Observation on Curative Effect of Self-made Wubeizi Decoction Combined with rhaFGF in Promoting Postoperative Wound Healing in Patients with Anal Fistula

[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value.

斜拉肋加劲钢管混凝土结构的研究进展

钢管混凝土柱承载力高、抗震性能优越、造价适中,是超高层结构和大型重载结构常用的竖向承重柱形式。方钢管混凝土柱与圆钢管混凝土柱相比,其截面相对开展,具有抗弯刚度大、抗弯承载力高、节点构造简单、加工施工方便、便于建筑空间布置与装修等优点,因此其在实际工程中应用广泛。然而,研究表明方钢管混凝土的组合效应较弱,需在其钢管内采取加劲措施以提升钢管与混凝土之间的组合作用;同时通常还需在方钢管内焊接剪力连接件提高钢管与混凝土界面的纵向剪力传递能力。已有加劲形式可归纳总结为点约束、横向封闭式约束及开放式纵向线约束。在方钢管的两邻边设置斜拉加劲肋(简称斜拉肋),是近年来新发展起来的高效加劲形式,斜拉肋可实现纵横向连续封闭式约束,同时具有剪力连接件功能。系统总结了斜拉肋加劲钢管混凝土构件、节点及体系的力学性能及设计方法。在构件层面,对柱的轴压、偏压和抗震性能进行了研究,建议了斜拉肋合理构造形式、钢管宽厚比限值、斜拉肋与钢管的厚度匹配关系及轴压比限值,提出了计算斜拉肋加劲钢管混凝土柱截面压弯承载力的修正塑性应力分布方法,揭示了超短柱的受剪机理并建立了抗剪模型及剪力–剪切变形关系。在节点层面,对斜拉肋加劲钢管混凝土柱–钢筋混凝土梁节点的轴压及抗震性能进行了研究,明确了节点轴压及受剪机理,建议了节点区合理构造以达到“强节点、弱构件”的要求,提出了考虑轴压比及柱受压区高度影响的修正黏结滑移计算公式,该公式可准确预测节点区梁筋的滑移行为。在体系层面,对斜拉肋加劲钢管混凝土柱–钢筋混凝土梁框架进行了静力弹塑性分析、增量动力分析(IDA)及地震易损性分析,明确了体系的屈服机制及抗倒塌机制。研究结果表明,斜拉加劲肋集合了已有的钢管混凝土加劲形式特点,能有效传递界面剪力、约束混凝土、避免或延缓钢管局部屈曲,显著提升了钢管混凝土的承载力、变形能力和抗震性能,具有较大的应用前景。最后列举了斜拉肋加劲钢管混凝土结构的主要工程应用场景,展望了该结构的发展方向和需进一步研究的问题。

两边连接钢板式交错桁架塑性设计方法研究

交错桁架框架结构体系(STF结构体系)具有高效、实用、经济的特点,符合建筑工业化发展的趋势,目前已经在我国低烈度抗震设防区域逐步推广应用,众多的优点使其对中高烈度抗震设防区域也有较大的吸引力,其桁架可采用混合式桁架、空腹式桁架或帕式桁架。相对于空腹式桁架以及帕式桁架,混合式桁架因其刚度适中,并且空腹区域可以设置为内走廊等优点,应用最为广泛。已有试验结果表明,虽然混合式STF结构体系受力性能良好,但耗能能力较弱,结构抗震性能有待提升。为改善混合式STF结构的抗震性能,提出在桁架跨中设置两边连接钢板(TSCSP),并将跨中作为消能段用以耗能的延性交错桁架框架结构称之为两边连接钢板式交错桁架框架结构(TSCSP-STF结构)。在多遇地震作用下,消能段中的钢板既不屈曲也不屈服;在罕遇地震作用下,仅消能段中的钢板屈服耗能,非消能段桁架保持弹性,从而提高混合式STF结构的延性和耗能能力,有效改善混合式STF结构易发生腹杆失稳破坏的问题。在分析了消能段剪切承载力需求的基础上,推导了两边连接钢板剪切承载力需求的计算方法,并将两边连接钢板等效为偏心交叉支撑,建立TSCSP-STF结构的简化分析模型,进而建立结构体系的塑性设计方法和流程。根据文中提出的塑性设计方法,设计一个10层的TSCSP-STF结构,并按照已有文献提出的塑性设计方法,设计一个10层混合式STF结构进行对比分析,设计目标是在两个结构设计条件相同且含钢率接近的情况下,使两种结构都能充分发挥消能段的耗能能力。对设计的两个试件分别采用振型分解反应谱法和Pushover方法对比分析其承载力以及抗震性能。有限元分析结果表明:在多遇地震作用下,构件均能保持弹性;在罕遇地震作用下,消能构件可以充分耗散地震能量,保护延性区段外构件不会破坏;STF试件的塑性铰集中在空腹节间的端部,沿楼层分布较均匀;TSCSP-STF试件的塑性铰主要出现在消能段的拉、压支撑杆上,分布也比较均匀;根据塑性设计方法设计的TSCSP-STF结构和混合式STF结构均能满足GB 50011—2010《建筑抗震设计规范》关于罕遇地震下对承载力、变形和稳定性的要求,而试件TSCSP-STF的层间位移分布得更为均匀,减小了薄弱层出现的可能性,延性相对更好。