Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients

AIM:To compare the trabecular meshwork(TM)and iris apoptosis of treated and untreated primary open angle glaucoma(POAG)patients.METHODS:Eight treatment-naive,newly diagnosed(group 1)and 11 medlcaiy treated(group 2)patients with POAG were included in the study.Each patient underwent a limbus-based trabeculectomy.The TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at-80t until they were assayed.Apoptosis in each group was assesed by TUNEL method.RESULTS:The mean patient age was 60.6±5.8 years(53-68 years)vs 58.9±8.9 years(47-70 years)in group 1and group 2(P=0.859).The mean treatment time in group 2 was 22.2±7.3 months(12-34 months).Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication(group 2)compared to treatment-naive POAG patients(group 1)(P=0.004,0.015;respectively).CONCLUSION:Long term administration of topical antiglaucoma medications causes additional toxic effects on TM.

眼睑皮肤松垂程度与年龄的关系——三级转诊中心的前瞻性研究（英文）

目的:调查眼睑皮肤松垂的位置和程度及是否伴随假性上睑下垂与年龄的关系。方法:选取113例眼睑皮肤松垂患者纳入本研究,记录患者的年龄,性别及体质指数。于第一眼位检测睑裂高度和睑缘至瞳孔反射点距离(MRD)。皮肤松垂的程度分为1级:皮肤松垂未及睑缘(至少距睑缘1 mm);2级:皮肤松垂达睑缘水平;3级:皮肤松垂越过睑缘前。结果:患者平均年龄为52.7±8.6(32~74)a。男36例(31.9%),女77例(68.1%)。平均体质指数为30.3±4.7(21.5~36.6)kg/m^2,平均睑裂高度为10.7+1.6(7~15)mm,平均MRD为3.8±1.2(1~5)mm。30例(26.5%)患者的皮肤松垂未及睑缘(1级)38例(33.6%)患者位于睑缘水平线(2级),而45例(39.8%)患者越过睑缘前(3级)。50例(44.2%)患者由于皮肤松垂引起假性上睑下垂。皮肤松垂程度在年龄方面的差异显著。皮肤松垂1级和2级患者的平均年龄(50.3±6.6,50.5±9.5岁)明显低于3级患者年龄(56.0±8.2岁)。假性上睑下垂患者(56.3±8.3岁)的平均年龄明显高于非假性上睑下垂患者(49.8±7.8岁)。对于皮肤松垂严重程度和假性上睑下垂患者体质指数无显著差别。结论:皮肤松垂严重程度和假性上睑下垂的发生率随年龄的增长而有所增加。