Although bone marrow mesenchymal stem cells(BMSCs)might have therapeutic potency in ischemic stroke,the benefits are limited.The current study investigated the effects of BMSCs engineered to overexpress vascular endot...Although bone marrow mesenchymal stem cells(BMSCs)might have therapeutic potency in ischemic stroke,the benefits are limited.The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor(VEGF)on behavioral defects in a rat model of transient cerebral ischemia,which was induced by middle cerebral artery occlusion.VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke.We found that compared with the stroke-only group and the vehicle-and BMSCs-control groups,the VEGF-BMSCs treated animals displayed the largest benefits,as evidenced by attenuated behavioral defects and smaller infarct volume 7 days after stroke.Additionally,VEGF-BMSCs greatly inhibited destruction of the blood-brain barrier,increased the regeneration of blood vessels in the region of ischemic penumbra,and reducedneuronal degeneration surrounding the infarct core.Further mechanistic studies showed that among all transplant groups,VEGF-BMSCs transplantation induced the highest level of brain-derived neurotrophic factor.These results suggest that BMSCs transplantation with vascular endothelial growth factor has the potential to treat ischemic stroke with better results than are currently available.展开更多
针对目前单目图像在深度估计中依然存在边缘以及深度最大区域预测不准确的问题,提出了一种基于金字塔分割注意力网络的单目深度估计方法(PS-Net)。首先,PS-Net以边界引导和场景聚合网络(BS-Net)为基础,引入金字塔分割注意力(PSA)模块处...针对目前单目图像在深度估计中依然存在边缘以及深度最大区域预测不准确的问题,提出了一种基于金字塔分割注意力网络的单目深度估计方法(PS-Net)。首先,PS-Net以边界引导和场景聚合网络(BS-Net)为基础,引入金字塔分割注意力(PSA)模块处理多尺度特征的空间信息并且有效建立多尺度通道注意力间的长期依赖关系,从而提取深度梯度变化剧烈的边界和深度最大的区域;然后,使用Mish函数作为解码器中的激活函数,以进一步提升网络的性能;最后,在NYUD v2(New York University Depth dataset v2)和iBims-1(independent Benchmark images and matched scans v1)数据集上进行训练评估。iBims-1数据集上的实验结果显示,所提网络在衡量定向深度误差(DDE)方面与BS-Net相比减小了1.42个百分点,正确预测深度像素的比例达到81.69%。以上表明所提网络在深度预测上具有较高的准确性。展开更多
The potential of medicinal plant extracts to control rice blast fungus Magnaporthe oryzae was investigated. We screened 48 extracts prepared from 8 medicinal plant species and identified 20 extracts with ≥ 10% inhibi...The potential of medicinal plant extracts to control rice blast fungus Magnaporthe oryzae was investigated. We screened 48 extracts prepared from 8 medicinal plant species and identified 20 extracts with ≥ 10% inhibitory activity against M. oryzae. Among them, ethanol extract of Paris polyphylla, ethyl acetate extract of Phellodendron chinense, and n-butanol extract of Menispermum dauricum plants exhibited 100%, 70% and 50% inhibition of M.展开更多
基金supported by Key Research and Development Plan of Xuzhou Science and Technology Bureau,No.KC21162(to XMZ)a grant from Jiangsu Key Laboratory of Brain Disease Bioinformationg,No.XZSYSKF2021018(to XMZ)+1 种基金Natural Science Fund for Colleges and Universities in Jiangsu Province,No.19KJB320024(to HNY)the Science and Technology Development Fund from Affiliated Hospital of Xuzhou Medical University,Nos.XYFM2021024(to XMZ),XYFM2021006(to DH).
文摘Although bone marrow mesenchymal stem cells(BMSCs)might have therapeutic potency in ischemic stroke,the benefits are limited.The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor(VEGF)on behavioral defects in a rat model of transient cerebral ischemia,which was induced by middle cerebral artery occlusion.VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke.We found that compared with the stroke-only group and the vehicle-and BMSCs-control groups,the VEGF-BMSCs treated animals displayed the largest benefits,as evidenced by attenuated behavioral defects and smaller infarct volume 7 days after stroke.Additionally,VEGF-BMSCs greatly inhibited destruction of the blood-brain barrier,increased the regeneration of blood vessels in the region of ischemic penumbra,and reducedneuronal degeneration surrounding the infarct core.Further mechanistic studies showed that among all transplant groups,VEGF-BMSCs transplantation induced the highest level of brain-derived neurotrophic factor.These results suggest that BMSCs transplantation with vascular endothelial growth factor has the potential to treat ischemic stroke with better results than are currently available.
文摘针对目前单目图像在深度估计中依然存在边缘以及深度最大区域预测不准确的问题,提出了一种基于金字塔分割注意力网络的单目深度估计方法(PS-Net)。首先,PS-Net以边界引导和场景聚合网络(BS-Net)为基础,引入金字塔分割注意力(PSA)模块处理多尺度特征的空间信息并且有效建立多尺度通道注意力间的长期依赖关系,从而提取深度梯度变化剧烈的边界和深度最大的区域;然后,使用Mish函数作为解码器中的激活函数,以进一步提升网络的性能;最后,在NYUD v2(New York University Depth dataset v2)和iBims-1(independent Benchmark images and matched scans v1)数据集上进行训练评估。iBims-1数据集上的实验结果显示,所提网络在衡量定向深度误差(DDE)方面与BS-Net相比减小了1.42个百分点,正确预测深度像素的比例达到81.69%。以上表明所提网络在深度预测上具有较高的准确性。
基金supported by the National Natural Science Foundation of China (Grant No. 31370306)the Fundamental Research Funds for the Central Universities,South-Central University for Nationalities (Grant No. CZZ22004)Hubei Province Natural Science Foundation of China (Grant No. 2019CFB804)。
文摘The potential of medicinal plant extracts to control rice blast fungus Magnaporthe oryzae was investigated. We screened 48 extracts prepared from 8 medicinal plant species and identified 20 extracts with ≥ 10% inhibitory activity against M. oryzae. Among them, ethanol extract of Paris polyphylla, ethyl acetate extract of Phellodendron chinense, and n-butanol extract of Menispermum dauricum plants exhibited 100%, 70% and 50% inhibition of M.
