基于图片矢量化处理的图像浮雕加工技术

针对现有图像浮雕加工技术在加工产品时出现的图形轮廓线条不连续、加工效果不佳的问题,提出一种图片矢量化处理的图像浮雕加工技术。首先,采用专业的矢量化软件对图片进行矢量化处理,得到连贯的图形轮廓线条;然后,将处理好的图片进行图像浮雕加工;最后,基于r2v软件处理的矢量化图片,采用CAXA制造工程师软件进行实际的图像浮雕加工仿真。通过仿真实验验证了该方法能较好地解决图像浮雕加工中图形轮廓线条不连续的问题。

超声结合BRAFV600E基因突变检测在桥本甲状腺炎合并甲状腺结节鉴别中的应用价值

目的采用超声、BRAFV600E基因突变检测桥本甲状腺炎合并甲状腺结节,探讨两者联合检测对桥本甲状腺炎合并甲状腺结节良恶性的诊断价值。方法选取2017年9月—2019年10月在惠州市中心人民医院就诊的桥本甲状腺炎合并甲状腺结节患者329例为研究对象,根据病理确诊甲状腺结节良恶性分为恶性组(177例)和良性组(152例)。采用超声、BRAFV600E基因突变检测桥本甲状腺炎合并甲状腺结节情况,并分析超声、BRAFV600E基因突变及两者联合检测对桥本甲状腺炎合并甲状腺结节良恶性的诊断价值。结果金标准、超声、BRAFV600E基因突变诊断甲状腺炎合并甲状腺结节恶性分别为177例、167例、163例,良性分别为152例、162例、166例。超声、BRAFV600E基因突变、两者联合检测桥本甲状腺炎合并甲状腺结节恶性的敏感性分别为72.31%、65.54%和85.31%,特异性分别为74.34%、69.08%和71.71%,准确度分别为73.25%、67.17%和79.03%。与超声比较,两者联合诊断敏感性较高(P<0.0125),BRAFV600E基因突变诊断准确度较低(P<0.0125);与BRAFV600E基因突变比较,两者联合诊断敏感性、准确度较高(P<0.0125)。结论超声、BRAFV600E基因突变均对桥本甲状腺炎合并甲状腺结节良恶性具有一定诊断价值,单两者联合优于单独诊断。

血浆髓过氧化物酶与房颤射频消融术后复发的关系研究

目的分析血浆髓过氧化物酶(MPO)与心房颤动(以下简称房颤)患者行射频消融术后复发的关系。方法前瞻性研究2017年9月-2018年3月中南大学湘雅医院行射频消融治疗的房颤患者45例,术前检测血浆MPO水平并行超声心动图等检查,术后随访1年,根据房颤复发情况分为复发组与未复发组。结果所有患者随访时间12个月。房颤术后复发率为31.1%(14/45),其中阵发性房颤复发率为25.0%(8/32),持续性房颤复发率为46.1%(6/13)。Cox多因素回归分析显示,术前MPO>50.5 ng/ml与房颤术后复发有关[H^R=4.292(95%CI:1.153,15.985),P=0.030]。结论房颤消融前血浆MPO水平>50.5 ng/ml与术后复发相关。

石英纤维含量对聚四氟乙烯基高介微波复合介质基板性能的影响

采用聚四氟乙烯(PTFE)树脂为基体,高介电陶瓷粉为填料,石英纤维作为增强材料,通过压延成型、热压烧结制备出高性能基板。扫描电镜(SEM)、热膨胀系数、力学性能测试结果表明经过压延工艺后,纤维主要沿X-Y平面分布,且随着纤维含量的提高,复合材料X/Y轴热膨胀系数和拉伸强度得到改善。而SEM、致密度和吸水率性能测试表明随着纤维含量的提高,PTFE-纤维-陶瓷粉构成的三相界面中出现空隙,导致复合材料密度降低、吸水率升高、损耗升高。当纤维含量为3%时,复合材料综合性能最佳,介电常数和介质损耗分别达到10.29和0.0026,吸水率达到0.052%,X/Y/Z轴平面热膨胀系数(CTE)为0.0261‰/0.0278‰/0.0394‰/℃,拉伸强度达到11.80 MPa。

Economic analysis of energy interconnection between Europe and China with 100% renewable energy generation

The economic benefits of interconnecting the power grids of Europe(EU) and China(CN) were assessed considering 100% reliance on renewable energy(RE). Four different scenarios, energy storage without interconnection, installing additional renewable energy sources without interconnection, energy storage with interconnection, and installing additional RE sources with interconnection, were considered for the economic benefit analysis. A comparative study of these four scenarios was conducted to identify the best option for achieving hourly power balance. Further, sensitivity analysis was carried out to demonstrate the robustness of the results. Electricity interconnection between CN and EU decreases the annual additional costs by more than 30% when compared to the absence of interconnection, which demonstrates the necessity and benefits of CN-EU electricity interconnection.

Amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs enable efficient oxygen evolution reaction: Ligands hybridization engineering

Development of high-efficiency and low-cost electrocatalyst for oxygen evolution reaction(OER) is very important for use at alkaline water electrolysis.Metal-organic frameworks(MOF) provide a rich platform for designing multi-functional materials due to their controllable composition and ultra-high surface area.Herein,we report our findings in the development of amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs via a simple "ligands hybridization engineering" strategy.These complexes' ligands contain inorganic ligands(H_2 O and NO_3) and organic ones,hexamethylenetetramine(HMT).Further,we investigated a series of mixed-metal with multi-ligands materials as OER catalysts to explore their possible advantages and features.It is found that the Ni doping is an effective approach for optimizing the electronic configuration,changing lattice ordering degree,and thus enhancing activities of HMT-based electrocatalysts.Also,the crystalline-amorphous boundaries of various HMTbased electrocatalyst can be easily controlled by simply changing amounts of Ni-precursor added.As a result,the optimized ultrathin(Co,0.3 Ni)-HMT nanosheets can reach a current density of 10 mA cm^(-2)at low overpotential of 330 mV with a small Tafel slope of 66 mV dec^(-1).Our findings show that the electronic structure changes induced by Ni doping,2 D nanosheet structure,and MOF frameworks with multiligands compositions play critical roles in the enhancement of the kinetically sluggish electrocatalytic OER.The present study emphasizes the importance of ligands and active metals via hybridization for exploring novel efficient electrocatalysts.

LaNiO3 as a Novel Anode for Lithium-Ion Batteries

Lithium-ion batteries(LIBs) have been developed for over 30 years;however, existing electrode materials cannot satisfy the increasing requirements of high-energy density, stable cycling, and low cost. Here, we present a perovskite-type LaNiO3 oxide(LNO) as a new negative electrode material. LNO was successfully synthesized by a sol-gel method. The microstructure and electrochemical performance of LNO calcined at various temperatures have been systematically investigated. The LNO electrode shows a high rate capability and long cycling stability. In a C-rate test, a specific capacity of 77 mAh/g was exhibited at 6 C. LNO can also deliver a specific capacity of 92 mAh/g after 200 cycles at 1 C. This paper presents a type of binary metal oxide as a new anode material for high-performance LIBs.

以肾功能不全为主要表现的结节性硬化症2例

结节性硬化症(tuberous sclerosis,TS)是临床上以面部血管纤维瘤、鲨鱼皮样斑、视网膜错构瘤、肾错构瘤(hamartoma of kidney,HK)、脏器结节、癫痫及智力障碍等特征为主的一类疾病,目前TS存在较多的误诊、漏诊。南昌大学第一附属医院近年收治2例以肾功能不全为主要临床表现的TS患者,现报道如下。

Investigate the Effect of the Magnetic Field on the Mechanical Properties of Silicone Rubber-Based Anisotropic Magnetorheological Elastomer during Curing Process

In this investigation,a new silicone rubber-based MRE material was prepared to be used as a forming medium in manufacturing thin-walled complexshaped Ni-based tubes through the bulging process.Thus,it is significant to investigate the effect of magnetic field intensity,magnetic field loading time,and angle on the mechanical properties of the prepared MRE material during the curing process.The obtained results showed that increasing the magnetic field intensity during the curing process can improve the orientation of the chain structure in the elastomer matrix effectively.However,its mechanical properties are the best under the corresponding magnetic field intensity of 321 mT.Besides,by extending the magnetic field loading time in the curing process,the orientation of the chain structure was optimized,at the same time,the mechanical properties were also improved,and the best loading time is about 20–25 min.By changing the loading angle of the magnetic field during the curing process,the mechanical properties of the MRE were improved.When the loading angle of the magnetic field is 90°,the elastomer showed the best compression mechanical properties and excellent compression reversibility.Besides,for the anisotropic MRE material,the performance with magnetic compression is always better than that without magnetic compression.

Study on the role of autophagy in the occurrence and development of liver diseases

Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.

Advances in the mechanism of bile acids in liver regeneration

Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studies have found that bile acids(BA)play an important role in the process of liver regeneration.In the early stages of PHx,bile acid overload occurs,and liver injury is aggravated by loading.Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration.In this paper,we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration,including protection of the liver and promotion of liver regeneration,and its double-edswordged"in Liver regeneration.This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.

Mechanism of action and targeted therapy of stellate cells in liver fibrosis

The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced,and some current therapeutic methods are summarized.These results suggest that stellate cells play an important role in liver fibrosis,and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis.However,there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments.In future animal experiments and clinical trials,more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.

Research progress of TCM multi-target intervention in the pathogenesis of liver failure

Liver failure is a serious liver damage caused by many factors,leading to severe impairment or decompensation of synthesis,detoxification,metabolism and biotransformation,and a group of clinical symptoms mainly manifested by jaundice and coagulation dysfunction.Traditional Chinese medicine belongs to the categories of"acute yellow"and"jaundice",and the incidence is mostly related to"poison,phlegm,stasis,and deficiency".Traditional Chinese medicine has the advantages of multi-component,multi-path and multi-target in the intervention of liver failure.This article summarizes the traditional Chinese medicine intervention in liver failure in terms of innate immunity,cytokine effects and oxidative stress.

Therapeutic effect of mesenchymal stem cells from different sources in the treatment of liver diseases

Hepatitis B Virus(HBV)is still one of the important problems threatening the health and safety of human life.If the virus can not be effectively controlled,it will gradually evolve into chronic hepatitis.Chronic hepatitis will not be treated for a long time,and will gradually develop into liver fibrosis,cirrhosis,liver cancer or even liver failure and other diseases with poor prognosis.However,there is no specific western medicine treatment for liver fibrosis,cirrhosis and other liver diseases.The main treatment methods are symptomatic treatment,internal medicine comprehensive treatment and prevention of complications.In recent years,the medical technology has been continuously developed and improved,scholars at home and abroad have focused on the effective ways to prevent and treat liver diseases.More and more studies have confirmed the mesenchymal stem cells Cell(MSC)plays an important role in the treatment of liver diseases.The author will describe the therapeutic effect of MSC from different sources on liver diseases.

Role of cytokines in the progression of hepatic fibrosis: A review

Hepatic fibrosis(HF)is the common pathological basis of all chronic liver diseases,and is a necessary stage for the development of chronic liver disease into cirrhosis.The pathogenesis of liver fibrosis is very complicated.Different cells and cytokines play a major role in the pathogenesis of liver fibrosis.This article focuses on the development mechanism of liver fibrosis,different cells and cytokines(macrophages,natural killer cells,natural killer T cells,tumor necrosis factor,IL-22,transforming growth factor-β,connective tissue growth factor,vascular endothelial growth factor)Its impact on the development of liver fibrosis is reviewed.

Study on Digitization of TCM Diagnosis Applied Extraction Method of Blood Vessel

This paper presents a study on digitization of Traditional Chinese Medicine diagnosis. The research consists of two aspects: a) algorithms for blood vessels extraction in sclera-conjunctiva images, which can be applied in syndrome differentiation by observing human eyes (named Ocular Diagnostic in Traditional Chinese Medicine);b) digitization of extracted vessels. First, sclera-conjunctiva region is isolated by optimal threshold segmentation and mathematical operation;Scanning and edge detection methods are used to gain the edge of the blood vessels. Moreover, the edge feature parameters are gained, which can be used to reconstruct the blood vessels. Experimental results show that blood vessels information can be obtained fast and accurately for the further TCM diagnosis by artificial system.

A Hybrid De-Noising Method on LASCA Images of Blood Vessels

A de-noising approach is proposed that based on the combination of wiener filtering, nonlinear filtering and wavelet fusion, which de-noise the LASCA (LAser Speckle Contrast Analysis) image of blood vessels in Small Animals. The approach first performs laser spectral contrast analysis on brain blood flow in rats, get their spatial and temporal contrast images. Then, a de-noising filtering method is proposed to deal with noise in LASCA. The image restoration is achieved by applying the proposed admixture filtering, and the subjective estimation and objective estimation are given to the de-noising images. As our experimental results shown, the proposed method provides clearer subjective sense and improved to over 25 db for PSNR.

苯基次磷酸盐离聚物/聚磷酸铵协效阻燃增韧改性聚乳酸

通过将双端羟基的聚己内酯(PCL)、聚乳酸(PLA)预聚物以及苯基次磷酸离子盐扩链得到一种含苯基次磷酸盐的离子共聚物,将其与聚磷酸铵(APP)复合用于协同改性聚乳酸,离聚物中苯基次磷酸盐结构与APP具有优异的协同阻燃PLA的作用,同时该离聚物中PLA与苯基次磷酸盐结构有效提升了APP在PLA中的分散能力,最后该离聚物中PCL柔性链段有效改善了PLA的韧性,最终得到更高效阻燃性能且韧性也较好改善的PLA/PCLA-PIU/APP复合材料.一方面,离聚物中苯基次磷酸盐结构与APP协同有效促进了PLA的成炭,形成更连续致密的炭层从而阻隔可燃气体的释放,达到更好的阻燃效果.锥形量热、残炭的扫描电子显微镜(SEM)、能谱分析(EDS)、拉曼光谱等测试证实了这一结果,与纯PLA以及仅使用APP的PLA/APP相比,PLA/PCLA-PIU/APP的热释放速率与总热释放均降低,同时残炭的石墨化程度更高,形成了更为致密的炭层.另一方面,力学性能测试结果表明,离聚物中PCL柔性链段的存在使得与APP复合改性后的PLA的韧性相比纯PLA和PLA/APP有较大的提升;SEM测试表明,离聚物中PLA与苯基次磷酸盐结构起到增容作用,提升了APP在PLA中的分散性.

带超级光滑噪声密度函数的小波自适应点态估计

利用小波方法在局部Holder空间中研究一类反卷积密度函数的点态估计问题.首先,针对超级光滑噪声给出该模型任一估计器的点态风险下界;其次,构造有限求和小波估计器,并证明其在超级光滑噪声条件下达到了最优收敛阶,即该估计器在点态风险下的收敛速度与下界一致.最后,还讨论了这类小波估计器的强收敛性.值得指出的是上述估计都是自适应的.

A Review on Electric Vehicle Charging Infrastructure Development in the UK

This paper focuses on the development of electric vehicle(EV)charging infrastructure in the UK,which is a vital part of the delivering ultra-low-emission vehicle(ULEV)and will transition into low emission energy systems in the near future.Following a brief introduction to global landscape of EV and its infrastructure,this paper presents the EV development in the UK.It then unveils the government policy in recent years,charging equipment protocols or standards,and existing EV charging facilities.Circuit topologies of charging infrastructure are reviewed.Next,three important factors to be considered in a typical site,i.e.,design,location and cost,are discussed in detail.Furthermore,the management and operation of charging infrastructure including different types of business models are summarized.Last but not least,challenges and future trends are discussed.