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Ocular surface changes in moderate-to-severe acne vulgaris 被引量:1
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作者 Ci-Yi Pan dong-jie sun +4 位作者 Han-Ling Li Li Ma Min Zhang Song-Yuan Tang Hui Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第6期1049-1057,共9页
AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.METHODS:This cross-sectional study included... AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.METHODS:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy controls.The participants completed the Ocular Surface Disease Index(OSDI)questionnaire.The following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)score.RESULTS:The stability of the tear film decreased in acne vulgaris patients.In the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P<0.05).There were no significant differences in the CFS score,SIT,or LLT score between the groups(P>0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P<0.05).There were no significant differences between OSDI,SIT,and CFS score(P>0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne vulgaris.Reduced tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye. 展开更多
关键词 acne vulgaris meibomian gland dysfunction dry eye tear film
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Bilateral macular edema secondary to nab-paclitaxel therapy for breast cancer
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作者 Zi-Yi Zhou Ya-Ting Ye +3 位作者 Jing-Ting Zhu dong-jie sun Yu-Sheng Wang Guo-Rui Dou 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第10期1963-1966,共4页
Dear Editor,Nanoparticle albumin bound(nab)–paclitaxel is a member of the taxane agents that has been proven efficient and widely applied in breast cancer as well as other kind of cancers.The taxane-induced macular e... Dear Editor,Nanoparticle albumin bound(nab)–paclitaxel is a member of the taxane agents that has been proven efficient and widely applied in breast cancer as well as other kind of cancers.The taxane-induced macular edema has been recognized as an uncommon side effect which might regress after the drug withdraw.Here we presented our case as a rarely observed macular edema secondary to nab–paclitaxel therapy as follows.The consent from the patient was achieved and the research was approved by the Ethics Committee of Xijing Hospital(KY20202009-C-1). 展开更多
关键词 EDEMA BREAST MACULAR
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Fundus autofluorescence in central serous chorioretinopathy: association with spectral-domain optical coherence tomography and fluorescein angiography 被引量:7
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作者 Peng Zhang Hai-Yan Wang +4 位作者 Zi-Feng Zhang dong-jie sun Jin-Ting Zhu Juan Li Yu-Sheng Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期1003-1007,共5页
and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus a... and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared fundus AF (IR -AF) and short-wave length fundus AF (SW -AF) with changes in spectral -domain optical coherence tomography (SD -OCT) and fluorescein angiography (FA) in central serous chorioretinopathy (CSC). METHODS: Two hundred and twenty consecutive patients with CSC were included. In addition to AF, patients were assessed by means of SD -OCT and FA. Abnormalities in images of IA -AF, SW -AF, FA were analyzed and correlated with the corresponding outer retinal alterations in SD-OCT findings. RESULTS: Eyes with abnormalities on either IR-AF or SW-AF were found in 256 eyes (58.18%), among them 256 eyes (100%) showed abnormal IR -AF, but SW-AF abnormalities were present only in 213 eyes (83.20%). The hypo-IR-AF corresponded to accumulation of subretinal liquid, collapse of retinal pigment epithelium (APE) or detachment of APE with or without RPE leakage point in the corresponding area. The hyper -IR -AF corresponded to the area with loss of the ellipsoid portion of the inner segments and sub -sensory retinal deposits or focal melanogenesis under sensory retina. The hypo-SW-AF corresponded to accumulation of subretinal liquid or atrophy of RPE. The hyper -SW -AF associated with sub -sensory retinal deposits, detachment of RPE and focal melanogenesis. CONCLUSION: IR-AF was more sensitive than SW-AF AF should be used as a common diagnostic tool for identifying pathological lesion in CSC. 展开更多
关键词 central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography
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自噬调节高浓度葡萄糖诱导的人晶状体上皮细胞上皮间质转化 被引量:3
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作者 马济远 叶巍 +6 位作者 李吉 裴瑞 何梦梅 苏静波 孙董洁 周其武 周健 《国际眼科杂志》 CAS 北大核心 2020年第5期759-767,共9页
目的:探究自噬水平变化对高糖诱导人晶状体上皮细胞上皮间质转化(EMT)的影响及其机制。方法:人晶状体上皮细胞(HLE-B3)分为正常对照组(NC组)和高糖处理组(HG组),分别用含5.5mmol/L葡萄糖的DMEM和添加了30mmol/L葡萄糖的上述DMEM培养12... 目的:探究自噬水平变化对高糖诱导人晶状体上皮细胞上皮间质转化(EMT)的影响及其机制。方法:人晶状体上皮细胞(HLE-B3)分为正常对照组(NC组)和高糖处理组(HG组),分别用含5.5mmol/L葡萄糖的DMEM和添加了30mmol/L葡萄糖的上述DMEM培养12、24、48h,用Western blot检测上皮间质转化标志蛋白(E-cadherin、α-SMA)和自噬标志蛋白(LC3、Beclin 1和SQSTM1/p62)的表达变化,用划痕实验观察细胞的移行能力以明确高糖对晶状体上皮细胞自噬和EMT的影响。利用雷帕霉素调节自噬水平,将细胞分为正常对照组(NC组)、高糖处理组(HG组),高糖处理细胞的同时添加DMSO溶剂组(DMSO组)和添加200nmol/L雷帕霉素的雷帕霉素组(RAPA组),处理细胞24h,用Transwell实验观察细胞的移行能力,用Western blot检测EMT、自噬标志蛋白和TGF-β信号通路蛋白(TGF-β2、Smad2/3、p-Smad2/3、Snail)的表达。用细胞免疫荧光染色观察SQSTM1/p62与Smad2/3在细胞内的表达,免疫共沉淀方法检测细胞中SQSTM1/p62与Smad2/3之间的相互结合。结果:在高糖刺激后12、24、48h,HG组细胞E-cadherin、LC3Ⅱ/Ⅰ和Beclin 1蛋白表达逐渐降低(F=67.52、163、206,均P<0.0001),而α-SMA、SQSTM1/p62蛋白表达增加(F=53.37、302.1,均P<0.0001),细胞移行也较NC组增加(均P<0.001),提示高糖刺激后细胞发生EMT,而自噬水平降低;雷帕霉素处理后,与HG组和DMSO组相比,RAPA组LC3Ⅱ/Ⅰ和E-cadherin蛋白表达水平增加,α-SMA、p-Smad2/Smad2、p-Smad3/Smad3及Snail蛋白表达降低(均P<0.05),TGF-β2表达无明显改变(均P>0.05),细胞移行被抑制(均P<0.001),提示雷帕霉素在提高自噬水平的同时下调了TGF-β信号通路分子的表达进而抑制了EMT。细胞免疫荧光染色结果显示SQSTM1/p62与Smad2/3在胞浆内存在共定位,免疫共沉淀实验证实了SQSTM1/p62与Smad2/3蛋白相互结合。结论:高糖可刺激HLE-B3细胞发生EMT,下调细胞的自噬水平;自噬通过SQSTM1/p62与Smad2/3相互作用,改变了TGF-β信号通路中Smad2/3的表达,实现对EMT的调节。 展开更多
关键词 自噬 上皮间质转化 晶状体上皮细胞 雷帕霉素 TGF-Β信号通路
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Infrared autofluorescence, short-wave autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytomas 被引量:3
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作者 Peng Zhang Yan-Nian Hui +4 位作者 Wen-Qin Xu Zi-Feng Zhang Hai-Yan Wang dong-jie sun Yu-Sheng Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第5期713-716,共4页
AIM: To investigate the findings of infrared fundus autofluorescence(IR-AF) and spectral-domain optical coherence tomography(SD-OCT) in eyes with optic disc melanocytoma(ODM).· METHODS: IR-AF findings and... AIM: To investigate the findings of infrared fundus autofluorescence(IR-AF) and spectral-domain optical coherence tomography(SD-OCT) in eyes with optic disc melanocytoma(ODM).· METHODS: IR-AF findings and those of other ophthalmologic imaging examinations, including short-wave autofluorescence(SW-AF), fluorescein angiography(FA), fundus color photography, and SD-OCT of 8 eyes of 8 consecutive cases with ODM were assessed.·RESULTS: The ODMs in all cases(100%) presented similar IR-AF, SW-AF, and FA findings. On IR-AF images, ODMs showed outstanding hyper-AF with well-defined outline. On SW-AF images, the area of ODMs presented as hypo-AF. FA images revealed the leaking retinal telangiectasia on the surface of the ODMs. On SDOCT images in 8 cases(100%), the ODMs were sloped with highly reflective surface, which were disorganized retina and optic nerve layers. In 7 cases(87.5%), peripapillary choroids were involved. The melanocytomas of 8 cases(100%) presented as optically empty spaces. Vitreous seeds were found in one case(12.5%).· CONCLUSION: IR-AF imaging may provide a new modality to evaluate the pathologic features of ODMs,and together with SW-AF imaging, offers a new tool to study biological characteristics associated with ODMs.SD-OCT is a valuable tool in delimitating the tumor extension and providing morphological information about the adjacent retinal tissue. 展开更多
关键词 MELANOCYTOMA ANGIOGRAPHY AUTOFLUORESCENCE optical coherence tomography
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基于GMPE模块OCT与眼底彩色照相法测量客观眼球旋转度的比较 被引量:3
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作者 李娜敏 郭长梅 +6 位作者 张璐 赵润泽 张桂鸥 朱锦婷 孙董洁 惠延年 窦国睿 《国际眼科杂志》 CAS 北大核心 2022年第8期1396-1401,共6页
目的:比较基于GMPE模块光学相干断层扫描(OCT)与传统眼底彩色照相法(FCP)测量客观眼球旋转度的一致性和可行性。方法:纳入2020-12/2021-03我院斜弱视门诊受检者,同一天用基于GMPE模块OCT与FCP两种方法测量客观眼球旋转度。FCP使用Adobe ... 目的:比较基于GMPE模块光学相干断层扫描(OCT)与传统眼底彩色照相法(FCP)测量客观眼球旋转度的一致性和可行性。方法:纳入2020-12/2021-03我院斜弱视门诊受检者,同一天用基于GMPE模块OCT与FCP两种方法测量客观眼球旋转度。FCP使用Adobe Photoshop软件手动定位测量黄斑中心凹-视盘中心夹角度数(FDA),基于GMPE模块OCT软件自动定位黄斑和视盘中心测量FDA。结果:纳入55例受检者,OCT测量FDA分别为右-6.6°±4.5°和左-8.8°±4.7°,FCP测量FDA分别为右-6.6°±4.7°和左-8.4°±4.1°,两种方法测量结果无差异(P_(右眼)=0.90,P_(左眼)=0.08)。外斜视患者OCT测量FDA分别为右-5.8°±4.9°和左-9.1°±4.5°,FCP测量FDA分别为右-5.7°±5.0°和左-8.6°±4.3°(P_(右眼)=0.75,P_(左眼)=0.15)。类似地,内斜视患者OCT测量FDA分别为右-9.0°±7.3°和左-11.3°±3.5°,而FCP测量FDA分别为右-10.0°±7.0°和左-10.1°±2.8°(P_(右眼)=0.21,P_(左眼)=0.10),两种测量方法在内外斜视患者中均无差异(P>0.05)。Pearson检验及Bland-Altman分析两种方法的结果高度相关一致(r_(右眼)=0.93,r_(左眼)=0.94,均P<0.01)。结论:基于GMPE模块OCT可用于客观眼球旋转度的测量,且可信度及重复度高,临床有望替代眼底彩色照相法。 展开更多
关键词 客观眼球旋转度 光学相干断层扫描(OCT) 眼底彩色照相 Adobe Photoshop软件
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下斜肌肌腹转位术治疗轻度下斜肌亢进伴小度数垂直斜视 被引量:1
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作者 郭长梅 张璐 +4 位作者 李娜敏 孙董洁 付梦 张桂鸥 窦国睿 《国际眼科杂志》 CAS 北大核心 2022年第5期839-843,共5页
目的:观察下斜肌肌腹转位(IOBT)术在单眼下斜肌轻度亢进伴小度数垂直斜视中的应用效果。方法:回顾性分析2019-09/2021-08在我院行IOBT术的患者,纳入标准为单眼下斜肌轻度亢进(2+及以下),并伴有轻度非共同性垂直斜视(4~9PD)。水平斜视按... 目的:观察下斜肌肌腹转位(IOBT)术在单眼下斜肌轻度亢进伴小度数垂直斜视中的应用效果。方法:回顾性分析2019-09/2021-08在我院行IOBT术的患者,纳入标准为单眼下斜肌轻度亢进(2+及以下),并伴有轻度非共同性垂直斜视(4~9PD)。水平斜视按照常规手术量和方式设计,同期单侧下斜肌亢进眼行单眼IOBT术。观察手术前后水平斜视度、垂直斜视度、侧方注视位垂直斜视度、黄斑视盘夹角及下斜肌亢进程度等。结果:纳入病例共16例16眼,年龄4~39岁。1例为先天性内斜视术后5a,单眼上斜肌轻度麻痹继发下斜肌功能亢进,余15例均为原发性下斜肌功能亢进伴水平斜视。随访时间为3~6mo。术前和术后平均下斜肌亢进程度分级分别为+2.00(2.00,2.00)级和0.00(0.00,0.00)级(Z=-3.704,P<0.001),平均改善2.00(1.25,2.00)级;水平斜视度从术前69.13±25.86PD减少到术后2.75±2.59PD(t=9.929,P<0.001);第一眼位垂直斜视从术前7.44±1.32PD减少到术后1.00±1.21PD(t=22.335,P<0.001),平均矫正上斜视为6.44±1.15PD;侧方注视垂直斜视从术前12.44±2.73PD减少到术后3.00±2.13PD,平均矫正9.44±2.73PD(t=13.819,P<0.001)。黄斑中心凹-视盘中心夹角度数(FDA)术前为-8.85°±6.53°,术后为-6.49°±7.01°(t=-2.384,P<0.001),平均减少2.36°。未见术后过矫及下斜肌功能不足等并发症。结论:IOBT术对矫正单侧轻度下斜肌亢进伴小度数垂直斜视是安全有效的。 展开更多
关键词 下斜肌肌腹转位术 下斜肌轻度亢进 小度数垂直斜视
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Gastrointestinal bleeding caused by syphilis: A case report
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作者 dong-jie sun Hai-Tao Li +3 位作者 Zhou Ye Bin-Bin Xu Da-Zhou Li Wen Wang 《World Journal of Clinical Cases》 SCIE 2021年第26期7909-7916,共8页
BACKGROUND Syphilis is a chronic,classic sexually transmitted disease caused by Treponema pallidum,which can invade almost all organs of the body and produce various symptoms and signs.Although there are some cases of... BACKGROUND Syphilis is a chronic,classic sexually transmitted disease caused by Treponema pallidum,which can invade almost all organs of the body and produce various symptoms and signs.Although there are some cases of colorectal bleeding caused by syphilis,small intestinal bleeding caused by syphilis is still rare.CASE SUMMARY A 58-year-old man had experienced recurrent abdominal pain and melena for 3 years.Repeated gastroenteroscopy and computed tomography angiography examinations failed to find bleeding lesions.During the same admission,multiple intestinal ulcers were found by capsule endoscopy,and syphilis was also diagnosed.With a history of atrial fibrillation and chronic pancreatitis,he had undergone mitral valve replacement and tricuspid valvuloplasty for valvular heart disease.After anti-syphilis treatment,the melena and abdominal pain disappeared and his hemoglobin gradually increased.It is considered that gastrointestinal bleeding,chronic pancreatitis,atrial fibrillation,and heart valvular disease may have been caused by syphilis.CONCLUSION This case report found that syphilis can mimic systemic disease and cause intestinal bleeding.In addition,treatment of the disease requires both sexual partners to be treated.Finally,although syphilis is easy to treat,it is more important to consider that bleeding could be caused by syphilis. 展开更多
关键词 Treponema pallidum Alimentary tract hemorrhage Small intestinal ulcer Gastrointestinal syphilis Infectious diseases Case report
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