Given the conflicts over the proposed formation mechanisms of Xiashu loess, the question of the provenance of sediments comprising the Xiashu loess in the Yangtze River Delta has not been satisfactorily resolved. In t...Given the conflicts over the proposed formation mechanisms of Xiashu loess, the question of the provenance of sediments comprising the Xiashu loess in the Yangtze River Delta has not been satisfactorily resolved. In this study, the provenance of aeolian sediments of the Yangtze River Delta, China was examined by applying the detrial zircon U–Pb dating technique, Sr–Nd isotopic and trace element compositional analysis. U-Pb dating analysis was conducted on the Xiashu loess at three locations over the Yangtze River Delta, including Huangnishan(HNS) hill, Shengshan(SS) island and the Xuancheng(XC) area. The Xiashu loess and the sediments of the Yangtze River Valley share considerable similarity in their zircon U-Pb age spectra with the same main age peak and comparable age distribution. By contrast, significant differences in the age spectra, existbetween the Xiashu loess and loess deposits of Chinese Loess Plateau(CLP). Coarse grains of the Yangtze River Delta loess may have a proximal material source identical to the sediments from the Yangtze River valley. Sr–Nd isotopic values of the Xiashu loess match those from the northern margin of the Tibetan Plateau. Rare earth element ratios independent of grain size illustrate that the values from loess of the Yangtze River Delta mostly overlap with those of CLP loess. This feature implies that loess from the Yangtze River Delta has a dominant source of distant material similar as the CLP loess. As such, we conclude that multi-proxy analysis of sediments can shed new light on tracing the provenance of aeolian loess in the Yangtze River Delta.展开更多
目的探讨伏格列波糖联合合艾塞那肽治疗2型糖尿病患者的疗效及对血清微小RNA(miR)-29a及miR-342-5p表达的影响。方法选取江苏省连云港市赣榆区人民医院2018年12月至2019年12月收治的106例2型糖尿病患者,根据治疗方法分为观察组与对照组,...目的探讨伏格列波糖联合合艾塞那肽治疗2型糖尿病患者的疗效及对血清微小RNA(miR)-29a及miR-342-5p表达的影响。方法选取江苏省连云港市赣榆区人民医院2018年12月至2019年12月收治的106例2型糖尿病患者,根据治疗方法分为观察组与对照组,各53例,对照组予以艾塞那肽进行治疗,观察组在对照组基础上给予伏格列波糖治疗,比较2组患者临床疗效和治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白(glycated hemoglobin,HbA_(1)c)等血糖指标水平,血清内皮素-1(endothelin-1,ET-1)、一氧化氮(NO)、动脉血流介导的内皮依赖性血管舒张功能(flow mediated dilation,FMD)等血管内皮功能指标水平和胰岛素(insulin,FINS)、胰岛素抵抗指数(homeostatic model assessment of insulin resistance,HOMA-IR)、胰岛素分泌指数(homeostasis model assessment-β,HOMA-β)等胰岛素β细胞功能及血清微RNA(miR)-29a及miR-342-5p水平表达情况。结果治疗后,观察组临床总有效率为96.2%(51/53),对照组临床总有效率为83.0%(44/53),2组比较差异有统计学意义(P<0.05)。2组患者空腹血糖、餐后2 h血糖和HbA_(1)c水平较治疗前降低,且观察组较对照组更低(P<0.05)。治疗后,2组患者ET-1水平较治疗前降低,且观察组较对照组更低(P<0.05),而NO和FMD水平较治疗前升高,且观察组较对照组更高(P<0.05)。治疗后,观察组FINS和HOMA-β较治疗前升高,而HOMA-IR较治疗前降低,且观察组优于对照组(P<0.05),而对照组治疗前后FINS、HOMA-β、HOMA-IR差异无统计学意义(P>0.05)。治疗后,2组患者血清miR-29a和血清miR-342-5p水平较治疗前降低,且观察组较对照组更低(P<0.05)。结论伏格列波糖联合艾塞那肽治疗2型糖尿病患者可有效降低其血糖水平,改善血管内皮功能,改善胰岛素抵抗情况,降低血清miR-29a及miR-342-5p水平,控制病情进展,对改善预后具有积极意义。展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 41371032, 41671003, 41601189, 41672349)
文摘Given the conflicts over the proposed formation mechanisms of Xiashu loess, the question of the provenance of sediments comprising the Xiashu loess in the Yangtze River Delta has not been satisfactorily resolved. In this study, the provenance of aeolian sediments of the Yangtze River Delta, China was examined by applying the detrial zircon U–Pb dating technique, Sr–Nd isotopic and trace element compositional analysis. U-Pb dating analysis was conducted on the Xiashu loess at three locations over the Yangtze River Delta, including Huangnishan(HNS) hill, Shengshan(SS) island and the Xuancheng(XC) area. The Xiashu loess and the sediments of the Yangtze River Valley share considerable similarity in their zircon U-Pb age spectra with the same main age peak and comparable age distribution. By contrast, significant differences in the age spectra, existbetween the Xiashu loess and loess deposits of Chinese Loess Plateau(CLP). Coarse grains of the Yangtze River Delta loess may have a proximal material source identical to the sediments from the Yangtze River valley. Sr–Nd isotopic values of the Xiashu loess match those from the northern margin of the Tibetan Plateau. Rare earth element ratios independent of grain size illustrate that the values from loess of the Yangtze River Delta mostly overlap with those of CLP loess. This feature implies that loess from the Yangtze River Delta has a dominant source of distant material similar as the CLP loess. As such, we conclude that multi-proxy analysis of sediments can shed new light on tracing the provenance of aeolian loess in the Yangtze River Delta.
文摘目的探讨伏格列波糖联合合艾塞那肽治疗2型糖尿病患者的疗效及对血清微小RNA(miR)-29a及miR-342-5p表达的影响。方法选取江苏省连云港市赣榆区人民医院2018年12月至2019年12月收治的106例2型糖尿病患者,根据治疗方法分为观察组与对照组,各53例,对照组予以艾塞那肽进行治疗,观察组在对照组基础上给予伏格列波糖治疗,比较2组患者临床疗效和治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白(glycated hemoglobin,HbA_(1)c)等血糖指标水平,血清内皮素-1(endothelin-1,ET-1)、一氧化氮(NO)、动脉血流介导的内皮依赖性血管舒张功能(flow mediated dilation,FMD)等血管内皮功能指标水平和胰岛素(insulin,FINS)、胰岛素抵抗指数(homeostatic model assessment of insulin resistance,HOMA-IR)、胰岛素分泌指数(homeostasis model assessment-β,HOMA-β)等胰岛素β细胞功能及血清微RNA(miR)-29a及miR-342-5p水平表达情况。结果治疗后,观察组临床总有效率为96.2%(51/53),对照组临床总有效率为83.0%(44/53),2组比较差异有统计学意义(P<0.05)。2组患者空腹血糖、餐后2 h血糖和HbA_(1)c水平较治疗前降低,且观察组较对照组更低(P<0.05)。治疗后,2组患者ET-1水平较治疗前降低,且观察组较对照组更低(P<0.05),而NO和FMD水平较治疗前升高,且观察组较对照组更高(P<0.05)。治疗后,观察组FINS和HOMA-β较治疗前升高,而HOMA-IR较治疗前降低,且观察组优于对照组(P<0.05),而对照组治疗前后FINS、HOMA-β、HOMA-IR差异无统计学意义(P>0.05)。治疗后,2组患者血清miR-29a和血清miR-342-5p水平较治疗前降低,且观察组较对照组更低(P<0.05)。结论伏格列波糖联合艾塞那肽治疗2型糖尿病患者可有效降低其血糖水平,改善血管内皮功能,改善胰岛素抵抗情况,降低血清miR-29a及miR-342-5p水平,控制病情进展,对改善预后具有积极意义。
