Recent Advances in Fibrous Materials for Hydroelectricity Generation

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable development.Hydroelectricity generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy crisis.Fibrous materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first introduced.Then,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are demonstrated.Afterward,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in detail.Moreover,the potential applications including power supply,energy storage,electrical sensor,and information expression are also discussed.Finally,some existing challenges are considered and prospects for future development are sincerely proposed.

用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线

Chemical resistant textiles are vital for safeguarding humans against chemical hazards in various settings.such as industrialproduction,chemicalaccidents,laboratory activities,and road transportation.However,the ideal integration of chemical resistance,thermal and moisture management,and wearer condition monitoring in conventional chemically protective textiles remains challenging.Herein,the design,manufacturing,and use of stretchable hierarchical core-shell yarns(HCSYs)for integrated chemical resistance,moisture regulation,and smart sensing textiles are demonstrated.These yarns con-tain helically elastic spandex,wrapped silver-plated nylon,and surface-structuredpolytetrafluo-roethylene(PTFE)yarns and are designed and manufactured based on a scalable fabrication process.In addition to their ideal chemical resistance performance,HCSYs can function as multifunctional stretch-able electronics for real-time human motion monitoring and as the basic element of intelligent textiles.Furthermore,a desirable dynamic thermoregulation function is achieved by exploiting the fabric structure with stretching modulation.Our HCSYs may provide prospective opportunities for the future development of smart protective textiles with high durability,flexibility,and scalability.

Impact Damage Testing Study of Shanxi-Beijing Natural Gas Pipeline Based on Decision Tree Rotary Tiller Operation

The North China Plain and the agricultural region are crossed by the Shanxi-Beijing natural gas pipeline.Resi-dents in the area use rototillers for planting and harvesting;however,the depth of the rototillers into the ground is greater than the depth of the pipeline,posing a significant threat to the safe operation of the pipeline.Therefore,it is of great significance to study the dynamic response of rotary tillers impacting pipelines to ensure the safe opera-tion of pipelines.This article focuses on the Shanxi-Beijing natural gas pipeline,utilizingfinite element simulation software to establish afinite element model for the interaction among the machinery,pipeline,and soil,and ana-lyzing the dynamic response of the pipeline.At the same time,a decision tree model is introduced to classify the damage of pipelines under different working conditions,and the boundary value and importance of each influen-cing factor on pipeline damage are derived.Considering the actual conditions in the hemp yam planting area,targeted management measures have been proposed to ensure the operational safety of the Shanxi-Beijing natural gas pipeline in this region.

Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease

Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus.Therefore,using these two treatments may help treat Parkinson's disease.To further investigate the mechanisms of action of these two compounds,we established a model of Parkinson's disease by treating mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and then subcutaneously injected them with the glucagon-like peptide-1 receptor agonist exendin-4 or the dipeptidyl peptidase 4 inhibitor linagliptin.We found that both exendin-4 and linagliptin reversed motor dysfunction,glial activation,and dopaminergic neuronal death in this model.In addition,both exendin-4 and linagliptin induced microglial polarization to the anti-inflammatory M2 phenotype and reduced pro-inflammatory cytokine secretion.Moreover,in vitro experiments showed that treatment with exendin-4 and linagliptin inhibited activation of the nucleotide-binding oligomerization domain-and leucine-rich-repeat-and pyrin-domaincontaining 3/caspase-1/interleukin-1βpathway and subsequent pyroptosis by decreasing the production of reactive oxygen species.These findings suggest that exendin-4 and linagliptin exert neuroprotective effects by attenuating neuroinflammation through regulation of microglial polarization and the nucleotidebinding oligomerization domain-and leucine-rich-repeat-and pyrin-domain-containing 3/caspase-1/interleukin-1βpathway in a mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Therefore,these two drugs may serve as novel anti-inflammatory treatments for Parkinson's disease.

An overview of fluids mixing in T-shaped mixers

In a T-shaped mixer,the two liquid streams in the inlet channels meet each other at the T-junction,and their liquid-liquid contacting face exhibits planar,swirling folds and the folds breaking to be chaos and turbulence,as the Reynolds number increases.The characteristic mixing scenario attracts long-time attention,given these mixings are of fundamental importance in fluid physics and also have been successfully used in engineering applications.The experimental and numerical studies of flow features and mixing characteristics in T-mixers are overviewed in this manuscript.This review introduces the experimental and numerical techniques in the studies,the flow and mixing characteristics in the corresponding regimes and application examples of the T-mixers at last,aiming at introducing fundamentals to researchers with initial interests on this topic.

不同类型弱视儿童视网膜结构和视觉诱发电位及立体视功能的差异性分析

目的:分析不同类型弱视儿童的视网膜结构和功能、视觉诱发电位及立体视功能的差异性。方法:选取2014-05/2018-05在我院眼科治疗的中度弱视儿童92例136眼为观察组(屈光参差性31例31眼,屈光不正性35例70眼,斜视性26例35眼),另选取在我院眼科检查视力正常的儿童29例58眼为对照组。采用光学相干断层扫描(OCT)成像仪检测黄斑中心凹厚度、视盘周围及各象限视网膜神经纤维层(RNFL)厚度,采用视觉眼电图检测视网膜功能变化,观察视觉诱发电位P100波幅值及潜伏期的特点,并进行立体视觉检查。结果:屈光参差性、屈光不正性弱视儿童黄斑中心凹厚度、视盘周围及各象限RNFL厚度均明显高于对照组和斜视性弱视儿童(P<0.01)。与对照组相比,屈光参差性弱视儿童视觉眼电图光峰电位偏低,光峰时间延长,屈光不正性弱视儿童中近视儿童暗谷电位偏高,Arden比和Gliern比减小(均P<0.01)。三种类型弱视儿童视觉诱发电位P100波幅值均明显低于对照组,且1°和15′空间频率潜伏期明显延迟(均P<0.01)。屈光不正性弱视儿童交叉视差、非交叉视差、近零视差、远立体视功能正常眼数显著高于斜视性弱视儿童(P<0.0167),但与屈光参差性弱视儿童上述各项指标无差异。结论:屈光参差性弱视、屈光不正性弱视儿童视网膜结构存在明显异常,且P100波潜伏期延迟;斜视性弱视对立体视功能影响最大,而屈光不正性弱视影响最小。

盐酸氮卓斯汀联合普拉洛芬治疗儿童变态反应性结膜炎

目的:探讨盐酸氮卓斯汀联合普拉洛芬治疗儿童变态反应性结膜炎的疗效。方法:选择我院2016-05/2018-06接诊的变态反应性结膜炎患儿80例160眼,根据治疗方法不同分为两组,对照组40例80眼给予普拉洛芬滴眼液治疗,观察组40例80眼在对照组基础上联合盐酸氮卓斯汀滴眼液进行辅助治疗。两组患儿均连续治疗1wk。比较两组患儿临床疗效、临床症状、泪膜稳定性、炎症因子的变化情况及不良反应。结果:治疗1wk后观察组临床总有效率为95.0%,高于对照组的85.0%(P=0.035)。观察组患儿眼痒、流泪、异物感、畏光的评分均低于对照组[(1.13±0.36)vs(2.28±0.41)分,(1.05±0.33)vs(2.14±0.49)分,(1.17±0.46)vs(2.28±0.59)分,(1.29±0.37)vs(1.84±0.55)分](P<0.05);观察组患儿的泪膜破裂时间(BUT)明显高于对照组,角膜荧光素染色试验(FL)明显低于对照组[(11.96±1.14)vs(5.85±0.92)s,(2.85±0.33)vs(6.21±0.68)分](P<0.05);观察组患儿泪液中组胺(HA)、嗜酸性细胞阳离子蛋白(ECP)和免疫球蛋白E(IgE)水平均低于对照组[(31.62±4.51)vs(65.03±6.48)μg/L,(2.20±0.28)vs(7.26±0.72)μg/L,(0.06±0.01)vs(0.18±0.04)mg/L](P<0.05);两组患儿治疗期间的不良反应总发生率无差异(χ2=1.897,P=0.168)。结论:盐酸氮卓斯汀联合普拉洛芬治疗儿童变态反应性结膜炎的效果明显,能有效改善炎症因子指标水平,促进泪膜稳定性的恢复,安全性好。

角膜新生血管的显影方法

角膜新生血管(corneal neovascularization,CNV)的产生是角膜盲的常见原因,但到目前为止,还没有十分有效的治疗方法。CNV面积这一参数在衡量药物或治疗方案效果好坏时具有重要参考价值。目前有多种方法可对CNV进行显影,包括墨汁灌注、免疫荧光染色等,近年来的光学相干断层成像技术等也是极有潜力的新方法。本文综述了显影CNV的相关方法,希望能对CNV的研究提供参考。

Effects of Local Testicular Heating on Bcl-2 and Bax Protein Expression in Spermatogenic Cells in Rats

Objective To investigate the expression of Bcl-2 and Bax in spermatogenic cells induced by local testicular heating in rats Methods Forty adult male SD rats were divided into experimental group and control group at random. According to day 0.5, 1, 3 and 6 after local testicular heating, each group was divided into 4 subgroups： experimental subgroup （n=6） and control subgroup （n=4）. The expression of Bcl-2 and Bax in the spermatogenic cells was detected on day 0.5, 1, 3 and 6 after heat exposure by using immunohistochemistry. Results Compared with control groups, the ratio of positive cells and content of Bcl-2 positive cells significantly decreased in all experimental subgroups （P〈0.01）. The content of Bax positive cells increased in all experimental subgroups （P〈0.01）, the ratio of positive cells which had no significant difference （P〉0.05） except 6 d group decreased （P〈0.01 ）. Redistribution of Bax from a cytoplasmic to perinuclear or nuclear localization could be observed after heating. Conclusions Expression of Bcl-2 would decrease and Bax would increase with redistribution in spermatogenic cells in rats after heating. The change of Bcl-2 and Bax expression in spermatogenic cells would be correlated with the spermatogenic cell apoptosis induced by heating.

Analysis of DNA Content of Various Types of Spermatogenic Cells in Rat after Testicular Heating with Flow Cytometry

To measure DNA contents of spermatogenic cells and analyze the efficiency of spermatogenesis after testicular heating in rat Methods Eighty adult male Sprague-Dawley rats were randomly divided into experimental group （43 ℃, 30 min） and control group （22 ℃, 30 min）. According to day 0.5, 1, 3, 6, 10, 25, 35 and 50 after local testicular heating, every group was divided into 8 subgroups： experimental subgroups （n=6） and control subgroups （n=4）. DNA contents of various types of germ cells were observed with flow cytometry （FCM） in all groups. Results Compared with control groups, percentages of 4C cell （primary spermatocyte） in 0.5-35 d groups and percentages of 1C cell （spermatid and sperm） in 6-50 d groups significantly decreased in experimental groups （P〈0.05）, and percentages of 2C cell （spermatogonium and second spermatocyte） in 3 -35 d experimental groups increased significantly after heating （P〈0.05）. 4C：2C in all of 8 experimental groups and 1C：2C in 3-35 d experimental groups were down （P〈0. 05）, and in 1 d experimental group 1C：4C was up after heating （P〈0.05）. Conclusions After being heated, the number of spermatocyte firstly decreased, and then that of spermatid and sperm decreased too. Heat influences several stages in spermatogenesis and results in suppression of spermatogenesis. Flow cytometry is an effective method for researching on the change of spermatogenesis and has significance on mechanism about changing of spermatogenic cells induced by heat.

Recent Advances in Fibrous Materials for Interfacial Solar Steam Generation

The scarcity of fresh water resources has become a serious issue hindering the sustainable development of modern civilization.The interfacial solar steam generation(ISSG)system that produces heat on material surface through photothermal conversion for desalination has been demonstrated as a promising candidate for practical application.Fibrous materials with unique flexibility,durability,processability,practicability,and multifunctionality have attracted considerable attention in the ISSG field.In this review,the basics of fibrous materials,such as their classification,manufacturing methods and flexible fibrous structure,are firstly introduced.Afterward,the outstanding properties of fibrous materials on different dimensions are demonstrated,as well as the versatile morphologies and structures that allow fibrous materials to carry out different roles in ISSG.Moreover,the practicability and multifunctionality of fibrous materials are illustrated in detail by combining specific cases to show their promising potential in practical ISSG application.Finally,existing challenges and future opportunities of fibrous material-based ISSG systems are discussed.

Molecular Simulations in Macromolecular Science

Molecular simulations are now an essential part of modern chemistry and physics,especially for the investigation of macromolecules.They have evolved into mature approaches that can be used effectively to understand the structure-to-property relationships of diverse macromolecular systems.In this article,we provide a tutorial on molecular simulations,focusing on the technical and practical aspects.Several prominent and classical simulation methods and software are introduced.The applications of molecular simulations in various directions of macromolecular science are thenfeatured by representative systems,including self-assembly,crystallization,chemical reaction,and some typical non-equilibrium systems.This tutorial paper provides a useful overview of molecular simulations in the rapid progress of macromolecular science,and suggests guidance for researchers who start exploiting molecular simulations in their study.

Fast and direct identification of SARS-CoV-2 variants via 2D InSe field-effect transistors

As the COVID-19 pandemic evolves and new variants emerge,the development of more efficient identification approaches of variants is urgent to prevent continuous outbreaks of SARS-CoV-2.Field-effect transistors(FETs)with two-dimensional(2D)materials are viable platforms for the detection of virus nucleic acids(NAs)but cannot yet provide accurate information on NA variations.Herein,2D Indium selenide(InSe)FETs were used to identify SARSCoV-2 variants.The device's mobility and stability were ensured by atomic layer deposition(ALD)of Al_(2)O_(3).The resulting FETs exhibited sub-fM detection limits ranging from 10^(–14)M to 10^(–8)M.The recognition of single-nucleotide variations was achieved within 15 min to enable the fast and direct identification of two core mutations(L452R,R203M)in Delta genomes(p<0.01).Such capability originated from the trap states in oxidized InSe(InSe_(1-x)O_(x))after ALD,resulting in traps-involved carrier transport responsive to the negative charges of NAs.In sum,the proposed approach might highly provide epidemiological information for timely surveillance of the COVID pandemic.

Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury

Acute lung injury(ALI),as a common clinical emergency,is pulmonary edema and diffuse lung infiltration caused by inflammation.The lack of non-invasive alert strategy,resulting in failure to carry out preventive treatment,means high mortality and poor prognosis.Stimulator of interferon genes(STING)is a key molecular biomarker of innate immunity in response to inflammation,but there is still a lack of STING-targeted strategy.In this study,a novel STING-targeted PET tracer,[~(18)F]FBTA,was labeled with high radiochemical yield(79.7±4.3%)and molar activity(32.5±2.9 GBq/μmol).We confirmed that[~(18)F]FBTA has a strong STING binding affinity(K_d=26.86±6.79 nmol/L)and can be used for PET imaging in ALI mice to alert early lung inflammation and to assess the efficacy of drug therapy.Our STING-targeted strategy also reveals that[~(18)F]FBTA can trace ALI before reaching the computed tomography(CT)diagnostic criteria,and demonstrates its better specificity and distribution than[~(18)F]fluorodeoxyglucose([~(18)F]FDG).

Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory

The development of biopolymers for biomedical applications has traditionally been based on new chemistries.However,there is growing recognition that the biological responses can be regulated by the physical as well as the chemical properties of biomaterials.Understanding the biophysicochemical principles regarding biopolymers is thereby of great importance in the generation of advanced biomaterials.Herein,this review article seeks to provide a conceptual framework demonstrating how the approaches of tailored computer simulations and theoretical analysis are harnessed to explore the physicochemical principles of biopolymer cellular interactions.We briefly introduce the theoretical and simulation methods used in this field,summarize the typical findings based on these approaches,and describe the correlations between theoretical results and experiments.Finally,the future prospects for the theoretical aspect of biopolymers and their biophysicochemical interactions are discussed.The knowledge might be critical from the perspective of advantageous and safe use of designer biomaterials.

0.05%阿托品联合角膜塑形镜在进展性近视中对离焦环的调控增效作用

目的:研究0.05%阿托品在配戴角膜塑形镜的进展性近视中对离焦环调控的增效作用。方法:前瞻性随机对照研究。随机选取2021年6月至2023年1月在重庆渥迪眼科配戴角膜塑形镜后监测1年眼轴仍增加0.34 mm的进行性近视患者90例(90眼),按照自愿原则随机分为2组。对照组45眼,采用角膜塑形镜联合0.01%阿托品眼液治疗;联合组45眼,采用角膜塑形镜联合0.05%阿托品眼液治疗。治疗前和治疗1年后测定患者的眼轴、亮瞳直径、暗瞳直径、亮瞳下离焦环与瞳孔的相对位置关系(分为离焦环大于瞳孔、离焦环等于瞳孔、离焦环小于瞳孔)以及不良反应发生情况。采用t检验和卡方检验进行2组间的分析。结果:与治疗前相比,对照组和联合组在1年的治疗后眼轴均显著增加(P<0.001),且联合组眼轴增加明显低于对照组(P<0.001)。治疗后联合组和对照组亮瞳和暗瞳直径与治疗前相比均显著增加(P<0.001)。治疗后,联合组和对照组亮瞳下离焦环与瞳孔的相对位置关系与治疗前比较均有改变,联合组差异有统计学意义(P=0.001),对照组差异无统计学意义(P>0.05)。治疗期间,联合组和对照组不良反应发生情况比较差异无统计学意义(P>0.05)。结论:角膜塑形镜联合0.01%、0.05%阿托品可协同增强青少年的近视控制效果,并具有良好的安全性。0.05%阿托品联合角膜塑形镜对进展性近视的控制效果更佳。

Hilbert-Huang transform with adaptive waveform matching extension and its application in power quality disturbance detection for microgrid

With the significant improvement of microgrid technology, microgrid has gained large-scale application.However, the existence of intermittent distributed generations, nonlinear loads and various electrical and electronic devices causes power quality problem in microgrid, especially in islanding mode. An accurate and fast disturbance detection method which is the premise of power quality control is necessary. Aiming at the end effect and the mode mixing of original Hilbert-Huang transform(HHT), an improved HHT with adaptive waveform matching extension is proposed in this paper. The innovative waveform matching extension method considers not only the depth of waveform, but also the rise time and fall time. Both simulations and field experiments have verified the correctness and validity of the improved HHT for power quality disturbance detection in microgrid.

Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019

During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection.

Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells

AIdo-keto reductase family 1 member C3 has recently been regarded as a potential therapeutic target in castrate-resistant prostate cancer. Herein, we investigated whether berberine delayed the progression of castrate-resistant prostate cancer by reducing androgen synthesis through the inhibition of Aldo-keto reductase family 1 member C3. Cell viability and cellular testosterone content were measured in prostate cancer cells. Aido-keto reductase family 1 member C3 mRNA and protein level were detected by RT-PCR and Western bolt analyses, respectively. Computer analysis with AutoDock Tools explored the molecular interaction of berberine with Aldo-keto reductase family 1 member C3. We found that berberine inhibited 22Rvl cells proliferation and decreased cellular testosterone formation in a dose-dependent manner. Berberine inhibited Aldo-keto reductase family I member C3 enzyme activity, rather than influenced mRNA and protein expressions. Molecular docking study demonstrated that berberine could enter the active center of Aldo-keto reductase family 1 member C3 and form π-π interaction with the amino-acid residue Phe306 and Phe311. In conclusion, the structural interaction of berberine with Aldo-keto reductase family 1 member C3 is attributed to the suppression of Aldo-keto reductase family I member C3 enzyme activity and the inhibition of 22Rvl prostate cancer cell growth by decreasing the intfacellular androgen synthesis. Our result provides the experimental basis for the design, research, and development of AKRlC3 inhibitors using berberine as the lead compound.

A Risk Prediction Model for In-hospital Mortality in Patients with Suspected Myocarditis

Background：Myocarditis is an inflammatory disease of the myocardium that may lead to cardiac death in some patients.However,little is known about the predictors of in-hospital mortality in patients with suspected myocarditis.Thus,the aim of this study was to identify the independent risk factors for in-hospital mortality in patients with suspected myocarditis by establishing a risk prediction model.Methods：A retrospective study was performed to analyze the clinical medical records of 403 consecutive patients with suspected myocarditis who were admitted to Ningbo First Hospital between January 2003 and December 2013.A total of 238 males （59%） and 165 females （41%） were enrolled in this study.We divided the above patients into two subgroups （survival and nonsurvival）,according to their clinical in-hospital outcomes.To maximize the effectiveness of the prediction model,we first identified the potential risk factors for in-hospital mortality among patients with suspected myocarditis,based on data pertaining to previously established risk factors and basic patient characteristics.We subsequently established a regression model for predicting in-hospital mortality using univariate and multivariate logistic regression analyses.Finally,we identified the independent risk factors for in-hospital mortality using our risk prediction model.Results：The following prediction model for in-hospital mortality in patients with suspected myocarditis,including creatinine clearance rate （Ccr）,age,ventricular tachycardia （VT）,New York Heart Association （NYHA） classification,gender and cardiac troponin T （cTnT）,was established in the study：P =ea/（1 ＋ ea） （where e is the exponential function,P is the probability of in-hospital death,and a =-7.34 ＋ 2.99× [Ccr 〈60 ml/min =1,Ccr ≥60 ml/min =0] ＋ 2.01 × [age ≥50 years =1,age 〈50 years =0] ＋ 1.93 × [VT =1,no VT =0] ＋ 1.39 × [NYHA ≥3 =1,NYHA 〈3 =0] ＋ 1.25 × [male =1,female =0] ＋ 1.13 × [cTnT ≥50 μg/L 1,cTnT 〈50 μg/L =0]）.The area under the receiver operating characteristic curve was 0.96 （standard error =0.015,95% confidence interval [CI]：0.93-0.99）.The model demonstrated that a Ccr 〈60 ml/min （odds ratio [OR] =19.94,95% CI：5.66-70.26）,an age ≥50 years （OR =7.43,95% CI：2.18-25.34）,VT （OR =6.89,95% CI：1.86-25.44）,a NYHA classification ≥3 （OR =4.03,95% CI：1.13-14.32）,male gender （OR =3.48,95% CI：0.99-12.20）,and a cTnT level ≥50 μg/L （OR =3.10,95% CI：0.91-10.62） were the independent risk factors for in-hospital mortality.Conclusions：A Ccr 〈60 ml/min,an age ≥50 years,VT,an NYHA classification ≥3,male gender,and a cTnT level ≥50 μg/L were the independent risk factors resulting from the prediction model for in-hospital mortality in patients with suspected myocarditis.In addition,sufficient life support during the early stage of the disease might improve the prognoses of patients with suspected myocarditis with multiple risk factors for in-hospital mortality.