We identified a novel gene ST13 from a subtraetive eDNA library of normal intestinal mueosa in 1993, more studies showed that ST13 was a co-chaperone of Hsp70s. Recently we detected the ST13 gene expression in tumor t...We identified a novel gene ST13 from a subtraetive eDNA library of normal intestinal mueosa in 1993, more studies showed that ST13 was a co-chaperone of Hsp70s. Recently we detected the ST13 gene expression in tumor tissue and adjacent normal tissue of the same colorectal cancer patient and investigated if the ST13 gene expression might have any prognostic value. Analysis was performed at molecular level by reverse transcription-PCR using real-time detection method. We measured two genes simultaneously, ST13 as the target gene and glyceraldehydes-3-phosphate dehydrogenase as a reference gene, in primary colorectal tumor specimens and tumor-adjacent normal mucosa specimens from 50 colorectal cancer patients. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa （P〈0.05）. But there were no significant differences in the expression of ST13 as compared depth, lymph node metastasis and disease-specific survival. with different Dukes＇ stage, tumor differentiation grade, invasion展开更多
AIM: To evaluate the efficacy of the 14-d moxifloxacinbased triple therapy for the second-line eradication of Helicobacter pylori(H. pylori) infection.METHODS: Between 2011 and 2013, we conducted a retrospective revie...AIM: To evaluate the efficacy of the 14-d moxifloxacinbased triple therapy for the second-line eradication of Helicobacter pylori(H. pylori) infection.METHODS: Between 2011 and 2013, we conducted a retrospective review of the medical records of 160 patients who had experienced failure of their first-line proton pump inhibitor-based eradication therapy and subsequently received the moxifloxacin-based triple therapy as a second-line eradication treatment regimen. The patients who were treated with the moxifloxacinbased triple therapy(oral 20 mg rabeprazole b.i.d., 1000 mg amoxicillin b.i.d., and 400 mg moxifloxacin q.d.) for 7 d were assigned to the RAM-7 group(n = 79) while those who took them for 14 days were assigned to RAM-14 group(n = 81). The eradication rates for both groups were determined by intentionto-treat(ITT) and per-protocol(PP) analyses. ITT analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally allocated. Successful eradication therapy for H. pylori infection was defined as the documentation of a negative 13C-urea breath test 4 wk after the end of the eradication treatment.RESULTS: The overall ITT eradication rate was 76.2%(122/160). The final ITT eradication rates were 70.8%(56/79; 95%CI: 63.3%-77.1%) in the RAM-7 group and 81.4%(66/81; 95%CI: 74.6%-88.3%) in the RAM-14 group(P = 0.034). The overall PP eradication rate was 84.1%(122/145), and the final PP eradication rates were 77.7%(56/72; 95%CI: 70.2%-85.3%) in the RAM-7 group and 90.4%(66/73; 95%CI: 82.8%-98.1%) in the RAM-14 group(P = 0.017). The H. pylori-eradication rates in the RAM-14 group were significantly higher compared with that of the RAM-7 group according to both the ITT(P = 0.034) and the PP analyses(P = 0.017). Both groups exhibited good treatment compliance(RAM-7/RAM-14 group: 100%/100%). The adverse event rates were19.4%(14/72)and 20.5%(15/73)in the RAM-7 and RAM-14 groups,respectively(P=0.441).Adverse events occurred in 14 of the 72 patients(19.4)in the RAM-7 group and in 15 of the 73 patients(20.5)in the RAM-14 group.No statistically significant differences(P=0.441)were observed.CONCLUSION:The 14-d moxifloxacin-based triple therapy is a significantly more effective secondline eradication treatment as compared to the 7-d alternative for H.pylori infection in South Korea.展开更多
An inclusion complex of b-cyclodextrin with andrographolide (Andro) was prepared by using a convenient method of microwave irradiation. The structure of the inclusion complex was determined by the 1H NMR, 2D NMR spect...An inclusion complex of b-cyclodextrin with andrographolide (Andro) was prepared by using a convenient method of microwave irradiation. The structure of the inclusion complex was determined by the 1H NMR, 2D NMR spectroscopy as well as the elemental analysis.展开更多
In this paper, we study elliptic partial differential equations with nonuniform growth, and obtain the strong convergence of the gradient of truncations of solutions and the strong convergence of the gradient of solut...In this paper, we study elliptic partial differential equations with nonuniform growth, and obtain the strong convergence of the gradient of truncations of solutions and the strong convergence of the gradient of solutions in the setting of some Musielak-Orlicz spaces. Our results are generalization of the corresponding results for elliptic partial differential equations with power growth.展开更多
Service and information resources are two kinds of major shared resources in virtual enterprises, where, service resources include third party’s service resources and enterprise’s legacy service resources,and inform...Service and information resources are two kinds of major shared resources in virtual enterprises, where, service resources include third party’s service resources and enterprise’s legacy service resources,and information resources include database resources and file resources. Since service and information resources have distributed, autonomic, remotely bound as well as some other similar characteristics, an implementation mechanism on managing shared resources based on UDDI are presented. XML instances are used to describe resources authorization information, WSDL based special XML instance represents information resource metadata, and these XML instances are referenced by tModel for realizing the purpose of managing shared resources metadata based on UDDI.展开更多
Continuation method solving forward kinematics problem of parallel robot was discussed. And through a coefficient-parameter continuation method the efficiency and feasibility of continuation method were improved. Usin...Continuation method solving forward kinematics problem of parallel robot was discussed. And through a coefficient-parameter continuation method the efficiency and feasibility of continuation method were improved. Using this method all forward solutions of a new parallel robot model which was put forward lately by Robot Open Laboratory of Science Institute of China were obtained. Therefore it provided the basis of mechanism analysis and real-time control for new model.展开更多
Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Ca...Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Cardiac outputs measured by Innocor (CORB) were compared with CO obtained by echocardiography (COEC), Swan-Ganz thermodilution (COTD), and left ventricle radiography (COLVR) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS. Results: There was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by ther-modilution and between COEC and COLVR values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66±0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding COEC and COLVR values. Conclusion: Innocor CORB is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.展开更多
Surface morphologies of the films of poly [styrene-b-（ethylene-co-butene）-b-styrene] （SEBS） have been studied by using tapping-mode atomic force microscopy （TM-AFM）. The films of block copolymer were prepared bo...Surface morphologies of the films of poly [styrene-b-（ethylene-co-butene）-b-styrene] （SEBS） have been studied by using tapping-mode atomic force microscopy （TM-AFM）. The films of block copolymer were prepared both by spin-coating on mica and by solvent-casting on different solution surfaces. For spin-coating samples, the effect of solution concentration, solvent, and annealing temperature are investigated. It is shown that changing the concentration of the solution makes no difference on the morphology of the film of the block copolymer. The microstructures are quite stable during thermal annealing; only the size of the domains changes toward the equilibrium configuration. However, solvent annealing can notably change the microstructures. When different selective solvents are used for film spin-coating, different morphologies can be obtained and explained by the different solubility parameters of the solvents. As expected, significant different morphologies in the top and the bottom surfaces of the casting films were observed. The images of the top surfaces reveal cylinder microdomains, while those of the bottom surfaces were spherical morphologies.展开更多
Large span spatial lattice structures have many natural frequencies in a narrow frequency range, the conventional frequency domain method is difficult to contain all significant contribution modes. Through numerical e...Large span spatial lattice structures have many natural frequencies in a narrow frequency range, the conventional frequency domain method is difficult to contain all significant contribution modes. Through numerical examples, it is found that some high order modes are likely to be overlooked because of their higher positions of modal order, in spite of their significance to wind response. According to the contributions of modes to strain energy of system, the paper presented an efficient method to compensate the errors owing to missing out some significant high order modes. The effectiveness of the proposed method is verified through a numerical analysis of the wind responses of a spherical dome.展开更多
Efficient Mukaiyama-type aldol reaction of 1, 2-bis(trimethylsiloxy)cyclobutene with aromatic aldehydes catalyzed by MgI2 is reported. The resulting succinoylation product of aldehyde was converted into the synthetic...Efficient Mukaiyama-type aldol reaction of 1, 2-bis(trimethylsiloxy)cyclobutene with aromatic aldehydes catalyzed by MgI2 is reported. The resulting succinoylation product of aldehyde was converted into the synthetic useful g-lactone and butenolide derivatives.展开更多
The property of fluid field of one-dimensional magnetohydrodynamics (MHD) transverse flow after the appearance of singularity is discussed. By the method of iteration, the strong discontinuity (shock wave) and entropy...The property of fluid field of one-dimensional magnetohydrodynamics (MHD) transverse flow after the appearance of singularity is discussed. By the method of iteration, the strong discontinuity (shock wave) and entropy solution are constructed and the estimations on the singularity of the solution near the point of blow-up are obtained.展开更多
UV-vis and luminescence spectroscopic titration experiments show that a novel Ru(II) complex exhibits off-on-off pH luminescent switching with a maximum on-off ratio of about 100.
Owing to both of its high carrier concentration and large band gap, ZnO:Al (ZAO) films which is an n-type degenerate semiconductor, exhibits low resistance and high transmittance in the visible range. This work studie...Owing to both of its high carrier concentration and large band gap, ZnO:Al (ZAO) films which is an n-type degenerate semiconductor, exhibits low resistance and high transmittance in the visible range. This work studies the crystal structure, optical and electrical properties and preparation methods of ZAO films, and discusses the existing problems and application prospective of ZAO films.展开更多
文摘We identified a novel gene ST13 from a subtraetive eDNA library of normal intestinal mueosa in 1993, more studies showed that ST13 was a co-chaperone of Hsp70s. Recently we detected the ST13 gene expression in tumor tissue and adjacent normal tissue of the same colorectal cancer patient and investigated if the ST13 gene expression might have any prognostic value. Analysis was performed at molecular level by reverse transcription-PCR using real-time detection method. We measured two genes simultaneously, ST13 as the target gene and glyceraldehydes-3-phosphate dehydrogenase as a reference gene, in primary colorectal tumor specimens and tumor-adjacent normal mucosa specimens from 50 colorectal cancer patients. The expression levels of the ST13 gene were significantly decreased in primary tumors compared with adjacent mucosa （P〈0.05）. But there were no significant differences in the expression of ST13 as compared depth, lymph node metastasis and disease-specific survival. with different Dukes＇ stage, tumor differentiation grade, invasion
文摘AIM: To evaluate the efficacy of the 14-d moxifloxacinbased triple therapy for the second-line eradication of Helicobacter pylori(H. pylori) infection.METHODS: Between 2011 and 2013, we conducted a retrospective review of the medical records of 160 patients who had experienced failure of their first-line proton pump inhibitor-based eradication therapy and subsequently received the moxifloxacin-based triple therapy as a second-line eradication treatment regimen. The patients who were treated with the moxifloxacinbased triple therapy(oral 20 mg rabeprazole b.i.d., 1000 mg amoxicillin b.i.d., and 400 mg moxifloxacin q.d.) for 7 d were assigned to the RAM-7 group(n = 79) while those who took them for 14 days were assigned to RAM-14 group(n = 81). The eradication rates for both groups were determined by intentionto-treat(ITT) and per-protocol(PP) analyses. ITT analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally allocated. Successful eradication therapy for H. pylori infection was defined as the documentation of a negative 13C-urea breath test 4 wk after the end of the eradication treatment.RESULTS: The overall ITT eradication rate was 76.2%(122/160). The final ITT eradication rates were 70.8%(56/79; 95%CI: 63.3%-77.1%) in the RAM-7 group and 81.4%(66/81; 95%CI: 74.6%-88.3%) in the RAM-14 group(P = 0.034). The overall PP eradication rate was 84.1%(122/145), and the final PP eradication rates were 77.7%(56/72; 95%CI: 70.2%-85.3%) in the RAM-7 group and 90.4%(66/73; 95%CI: 82.8%-98.1%) in the RAM-14 group(P = 0.017). The H. pylori-eradication rates in the RAM-14 group were significantly higher compared with that of the RAM-7 group according to both the ITT(P = 0.034) and the PP analyses(P = 0.017). Both groups exhibited good treatment compliance(RAM-7/RAM-14 group: 100%/100%). The adverse event rates were19.4%(14/72)and 20.5%(15/73)in the RAM-7 and RAM-14 groups,respectively(P=0.441).Adverse events occurred in 14 of the 72 patients(19.4)in the RAM-7 group and in 15 of the 73 patients(20.5)in the RAM-14 group.No statistically significant differences(P=0.441)were observed.CONCLUSION:The 14-d moxifloxacin-based triple therapy is a significantly more effective secondline eradication treatment as compared to the 7-d alternative for H.pylori infection in South Korea.
文摘An inclusion complex of b-cyclodextrin with andrographolide (Andro) was prepared by using a convenient method of microwave irradiation. The structure of the inclusion complex was determined by the 1H NMR, 2D NMR spectroscopy as well as the elemental analysis.
文摘In this paper, we study elliptic partial differential equations with nonuniform growth, and obtain the strong convergence of the gradient of truncations of solutions and the strong convergence of the gradient of solutions in the setting of some Musielak-Orlicz spaces. Our results are generalization of the corresponding results for elliptic partial differential equations with power growth.
文摘Service and information resources are two kinds of major shared resources in virtual enterprises, where, service resources include third party’s service resources and enterprise’s legacy service resources,and information resources include database resources and file resources. Since service and information resources have distributed, autonomic, remotely bound as well as some other similar characteristics, an implementation mechanism on managing shared resources based on UDDI are presented. XML instances are used to describe resources authorization information, WSDL based special XML instance represents information resource metadata, and these XML instances are referenced by tModel for realizing the purpose of managing shared resources metadata based on UDDI.
文摘Continuation method solving forward kinematics problem of parallel robot was discussed. And through a coefficient-parameter continuation method the efficiency and feasibility of continuation method were improved. Using this method all forward solutions of a new parallel robot model which was put forward lately by Robot Open Laboratory of Science Institute of China were obtained. Therefore it provided the basis of mechanism analysis and real-time control for new model.
文摘Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Cardiac outputs measured by Innocor (CORB) were compared with CO obtained by echocardiography (COEC), Swan-Ganz thermodilution (COTD), and left ventricle radiography (COLVR) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS. Results: There was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by ther-modilution and between COEC and COLVR values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66±0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding COEC and COLVR values. Conclusion: Innocor CORB is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.
基金Supported by the National Natural Science Foundation of China (No. 20476025, No. 20236010, No. 20490200) and ShanghaiMunicipal Education Commission of China
文摘Surface morphologies of the films of poly [styrene-b-（ethylene-co-butene）-b-styrene] （SEBS） have been studied by using tapping-mode atomic force microscopy （TM-AFM）. The films of block copolymer were prepared both by spin-coating on mica and by solvent-casting on different solution surfaces. For spin-coating samples, the effect of solution concentration, solvent, and annealing temperature are investigated. It is shown that changing the concentration of the solution makes no difference on the morphology of the film of the block copolymer. The microstructures are quite stable during thermal annealing; only the size of the domains changes toward the equilibrium configuration. However, solvent annealing can notably change the microstructures. When different selective solvents are used for film spin-coating, different morphologies can be obtained and explained by the different solubility parameters of the solvents. As expected, significant different morphologies in the top and the bottom surfaces of the casting films were observed. The images of the top surfaces reveal cylinder microdomains, while those of the bottom surfaces were spherical morphologies.
文摘Large span spatial lattice structures have many natural frequencies in a narrow frequency range, the conventional frequency domain method is difficult to contain all significant contribution modes. Through numerical examples, it is found that some high order modes are likely to be overlooked because of their higher positions of modal order, in spite of their significance to wind response. According to the contributions of modes to strain energy of system, the paper presented an efficient method to compensate the errors owing to missing out some significant high order modes. The effectiveness of the proposed method is verified through a numerical analysis of the wind responses of a spherical dome.
基金This work was subsidized by the Special Funds for Major State Basic Research Projects(G 1999064800)the National Natural Science Foundation (2973414150103012) and SKLEP (0062).
文摘Two novel iron-based catalysts have been synthesized with high catalytic activity (about 108g oligomers/molFe穐) for ethylene oligomerization.
基金We are grateful for the financial supports from the National Outstanding Youth Fund (No. 29925204) the Foundation for University Key Teacher by the Ministry of Education of China and a Visiting Fund of the National Laboratory of Applied Organic Chem
文摘Efficient Mukaiyama-type aldol reaction of 1, 2-bis(trimethylsiloxy)cyclobutene with aromatic aldehydes catalyzed by MgI2 is reported. The resulting succinoylation product of aldehyde was converted into the synthetic useful g-lactone and butenolide derivatives.
文摘The property of fluid field of one-dimensional magnetohydrodynamics (MHD) transverse flow after the appearance of singularity is discussed. By the method of iteration, the strong discontinuity (shock wave) and entropy solution are constructed and the estimations on the singularity of the solution near the point of blow-up are obtained.
基金supported by the State Key Program of Fundamental Research (G1998061308) NNSFC (29971005+3 种基金 20023005 20071004) Beijing Natural Science Foundation (2002007) National Key Program for Fundamental Research (2001 CCD 04300) and Scientific Research Foun
文摘UV-vis and luminescence spectroscopic titration experiments show that a novel Ru(II) complex exhibits off-on-off pH luminescent switching with a maximum on-off ratio of about 100.
基金Funded by the foundation for key projects in 2000 of the Science and Technology Committee of Chongqing China (No.2000-6214).
文摘Owing to both of its high carrier concentration and large band gap, ZnO:Al (ZAO) films which is an n-type degenerate semiconductor, exhibits low resistance and high transmittance in the visible range. This work studies the crystal structure, optical and electrical properties and preparation methods of ZAO films, and discusses the existing problems and application prospective of ZAO films.
