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Visualization Analysis of the Impact of Rubber Agroforestry Ecosystem on Soil Microbial Community
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作者 Jianan Liu Dongling Qi +5 位作者 chuan yang Zhixiang Wu Yingying Zhang Qingmao Fu Xianlei Jiang Ruxin Lin 《Advances in Bioscience and Biotechnology》 CAS 2024年第8期486-502,共17页
Rubber agroforestry systems positively impact soil microbial communities. This study employed a bibliometric approach to explore the research status, hotspots, and development trends related to these effects. Using Ci... Rubber agroforestry systems positively impact soil microbial communities. This study employed a bibliometric approach to explore the research status, hotspots, and development trends related to these effects. Using CiteSpace software, we visually analyzed research literature from the Web of Science (WOS) core database, spanning 2004 to 2024. The focus was on the impact of rubber agroforestry ecosystems on soil microbial communities. The results indicate significant attention from Chinese researchers, who have published numerous influential papers in this field. Authors Liu Wenjie have contributed the most papers, although no stable core author group exists. The Chinese Academy of Sciences is the leading research institution in terms of publication volume. While there is close collaboration between different institutions and countries, the intensity of researcher cooperation is low. The most cited literature emphasizes soil nutrients and structure in rubber agroforestry, laying a foundation for soil microorganism studies. Most cited journals are from countries like Netherlands and the United Kingdom. Key research areas include the effects of rubber intercropping on soil microbial communities, agroforestry management, and soil health. Research development can be divided into three stages: the initial stage (2010-2015), the development stage (2015-2020), and the mature stage (2020-2024). Current studies show that rubber intercropping and rubber-based agroforestry systems enhance soil microbial communities, positively impacting soil health. This paper provides a theoretical basis for the sustainable development of rubber agroforestry systems and improved management plans. Future research could explore the effects of species composition on soil microbiological characteristics and develop methods for species interactions. An in-depth study of the soil microbial community’s structure and function, and its relationship with rubber trees, is crucial. Developing effective, rationally designed rubber agroforestry systems and underground soil microbiome technology will promote sustainability and improve plantation productivity. 展开更多
关键词 Rubber (Hevea brasiliensis) Agroforestry Ecosystem MICROBE CiteSpace BIBLIOMETRICS Rubber Intercropping
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Exploration and Practice of Rubber Based Agroforestry Complex Systems in China
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作者 Dongling Qi Zhixiang Wu +4 位作者 chuan yang Zhongliang Tao Linlin Zhao Yingying Zhang Qingmao Fu 《Advances in Bioscience and Biotechnology》 2023年第12期479-491,共13页
Agroforestry ecosystems are constructed by simulating natural ecosystems, applying the principles of symbiosis in nature, and organizing multiple plant populations to coexist, while conducting targeted cultivation and... Agroforestry ecosystems are constructed by simulating natural ecosystems, applying the principles of symbiosis in nature, and organizing multiple plant populations to coexist, while conducting targeted cultivation and structural control scientifically. Rubber agroforestry complex ecosystems aim for sustainable development in terms of industry, ecology, resource utilization, and the livelihoods of producers. Rubber agroforestry complex ecosystems create a complex production structure system that integrates biology, society, and the economy through species combinations. Rubber trees and associated biological components coordinate with each other, mutually promote growth, and yield a variety of products for producers. Cultivation techniques and patterns of rubber agroforestry are essential components of these ecosystems. This study analyzes the production practices of rubber agroforestry complex cultivation, with a focus on the development and characteristics (complexity, systematicity, intensity, and hierarchy) of rubber agroforestry systems using a literature analysis and a survey approach. It explores the types and scales of complex planting, specifications and forms, and major effects of complex cultivation. This study identifies successful rubber agroforestry cultivation patterns and practical techniques, as well as the potential benefits of developing rubber agroforestry cultivation. It also points out the shortcomings in the development of complex planting, including an emphasis on production practices but insufficient theoretical research, a focus on production but inadequate attention to the market, and an emphasis on yield while overlooking the improvement of standards, brands, and added value. There are various complex patterns for young rubber plantations, but relatively fewer for mature plantations. Based on this analysis, this study suggests that future efforts should focus on in-depth research on interspecies and environmental interactions in rubber agroforestry ecosystems, clearly define key roles, accelerate the innovation of development patterns, and strengthen the foundation for development. It recommends promoting and demonstrating successful rubber agroforestry complex patterns and providing technical training, developing product branding for rubber agroforestry patterns, enhancing product value, expanding the application functions of rubber-forest mixed crop products, and establishing a stable and sustainable industry chain. This study provide practical experience and theoretical insights in rubber agroforestry complex systems from China the potential to enrich the knowledge of rubber agroforestry composite systems, provide practical experience to improve the operating income of smallholders, and even promote the sustainable development of rubber plantations. 展开更多
关键词 Rubber Tree (Hevea brasiliensis) Agroforestry Ecosystem Rubber Intercropping Complex Ecological Cultivation Land Resource
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Preliminary Study on the Effect of Different Ecological Cultivation Modes on the Water Stability of Soil Aggregates in Rubber Based Agroforestry Systems
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作者 Shiyun Zhan Fengyue Qin +4 位作者 Dongling Qi Zhixiang Wu chuan yang Yingying Zhang Qingmao Fu 《Open Journal of Ecology》 2023年第11期782-793,共12页
Rubber trees (Hevea brasiliensis Müll. Arg.) have been commercially cultivated for a century and a half in Asia, particularly in China, and they constitute a common element of plantation ecosystems in tropical re... Rubber trees (Hevea brasiliensis Müll. Arg.) have been commercially cultivated for a century and a half in Asia, particularly in China, and they constitute a common element of plantation ecosystems in tropical regions. Soil health is fundamental to the sustainable development of rubber plantations. The objective of the study is to explore the influence of different complex ecological cultivation modes on the stability of soil aggregates in rubber based agroforestry systems. In this study, the ecological cultivation mode of rubber—Alpinia oxyphylla plantation, the ecological cultivation mode of rubber—Phrynium hainanense plantations, the ecological cultivation mode of rubber—Homalium ceylanicum plantations and monoculture rubber plantations were selected, and the particle size distribution of soil aggregates and their water stability characteristics were analyzed. The soil depth of 0 - 20 cm and 20 - 40 cm was collected for four cultivation modes. Soil was divided into 6 particle levels > 20 cm. soil was divided into 6 particle levels > 5 mm, 2 - 5 mm, 1 - 2 mm, 0.5 - 1 mm, 0.25 - 0.5 mm, and 0.053 - 0.25 mm according to the wet sieve method. The particle size proportion and water stability of soil aggregates were determined by the wet sieve method. The particle size proportion and water stability of soil aggregates under different ecological cultivation modes were analyzed. The results showed that under different ecological cultivation modes in the shallow soil layer (0 - 20 cm), the rubber—Alpinia oxyphylla plantation and the rubber—Phrynium hainanense plantation promoted the development of dominant soil aggregates towards larger size classes, whereas the situation is the opposite for rubber—Homalium ceylanicum plantation. In soil layer (20 - 40 cm), the ecological cultivation mode of rubber—Phrynium hainanense plantation developed the dominant radial level of soil aggregates to the diameter level of large aggregates. Rubber—Alpinia oxyphylla plantation and rubber—Homalium ceylanicum plantation, three indicators, including the water-stable aggregate content R<sub>0.25</sub> (>0.25 mm water-stable aggregates), mean weight diameter (MWD), and geometric mean diameter (GMD), were all lower than those in the rubber monoculture mode. However, in the rubber—Phrynium hainanense plantation, the water-stable aggregate content R<sub>0.25</sub>, mean weight diameter, and geometric mean diameter were higher than in the rubber monoculture mode, although these differences did not reach statistical significance. 展开更多
关键词 Ecological Complex Cultivation Rubber Plantation Soil Aggregates Soil Aggregate Water Stability Rubber Based Agroforestry Systems
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行动者网络理论视域下乡村学前教育发展的内生路径 被引量:10
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作者 杨川 周蕾 鄢超云 《学前教育研究》 CSSCI 北大核心 2022年第1期70-82,共13页
近年来,乡村学前教育在实现跨越发展的同时也表现出过分、单一依赖政府的倾向,缺乏整体观与内生力。在行动者网络理论视域下,本研究对39名乡村学前教育相关人员进行深度访谈,借助NVivo 12软件对访谈资料进行编码分析,以探索乡村学前教... 近年来,乡村学前教育在实现跨越发展的同时也表现出过分、单一依赖政府的倾向,缺乏整体观与内生力。在行动者网络理论视域下,本研究对39名乡村学前教育相关人员进行深度访谈,借助NVivo 12软件对访谈资料进行编码分析,以探索乡村学前教育发展的内生路径。结果发现,行动者识别不足、核心行动者定位不准,异质行动者之间需求、视角差异大,发展不均衡、队伍不稳定,外力扶持发展惯性强、缺乏内驱力是制约乡村学前教育发展的重要内因。乡村学前教育发展应实现从外力扶持向内生发展的路径转型,为此应全面识别异质行动者,明确核心行动者;锁定强制通行点,形成动态发展利益联盟;打通多元渠道,提升乡村学前教育质量;凸显乡村学前教育在乡村发展过程中的多重功能,尊重乡村文化,创新师资培养方式,实施乡村教师本土化培养,完善乡村教师保障机制,实现城乡学前教育公平。 展开更多
关键词 乡村学前教育 行动者 行动者网络理论
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Dynamics of Soil N<span>H</span><sup>+</sup><sub style="margin-left:-10px;">4</sub>-N and N<span>O</span><sup>-</sup><sub style="margin-left:-4px;">3</sub>-N in Rubber Plantation in Wenchang, South China
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作者 Dongling Qi chuan yang +2 位作者 Zimin Li Qing Chen Zhixiang Wu 《Agricultural Sciences》 2020年第8期707-714,共8页
In this study, the dynamics of soil available nitrogen in rubber plantations was studied to provide a basis for the sustainable management of soil nutrients in rubber plantations. Soil samples were collected from 0 - ... In this study, the dynamics of soil available nitrogen in rubber plantations was studied to provide a basis for the sustainable management of soil nutrients in rubber plantations. Soil samples were collected from 0 - 20 cm and 21 - 40 cm depth of rubber plantations in Wenchang area of Hainan Province to determine the soil ammonium nitrogen and nitrate nitrogen in March, June, September and December. The results showed that the total available nitrogen in the rubber plantation soil was mainly composed of nitrate nitrogen (>57%), and this nitrate nitrogen was always the absolute composition advantage in the total available nitrogen composition, and this composition advantage did not change with the change of soil depth. Nitrate and ammonium nitrogen in rubber plantation soil showed obvious seasonal variation characteristics in 0 - 20 cm soil layer and 21 - 40 cm soil depth. With the seasonal time change, the contents of soil nitrate and ammonium nitrogen increased first and then decreased. Summer and autumn were the most active periods of soil nitrate and ammonium nitrogen. There was a significant positive correlation between soil nitrate nitrogen content and ammonium nitrogen content (r = 0.6532**). Based on the correlat<span style="font-family:Verdana;">ion between soil ammonium nitrogen content and nitrate nitrogen content, the content of ammonium nitrogen in soil can be estimated according to the amount</span><span style="font-family:Verdana;"> of soil nitrate nitrogen.</span> 展开更多
关键词 Rubber Tree (Hevea brasiliensis) Soil NH+ style="margin-left:-10px ">4-N soil NO- style="margin-left:-4px ">3-N Wenchang Correlation
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Overexpression of Csk-binding protein decreases growth,invasion,and migration of esophageal carcinoma cells by controlling Src activation 被引量:5
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作者 Dong Zhou Peng Dong +7 位作者 Yu-Min Li Fa-Cai Guo An-Ping Zhang Run-Ze Song Ya-Min Zhang Zhi-Yong Li Dong Yuan chuan yang 《World Journal of Gastroenterology》 SCIE CAS 2015年第6期1814-1820,共7页
AIM:To investigate the mechanisms by which Cskbinding protein(CBP)inhibits tumor progression in esophageal carcinoma.METHODS:A CBP overexpressing esophageal carcinoma cell line(TE-1)was established.The growth,invasion... AIM:To investigate the mechanisms by which Cskbinding protein(CBP)inhibits tumor progression in esophageal carcinoma.METHODS:A CBP overexpressing esophageal carcinoma cell line(TE-1)was established.The growth,invasion,and migration of CBP-TE-1 cells,as well as the expression of Src were then determined and compared with those in normal TE-1 cells.RESULTS:The expression of Src was decreased by the overexpression of CBP in TE-1 cells.The growth,invasion,and migration of TE-1 cells were decreased by the overexpression of CBP.CONCLUSION:This study indicates that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src.CBP may be a potential tumor suppressor and targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma. 展开更多
关键词 Csk-binding protein ESOPHAGEAL carcinoma Cell GROW
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Preliminary Study on Seedling Growth Rhythm and Grey Correlation Analysis of Rubber (Hevea brasiliensis) Seedlings in Danzhou District, Hainan 被引量:5
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作者 Dongling Qi chuan yang +2 位作者 Guishui Xie Zhixiang Wu Zhixiang Wu 《American Journal of Plant Sciences》 2014年第26期3866-3872,共7页
The rubber tree physiological and ecological process quantitatively described by using mathematical method is an important means to the analysis of rubber tree growth process and mechanism. The study on growth simulat... The rubber tree physiological and ecological process quantitatively described by using mathematical method is an important means to the analysis of rubber tree growth process and mechanism. The study on growth simulation model of rubber tree will lay the foundation for the application of rubber tree cultivation intelligent decision system. A Richards equation was formulated to describe the height and stem diameter growth dynamics of the annual rubber seedlings. An area correlation analysis was done according to the closeness of the observed parameters to the dynamic curve on the gray system composed of the seedling growth increment and the meteorological factors including aerial temperature, precipitation and solar radiation hours that influence upon the seedling growth. The results showed that rubber seedling response fitted the Richards equation quite well. The growth increment displayed a distinct alternation of 'slow—fast—slow— fast—slow' rhythm. The growth course of the seedlings might be partitioned into three periods of time by the sequential clustering analysis, namely pre-growing, fast-growing, late-growing stage. The tray correlation analysis revealed that air temperature had the most significant influence while precipitation had the least impact on height growth of the rubber seedlings. In conclusion, the air temperature had the most significant influence while solar radiation hours had the least impact on stem diameter growth of the rubber seedlings. 展开更多
关键词 RUBBER (Hevea brasiliensis) RICHARDS Equation Growth RHYTHM Gray Correlation
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Combination of eddy current and heat treatment for crack healing and mechanical-property improvement in magnesium alloy tube 被引量:2
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作者 Wenchen Xu chuan yang +4 位作者 Haiping Yu Xueze Jin Guojing yang Debin Shan Bin Guo 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第5期1788-1801,共14页
The continuous eddy current pulse treatment(ECPT)combined with heat treatment was employed to heal the microcracks in spin formed Mg alloy tubes and improve their mechanical properties in this study.The results show t... The continuous eddy current pulse treatment(ECPT)combined with heat treatment was employed to heal the microcracks in spin formed Mg alloy tubes and improve their mechanical properties in this study.The results show that all the microcracks in different tube specimens were almost healed after different continuous ECPT schemes up to 15 cycles.The schemes with less cooling intervals exhibited better healing effect and increased the strength and elongation of Mg alloy tubes more obviously.After aging treatment,the strength improvement of the specimens with ECPT was more remarkable than that of the specimens without ECPT,and the elongation decrease of the specimens with ECPT was less evident than that of specimens without ECPT due to the segregation of RE elements on the crack surface.Besides,after solution treatment,the strength reduction and ductility improvement of the specimens with ECPT were more pronounced than that of the specimens without ECPT owing to the notable decrease of dislocation density of the specimens with ECPT.Both narrowed cracks induced by ECPT and the segregation of precipitates in the vicinity of microcrack surface during aging treatment contributed to the maximum strength in the as-spun specimens with ECPT followed by aging treatment. 展开更多
关键词 MICROCRACK HEALING Eddy current pulse treatment Heat treatment
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miRNA-613在乳腺癌中的表达及作用机制 被引量:1
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作者 朱克鹏 肖勋蓉 +4 位作者 罗义 弋文 尹均明 杨川 杜果城 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第14期718-722,共5页
目的:探讨乳腺癌中微小RNA(microRNA,miRNA)-613表达及作用机制.方法:收集2017年5月至2018年5月91例于南充市中心医院手术切除的乳腺癌患者的组织标本,实时荧光定量PCR检测乳腺癌组织及癌旁组织标本、乳腺癌细胞系(MDA-MB-231、MDA-MB-... 目的:探讨乳腺癌中微小RNA(microRNA,miRNA)-613表达及作用机制.方法:收集2017年5月至2018年5月91例于南充市中心医院手术切除的乳腺癌患者的组织标本,实时荧光定量PCR检测乳腺癌组织及癌旁组织标本、乳腺癌细胞系(MDA-MB-231、MDA-MB-468、MCF-7)和正常乳腺上皮细胞系HBL-100中miRNA-613的表达水平,分析其与乳腺癌患者临床病理特征的关系.TCGA数据库分析miRNA-613与乳腺癌患者预后的关系.双荧光素酶报告实验检测miRNA-613与SOX9的3'UTR区的结合情况.将miRNA-613模拟物转染至MDA-MB-231细胞,CCK-8法和Transwell侵袭及迁移实验分别检测细胞增殖活性、侵袭和迁移能力的变化,Western blot检测细胞中SOX9、β-catenin、E-Cadherin和Vimentin蛋白的表达变化.结果:miRNA-613在乳腺癌组织中表达明显低于癌旁组织(P<0.05),并且miRNA-613表达与TNM分期和淋巴结转移密切相关(P<0.05),TCGA生存数据显示miRNA-613表达与乳腺癌患者的总生存率无关(P>0.05).乳腺癌细胞系中miRNA-613的表达明显低于正常乳腺上皮细胞系(P<0.05),并且高侵袭转移性乳腺癌细胞系MDA-MB-231、MDA-MB-468中miRNA-613的表达明显低于低侵袭转移性乳腺癌细胞系MCF-7(P<0.05).双荧光素酶报告实验显示miRNA-613可与SOX9的3'UTR特异性结合.上调miRNA-613的表达能抑制MDA-MB-231细胞的增殖和侵袭迁移能力(P<0.05),同时下调SOX9、β-catenin和Vimentin蛋白的表达(P<0.05),并上调E-Cadherin蛋白的表达(P<0.05).结论:在乳腺癌组织和细胞中miRNA-613异常低表达,miRNA-613可能通过调控SOX9、Wnt/β-catenin信号通路抑制乳腺癌细胞的增殖、侵袭转移及上皮间质转化. 展开更多
关键词 微小RNA-613 乳腺癌 增殖 转移 SOX转录因子类
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Bleeding of two lumbar arteries caused by one puncture following percutaneous nephrolithotomy:A case report 被引量:1
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作者 Qian Liu chuan yang +1 位作者 Kai Lin Dong yang 《World Journal of Clinical Cases》 SCIE 2020年第22期5790-5794,共5页
BACKGROUND Lumbar artery bleeding is an uncommon complication of percutaneous nephrolithotomy(PCNL).This report presents a rare complication where two lumbar arteries were injured by a single puncture following PCNL.O... BACKGROUND Lumbar artery bleeding is an uncommon complication of percutaneous nephrolithotomy(PCNL).This report presents a rare complication where two lumbar arteries were injured by a single puncture following PCNL.Only scarce reports of this complication have been reported.CASE SUMMARY A 24-year-old man presented with a 2.2 cm right renal calculus,which was managed by PCNL.During nephrostomy tube removal on the 6th postoperative day,intense bleeding was observed in the fistula and the catheter.Renal angiography was undertaken immediately;however,an initial selective renal angiogram revealed no evidence of renal vascular injury.One of these injuries involved a pseudoaneurysm from a peripheral branch in the first right lumbar artery,while the other involved an arteriovenous fistula from a peripheral branch in the second right lumbar artery.Subsequently,coil embolization was performed successfully.CONCLUSION This case is being reported to inform clinicians that lumbar artery damage is one of the causes of severe bleeding after PCNL and could involve damage of more than one artery. 展开更多
关键词 Percutaneous nephrolithotomy Lumbar artery PSEUDOANEURYSM Arteriovenous fistula EMBOLIZATION Case report
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Breeding of Saccharomyces cerevisiae 被引量:1
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作者 chuan yang Jinglong LI 《Agricultural Biotechnology》 CAS 2019年第4期145-148,共4页
With three Saccharomyces cerevisiae strains collected by Institute of Modern Brewing Apparatus and Technology of Qilu University of Technology as experimental materials,an excellent S.cerevisiae strain,R2-b,was select... With three Saccharomyces cerevisiae strains collected by Institute of Modern Brewing Apparatus and Technology of Qilu University of Technology as experimental materials,an excellent S.cerevisiae strain,R2-b,was selected by the plate separation culture method through the selection of separation medium,observation of appearance of yeast colonies,cell morphology and cell size,and the determination of cell death rate,diacetyl content,reducing power and fermentation power.The yeast strain can meet the demand for fermentation of fresh beer. 展开更多
关键词 YEAST SEPARATION and PURIFICATION BEER BREEDING
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Changes in biological behaviors of rat dermal f ibroblasts induced by high expression of MMP9 被引量:1
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作者 Sheng-neng Xue Juan Lei +2 位作者 Diao-zhu Lin chuan yang Li Yan 《World Journal of Emergency Medicine》 CAS 2014年第2期139-143,共5页
BACKGROUND: The high level of matrix metalloproteinase 9(MMP9) is thought to slow down the healing of diabetic foot ulcers. Whether it can influence the biological behaviors of skin fi broblasts and affect wound heali... BACKGROUND: The high level of matrix metalloproteinase 9(MMP9) is thought to slow down the healing of diabetic foot ulcers. Whether it can influence the biological behaviors of skin fi broblasts and affect wound healing is still unclear. The present study aimed to observe changes in the biological behaviors of rat dermal fi broblasts induced by high expression of MMP9 and to clarify the possible mechanisms of wound healing for diabetic foot.METHODS: A cell model of skin f ibroblast with high expression of MMP9 was established by coculture of high glucose(22.0 mmol/L) and homocysteine(100 μmol/L). A control group was incubated with normal glucose(5.5 mmol/L). Realtime PCR, ELISA and gelatin zymography were used to detect the MMP9 mRNA, protein expression and activity of MMP9. Flow cytometry, CCK-8, ELISA assay, scratch test and transwell were used to detect cell proliferation, viability, collagen(hydroxyproline) secretion, horizontal migration and vertical migration of cells. The data were expressed as mean±SD. P value less than 0.05 was considered statistically signif icant.RESULTS: The expression of MMP9 mRNA, protein levels and the activity of MMP9 were much higher in the high MMP9 group than in the control group(7.05±1.02 vs. 1.00±0.00, 206.9±33.6 pg/mL vs. 40.4±5.9 pg/mL, and 1.47±0.13 vs. 0.57±0.12, respectively, P<0.01). The proportion of S-phase cells, proliferation index, cell viability, collagen(hydroxyproline) secretion, horizontal migration rate and the number of vertical migration cells were lower in the high MMP9 group than in the control group(P<0.01).CONCLUSION: Fibroblasts with a high expression of MMP9 decreased proliferation, activity, secretion and migration of collagens, suggesting that MMP9 may inhibit the biological behaviors of fi broblasts. 展开更多
关键词 Matrix metalloproteinase 9 FIBROBLAST Biological behaviors Diabetic foot
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The NO<sub>x</sub>Storage and Desorption Activity of Mg/Al/Cu-NH<sub>3</sub>&middot;H<sub>2</sub>O Hydrotalcites at Low Temperature
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作者 Chunyana Liu Weijun Liu +4 位作者 Liwen Wang Yuyingnan Liu chuan yang Fengbai Zhang Shuhua Zhang 《Journal of Minerals and Materials Characterization and Engineering》 2017年第5期311-322,共12页
Ammonium containing catalyst Mg/Al/Cu-NH3·H2O hydrotalcite (HT) is prepared via co-precipitation, which is effective for NOx storage under 160℃. XRD and FT-IR are employed to characterize its structure and show ... Ammonium containing catalyst Mg/Al/Cu-NH3·H2O hydrotalcite (HT) is prepared via co-precipitation, which is effective for NOx storage under 160℃. XRD and FT-IR are employed to characterize its structure and show that ammonium is successfully incorporated into HT. Meanwhile, the HT still retains the typical structure of hydrotalcite-like compounds. NOx storage activity tests indicate Mg/Al/Cu-NH3·H2O HT shows the significant NOx removal activity at 156℃ with a little Oxygen existence. TGA and DTG reveal the reaction of the released ammonium with NOx and storage NOx as nitrates will be responsible for the high NOx storage activity. Additionally, the temperature programmed desorption test of NOx adsorbed sample under 175℃ proves NOx is stored successfully into Mg/Al/Cu-NH3·H2O HT further. 展开更多
关键词 HYDROTALCITES NOx STORAGE and DESORPTION TG and DTG Analysis FT-IR Characterization
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Small-molecule agents for cancer immunotherapy 被引量:1
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作者 Fang Wang Kai Fu +14 位作者 Yujue Wang Can Pan Xueping Wang Zeyu Liu chuan yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第3期905-952,共48页
Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regress... Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer therapy.They induce long-term tumor regression and overall survival benefit in many types of cancer.With the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for immunotherapy.Small molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively investigated.Monotherapy of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor resistance.Here,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations. 展开更多
关键词 Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment
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A Deep Mantle Source for the Late Neoarchean Metamorphosed Basalts in Eastern Hebei,North China Craton:Insights from Whole-Rock Geochemistry and Sm-Nd Isotopes,and Zircon U-Pb-Hf Isotopes 被引量:1
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作者 Zhuang Li Chunjing Wei +1 位作者 chuan yang Xi Zhang 《Journal of Earth Science》 SCIE CAS CSCD 2024年第1期29-40,共12页
The basalts within the greenstone belt worldwide serve as an ideal target to decipher the nature of Archean mantle sources and further to extend the understanding of the early stages of Earth's evolution.To provid... The basalts within the greenstone belt worldwide serve as an ideal target to decipher the nature of Archean mantle sources and further to extend the understanding of the early stages of Earth's evolution.To provide important insights into the issues,we carried out a detailed investigation of whole-rock geochemistry and Sm-Nd isotopes,and zircon U-Pb-Hf isotopes for the Late Neoarchean metamorphosed basalts in eastern Hebei,North China Craton.U-Pb isotopic dating using the LA-ICPMS on zircons reveals that the basalts in eastern Hebei erupted at ca.2.48-2.51 Ga and subsequently experienced multiple regional metamorphic events at 2477 and 1798 Ma,respectively.The metamorphosed basalts are featured by low SiO_(2),MgO,K_(2)O+Na_(2)O,and high Fe O contents,endowed with the subalkaline and high-Fe tholeiitic affinities.The radiogenic initial Nd and Hf isotope values and correlations among V,Ni and Cr contents strongly imply that the basalts experienced significant clinopyroxene and olivine fractionation and minor crustal contamination during magma evolution.They are also characterized by the relatively low total REE contents and exhibit significant depletions to moderate enrichments in the LREE contents,indicating the derivation from a deep mantle source in an Archean proto-mantle plume setting. 展开更多
关键词 zircon U-Pb-Hf isotopes geochemistry Late Neoarchean basaltic magmatism North China Craton Archean proto-mantle plume
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A graph deep learning method for landslide displacement prediction based on global navigation satellite system positioning 被引量:1
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作者 chuan yang Yue Yin +2 位作者 Jiantong Zhang Penghui Ding Jian Liu 《Geoscience Frontiers》 SCIE CAS CSCD 2024年第1期29-38,共10页
The accurate prediction of displacement is crucial for landslide deformation monitoring and early warning.This study focuses on a landslide in Wenzhou Belt Highway and proposes a novel multivariate landslide displacem... The accurate prediction of displacement is crucial for landslide deformation monitoring and early warning.This study focuses on a landslide in Wenzhou Belt Highway and proposes a novel multivariate landslide displacement prediction method that relies on graph deep learning and Global Navigation Satellite System(GNSS)positioning.First model the graph structure of the monitoring system based on the engineering positions of the GNSS monitoring points and build the adjacent matrix of graph nodes.Then construct the historical and predicted time series feature matrixes using the processed temporal data including GNSS displacement,rainfall,groundwater table and soil moisture content and the graph structure.Last introduce the state-of-the-art graph deep learning GTS(Graph for Time Series)model to improve the accuracy and reliability of landslide displacement prediction which utilizes the temporal-spatial dependency of the monitoring system.This approach outperforms previous studies that only learned temporal features from a single monitoring point and maximally weighs the prediction performance and the priori graph of the monitoring system.The proposed method performs better than SVM,XGBoost,LSTM and DCRNN models in terms of RMSE(1.35 mm),MAE(1.14 mm)and MAPE(0.25)evaluation metrics,which is provided to be effective in future landslide failure early warning. 展开更多
关键词 Landslide displacement prediction GNSS positioning Graph deep learning
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Cryogenian and Ediacaran integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas
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作者 Lang SUN Malik Muhammad Saud Sajid KHAN +13 位作者 chuan yang Zhixin SUN Bing PAN Shehryar AHMED Lanyun MIAO Weichen SUN Chunlin HU Xiaojuan SUN Cui LUO Bo CHEN Zongjun YIN Fangchen ZHAO Guoxiang LI Maoyan ZHU 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第4期919-949,共31页
The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas,including the continental blocks(Indian,Lhasa,South Qiangtang,Tarim,Olongbuluk,Central Qilian,Alxa,North China,Yangtze,Central ... The complex evolutionary history of the Qinghai-Tibetan Plateau and its surrounding areas,including the continental blocks(Indian,Lhasa,South Qiangtang,Tarim,Olongbuluk,Central Qilian,Alxa,North China,Yangtze,Central Iran and Oman)and the orogenic belts between them,has long been the frontier in Earth science research.The Cryogenian and Ediacaran strata are extensively distributed in these blocks.Specifically,relatively complete Cryogenian and Ediacaran successions have been discovered in Oman,Indian,Yangtze,and Tarim blocks,while only the Ediacaran successions have been reported in Iran,the South Qiangtang,Central Qilian,Alxa,and North China blocks.Based on previous studies together with the integration of new materials and advancement obtained through the Second Tibetan Plateau Scientific Expedition and Research,this review aims to synthesize a correlative stratigraphic framework of the representative Cryogenian and Ediacaran sequences from the Qinghai-Tibetan Plateau and its surrounding areas.Furthermore,the Cryogenian and Ediacaran biotas and major geological events in these areas are comprehensively discussed in aspects of current research status.The results indicate that,in general,Ediacaran fossils of each area exhibit distinct features in preservation and assemblage composition,but the typical late Ediacaran fossils Cloudina and Shaanxilithes have been reported from most of these areas.In addition to the two global Cryogenian glaciations,late Ediacaran glaciogenic deposits are extensively recorded in the areas within and around the northern QinghaiTibetan Plateau(including the North China,Alxa,Central Qilian,Olongbuluk,and Tarim blocks,and the North Qilian Accretionary Belt),as well as central and southern Iran.However,further research is required to determine the age,distribution,and origin of these late Ediacaran glaciogenic deposits.Meanwhile,the middle Ediacaran DOUNCE/Shuram Excursion is widely documented in the Qinghai-Tibetan Plateau and its surrounding areas.The available data show that,after the break-up of the Rodinia supercontinent,most of the continental blocks in the areas were located along the northern margin of East Gondwana and a few(such as North China)were located between the Gondwana and Laurentia.In general,the paleogeographic evolution of most of these blocks during the Cryogenian and Ediacaran remains disputatious,necessitating further research to resolve the controversies surrounding their paleogeographic reconstruction models during this critical time interval. 展开更多
关键词 Qinghai-Tibetan Plateau CRYOGENIAN EDIACARAN STRATIGRAPHY PALAEOGEOGRAPHY BIOTA GONDWANA
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Cambrian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas
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作者 Zhixin SUN Lang SUN +8 位作者 Fangchen ZHAO Bing PAN Malik Muhammad Saud Sajid KHAN Shehryar AHMED chuan yang Lanyun MIAO Zongjun YIN Guoxiang LI Maoyan ZHU 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第4期950-970,共21页
The Qinghai-Tibetan Plateau and its surrounding areas have a long and complex tectonic evolutionary history.Cratons and blocks,such as northern India,Lhasa,Qiangtang,Qaidam and Central Qilian,and their in-between orog... The Qinghai-Tibetan Plateau and its surrounding areas have a long and complex tectonic evolutionary history.Cratons and blocks,such as northern India,Lhasa,Qiangtang,Qaidam and Central Qilian,and their in-between orogenic belts constitute the main part of the Qinghai-Tibetan Plateau.During the Cambrian Period,most of these cratons and blocks were on the northwestern periphery of Gondwana,and were associated with the surrounding blocks,e.g.Arabian,Central Iran,Afghanistan,Tarim,Alxa,North China,South China and Sibumasu through the Proto-Tethys Ocean.The Cambrian stratigraphic sequences on these stable blocks are composed of mixed siliciclastic and carbonate rocks deposited in the shallow-water marine environments,and contain the trilobite assemblages of shelf facies.The Cambrian stratigraphic sequences in the Qilian tectonic belts,however,are characterized by the intermediate-basic igneous rocks and silicates formed in the Proto-Tethys Ocean,and contain the trilobite assemblages of deep-water slope facies.Combining with previous data,field observations and newly discovered fossils through funding by the Second Tibetan Plateau Scientific Expedition and Research,the general characteristics of the Cambrian strata in different tectonic units of the Qinghai-Tibetan Plateau and its surrounding areas have been summarized in this paper.Furthermore,efforts have been made to subdivide and correlate the Cambrian strata across these areas by utilizing available biostratigraphic and geochronological data.As a result,a comprehensive litho-and biostratigraphy chart has been compiled.Finally,from the biogeographic perspective,this paper also provides a brief overview of the Cambrian paleogeographical reconstruction of the major tectonic blocks,and discusses the problems associated with the evolution of the ProtoTethys tectonic belt. 展开更多
关键词 Qinghai-Tibetan Plateau CAMBRIAN STRATIGRAPHY PALEOGEOGRAPHY BIOTA GONDWANA Proto-Tethys Ocean
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The position of Cathaysia in Nuna and during the Nuna-Rodinia transition
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作者 chuan yang Zheng-Xiang Li +1 位作者 yang Li Xian-Hua Li 《Science Bulletin》 SCIE EI CAS CSCD 2024年第17期2693-2697,共5页
The assembly and breakup of Nuna and Rodinia, two successive supercontinents in the Proterozoic, provide key evidence for the establishment of supercontinent cycles. Reliable palaeogeographic reconstructions at the co... The assembly and breakup of Nuna and Rodinia, two successive supercontinents in the Proterozoic, provide key evidence for the establishment of supercontinent cycles. Reliable palaeogeographic reconstructions at the cores of the two supercontinents are critical for understanding the evolution and geodynamics of the supercontinent cycles. In addition, there are fundamental aspects of the Nuna-Rodinia transition that remain poorly understood, including the ways in which Nuna broke up and Rodinia assembled, either through introversion [1] or extroversion [2]. 展开更多
关键词 CONTINENT RODINIA TRANSITION
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Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
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作者 chuan yang Xueping Wang +11 位作者 Kenneth K.W.To Caimei Cui Min Luo Shaocong Wu Lamei Huang Kai Fu Can Pan Zeyu Liu Teng Fan Caibo yang Fang Wang Liwu Fu 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2024年第5期2114-2131,共18页
Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the ... Circulating tumor cells(CTCs)are precursors of distant metastasis in a subset of cancer patients.A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therapeutic prevention of cancer metastasis.It remains elusive how CTCs evade immune surveillance and elimination by immune cells.In this study,we unequivocally identified a subpopulation of CTCs shielded with extracellular vesicle(EVs)-derived CD45(termed as CD45^(+)CTCs)that resisted T cell attack.A higher percentage of CD45^(+)CTCs was found to be closely correlated with higher incidence of metastasis and worse prognosis in cancer patients.Moreover,CD45^(+)tumor cells orchestrated an immunosuppressive milieu and CD45^(+)CTCs exhibited remarkably stronger metastatic potential than CD45−CTCs in vivo.Mechanistically,CD45 expressing on tumor surfaces was shown to form intercellular CD45-CD45 homophilic interactions with CD45 on T cells,thereby preventing CD45 exclusion from TCR-pMHC synapse and leading to diminished TCR signaling transduction and suppressed immune response.Together,these results pointed to an underappreciated capability of EVs-derived CD45-dressed CTCs in immune evasion and metastasis,providing a rationale for targeting EVs-derived CD45 internalization by CTCs to prevent cancer metastasis. 展开更多
关键词 CD45 METASTASIS PREVENTION
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