Robust Space-Time Adaptive Track-Before-Detect Algorithm Based on Persymmetry and Symmetric Spectrum

Underwater monopulse space-time adaptive track-before-detect method,which combines space-time adaptive detector(STAD)and the track-before-detect algorithm based on dynamic programming(DP-TBD),denoted as STAD-DP-TBD,can effectively detect low-speed weak targets.However,due to the complexity and variability of the underwater environment,it is difficult to obtain sufficient secondary data,resulting in a serious decline in the detection and tracking performance,and leading to poor robustness of the algorithm.In this paper,based on the adaptive matched filter(AMF)test and the RAO test,underwater monopulse AMF-DP-TBD algorithm and RAO-DP-TBD algorithm which incorporate persymmetry and symmetric spectrum,denoted as PSAMF-DP-TBD and PS-RAO-DP-TBD,are proposed and compared with the AMF-DP-TBD algorithm and RAO-DP-TBD algorithm based on persymmetry array,denoted as P-AMF-DP-TBD and P-RAO-DP-TBD.The simulation results show that the four methods can work normally with sufficient secondary data and slightly insufficient secondary data,but when the secondary data is severely insufficient,the P-AMF-DP-TBD and P-RAO-DP-TBD algorithms has failed while the PSAMF-DP-TBD and PS-RAO-DP-TBD algorithms still have good detection and tracking capabilities.

Bioinformatics and Activity Analysis of Antioxidant Enzymes in Wheat Seedlings under Salt Stress and Their Malondialdehyde Content Changes

[Objectives]This study was conducted to improve crop yield and select excellent wheat varieties.[Methods]Wheat seedlings were treated with different concentrations of NaCl solution,and the activities of superoxide dismutase(SOD)and peroxidase(POD)and the content changes of malondialdehyde(MDA)in the leaves of seedlings were determined.A control group(distilled water)and three treatment groups(NaCl concentrations of 1,2 and 3 mmol/L)were set up.When the wheat seedlings grew to two leaves and one heart,they should be treated with different concentrations of NaCl solution(the wheat seedlings grew uniformly,and 20 ml of each NaCl concentration was used for treatment of wheat).When the wheat seedlings grew to four leaves and one heart under stress,samples were taken separately,once every 2 d,for three times,with 5 g of leaves each time.The SOD and POD activities and MDA content of seedlings in the control group and treatment groups were determined,and related protein sequences were analyzed by bioinformatics,including signal peptide prediction,transmembrane domain prediction,phosphorylation prediction and protein structure prediction.[Results]Under NaCl stress,the growth rates of seedling length and root length of wheat decreased obviously,and SOD and POD in leaves decreased,while the MDA content in leaves after treatment increased compared with the control group.SOD had no signal peptide,while POD had signal peptides and a transmembrane region.SOD and POD were different in terms of secondary and tertiary structures and the number of phosphorylation sites.[Conclusions]These results lays a solid theoretical foundation and application prospect for the study on salt tolerance mechanism of wheat seedlings in the later stage.

豚鼠感染模型评价胞内分枝杆菌毒力的研究

目的建立豚鼠感染模型,评价胞内分枝杆菌的毒力,为预防与治疗胞内分枝杆菌感染提供科学依据。方法培养胞内分枝杆菌CHPC 1.5701,菌悬液用0.9%氯化钠溶液分别稀释至1×10^(10) CFU/mL、1×10^(9 )CFU/mL、1×10^(8) CFU/mL、1×10^(7 )CFU/mL和1×10^(6) CFU/mL。筛选结核菌素纯蛋白衍生物皮肤试验呈阴性的健康Hartly豚鼠,随机分为6组,每组10只,雌雄各半。实验组豚鼠5组,分别腹腔注射5种不同浓度菌悬液1.0 mL/只,对照组豚鼠腹腔注射0.9%氯化钠溶液1.0 mL/只。观察豚鼠一般表现,每周称重,5周后解剖,取肺、脾、肝组织,分析组织病变及荷菌量。结果攻毒试验对雄性豚鼠体重无影响(P>0.05),可使雌性豚鼠体重减轻(P<0.01),攻毒试验组均观察到豚鼠肺、脾、肝组织病理改变,显微镜下可见肺泡壁肺泡上皮增生,肝脏、脾脏单核细胞浸润,炎性肉芽肿等,病变程度与攻毒剂量有关。部分脏器组织培养可分离到胞内分枝杆菌,其中脾脏荷菌量较大。结论腹腔注射胞内分枝杆菌CHPC 1.5701可影响雌性豚鼠体重,造成肺脏、肝脏、脾脏感染和病变,胞内分枝杆菌对豚鼠具有一定的毒力,属于低毒力、低致病性细菌。

A New Two-Stage Tunable Space-Time Adaptive Detector

In order to improve the rejection capability of mismatched interferer signals,a new two-stage detector is proposed under homogeneous scenarios with unknown covariance matrix,which is obtained by cascading the adaptive matched filter(AMF)detector and the enhanced RAO(EnRAO)detector.The new detector has constant false alarm performance,and the closed-form expression of probability of false alarm and probability of detection is derived.The performance of the new detector is assessed,and analyzed in comparison with other detectors.The results show that,the proposed detector can provide enhanced rejection capability in the case of mismatch,but the performance of the detector is slightly lost under the condition of matching.

Ultrathin poly(cyclocarbonate-ether)-based composite electrolyte reinforced with high-strength functional skeleton

Composite polymer electrolytes(CPEs)are considered to be the most promising to break through the performance and safety limitations of traditional lithium-ion batteries because of their excellent electrochemical and mechanical properties.Aiming at the performance limitations of the most common polyether matrix such as poly(ethylene oxide)(PEO),a novel poly(cyclocarbonate-ether)polymer matrix was prepared by in-situ thermal curing,the weaker interaction between its C=O bond and Li^(+)can promote the rapid transport of Li^(+).Adding ionic liquid and active filler LLZTO to the matrix can synergistically reduce the crystallinity of matrix and promote the dissociation of lithium salts.In addition,a 3D functional skeleton made of polyacrylonitrile(PAN)and lithium fluoride(LiF)can greatly improve the mechanical strength of polymer matrix after cold pressing,and Li F is also conducive to interface stability.The thickness of the optimal sample(VP6L/CPL)was only 25μm,and its ionic conductivity,lithium ion transference number,and electrochemical stability window were as high as 7.17×10^(-4)S cm^(-1)(25℃),0.54 and 5.4 V,respectively,while the mechanical strength reaches 6.1 MPa,which can fully inhibit the growth of lithium dendrites.The excellent electrochemical performance and mechanical strength enable the assembled Li|VP6L/CPL|Li battery to be continuously charged for over 200 h and cycled stably for more than 2300 h,and Li|VP6L/CPL|LFP battery can be stably cycled for more than 400 and 550 cycles at 1 C(40℃)and 0.5 C(25℃),respectively.

ALTERNATING DIRECTION IMPLICIT OSC SCHEME FOR THE TWO-DIMENSIONAL FRACTIONAL EVOLUTION EQUATION WITH A WEAKLY SINGULAR KERNEL

In this paper, a new kind of alternating direction implicit （ADI） Crank-Nicolson-type orthogonal spline collocation （OSC） method is formulated for the two-dimensional frac-tional evolution equation with a weakly singular kernel arising in the theory of linear viscoelas-ticity. The novel OSC method is used for the spatial discretization, and ADI Crank-Nicolson-type method combined with the second order fractional quadrature rule are considered for thetemporal component. The stability of proposed scheme is rigourously established, and nearlyoptimal order error estimate is also derived. Numerical experiments are conducted to supportthe predicted convergence rates and also exhibit expected super-convergence phenomena.

Effects of Layer Thickness on the Residual Stresses of CIGS Solar Cells with Polyimide Substrate

In this paper, we investigate the effect of layer thickness on the residual stresses of copper indium gallium diselenide (CIGS) solar cells with polyimide substrate caused by CIGS layer deposition at 400?C and then cooling down to room temperature using the Finite Element Method (FEM). Moreover, we also examined the effect of layer thickness on residual stress of CIGS solar cells after cooling down to room temperature from the hotspot temperatures of 200?C, 300?C, and 400?C. Our simulated CIGS is composed of five layers: ZnO, CdS, CIGS, Mo, and PI substrate. We were able to quantify the effect of each layer’s thickness and hotspot temperature on the average stresses of each layer for the CIGS solar cells. We found that the PI substrate layer has the most significant effect on the residual stress of CIGS solar cells. Our simulation results reveal that the stress type (tensile vs. compressive) and the magnitude of stress of the CIGS layer (main absorber layer) can be controlled by changing the thickness of the PI substrate while applying a heat to CIGS solar cells. Quantitative analysis of relationship between layer thickness and thermo-mechanical stress of thin film solar cells can help solar cell manufacturers design more robust and reliable solar cells. For example, fabricating PI layer thickness less than 17 μm can improve the performance of CIGS solar cells by nullifying the compressive residual stress in the CIGS absorber layer.

Simulation of the influence of imperfections on dynamical decoupling of a superconducting qubit

Dynamical decoupling is widely used in many quantum computing systems to combat decoherence. In a practical superconducting quantum system, imperfections can plague decoupling performance. In this work, imperfections in a superconducting qubit and its control system are modeled via modified Hamiltonian and collapse operator. A master equation simulation is carried out on the qubit under 1/f environment noise spectrum. The average dephasing rate of qubit is extracted to characterize the impact of different imperfections on the decoupling from dephasing. We find that the precision of pulse position, on–off ratio, and filtering effect are most critical. Bounded pulses have weaker impact,while variation in pulse width and qubit relaxation are insignificant. Consequently, alternative decoupling protocols, jitter mitigation, cascaded mixers, and pulse shaping can be conducive to the performance of decoupling. This work may assist the analysis and optimization of dynamical decoupling on noisy superconducting quantum systems.

Observation of nonlinearity and heating-induced frequency shifts in cavity magnonics

When there is a certain amount of field inhomogeneity,the biased ferrimagnetic crystal can exhibit the higher-order magnetostatic(HMS)mode in addition to the uniform-precession Kittel mode.In cavity magnonics,we show the nonlinearity and heating-induced frequency shifts of the Kittel mode and HMS mode in a yttrium-iron-garnet(YIG)sphere.When the Kittel mode is driven to generate a certain number of excitations,the temperature of the whole YIG sample rises and the HMS mode can display an induced frequency shift,and vice versa.This cross effect provides a new method to study the magnetization dynamics and paves a way for novel cavity magnonic devices by including the heating effect as an operational degree of freedom.

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma:a multi-center integrated analysis of microbiome,metabolome,and transcriptome data

Dear editor,Patients with clear-cell renal cell carcinoma(ccRCC)potentially have a high recurrence rate of more than 40%[1].Patients receive radical or partial nephrectomy,sometimes assisted by targeted therapies or/and immune checkpoint inhibitors(ICIs),to improve overall survival(OS)[2].Large-cohort studies and large-scale human tissue sequencing have provided a series of molecular subtyping methods for precision medicine-based ccRCC risk stratification and therapeutic regimens,such as ClearCode34,the prognostic risk predictor[3],and seven subsets for ICI and angiogenesis blockade outcomes[4].However,these subtyping results are all based on human genomes without including the host microbiota,which may be non-negligible genome components.

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

Enolase 2(ENO2)is a key glycolytic enzyme in the metabolic process of glycolysis,but its potential function in pancreatic ductal adenocarcinoma(PDAC)is unclear.In this study,we observed a significant overexpression of ENO2 in PDAC tissues,and its expression was correlated with metastasis and poor prognosis in PDAC patients.K394 was identified as a major acetylation site in ENO2 that regulates its enzymatic activity,cell metabolism and PDAC progression.Knockdown of ENO2 suppressed tumor growth and liver metastasis in PDAC.Re-expression of wild-type(WT)ENO2,but not the K394 acetylation mimetic mutant,could reverse the decreased tumor malignancy.We further characterized histone deacetylase 3(HDAC3)and P300/CBP-associated factor(PCAF)as the potential deacetylase and acetyltransferase for ENO2,respectively.HDAC3-mediated deacetylation was shown to lead to ENO2 activation and enhancement of glycolysis.Importantly,insulin-like growth factor-1(IGF-1)was found to decrease K394 acetylation and stimulate ENO2 activity in a dose-and time-dependent manner.The PI3K/AKT/mTOR pathway facilitated the phosphorylation of HDAC3 on S424,which promoted K394 deacetylation and activation of ENO2.Linsitinib,an oral small-molecule inhibitor of IGF-1R,could inhibit IGF-1-induced ENO2 deacetylation by HDAC3 and the PI3K/AKT/mTOR pathway.Furthermore,linsitinib showed a different effect on the growth and metastasis of PDAC depending on the overexpression of WT versus K394-mutant ENO2.Our results reveal a novel mechanism by which acetylation negatively regulates ENO2 activity in the metastasis of PDAC by modulating glycolysis.Blockade of IGF-1-induced ENO2 deacetylation represents a promising strategy to prevent the development of PDAC.

多功能多场景应用辐射定标光源光学系统设计

目前空间遥感相机地面标定设备缺乏对各种谱线分布的精确模拟以及无法实现同时进行宽带和窄带的光谱辐射定标,导致空间遥感相机地面辐射定标精度低、宽带和窄带定标过程漫长复杂、无法实现多谱段光谱范围辐射定标测试。针对上述难题,提出一种基于前置准直扩束系统凹柱面光栅的光谱辐射定标系统的设计方法,针对凹柱面光栅的场曲特性,设计了楔形场曲补偿棱镜,并通过准直扩束系统减小系统的成像视场,提高凹柱面光栅分光系统的光谱分辨率,将整个系统的光谱分辨率提升了1倍多,由5 nm提升至2 nm。最后,对系统性能进行了测试,测试结果表明在宽带模式下,实现了500~900 nm光谱范围内3 000 K、6 400 K和9 000 K色温模拟,模拟误差优于5%;在窄带模式下,系统输出光束半峰宽度小于3 nm;在多谱段模式下,等能光谱的光谱模拟误差分别为545~600 nm处1.1%、630~690 nm处2.5%、680~725 nm处1.5%。所设计的系统满足空间相机、姿态导航系统以及遥感仪器的宽带、窄带辐射定标和多功能测试标定需求。

Proportional Mean Residual Life Model with Varying Coefficients for Length-Biased and Right-Censored Data

Length-biased data are encountered in many fields,including economics,engineering and epidemiological cohort studies.There are two main challenges in the analysis of such data:the assumption of independent censoring is violated and the assumed model for the underlying population is no longer satisfied for the observed data.In this paper,a proportional mean residual life varyingcoefficient model for length-biased data is considered and a local pseudo likelihood method is proposed for estimating the coefficient functions in the model.Asymptotic properties are investigated for the proposed estimators.The finite sample performance of the proposed methodology is demonstrated by simulation studies.Finally,the method is applied to a real data set concerning the Academy Awards.

CEPC Technical Design Report

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.

The combination of PD-1 blockade with interferon-αhas a synergistic effect on hepatocellular carcinoma

Background The efficacy of immune checkpoint inhibitors(ICIs),such as programmed cell death protein-1(PD-1)or its ligand 1(PD-L1)antibody,in hepatocellular carcinoma(HCC)is limited,and it is recommended that they be combined with other therapies.We evaluated the combination of pegylated interferon-α(Peg-IFNα)with PD-1 blockade in HCC mouse models.Methods We analyzed the effects of Peg-IFNαon tumor-infiltrating immune cells and PD-1 expression in the HCC immune microenvironment and examined the underlying mechanism of its unique effect on the PD-1 pathway.The in vivo efficacy of anti-PD-1 and Peg-IFNαwas evaluated in both subcutaneous and orthotopic mouse models of HCC.Results The combination of Peg-IFNαwith PD-1 blockade dramatically enhanced T-cell infiltration,improved the efficacy of PD-1 antibody and prolonged mouse survival compared with PD-1 antibody monotherapy.Mechanistically,Peg-IFNαcould recruit cytotoxic CD8+T cells to infiltrate the HCC microenvironment by inducing tumor cells to secrete the chemokine CCL4.Nevertheless,the HCC microenvironment quickly overcame the immune responses by upregulating PD-1 expression in CD8+T cells via the IFNα-IFNAR1-JAK1-STAT3 signaling pathway.The combination of PD-1 blockade with Peg-IFNαcould restore the cytotoxic capacity of CD8+T cells and exerted a significant synergistic effect on HCC.Conclusion These results indicate that in addition to initiating the antitumor immune response itself,Peg-IFNαcan also generate a microenvironment favoring PD-1 blockade.Thus,the combination of Peg-IFNαand PD-1 blockade can be a promising strategy for HCC.

Spontaneous T-symmetry breaking and exceptional points in cavity quantum electrodynamics systems

Spontaneous symmetry breaking has revolutionized the understanding in numerous fields of modern physics. Here, we theoretically demonstrate the spontaneous time-reversal symmetry breaking in a cavity quantum electrodynamics system in which an atomic ensemble interacts coherently with a single resonant cavity mode. The interacting system can be effectively described by two coupled oscillators with positive and negative mass, when the two-level atoms are prepared in their excited states. The occurrence of symmetry breaking is controlled by the atomic detuning and the coupling to the cavity mode,which naturally divides the parameter space into the symmetry broken and symmetry unbroken phases.The two phases are separated by a spectral singularity, a so-called exceptional point, where the eigenstates of the Hamiltonian coalesce. When encircling the singularity in the parameter space, the quasiadiabatic dynamics shows chiral mode switching which enables topological manipulation of quantum states.

Ultrathin-shell epitaxial Ag@Au core-shell nanowires for high-performance and chemically-stable electronic, optical, and mechanical devices

Silver nanowires (AgNWs) hold great promise for applications in wearable electronics, flexible solar cells, chemical and biological sensors, photonic/plasmonic circuits, and scanning probe microscopy (SPM) due to their unique plasmonic, mechanical, and electronic properties. However, the lifetime, reliability, and operating conditions of AgNW-based devices are significantly restricted by their poor chemical stability, limiting their commercial potentials. Therefore, it is crucial to create a reliable oxidation barrier on AgNWs that provides long-term chemical stability to various optical, electrical, and mechanical devices while maintaining their high performance. Here we report a room-temperature solution-phase approach to grow an ultra-thin, epitaxial gold coating on AgNWs to effectively shield the Ag surface from environmental oxidation. The Ag@Au core-shell nanowires (Ag@Au NWs) remain stable in air for over six months, under elevated temperature and humidity (80 °C and 100% humidity) for twelve weeks, in physiological buffer solutions for three weeks, and can survive overnight treatment of an oxidative solution (2% H2O2). The Ag@Au core-shell NWs demonstrated comparable performance as pristine AgNWs in various electronic, optical, and mechanical devices, such as transparent mesh electrodes, surface-enhanced Raman spectroscopy (SERS) substrates, plasmonic waveguides, plasmonic nanofocusing probes, and high-aspect-ratio, high-resolution atomic force microscopy (AFM) probes. These Au@Ag core-shell NWs offer a universal solution towards chemically-stable AgNW-based devices without compromising material property or device performance.

The Epidemiological Characteristics of Pulmonary Tuberculosis——Kashgar Prefecture,Xinjiang Uygur Autonomous Region,China,2011-2020

Introduction:National Notifiable Disease Reporting System(NNDRS)plays an important role in the early detection and control of tuberculosis(TB)in China.This study analyzed the epidemiological characteristics of pulmonary tuberculosis(PTB)in Kashgar Prefecture,Xinjiang Uygur Autnomous Region,China from 2011 to 2020 to provide a scientific basis for developing TB control strategies and measures in Kashgar.Methods:The data were collected from the NNDRS,which included the geographical distribution,age,sex,occupation,and pathogenic classification of reported PTB cases in 12 counties/cities of Kashgar Prefecture from 2011 to 2020.Descriptive statistics were used to describe the characteristic of PTB epidemic in Kashgar.Results:There were 189,416 PTB cases reported during 2011–2020,with a mean annual PTB case notification rate(CNR)of 451.29/100,000.A rising trend in the rate of reported PTB between 2011 and 2017(χ2 trend=26.09,P<0.01)and a declining trend between 2018 and 2020(χ2 trend=314.44,P<0.01)were observed.The months with the highest reported number of PTB cases were March to May and November to December.The mean annual rate of reported PTB was 451.88/100,000 for males and 450.67/100,000 for females.In addition,19.76%of patients were bacteriologically-confirmed(Bac+)cases(37,425/189,416),and the mean annual Bac+CNR was 89.17/100,000,rising from 64.76/100,000 in 2011 to 139.12/100,000 in 2020(χ^(2)_(trend)=74.44,P<0.01).Conclusions:The CNR of reported PTB in Kashgar showed a significant declining trend in the past three years.Males,elderly population,winter and spring,and farmers as an occupation were the main factors associated with high incidence of tuberculosis in Kashgar.Targeted prevention and treatment of TB should be strengthened in key groups in this region.

A Compact Difference Scheme for an Evolution Equation with a Weakly Singular Kernel

This paper is concerned with a compact difference scheme with the truncation error of order 3/2 for time and order 4 for space to an evolution equation with a weakly singular kernel.The integral term is treated by means of the second order convolution quadrature suggested by Lubich.The stability and convergence are proved by the energy method.A numerical experiment is reported to verify the theoretical predictions.

Human U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis

Background： Human U three protein 14a （hUTP 14a） promotes p53 degradation. Moreover, hUTP 14a expression is upregulated in several types of tumors. However, the expression pattern of hUTP 14a in hepatocellular carcinoma （HCC） remains unknown. The aim of this study was to investigate hUTP 14a expression and its prognostic value in HCC. Methods： The hUTP 14a expression was evaluated using immunohistochemistry （IHC） in HCC tissue specimens. The correlations between hUTP 14a expression and clinicopathological variables were analyzed. The Kaplan-Meier method was used to analyze the association between hUTP14a expression and survival. Independent prognostic factors associated with overall survival （OS） and disease-free survival （DFS） were analyzed using the Cox proportional-hazards regression model. Results： The IHC data revealed that the hUTP 14a positivity rate in HCC tissue specimens was significantly higher than that in nontumorous tissue specimens （89.9% vs. 72.7%, P 〈 0,05）. The hUTP14a expression was detected in both the nucleolus and the cytoplasm. The positivity rate of nucleolar hUTP14a expression in HCC tissue specimens was higher than that in the nontumorous tissue specimens （29.3% vs. 10.1%, P 〈 0.05）. No significant difference was found between HCC and nontumorous tissue specimens of cytoplasmic hUTP 14a expression （60.6% vs. 62.6%, P 〉 0.05）. In addition, no significant correlation was found between nucleolar hUTP 14a expression and other clinicopathological variables. The 5-year OS and DFS rates in patients with positive nucleolar hUTP14a expression were significantly lower than those in patients with negative hUTP 14a expression （P = 0.004 for OS, P = 0.003 for DFS）. Multivariate analysis showed that nucleolar hUTP 14a expression was an independent prognostic factor for OS （P = 0.004） and DFS （P 〈 0.001 ）. Conclusions： The positivity rate of hUTP 14a expression was significantly higher in HCC specimens. Positive expression of nucleolar hUTP 14a might act as a novel prognostic predictor for patients with HCC.