目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组...目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组给予拉贝洛尔联合低分子肝素治疗。比较两组治疗前后凝血功能指标、血压、血脂水平、母婴结局、新生儿Apgar评分及不良反应发生情况。结果治疗后,B组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均长于A组,新生儿5、10 min Apgar评分均高于A组,纤维蛋白原(FIB)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平及不良新生儿结局、不良妊娠结局发生率均低于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论拉贝洛尔联合低分子肝素治疗早发型重度子痫前期,可改善患者凝血功能、血脂及血压水平,改善母婴结局,且安全性较高。展开更多
Fossils of Orsten-type preservation represented by the crustacean Skaracarida and Phosphatocopida were found in western Hunan, South China in 2005, including the important phosphatocopid species Vestrogothia spinata b...Fossils of Orsten-type preservation represented by the crustacean Skaracarida and Phosphatocopida were found in western Hunan, South China in 2005, including the important phosphatocopid species Vestrogothia spinata based on exquisitely preserved soft-bodied specimens that allow the first growth stage to be reestablished. The taxonomy of Vestrogothia spinata is revised employing the character of a two-divided limb stem of the mandible. A new foundation for the phylogeny of the Phosphatocopina using mandible characters related to crustacean appendages is postulated. Vestrogothia spinata has only previously been found from Sweden.展开更多
The exquisitely preserved fossil embryos of Markuelia recovered from the limestones of the Middle Cambrian Haoqiao Formation and Upper Cambrian Bitiao formation in western Hunan, South China are described and illustra...The exquisitely preserved fossil embryos of Markuelia recovered from the limestones of the Middle Cambrian Haoqiao Formation and Upper Cambrian Bitiao formation in western Hunan, South China are described and illustrated in detail for the first time. A new species Markuelia elegans sp. nov. is established based mainly on embryos from the Upper Cambrian. A few of animal＇s resting eggs, which are comparable with those of the Ediacaran Doushantuo Formation, have been also found in the Upper Cambrian of western Hunan. The membrane of one egg from the uppermost Cambrian has been replaced by pyrite and the overgrowth of the pyrite crystals exhibits a unique inorganic pattern termed herein ＇Pseudoembryo＇. The taphonomic setting in deeper water with possible strong reducing conditions promoted the excellent preservation for the Markuelia specimens. The study of Markuelia provides not only constraint on the anatomy, affinity, embryonic development and phylogenetic significance of this wormlike animal and but also opens a new window onto the evolution and development of the earliest animals.展开更多
In the light of Synchrotron Radiation X-ray Tomographic Microscopy （SRXTM）, the internal structure of Markuelia hunanensis is revealed. In one example, vitrification and peeling show the annuli hidden under the chor...In the light of Synchrotron Radiation X-ray Tomographic Microscopy （SRXTM）, the internal structure of Markuelia hunanensis is revealed. In one example, vitrification and peeling show the annuli hidden under the chorion. Sectioning and 3-D reconstruction display an intact digestive tract from the inverted introvert to the terminal anus. The inverted introvert forms a rugby cavum. The following digestive tract is rope-like coiling, parallel to the body axis, about 650 μm in length, and uniform in diameter （-80 μm）. An exquisitely preserved pipe-like structure is hidden in the middle of the rope-like structure, diameter 20--40 lam, with a length of -120 μm. We interpret this pipe-like structure as the possible epidermis of the gut and its surroundings as the possible residue of musculature, similar to that in Priapulans. The two symmetrical rod-shape structures connecting the body wall and digestive tract are interpreted as the possible retractor muscles. After comparing the well preserved Left-form and Right-form Body of Markuelia, we suggest that they may represent a dimorphism. Counted directly, one sample of Markuelia hunanensis possesses 62 annulations and the other 68.展开更多
文摘目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组给予拉贝洛尔联合低分子肝素治疗。比较两组治疗前后凝血功能指标、血压、血脂水平、母婴结局、新生儿Apgar评分及不良反应发生情况。结果治疗后,B组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均长于A组,新生儿5、10 min Apgar评分均高于A组,纤维蛋白原(FIB)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平及不良新生儿结局、不良妊娠结局发生率均低于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论拉贝洛尔联合低分子肝素治疗早发型重度子痫前期,可改善患者凝血功能、血脂及血压水平,改善母婴结局,且安全性较高。
基金supported by the NationalNatural Science Foundation of China(Grant Nos.40772008 and 40572003)the Research Fund for DoctoralProgram of High Education(Grant No.20060001059)State Key Laboratory of Palaeobiology and Stratigraphy,Nanjing Institute of Geology and Palaeontology,ChineseAcademy of Sciences(Grant No.083101)
文摘Fossils of Orsten-type preservation represented by the crustacean Skaracarida and Phosphatocopida were found in western Hunan, South China in 2005, including the important phosphatocopid species Vestrogothia spinata based on exquisitely preserved soft-bodied specimens that allow the first growth stage to be reestablished. The taxonomy of Vestrogothia spinata is revised employing the character of a two-divided limb stem of the mandible. A new foundation for the phylogeny of the Phosphatocopina using mandible characters related to crustacean appendages is postulated. Vestrogothia spinata has only previously been found from Sweden.
基金supported by the NationalNatural Science Foundation of China(Grant Nos.40772008 and 40572003)the Research Fund for DoctoralProgram of High Education(Grant No.20060001059)State Key Laboratory of Paleobiology and Stratigraphy,Nanjing Institute of Geology and Palaeontology,ChineseAcademy of Sciences(Grant No.083101)
文摘The exquisitely preserved fossil embryos of Markuelia recovered from the limestones of the Middle Cambrian Haoqiao Formation and Upper Cambrian Bitiao formation in western Hunan, South China are described and illustrated in detail for the first time. A new species Markuelia elegans sp. nov. is established based mainly on embryos from the Upper Cambrian. A few of animal＇s resting eggs, which are comparable with those of the Ediacaran Doushantuo Formation, have been also found in the Upper Cambrian of western Hunan. The membrane of one egg from the uppermost Cambrian has been replaced by pyrite and the overgrowth of the pyrite crystals exhibits a unique inorganic pattern termed herein ＇Pseudoembryo＇. The taphonomic setting in deeper water with possible strong reducing conditions promoted the excellent preservation for the Markuelia specimens. The study of Markuelia provides not only constraint on the anatomy, affinity, embryonic development and phylogenetic significance of this wormlike animal and but also opens a new window onto the evolution and development of the earliest animals.
基金supported by the National Natural Science Foundation of China(Grant Nos.41072006,40772008)the Research Fund for Doctoral Program of High Education(Grant No.20060001059)State Key Laboratory of Paleobiology,and Stratigraphy,Nanjing Institute of Geology and Palaeontology,Chinese Academy of Sciences(Grant No.103102)
文摘In the light of Synchrotron Radiation X-ray Tomographic Microscopy （SRXTM）, the internal structure of Markuelia hunanensis is revealed. In one example, vitrification and peeling show the annuli hidden under the chorion. Sectioning and 3-D reconstruction display an intact digestive tract from the inverted introvert to the terminal anus. The inverted introvert forms a rugby cavum. The following digestive tract is rope-like coiling, parallel to the body axis, about 650 μm in length, and uniform in diameter （-80 μm）. An exquisitely preserved pipe-like structure is hidden in the middle of the rope-like structure, diameter 20--40 lam, with a length of -120 μm. We interpret this pipe-like structure as the possible epidermis of the gut and its surroundings as the possible residue of musculature, similar to that in Priapulans. The two symmetrical rod-shape structures connecting the body wall and digestive tract are interpreted as the possible retractor muscles. After comparing the well preserved Left-form and Right-form Body of Markuelia, we suggest that they may represent a dimorphism. Counted directly, one sample of Markuelia hunanensis possesses 62 annulations and the other 68.
