Populus trinervis is native to China and plays an irreplaceable role in maintaining the ecological balance of boreal and temperate forests.P.trinervis mainly grows in high-altitude areas.At present,there are limited s...Populus trinervis is native to China and plays an irreplaceable role in maintaining the ecological balance of boreal and temperate forests.P.trinervis mainly grows in high-altitude areas.At present,there are limited studies on the response of P.trinervis to different light qualities,so it is necessary to investigate the photosynthetic physiological changes of P.trinervis in different light environments.In our study,P.trinervis was grown for 8 months under light filtered by three different colored films.The three treatments were blue film,green film,and white plastic film.The effects of blue(B),green(G),and white(W)light on photosynthetic pigment content,absolute growth,photosynthetic parameters,soluble sugar content,and chlorophyll fluorescence parameters were studied,respectively.Compared to the Wtreatment,the chlorophyll a and b,carotenoids,total chlorophyll content(a+b),absolute growth of seedling height,net photosynthetic rate(PN),water use efficiency(WUE),total soluble sugars,sucrose,and nonphotochemical quenching(NPQ)of P.trinervis were significantly increased under B treatment.Meanwhile,chlorophyll a and b,carotenoids,total chlorophyll(a+b),transpiration rate(Tr),intercellular CO_(2) concentration(Ci),stomatal conductance(gs),absolute growth of seedling height and leaf length,reducing sugar,total soluble sugar content,and NPQ were significantly increased under G treatment.The results showed that the absolute growth and chlorophyll content of P.trinervis were increased under B light,while the sugar and photosynthetic parameters were increased under G light.Additional studies may look into how B light impacts absolute growth and promotional mechanisms,as well as how G light affects the accumulation of sugar levels.展开更多
It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and indivi...It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted.展开更多
Purpose The patients who have nasopharyngeal carcinoma(NPC)have high possibility to metastases.Therefore,it is of great practical significance to explore the molecular mechanism of invasion and metastases in NPC.Metho...Purpose The patients who have nasopharyngeal carcinoma(NPC)have high possibility to metastases.Therefore,it is of great practical significance to explore the molecular mechanism of invasion and metastases in NPC.Methods Herein summarizes some molecular mechanisms reported by our previous investigation.Results Recent studies have reported the crucial roles of noncoding RNAs(ncRNAs)in tumor progression.In this letter,we summarize some newfound non-coding RNAs(miRNAs,lncRNAs,circRNAs)and coding RNAs,which could regulate invasion or metastasis in NPC by downstream genes.Conclusion We elaborated on the clinical and therapeutic implications of partial putative markers for the treatment of invasion and metastasis in NPC.展开更多
基金Applied Basic Research Foundation of Yunnan Province(Grant No.202101AU070144)the Joint Agricultural Project of Yunnan Province(Grant No.202101BD070001-127).
文摘Populus trinervis is native to China and plays an irreplaceable role in maintaining the ecological balance of boreal and temperate forests.P.trinervis mainly grows in high-altitude areas.At present,there are limited studies on the response of P.trinervis to different light qualities,so it is necessary to investigate the photosynthetic physiological changes of P.trinervis in different light environments.In our study,P.trinervis was grown for 8 months under light filtered by three different colored films.The three treatments were blue film,green film,and white plastic film.The effects of blue(B),green(G),and white(W)light on photosynthetic pigment content,absolute growth,photosynthetic parameters,soluble sugar content,and chlorophyll fluorescence parameters were studied,respectively.Compared to the Wtreatment,the chlorophyll a and b,carotenoids,total chlorophyll content(a+b),absolute growth of seedling height,net photosynthetic rate(PN),water use efficiency(WUE),total soluble sugars,sucrose,and nonphotochemical quenching(NPQ)of P.trinervis were significantly increased under B treatment.Meanwhile,chlorophyll a and b,carotenoids,total chlorophyll(a+b),transpiration rate(Tr),intercellular CO_(2) concentration(Ci),stomatal conductance(gs),absolute growth of seedling height and leaf length,reducing sugar,total soluble sugar content,and NPQ were significantly increased under G treatment.The results showed that the absolute growth and chlorophyll content of P.trinervis were increased under B light,while the sugar and photosynthetic parameters were increased under G light.Additional studies may look into how B light impacts absolute growth and promotional mechanisms,as well as how G light affects the accumulation of sugar levels.
基金supported by the National Natural Science Foundation of China(Grant No.81872192)China International Medical Foundation(Grant No.Z-2014-06-19392).
文摘It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted.
基金supported by the grant from National Natural Science Foundation of China[No.81872192].
文摘Purpose The patients who have nasopharyngeal carcinoma(NPC)have high possibility to metastases.Therefore,it is of great practical significance to explore the molecular mechanism of invasion and metastases in NPC.Methods Herein summarizes some molecular mechanisms reported by our previous investigation.Results Recent studies have reported the crucial roles of noncoding RNAs(ncRNAs)in tumor progression.In this letter,we summarize some newfound non-coding RNAs(miRNAs,lncRNAs,circRNAs)and coding RNAs,which could regulate invasion or metastasis in NPC by downstream genes.Conclusion We elaborated on the clinical and therapeutic implications of partial putative markers for the treatment of invasion and metastasis in NPC.
