本文为回顾性研究,遵守《赫尔辛基宣言》,经过兰州大学第二医院伦理委员会批准,免除受试者知情同意,批准文号:2023A-169。患者女,60岁,因“右上肢麻木无力三个月,加重一周”于2018年5月至兰州大学第二医院就诊。专科检查:神志清,格拉斯...本文为回顾性研究,遵守《赫尔辛基宣言》,经过兰州大学第二医院伦理委员会批准,免除受试者知情同意,批准文号:2023A-169。患者女,60岁,因“右上肢麻木无力三个月,加重一周”于2018年5月至兰州大学第二医院就诊。专科检查:神志清,格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)15分,查体合作,自动体位,言语清晰,记忆力、理解力、定向力检查未见异常。双侧瞳孔等大等圆,对光反射存在。四肢肌张力正常,四肢体肌力5级,四肢未见肌肉萎缩及震颤。右上肢麻木,以右手手指为著,其余四肢深浅感觉检查未见异常,双侧指鼻试验、跟膝胫试验正常。闭目难立征(−)。颈软无抵抗,双侧克氏征、布氏征均为阴性。实验室检查结果未见明显异常。展开更多
Objective To observe the value of grey-level histogram analysis based on T2WI for differentiating consistency of meningioma.Methods Data of 109 patients with meningioma were retrospectively analyzed.The patients were ...Objective To observe the value of grey-level histogram analysis based on T2WI for differentiating consistency of meningioma.Methods Data of 109 patients with meningioma were retrospectively analyzed.The patients were divided into hard group(n=71)and soft group(n=38)according to the consistency of tumors.Tumor ROI was outlined on axial T2WI showing the largest tumor section,gray levels were extracted and histogram analysis was performed.The value of each histogram parameter were compared between groups.Then receiver operating characteristic curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficiency for differentiating soft and hard meningioma.Results P 1,P 10,P 50,P 90,P 99 and the mean grey levels on T2WI in soft group were all higher than those in hard group(all P<0.05),while the variance,the kurtosis and the skewness were not significantly different between groups(all P>0.05).The differentiating efficiency of P 1,P 10,P 50,P 90,P 99 and the mean grey levels on T2WI were all fine,with AUC of 0.774 to 0.833,and no significant difference was found(all P>0.05).Conclusion Parameters of grey-level histogram analysis such as P 1,P 10,P 50,P 90,P 99 and the mean values based on T2WI were all valuable for differentiating soft and hard meningioma.展开更多
文摘目的探讨表观扩散系数(apparent diffusion coefficient,ADC)鉴别诊断肺癌脑转移瘤组织学分型的价值及其与Ki-67增殖指数之间的关系。材料与方法回顾性分析经手术病理证实的20例小细胞肺癌脑转移瘤和41例非小细胞肺癌脑转移瘤患者的资料,并测定其Ki-67增殖指数。在ADC图上测量肿瘤实性部分的最小ADC值(the minimum ADC,ADCmin)、平均ADC值(the mean ADC,ADCmean)及对侧正常脑白质ADC值,并计算相对ADCmin(relative ADCmin,rADCmin)及相对ADCmean(relative ADCmean,rADCmean)。对比分析二者ADC值的差异,绘制受试者工作特征(receiver operating characteristic,ROC)曲线评价ADC值的鉴别诊断价值,并计算ADC值与Ki-67增殖指数之间的相关性。结果小细胞肺癌脑转移瘤组的ADCmin、ADCmean、rADCmin及rADCmean值均小于非小细胞肺癌脑转移瘤组,组间差异均具有统计学意义(P<0.05)。各ADC值均能对小细胞肺癌脑转移瘤及非小细胞肺癌脑转移瘤进行有效鉴别,其中rADCmean值的鉴别诊断效能最好,曲线下面积(area under the curve,AUC)为0.950[95%置信区间(confidence interval,CI):0.907~0.994],最佳截断值为0.955,相应的敏感度和特异度分别为96.23%、83.87%,准确度为91.67%。小细胞肺癌脑转移瘤组的Ki-67增殖指数大于非小细胞肺癌脑转移瘤组,组间差异具有统计学意义(P<0.05)。61例肺癌脑转移瘤患者的ADCmin、ADCmean、rADCmin及rADCmean值均与Ki-67增殖指数呈不同程度的负相关(r=-0.506、r=-0.480、r=-0.569、r=-0.541)。结论ADC值可以对肺癌脑转移瘤的组织学分型进行鉴别诊断,并可以预测Ki-67增殖指数的表达水平。
文摘本文为回顾性研究,遵守《赫尔辛基宣言》,经过兰州大学第二医院伦理委员会批准,免除受试者知情同意,批准文号:2023A-169。患者女,60岁,因“右上肢麻木无力三个月,加重一周”于2018年5月至兰州大学第二医院就诊。专科检查:神志清,格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)15分,查体合作,自动体位,言语清晰,记忆力、理解力、定向力检查未见异常。双侧瞳孔等大等圆,对光反射存在。四肢肌张力正常,四肢体肌力5级,四肢未见肌肉萎缩及震颤。右上肢麻木,以右手手指为著,其余四肢深浅感觉检查未见异常,双侧指鼻试验、跟膝胫试验正常。闭目难立征(−)。颈软无抵抗,双侧克氏征、布氏征均为阴性。实验室检查结果未见明显异常。
文摘Objective To observe the value of grey-level histogram analysis based on T2WI for differentiating consistency of meningioma.Methods Data of 109 patients with meningioma were retrospectively analyzed.The patients were divided into hard group(n=71)and soft group(n=38)according to the consistency of tumors.Tumor ROI was outlined on axial T2WI showing the largest tumor section,gray levels were extracted and histogram analysis was performed.The value of each histogram parameter were compared between groups.Then receiver operating characteristic curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficiency for differentiating soft and hard meningioma.Results P 1,P 10,P 50,P 90,P 99 and the mean grey levels on T2WI in soft group were all higher than those in hard group(all P<0.05),while the variance,the kurtosis and the skewness were not significantly different between groups(all P>0.05).The differentiating efficiency of P 1,P 10,P 50,P 90,P 99 and the mean grey levels on T2WI were all fine,with AUC of 0.774 to 0.833,and no significant difference was found(all P>0.05).Conclusion Parameters of grey-level histogram analysis such as P 1,P 10,P 50,P 90,P 99 and the mean values based on T2WI were all valuable for differentiating soft and hard meningioma.
