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Prognostic role of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in patients with non-metastatic and metastatic prostate cancer:A meta-analysis and systematic review
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作者 Stefano Salciccia Marco Frisenda +11 位作者 Giulio Bevilacqua Pietro Viscuso Paolo Casale ettore de berardinis Giovanni Battista Di Pierro Susanna Cattarino Gloria Giorgino Davide Rosati Francesco del Giudice Alessandro Sciarra Gianna Mariotti Alessandro Gentilucci 《Asian Journal of Urology》 CSCD 2024年第2期191-207,共17页
Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratif... Objective: To analyze data available in the literature regarding a possible prognostic value of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in prostate cancer (PCa) patients stratified in non-metastatic and metastatic diseases.Methods: A literature search process was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In our meta-analysis, the pooled event rate estimated and the pooled hazard ratio were calculated using a random effect model.Results: Forty-two articles were selected for our analysis. The pooled risk difference for non-organ confined PCa between high and low NLR cases was 0.06 (95% confidence interval [CI]: −0.03-0.15) and between high and low PLR cases increased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazard ratio for overall mortality between high and low NLR was 1.33 (95% CI: 0.78-1.88) and between high and low PLR was 1.47 (95% CI: 0.91-2.03), whereas in metastatic PCa cases, between high and low NLR was 1.79 (95% CI: 1.44-2.13) and between high and low PLR was 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic values of NLR and PLR in terms of PCa characteristics and responses after treatment show a high level of heterogeneity of results among studies. These two ratios can represent the inflammatory and immunity status of the patient related to several conditions. A higher predictive value is related to a high NLR in terms of risk for overall mortality in metastatic PCa cases under systemic treatments. 展开更多
关键词 Prostatic neoplasm Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyteratio META-ANALYSIS Radical prostatectomy METASTATIC
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Voltage Control in Smart Grids: An Approach Based on Sensitivity Theory 被引量:1
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作者 Morris Brenna ettore de berardinis +2 位作者 Federica Foiadelli Gianluca Sapienza Dario Zaninelli 《Journal of Electromagnetic Analysis and Applications》 2010年第8期467-474,共8页
Due to the development of Distributed Generation (DG), which is installed in Medium-Voltage Distribution Networks (MVDNs) such as generators based on renewable energy (e.g., wind energy or solar energy), voltage contr... Due to the development of Distributed Generation (DG), which is installed in Medium-Voltage Distribution Networks (MVDNs) such as generators based on renewable energy (e.g., wind energy or solar energy), voltage control is currently a very important issue. The voltage is now regulated at the MV busbars acting on the On-Load Tap Changer of the HV/MV transformer. This method does not guarantee the correct voltage value in the network nodes when the distributed generators deliver their power. In this paper an approach based on Sensitivity Theory is shown, in order to control the node voltages regulating the reactive power exchanged between the network and the dispersed generators. The automatic distributed voltage regulation is a particular topic of the Smart Grids. 展开更多
关键词 VOLTAGE REGULATION REACTIVE Power INJECTION Distributed Generation Smart Grids Sensitivity THEORY RENEWABLE Energy
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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?
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作者 Gian Maria Busetto Andrea Checchia +16 位作者 Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru Luca Di Gianfrancesco Angelo Porreca Francesco del Giudice ettore de berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri 《Asian Journal of Andrology》 SCIE CAS CSCD 2024年第2期135-143,共9页
The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).... The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male LUTS.The aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTIND).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still lacking.Most of them are still under investigation and,to date,only a few options have been given as a recommendation for use.They cannot be considered as standard of care and are not suitable for all patients.Advantages and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance. 展开更多
关键词 aquablation iTIND prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy
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A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility 被引量:6
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作者 Francesco del Giudice Gian Maria Busetto +6 位作者 ettore de berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg 《Asian Journal of Andrology》 SCIE CAS CSCD 2020年第4期360-367,共8页
Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particula... Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. 展开更多
关键词 aromatase inhibitor HYPOGONADISM male infertility META-ANALYSIS systematic review
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