Science and Technology Commissioners Supporting High-Quality Development Project for Hundreds of Counties, Thousands of Towns, and Myriads of Villages in the Context of Rural Revitalization

This paper discusses the important role of science and technology commissioners in the high-quality development of hundreds of counties,thousands of towns,and myriads of villages in the context of rural revitalization,including building bridges,accelerating the transformation of achievements,promoting the value-added of the whole agricultural industry chain,and promoting the rapid development of rural industrial economy.It also discusses the working achievements of science and technology commissioners,in order to promote further development of rural revitalization in Guangdong Province.

Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study

Objective:China is a developing country with urban–rural disparities and accelerating population aging.Therefore,quantifying the effects of population aging on the cancer mortality burden is urgently needed.Methods:Using data from China’s death surveillance datasets(2004–2017),we decomposed and quantified the effects of population aging and factor variations on cancer mortality rates in urban and rural China during 2004–2017 through a decomposition method.R ratios were used to assess the extent of the mortality decreases attributable to factor variations offsetting the increases attributable to population aging for 4 aging-related cancers(lung,colorectal,esophageal,and stomach cancer).Results:Overall,population aging has led to continued increases in cancer mortality rates in China during 2004–2017(mortality rates attributable to population aging:8.63/100,000 for urban men,4.21/100,000 for urban women,11.95/100,000 for rural men,and 5.66/100,000 for rural women).The 4 cancers displayed 3 patterns.The mortality rates from lung cancer in rural China and from colorectal cancer nationwide increased because of both population aging and factor variations.Population aging was primarily responsible for the growing mortality due to lung cancer in urban areas.However,for esophageal and stomach cancer,the effect of population aging was not dominant,thus resulting in decreases in mortality rates.Conclusions:Health resource allocation should prioritize areas or cancers more adversely affected by population aging.The burden of cancer will continue to increase in the future,because of rapid population aging,but can still be offset or even reversed with enhanced cancer control and prevention.

SIR Model of Spread of Zika Virus Infections: ZIKV Linked to Microcephaly Simulations

An SIR model of Zika virus (ZIKV) spread is formulated that includes ZIKV infections to newborns. Analytically, the model has one disease free and one endemic equilibrium point. The free one is stable for some conditions when R0 and unstable when R0>1. In Brazil, when R0≈2>1 ZIKV infections expand and for R0 = 0.875R0) of the model. There are parameters for human-mosquito transmission and some for sexual-transmission factor. It appears that controlling spread of ZIKV infections by human-mosquito transmission may greatly reduce the value of R0.

Evolutionary Plasmonic Properties of Single Truncated Ag Nanowire-on-Au Film Nanocavity

Noble metal nanocavities have been widely demonstrated to possess great potential applications in nanooptics and nanophotonics due to their extraordinary localized surface plasmon resonance.However,most metal nanocrystals synthesized by chemical methods often suffer from truncation with different degrees due to oxidation and dissolution of metal atoms at corner and edges.We investigate the influence of shape truncation on the plasmonic properties of single Ag nanowire on Au film nanocavity using the finite difference time domain method.When the Ag nanowire(the circumradius R_(2)=50 nm)is gradually truncated from pentagonal to circular geometry,the scattering peak position of the nanocavity shows prominent blue shift from 962 nm to 608 nm,suggesting a nonnegligible role of truncation on plasmonic properties.The electric field strength and charge distribution of the structure reveal the evolution from dipole mode to quadrupole mode.It is also found that the plasmon resonance wavelength is linearly dependent on the truncation ratio R_(1)/R_(2)(R_(1) is the inradius)and the modulation slope is also reliable to the size of Ag nanowire.Our observations could shed light on developing high-performance tunable optical nano-devices in future.

Balancing Openness and Protection:Homogenization of Regulatory Laws in Digital Service Trade

Digital service trade has emerged as a pivotal engine for global economic transformation and development.However,the implementation of differentiated regulatory measures for trade in digital services among economies has led to increasingly frequent trade disputes.This paper constructs a regulatory homogeneity network for digital service trade in 60 major economies,and systematically evaluates the structural characteristics of the network and the regulatory homogeneity among economies from 2014 to 2021.Furthermore,this paper empirically examines the impact of the partnership characteristics of regulatory homogenization in the network of major economies on their exports.The analysis of the network structure shows that major economies are more inclined to optimize and simplify existing trade partnerships,and are moving towards more diversified restrictive measures in the regulatory model of digital services trade,which has led to the rise of trade protectionism.The empirical text results show that expanding and deepening the regulatory homogeneous partnership of trade in digital services promotes the export of digital services in major economies.This promotion effect is mainly achieved by reducing the cost of digital service trade and enhancing business trust.In addition,the export promotion effect of developing regulatory homogenization partnerships is better than that of increasing the openness of digital service trade,and the homogenization of policies between openness and protection is more important.This paper provides important implications for coordinating the openness and security of digital services trade:China should actively cooperate with multilateral and bilateral digital service trade partners to jointly build a homogeneous environment for regulatory regulations.In particular,it is necessary to deepen the regulatory homogeneity partnership with Asian and developing economies to expand the infl uence of the“China model”in the global regulation of digital services trade.

Input-occupancy-output models of the non-competitive type and their application - an examination of the China-US trade surplus

In this paper we construct an extended non-competitive input-occupancy-output model that captures China＇s processing trade and also develop a methodology to estimate the domestic value-added and employment generated by each unit of total exports, of exports by sector, and of exports by commodity, respectively. We also prove mathematically that the gross value of exports is equal to the sum of total value added and total imports. Based on the methodology proposed here, we compile the 2002 extended Chinese non-competitive input-occupancy-output table and the United States non-competitive input-occupancy- output table, and then estimate and analyze the effects of China＇s exports and US exports on their respective domestic value added and employment.

Does the Domestic Value Added Induced by China's Exports Really Belong to China?

Since 2001, the exports of foreign-invested enterprises （FIEs） have accounted for more than 50percent of China＇s total exports. As foreign capital occupies a high proportion of the total capital of FIEs, most FIEs ＇ capital gains are foreign factor income. Although these gains are calculated as apart of China＇s GDP, they do not belong to China＇s national income. To determine the real contribution of exports to China ＂s welfare, the present paper analyses the impact of exports on China ＂s national income using a non-competitive input output model capturing processing trade. The results show that every US$1000 of China＇s exports generates US$506.8 of national income. The real contribution of exports to China ＂s welfare is much smaller than what we expected. This suggests that China should endeavor to improve the gains from international markets orfind another engine to maintain its economic growth.

Predictions of mortality related to four major cancers in China,2020 to 2030

Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource allocation.In this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco smoking.Methods:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population projections.Smoking prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian studies.We predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression models.The tobacco smoking related burden of these four major cancers was estimated using the population attributable fraction.Results:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next decade.The number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in 2030.The age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 years.In 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these cancers.Tobacco smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 deaths.Conclusions:The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade;however,the corresponding death toll is expected to surge,in the context of China’s population aging and high smoking prevalence.These estimates provide data-driven evidence for China to implement effective cancer control measures in the future.

STRUCTURAL DECOMPOSITION ANALYSIS ON CHINA'S ENERGY INTENSITY CHANGE FOR 1987-2005

There has been considerable debate about the major factors responsible for the dramatic decline of China＇s energy intensity in the 1980s and 1990s. However, few detailed analysis has been done to explain the fluctuation in energy intensity during 2002-005. In this paper, we use the structural decomposition analysis （SDA） to decompose energy intensity into five determining factors： Energy input coefficient, technology coefficient （Leontief inverse coefficient）, final demands structure by product, final demands by category and final energy consumption coefficient. We then further decompose two coefficients, energy input coefficient and technology coefficient, into structure and real coefficient. Empirical study is carried out based on the energy-input-output tables from 1987 to 2005 in 2000 constant price. The results show that between 1987 and 2002, energy input structure accounts for most of the decline in energy intensity. However, the input structure and final demands structure by product explain the increase of the energy intensity between 2002 and 2005.

An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

This study reports the fabrication of a novel photothermal material formed via the physical blending of excess lauric acid(LA)and cupric acetate,followed by efficient ligand exchange.Surprisingly,the copper–LA complex exhibited a 12-fold enhancement of the molar extinction coefficient in the nearinfrared(NIR)region relative to aqueous cupric acetate.Inspired by this interesting finding,we formulated these photothermal materials into colloidally dispersed nanoparticles via a technique that combined nanoprecipitation and in situ surface polymerization for antibacterial studies.The resultant nanoparticles exhibited rapid and stable photothermal responses to NIR irradiation,with a 4-fold enhanced photothermal conversion efficiency relative to aqueous cupric acetate.Since a positively charged monomer was incorporated during in situ surface polymerization,these positively charged nanoparticles were ingested efficiently and subsequently digested by drug-resistant bacteria.By combining the LA-mediated membrane-damaging effect,copper-mediated Fenton-like reaction,as well as the photothermal effect of the copper–LA complex,a broad-spectrum,multimodal,and synergistic antibacterial effect was achieved both in vitro and in vivo,with the killing efficiency up to 99.99%for ampicillin-resistant Escherichia coli(Ampr E.coli)and 99.9999%for methicillinresistant Staphylococcus aureus(MRSA).Our newly developed nanobiocide represents a class of exceptional broad-spectrum antibacterial materials,holding great potential for treating drug-resistant infections in clinical settings.

Research on the Determinants of Government Investment Effect

Government investment plays an important role in promoting and guiding the economic and social development in China.Xinjiang is the core province of the Belt and Road and its economic growth is mainly driven by investment.This paper decomposes the determinants of government investment effect into economic structure change,technological change and investment structure change,using the non-competitive input-output table of Xinjiang province in 2007,2012 and 2015 and structural decomposition analyses.The results show that,the government investment effect in Xinjiang shows a slight decline trend.During the period,the change of economic structure and investment structure have the negative impact on government investment effect,while the change of technology has the positive impact on government investment effect.In addition,these impacts have strong sectoral heterogeneity.

Can Talent Policies Attract Population Inflows?—An Empirical Analysis Based on Spatial Panel Modeling

To analyze the spatial influence mechanism of talent policy on population flow, this study compares the government work reports of 31 provinces between 2008 and 2020, and quantifies regional talent policies in nine aspects, including talent evaluation and incentives, utilizing a comprehensive, standardized, and continuous approach. Additionally, this paper develops a spatial econometric analysis model and expands on the conventional neighborhood, distance, and economic matrices by constructing a spatial weight matrix that reflects talent flow. The findings indicate that population movement exhibits spatial clustering patterns. The regional government's talent policy, primarily based on talent evaluation and incentives, positively influences population inflow. Moreover, during the implementation of talent policies, local governments demonstrate cooperative relationships. The inter-regional spillover effect between talent evaluation and talent incentives is significantly positive. In other words, a stronger local talent evaluation policy, along with robust talent incentives, encourages population inflow from neighboring provinces. However, this conclusion may vary in different regions and over time. Recently, the spatial spillover effect of population inflow and the impact of talent policies have not shown significant results. Additionally, the attractiveness of talent evaluation in the eastern region surpasses that of talent incentives, while the opposite holds true for the central and western regions. This study investigates the impact of local government talent policies on population inflow and its spatial spillover effect, offering theoretical support for intergovernmental cooperation.

Selectively enhancing radiosensitivity of cancer cells via in situ enzyme-instructed peptide self-assembly

The radiotherapy modulators used in clinic have disadvantages of high toxicity and low selectivity.For the first time,we used the in situ enzyme-instructed self-assembly(EISA)of a peptide derivative(Nap-GDFDFpYSV)to selectively enhance the sensitivity of cancer cells with high alkaline phosphatase(ALP)expression to ionizing radiation(IR).Compared with the in vitro pre-assembled control formed by the same molecule,assemblies formed by in situ EISA in cells greatly sensitized the ALPhigh-expressing cancer cells to y-rays,with a remarkable sensitizer enhancement ratio.Our results indicated that the enhancement was a result of fixing DNA damage,arresting cell cycles and inducing cell apoptosis.Interestingly,in vitro pre-formed assemblies mainly localized in the lysosomes after incubating with cells,while the assemblies formed via in situ EISA scattered in the cell cytosol.The accumulation of these molecules in cells could not be inhibited by endocytosis inhibitors.We believed that this molecule entered cancer cells by diffusion and then in situ self-assembled to form nanofibers under the catalysis of endogenous ALP.This study provides a successful example to utilize intracellular in situ EISA of small molecules to develop selective tumor radiosensitizers.

Analyzing Factors Influencing Willingness for Intercity Talent Mobility Based on the Logit Model

Based on a questionnaire data from 553 cities in China, this study used logistic regression to examine the effects of age, education, gender, occupation, and region on intercity talent mobility.The results revealed that individuals aged 26~45 years with work experience are more willing to relocate compared with most college students or individuals with little work experience. Furthermore,individuals who have acquired a bachelor’s degree are willing to relocate, whereas those who have acquired a master’s degree and above are less willing to relocate. In addition, cities offer a higher pay and better prospects for highly qualified individuals, so mobility seems less likely happen. Moreover,intercity mobility is higher for scientific research institutions than that for other industries. Talents tend to flow from central and western cities to eastern cities. Factors determining intercity talent mobility differ from region to region. Therefore, local governments, especially in central and western cities, should actively conduct research on talent strategies while promoting the construction of the city’s regional economy;formulate scientific policies on talent mobility;promote the reasonable flow of talent;and provide an effective talent pool for urban development.