE MAGNETOMETER proton MAGNETOMETER
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Simulation of the water level influence on the difference within the water-tube tiltmeter in Shuangyang Lake 被引量:1
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作者 chong yue Chuncheng Tang +5 位作者 Wei Yan Xiaodong Pan Xueme Li Yuwen Tan Zongfeng Zhang Tianlong Yu 《Earthquake Research Advances》 CSCD 2021年第2期33-39,共7页
This article analyzes the relationship between the water level and the water-tube tilting in Shuangyang lake,based on the differential deformation features reflected by the NS and EW components of the water-tube tiltm... This article analyzes the relationship between the water level and the water-tube tilting in Shuangyang lake,based on the differential deformation features reflected by the NS and EW components of the water-tube tiltmeter.The results show a good spatiotemporal consistency between the variation of water level and the NS tilt component,which is considered to be affected by the magnitude and duration of the water level variation in Shuangyang Lake.The article uses Landsat remote sensing image data to extract the water boundary of Shuan-gyang Lake,and takes advantage of the finite element numerical simulation method to build three-dimensional models for different geological structural conditions of the Shuangyang seismostation.The simulation results show that when the underground medium is granite,the effect of water level variation on the vertical displacement of the surface is non-directional.With a 50-m soil layer in Model 2,the simulated NS tilt variation is equivalent to the actual observed water-tube tiltmeter NS component when the water level variation is 0.44 m and 0.8m.When the variation of water level reaches 2.0m,the simulation result of the NS component is 79.6 ms,which is slightly larger than the observed result of 60.32 ms.However,the simulation results show that the variation of the EW component is significantly smaller than that of the NS one.Due to the fact that the Shuan-gyang lake is long in the NS direction and short in the EW direction,the existence of the soil layer tends to generate ground deformation along the NS direction in the vicinity of the lake after the increase of water level,thereby resulting in the difference of the ground deformation in the two directions. 展开更多
关键词 Water-tube tiltmeter at shuangyang seismostation Water level of shuangyang lake Finite element method Difference of the ground deformation
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Experimental study on cyclic deformation properties of saturated Fujian sand at different loading frequencies
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作者 chong yue Ke Liang +1 位作者 Chengshun Xu Xiuli Du 《Underground Space》 SCIE EI CSCD 2023年第6期150-165,共16页
In this study,a series of undrained cyclic torsional shear tests were conducted to investigate the effect of cyclic loading frequency f on the pre-liquefaction(shearing contractive(SC)period and initial shearing dilat... In this study,a series of undrained cyclic torsional shear tests were conducted to investigate the effect of cyclic loading frequency f on the pre-liquefaction(shearing contractive(SC)period and initial shearing dilative(ISD)period)and post-liquefaction(late shearing dilative(LSD)period)deformation properties of saturated Fujian sand.The secant shear modulus G and damping ratioλin the entire cyclic loading process,and the unloading tangent shear modulus G_(L1)and flow deformation tangent shear modulus GL2 in the ISD and LSD periods were adopted to quantitatively characterize the evolution of hysteresis loop with an increase in shear strain amplitude ca.The test results show that the effect of f on G of saturated Fujian sand in the SC period is not apparent.However,all the G-γ_(a),G_(L1)-γ_(a),and GL2-ca curves in the ISD and LSD periods showed a downward trend with an increase in f.This study also proposes a modified method for calculatingλto compensate for the analytical error caused by the non-closure of hysteresis loop.Compared with the classical curves that mainly applied in geotechnical engineering,theλfirst increases and then decreases with the increase ofγa.Furthermore,theλevaluated by the modified method is approximately 10%–15%more than theλevaluated by the traditional method when theλreaches its peak value. 展开更多
关键词 Sand liquefaction Cyclic loading frequency Hysteresis loop shape Shear modulus Damping ratio
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