A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve cure.Palliative options are focusing on downstaging a locally advanced dis...A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve cure.Palliative options are focusing on downstaging a locally advanced disease.It is wellsupported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with surgery.Hepatic artery infusion chemotherapy can be a potential downstaging strategy,since recent studies have demonstrated excellent outcomes in patients with colorectal liver metastatic disease as well as primary liver malignancies.展开更多
Over the last decade,obesity rates have continued to rise in the United States as well as worldwide and are showing no signs of slowing down.This rise is in parallel with the increasing rates of type 2 diabetes mellit...Over the last decade,obesity rates have continued to rise in the United States as well as worldwide and are showing no signs of slowing down.This rise is in parallel with the increasing rates of type 2 diabetes mellitus(T2DM).Given the association between obesity and T2DM and their strong correlation with increased morbidity and mortality in addition to healthcare expenditure,it is important to recognize the most effective ways to combat them.Thus,we performed a review of literature that focused on assessing the outcomes of T2DM following bariatric surgery.Available evidence suggests that bariatric surgery provides better T2DM resolution in obese patients when compared to best medical management alone.Additionally,Biliopancreatic diversion with duodenal switch as well as Roux-en-Y gastric bypass have demonstrated higher rates of T2DM resolution when compared with other bariatric procedures.展开更多
文摘A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve cure.Palliative options are focusing on downstaging a locally advanced disease.It is wellsupported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with surgery.Hepatic artery infusion chemotherapy can be a potential downstaging strategy,since recent studies have demonstrated excellent outcomes in patients with colorectal liver metastatic disease as well as primary liver malignancies.
文摘Over the last decade,obesity rates have continued to rise in the United States as well as worldwide and are showing no signs of slowing down.This rise is in parallel with the increasing rates of type 2 diabetes mellitus(T2DM).Given the association between obesity and T2DM and their strong correlation with increased morbidity and mortality in addition to healthcare expenditure,it is important to recognize the most effective ways to combat them.Thus,we performed a review of literature that focused on assessing the outcomes of T2DM following bariatric surgery.Available evidence suggests that bariatric surgery provides better T2DM resolution in obese patients when compared to best medical management alone.Additionally,Biliopancreatic diversion with duodenal switch as well as Roux-en-Y gastric bypass have demonstrated higher rates of T2DM resolution when compared with other bariatric procedures.
