Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investi...Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.展开更多
BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross ...BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.CASE SUMMARY An 8-year-old boy experienced pain in his left forearm when he accidentally fell while skateboarding.Physical examination revealed swelling and deformity of the left forearm.We performed imaging and the results revealed left radial head dislocation,left distal radial epiphyseal separation from the shaft,and interruption of the continuity of the dorsal cortex of the left distal ulna.Anteroposterior and lateral X-ray films showed that the radius and ulna were crisscrossed.A diagnosis of superior radioulnar joint dislocation,left distal radial epiphyseal injury,and left distal ulnar fracture was made.After unsuccessful manual reduction,we adopted a minimally invasive procedure and succeeded.After a 14-wk period of follow-up,the patient had good left upper limb function,no complaints of pain or limited range of motion,and good follow-up results.CONCLUSION This is the first report of a child with a forearm crisscross injury in which the mechanism and the differences from adult crisscross injury are analyzed.Minimally invasive surgery with intramedullary fixation can achieve a good therapeutic effect.This case provides a reference for the treatment of similar patients in the future.展开更多
文摘Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, and their amplitudes greater, after combination therapy than after monotherapy. These findings indicate that Schwann cell transplantation combined with hyperbaric oxygen therapy is more effective than either treatment alone in promoting the recovery of spinal cord in rats after injury.
文摘BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.CASE SUMMARY An 8-year-old boy experienced pain in his left forearm when he accidentally fell while skateboarding.Physical examination revealed swelling and deformity of the left forearm.We performed imaging and the results revealed left radial head dislocation,left distal radial epiphyseal separation from the shaft,and interruption of the continuity of the dorsal cortex of the left distal ulna.Anteroposterior and lateral X-ray films showed that the radius and ulna were crisscrossed.A diagnosis of superior radioulnar joint dislocation,left distal radial epiphyseal injury,and left distal ulnar fracture was made.After unsuccessful manual reduction,we adopted a minimally invasive procedure and succeeded.After a 14-wk period of follow-up,the patient had good left upper limb function,no complaints of pain or limited range of motion,and good follow-up results.CONCLUSION This is the first report of a child with a forearm crisscross injury in which the mechanism and the differences from adult crisscross injury are analyzed.Minimally invasive surgery with intramedullary fixation can achieve a good therapeutic effect.This case provides a reference for the treatment of similar patients in the future.
