BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara.This has the potential to e...BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara.This has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and postpartum.AIM To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with primipara.METHODS A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May 2022.These cases were divided into two groups,namely the observation group and the control group,with 40 cases in each group.The nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior change.The study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both groups.RESULTS After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control group.CONCLUSION The integration of timing theory and behavior change integrated theory has been found to be an effective approach in alleviating negative mood and stress experienced by primipara individuals,while also enhancing their selfefficacy and overall quality of life.This study focuses on the key concepts of timing theory,behavior change,primipara individuals,negative mood,and quality of life.展开更多
BACKGROUND Cesarean hemorrhage is one of the serious complications,and short-term massive blood transfusion can easily cause postoperative infection and physical stress response.However,predictive nursing intervention...BACKGROUND Cesarean hemorrhage is one of the serious complications,and short-term massive blood transfusion can easily cause postoperative infection and physical stress response.However,predictive nursing intervention has important clinical significance for it.AIM To explore the effect of predictive nursing intervention on the stress response and complications of women undergoing short-term mass blood transfusion during cesarean section(CS).METHODS A clinical medical record of 100 pregnant women undergoing rapid mass blood transfusion during sections from June 2019 to June 2021.According to the different nursing methods,patients divided into control group(n=50)and observation group(n=50).Among them,the control group implemented routine nursing,and the observation group implemented predictive nursing intervention based on the control group.Moreover,compared the differences in stress res-ponse,complications,and pain scores before and after the nursing of pregnant women undergoing rapid mass blood transfusion during CS.RESULTS The anxiety and depression scores of pregnant women in the two groups were significantly improved after nursing,and the psychological stress response of the observation group was significantly lower than that of the control group(P<0.05).The heart rate and mean arterial pressure(MAP)of the observation group during delivery were lower than those of the control group,and the MAP at the end of delivery was lower than that of the control group(P<0.05).Moreover,different pain scores improved significantly in both groups,with the observation group considerably less than the control group(P<0.05).After nursing,complications such as skin rash,urinary retention,chills,diarrhea,and anaphylactic shock in the observation group were 18%,which significantly higher than in the control group(4%)(P<0.05).CONCLUSION Predictive nursing intervention can effectively relieve the pain,reduce the incidence of complications,improve mood and stress response,and serve as a reference value for the nursing of women undergoing rapid mass transfusion during CS.展开更多
Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic implants.In this research,we investigate the impact of laser power and scanning speed on the develop...Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic implants.In this research,we investigate the impact of laser power and scanning speed on the development of surface quality,relative densification,and texture during LPBF of Zn implants.Increasing laser power was able to decrease melt viscosity and surface tension,which improved the metallurgical bonding between adjacent tracks.Uneven and twisted tracks also became continuous and straight.Scanning speed could controlmolten-pool temperature to restrain grain natural orientation,achieving various crystal orientations and a weakened texture.Importantly,it further avoided the thermal expansion and contraction caused by excessive energy storage and accumulation in the matrix,thus reducing the generation of high-dislocation density.As a result,by selecting a reasonable laser power and scanning speed,the LPBF parts exhibited a flat surface morphology and a high density over 99.5%.Their average hardness,mechanical strength,and elongation reached 50.2 HV,127.8 MPa,and 7.6%,respectively.Additionally,the parts displayed a moderate degradation rate and excellent osteogenic properties.All these results provide a basis for selecting process parameters to optimize the comprehensive properties of LPBF-processed Zn parts for biodegradable applications.展开更多
Dear Editor,This letter is concerned with developing meta-learning models for fast,stable,and effective few-shot learning across tasks over a few training samples.Nowadays,deep and reinforcement learning(RL)is widely ...Dear Editor,This letter is concerned with developing meta-learning models for fast,stable,and effective few-shot learning across tasks over a few training samples.Nowadays,deep and reinforcement learning(RL)is widely used in autonomous intelligent systems(e.g.,target recognition[1],path planning[2],and robot control[3],[4]).展开更多
Soil salinity is a growing concern for global crop production and the sustainable development of humanity.Therefore,it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance cr...Soil salinity is a growing concern for global crop production and the sustainable development of humanity.Therefore,it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance crop tolerance to salt stress.Suaeda glauca,a halophyte species well adapted to the seawater environment,possesses a unique ability to absorb and retain high salt concentrations within its cells,particularly in its leaves,suggesting the presence of a distinct mechanism for salt tolerance.In this study,we performed de novo sequencing of the S.glauca genome.The genome has a size of 1.02 Gb(consisting of two sets of haplotypes)and contains 54761 annotated genes,including alleles and repeats.Comparative genomic analysis revealed a strong synteny between the genomes of S.glauca and Beta vulgaris.Of the S.glauca genome,70.56%comprises repeat sequences,with retroelements being the most abundant.Leveraging the allele-aware assembly of the S.glauca genome,we investigated genome-wide allele-specific expression in the analyzed samples.The results indicated that the diversity in promoter sequences might contribute to consistent allele-specific expression.Moreover,a systematic analysis of the ABCE gene families shed light on the formation of S.glauca’s flower morphology,suggesting that dysfunction of A-class genes is responsible for the absence of petals in S.glauca.Gene family expansion analysis demonstrated significant enrichment of Gene Ontology(GO)terms associated with DNA repair,chromosome stability,DNA demethylation,cation binding,and red/far-red light signaling pathways in the co-expanded gene families of S.glauca and S.aralocaspica,in comparison with glycophytic species within the chenopodium family.Time-course transcriptome analysis under salt treatments revealed detailed responses of S.glauca to salt tolerance,and the enrichment of the transition-upregulated genes in the leaves associated with DNA repair and chromosome stability,lipid biosynthetic process,and isoprenoid metabolic process.Additionally,genome-wide analysis of transcription factors indicated a significant expansion of FAR1 gene family.However,further investigation is needed to determine the exact role of the FAR1 gene family in salt tolerance in S.glauca.展开更多
An adaptive unscented Kalman filter (AUKF) and an augmented state method are employed to estimate the timevarying parameters and states of a kind of nonlinear high-speed objects. A strong tracking filter is employed...An adaptive unscented Kalman filter (AUKF) and an augmented state method are employed to estimate the timevarying parameters and states of a kind of nonlinear high-speed objects. A strong tracking filter is employed to improve the tracking ability and robustness of unscented Kalman filter (UKF) when the process noise is inaccuracy, and wavelet transform is used to improve the estimate accuracy by the variance of measurement noise. An augmented square-root framework is utilized to improve the numerical stability and accuracy of UKF. Monte Carlo simulations and applications in the rapid trajectory estimation of hypersonic artillery shells confirm the effectiveness of the proposed method.展开更多
Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions un...Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.展开更多
Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the bi...Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.展开更多
High-order accurate schemes are employed to numerically simulate the interaction of a supersonic jet and a co-directional supersonic inflow. A double backward-facing step model is proposed to investigate the interacti...High-order accurate schemes are employed to numerically simulate the interaction of a supersonic jet and a co-directional supersonic inflow. A double backward-facing step model is proposed to investigate the interaction between the jet shear layer and the supersonic inflow shear layer. It is found that due to the interaction of the shear layer, a secondary jet is injected into the recirculation zone at the intersection of the two shear layers. The secondary jet produced by the interaction of the two shear layers has a periodicity because of shear layers interaction. The distinction in the shape of double backward-facing steps will induce changes in the period of the secondary jet. The analysis and discussion of the periodicity of the secondary jet are mainly focused in this letter.展开更多
Recent studies suggest that the activation of the Wnt signaling pathway improves memory function in rats.This study investigated the effects of Wnt-5a on amyloid β (Aβ)-induced cognitive impairment.Aβ25-35 was in...Recent studies suggest that the activation of the Wnt signaling pathway improves memory function in rats.This study investigated the effects of Wnt-5a on amyloid β (Aβ)-induced cognitive impairment.Aβ25-35 was injected into the rat right lateral ventricle to induce Alzheimer's disease-associated pathology,and Wnt-5a was injected as a potential therapeutic treatment.Immunofluorescence staining showed that compared with normal rats,Aβ25-35 significantly decreased postsynaptic density-95 protein expression in the rat hippocampal CA1 region,but Wnt-5a pretreatment blocked this decrease.This study shows that Wnt-5a can reduce Aβ-induced cognitive impairment,and that it has the potential to be a new therapeutic strategy for the treatment of Alzheimer's disease.展开更多
The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. T...The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.展开更多
This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information.First,a two-stage cooperative guidance strategy,namely the cooperative g...This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information.First,a two-stage cooperative guidance strategy,namely the cooperative guidance and the Proportional Navigation Guidance(PNG)stage strategy,is developed to realize the spatial-temporal constraints in two dimensions.At the former stage,two controllers are designed and superimposed to satisfy both impact time consensus and impact angle constraints.Once the convergent conditions are satisfied,the flight vehicles will switch to the PNG stage to ensure zero miss distance.To further extend the results to three dimensions,a planar pursuit guidance stage is additionally imposed at the beginning of guidance.Due to the inde-pendence of time-to-go estimation,the proposed guidance strategy possesses great performance in satisfying complex spatial-temporal constraints even under flight speed variation.Finally,several numerical simulations are implemented to verify the effectiveness and advantages of the proposed results under different scenarios.展开更多
The molten salt method focuses on improving the crystallinity of synthetic materials and avoiding the high energy consumption of traditional synthesis processes.In this work,a novel BiOBr/Bi_(2)S_(3)high-low junction ...The molten salt method focuses on improving the crystallinity of synthetic materials and avoiding the high energy consumption of traditional synthesis processes.In this work,a novel BiOBr/Bi_(2)S_(3)high-low junction with large contact area was constructed by the molten salt method combined with the ion exchange strategy.Its unique energy band structure and new charge transfer mechanism realize the rapid migration of photogenerated charges between different components.Specifically,Bi_(2)S_(3)was grown on BiOBr in situ by a high-temperature molten salt reaction.Due to the deep valence band position of BiOBr and the narrow band gap of Bi_(2)S_(3),an intrinsic internal electric field and band bending are produced at the interface,forming a high-low junction photocatalyst with an intimate interface.In addition,the BiOBr/Bi_(2)S_(3)composite maintains a high oxidation potential and produces high and robust photocatalytic oxidation activity.In the molten state,the close binding of BiOBr and Bi_(2)S_(3)can be promoted through the ion-exchange strategy,resulting in excellent photocatalytic degradation rates of bisphenol A and tetracycline and in-situ generation of H_(2)O_(2).Finally,the mechanism of carriers separation and transfer in BiOBr/Bi_(2)S_(3)high-low junction is also discussed.Density functional theory(DFT)results found that the improvement of O_(2)adsorption ability would promote the occurrence of oxygen reduction reaction(ORR),and make positive contributions to the enhanced H_(2)O_(2)production activity.This study will provide a new perspective for broadening the spectral response range of Bi-based photocatalytic materials and preparing high-low junction photocatalysts with dense interface by the molten salt method.展开更多
Realizing efficient charge separation and directional transfer is a challenge for single-component semiconductors.The spatial electric field generated by dipole moment could promote charge separation.Here,three-dimens...Realizing efficient charge separation and directional transfer is a challenge for single-component semiconductors.The spatial electric field generated by dipole moment could promote charge separation.Here,three-dimensional hierarchical Cu Co_(2)S_(4)microspheres with lattice distortion were prepared,and lattice distortion was modulated by changing feed Co/Cu molar ratios in synthesis.Cu Co_(2)S_(4)showed asymmetric crystal structure,leading to generation of dipole moment.The charge separation efficiency of Cu Co_(2)S_(4)was related to lattice distortion,and lattice expansion was in favor for charge separation.The Cu Co_(2)S_(4)with feed Cu/Co molar ratio of 1:4 (CCS-4) showed the maximum lattice expansion and exhibited the highest photocatalytic activity,which was attributable to the highest charge separation efficiency and the largest specific surface area.CCS-4 can remove 95.4%of tetracycline hydrochloride within 40 min photocatalysis,and effectively improve the biodegradability of pharmaceutical wastewater.Importantly,this study provides a new vision for constructing single-component photocatalysts with high photocatalytic performance.展开更多
文摘BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for primipara.This has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and postpartum.AIM To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with primipara.METHODS A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May 2022.These cases were divided into two groups,namely the observation group and the control group,with 40 cases in each group.The nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior change.The study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both groups.RESULTS After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control group.CONCLUSION The integration of timing theory and behavior change integrated theory has been found to be an effective approach in alleviating negative mood and stress experienced by primipara individuals,while also enhancing their selfefficacy and overall quality of life.This study focuses on the key concepts of timing theory,behavior change,primipara individuals,negative mood,and quality of life.
文摘BACKGROUND Cesarean hemorrhage is one of the serious complications,and short-term massive blood transfusion can easily cause postoperative infection and physical stress response.However,predictive nursing intervention has important clinical significance for it.AIM To explore the effect of predictive nursing intervention on the stress response and complications of women undergoing short-term mass blood transfusion during cesarean section(CS).METHODS A clinical medical record of 100 pregnant women undergoing rapid mass blood transfusion during sections from June 2019 to June 2021.According to the different nursing methods,patients divided into control group(n=50)and observation group(n=50).Among them,the control group implemented routine nursing,and the observation group implemented predictive nursing intervention based on the control group.Moreover,compared the differences in stress res-ponse,complications,and pain scores before and after the nursing of pregnant women undergoing rapid mass blood transfusion during CS.RESULTS The anxiety and depression scores of pregnant women in the two groups were significantly improved after nursing,and the psychological stress response of the observation group was significantly lower than that of the control group(P<0.05).The heart rate and mean arterial pressure(MAP)of the observation group during delivery were lower than those of the control group,and the MAP at the end of delivery was lower than that of the control group(P<0.05).Moreover,different pain scores improved significantly in both groups,with the observation group considerably less than the control group(P<0.05).After nursing,complications such as skin rash,urinary retention,chills,diarrhea,and anaphylactic shock in the observation group were 18%,which significantly higher than in the control group(4%)(P<0.05).CONCLUSION Predictive nursing intervention can effectively relieve the pain,reduce the incidence of complications,improve mood and stress response,and serve as a reference value for the nursing of women undergoing rapid mass transfusion during CS.
基金The National Natural Science Foundation of China(Nos.51935014,52165043,52105352,and 82072084)Jiangxi Provincial Natural Science Foundation of China(No.20212BAB214026)+1 种基金The Project of State Key Laboratory of High Performance Complex ManufacturingThe Project of Science and Technology of Jiangxi Provincial Education Department(No.GJJ210835).
文摘Laser powder bed fusion(LPBF)makes it possible for biodegradable zinc(Zn)to be used to produce customized orthopedic implants.In this research,we investigate the impact of laser power and scanning speed on the development of surface quality,relative densification,and texture during LPBF of Zn implants.Increasing laser power was able to decrease melt viscosity and surface tension,which improved the metallurgical bonding between adjacent tracks.Uneven and twisted tracks also became continuous and straight.Scanning speed could controlmolten-pool temperature to restrain grain natural orientation,achieving various crystal orientations and a weakened texture.Importantly,it further avoided the thermal expansion and contraction caused by excessive energy storage and accumulation in the matrix,thus reducing the generation of high-dislocation density.As a result,by selecting a reasonable laser power and scanning speed,the LPBF parts exhibited a flat surface morphology and a high density over 99.5%.Their average hardness,mechanical strength,and elongation reached 50.2 HV,127.8 MPa,and 7.6%,respectively.Additionally,the parts displayed a moderate degradation rate and excellent osteogenic properties.All these results provide a basis for selecting process parameters to optimize the comprehensive properties of LPBF-processed Zn parts for biodegradable applications.
基金supported in part by the National Key R&D Program of China(2021YFB1714800)the National Natural Science Foundation of China(62173034,61925303,62025301,62088101)the CAAI-Huawei MindSpore Open Fund。
文摘Dear Editor,This letter is concerned with developing meta-learning models for fast,stable,and effective few-shot learning across tasks over a few training samples.Nowadays,deep and reinforcement learning(RL)is widely used in autonomous intelligent systems(e.g.,target recognition[1],path planning[2],and robot control[3],[4]).
基金supported by the National Natural Science Foundation of China(32170380)the Science and Technology Innovation Project of Pingtan Institute of Science and Technology(PT2021001)the Postdoctoral Foundation of China(2018 M642550).
文摘Soil salinity is a growing concern for global crop production and the sustainable development of humanity.Therefore,it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance crop tolerance to salt stress.Suaeda glauca,a halophyte species well adapted to the seawater environment,possesses a unique ability to absorb and retain high salt concentrations within its cells,particularly in its leaves,suggesting the presence of a distinct mechanism for salt tolerance.In this study,we performed de novo sequencing of the S.glauca genome.The genome has a size of 1.02 Gb(consisting of two sets of haplotypes)and contains 54761 annotated genes,including alleles and repeats.Comparative genomic analysis revealed a strong synteny between the genomes of S.glauca and Beta vulgaris.Of the S.glauca genome,70.56%comprises repeat sequences,with retroelements being the most abundant.Leveraging the allele-aware assembly of the S.glauca genome,we investigated genome-wide allele-specific expression in the analyzed samples.The results indicated that the diversity in promoter sequences might contribute to consistent allele-specific expression.Moreover,a systematic analysis of the ABCE gene families shed light on the formation of S.glauca’s flower morphology,suggesting that dysfunction of A-class genes is responsible for the absence of petals in S.glauca.Gene family expansion analysis demonstrated significant enrichment of Gene Ontology(GO)terms associated with DNA repair,chromosome stability,DNA demethylation,cation binding,and red/far-red light signaling pathways in the co-expanded gene families of S.glauca and S.aralocaspica,in comparison with glycophytic species within the chenopodium family.Time-course transcriptome analysis under salt treatments revealed detailed responses of S.glauca to salt tolerance,and the enrichment of the transition-upregulated genes in the leaves associated with DNA repair and chromosome stability,lipid biosynthetic process,and isoprenoid metabolic process.Additionally,genome-wide analysis of transcription factors indicated a significant expansion of FAR1 gene family.However,further investigation is needed to determine the exact role of the FAR1 gene family in salt tolerance in S.glauca.
基金supported by the National Natural Science Foundation of China (61304254)the National Science Foundation for Distinguished Young Scholars of China (60925011)the Provincial and Ministerial Key Fund of China (9140A07010511BQ0105)
文摘An adaptive unscented Kalman filter (AUKF) and an augmented state method are employed to estimate the timevarying parameters and states of a kind of nonlinear high-speed objects. A strong tracking filter is employed to improve the tracking ability and robustness of unscented Kalman filter (UKF) when the process noise is inaccuracy, and wavelet transform is used to improve the estimate accuracy by the variance of measurement noise. An augmented square-root framework is utilized to improve the numerical stability and accuracy of UKF. Monte Carlo simulations and applications in the rapid trajectory estimation of hypersonic artillery shells confirm the effectiveness of the proposed method.
基金supported by the National Natural Science Foundation of China(General Program),No.81271293the National Science Foundation for Young Scientists of China,No.81000490
文摘Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings re-garding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Peli-zaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.
基金This study was supported by the following funds:(1)National Natural Science Foundation of China(Nos.51935014,82072084,and 81871498)(2)Jiangxi Provincial Natural Science Foundation of China(Nos.20192ACB20005 and 2020ACB214004)+6 种基金(3)The Provincial Key R&D Projects of Jiangxi(No.20201BBE51012)(4)Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2018)(5)Shenzhen Science and Technology Plan Project(No.JCYJ20170817112445033)(6)Innovation Team Project on University of Guangdong Province(No.2018GKCXTD001)(7)Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020(No.PT2020E002)(8)Open Research Fund of Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology(9)China Postdoctoral Science Foundation(No.2020M682114).
文摘Hydroxyapatite(HA)nanoparticles and silver(Ag)nanoparticles are expected to enable desirable bioactivity and antibac-terial properties on biopolymer scaffolds.Nevertheless,interfacial adhesion between HA/Ag and the biopolymer is poor due to the large physicochemical differences between these components.In this study,poly L-lactic acid(PLLA)powder was first surface-modified with bioactive polydopamine(PDA)in an alkaline environment.Next,HA and Ag nanoparticles were grown in situ on the PDA-coated PLLA powder,which was then adhered to the porous bone scaffold using a selective laser-sintering process.Results showed that HA and Ag nanoparticles were homogenously distributed in the matrix,with enhanced mechanical properties.Simulated body fluid bioactivity tests showed that the in situ grown HA-endowed scaffold shows excellent bioactivity.In vitro tests confirmed that the scaffold exhibits favorable biocompatibility with human umbilical cord mesenchymal stem cells,as well as strong antibacterial activity against Gram-negative Escherichia coli.Furthermore,in vivo assays indicated that the scaffold promoted bone generation,with a new bone area fraction of 71.8%after 8 weeks’implantation,without inflammation.
基金supported by the National Key Research and Development Program of China(Grant 2016YFA0401201)the National Natural Science Foundation of China(Grants 11872066,11472281,11727901,and 11532014)。
文摘High-order accurate schemes are employed to numerically simulate the interaction of a supersonic jet and a co-directional supersonic inflow. A double backward-facing step model is proposed to investigate the interaction between the jet shear layer and the supersonic inflow shear layer. It is found that due to the interaction of the shear layer, a secondary jet is injected into the recirculation zone at the intersection of the two shear layers. The secondary jet produced by the interaction of the two shear layers has a periodicity because of shear layers interaction. The distinction in the shape of double backward-facing steps will induce changes in the period of the secondary jet. The analysis and discussion of the periodicity of the secondary jet are mainly focused in this letter.
文摘Recent studies suggest that the activation of the Wnt signaling pathway improves memory function in rats.This study investigated the effects of Wnt-5a on amyloid β (Aβ)-induced cognitive impairment.Aβ25-35 was injected into the rat right lateral ventricle to induce Alzheimer's disease-associated pathology,and Wnt-5a was injected as a potential therapeutic treatment.Immunofluorescence staining showed that compared with normal rats,Aβ25-35 significantly decreased postsynaptic density-95 protein expression in the rat hippocampal CA1 region,but Wnt-5a pretreatment blocked this decrease.This study shows that Wnt-5a can reduce Aβ-induced cognitive impairment,and that it has the potential to be a new therapeutic strategy for the treatment of Alzheimer's disease.
基金supported by Natural Science Foundation of China (51741806, 51238002, 51720105001)Science Fund for Excellent Young Scholars of Jiangxi Province (20162BCB23038)Natural Science Foundation of Jiangxi Province (20161BAB206117)
文摘The effect of synthesis temperature and reaction time on the visible-light photocatalytic activity of hierarchical network-like SnIn4S8 microspheres was investigated by the low-temperature co-precipitation strategy. The preparation temperature and reaction time have great influence on the photocatalytic activity of SnIn4S8, and the optimal preparation temperature and reaction time are 70℃ and 3 h, respectively.The SnIn4S8 shows good reusability and high stability with no observable decrease of photocatalytic activity in five consecutive cycles.
基金the National Science Fund for Distinguished Young Scholars of China (No.62025301)the National Natural Science Foundation of China (Nos.62273043 and 62373055)+1 种基金the China National Postdoctoral Program for Innovative Talents (No.BX20230461)the China Postdoctoral Science Foundation (No.2023M740249)。
文摘This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go information.First,a two-stage cooperative guidance strategy,namely the cooperative guidance and the Proportional Navigation Guidance(PNG)stage strategy,is developed to realize the spatial-temporal constraints in two dimensions.At the former stage,two controllers are designed and superimposed to satisfy both impact time consensus and impact angle constraints.Once the convergent conditions are satisfied,the flight vehicles will switch to the PNG stage to ensure zero miss distance.To further extend the results to three dimensions,a planar pursuit guidance stage is additionally imposed at the beginning of guidance.Due to the inde-pendence of time-to-go estimation,the proposed guidance strategy possesses great performance in satisfying complex spatial-temporal constraints even under flight speed variation.Finally,several numerical simulations are implemented to verify the effectiveness and advantages of the proposed results under different scenarios.
基金financially supported by the National Natural Science Foundation of China(Nos.22262024,51962023,52272063 and 51978324)the Zhejiang Province Key Research and Development Project(2023 C01191)the Double Thousand Talent Plan of Jiangxi Province,the Jiangxi Academic and Technical Leader of Major Disciplines(No.20213BCJL22053).
文摘The molten salt method focuses on improving the crystallinity of synthetic materials and avoiding the high energy consumption of traditional synthesis processes.In this work,a novel BiOBr/Bi_(2)S_(3)high-low junction with large contact area was constructed by the molten salt method combined with the ion exchange strategy.Its unique energy band structure and new charge transfer mechanism realize the rapid migration of photogenerated charges between different components.Specifically,Bi_(2)S_(3)was grown on BiOBr in situ by a high-temperature molten salt reaction.Due to the deep valence band position of BiOBr and the narrow band gap of Bi_(2)S_(3),an intrinsic internal electric field and band bending are produced at the interface,forming a high-low junction photocatalyst with an intimate interface.In addition,the BiOBr/Bi_(2)S_(3)composite maintains a high oxidation potential and produces high and robust photocatalytic oxidation activity.In the molten state,the close binding of BiOBr and Bi_(2)S_(3)can be promoted through the ion-exchange strategy,resulting in excellent photocatalytic degradation rates of bisphenol A and tetracycline and in-situ generation of H_(2)O_(2).Finally,the mechanism of carriers separation and transfer in BiOBr/Bi_(2)S_(3)high-low junction is also discussed.Density functional theory(DFT)results found that the improvement of O_(2)adsorption ability would promote the occurrence of oxygen reduction reaction(ORR),and make positive contributions to the enhanced H_(2)O_(2)production activity.This study will provide a new perspective for broadening the spectral response range of Bi-based photocatalytic materials and preparing high-low junction photocatalysts with dense interface by the molten salt method.
基金financially supported by the National Natural Science Foundation of China (Nos. 51978324, 51720105001, 51938007)Natural Science Foundation of Jiangxi Province (Nos. 20213BCJL22053, 20192ACBL20043, 20192ACBL21047)+1 种基金Natural Science Foundation of Jiangxi Province, China (No. 20212BAB204045)Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle (Nanchang Hangkong University) (No. ES202002077)。
文摘Realizing efficient charge separation and directional transfer is a challenge for single-component semiconductors.The spatial electric field generated by dipole moment could promote charge separation.Here,three-dimensional hierarchical Cu Co_(2)S_(4)microspheres with lattice distortion were prepared,and lattice distortion was modulated by changing feed Co/Cu molar ratios in synthesis.Cu Co_(2)S_(4)showed asymmetric crystal structure,leading to generation of dipole moment.The charge separation efficiency of Cu Co_(2)S_(4)was related to lattice distortion,and lattice expansion was in favor for charge separation.The Cu Co_(2)S_(4)with feed Cu/Co molar ratio of 1:4 (CCS-4) showed the maximum lattice expansion and exhibited the highest photocatalytic activity,which was attributable to the highest charge separation efficiency and the largest specific surface area.CCS-4 can remove 95.4%of tetracycline hydrochloride within 40 min photocatalysis,and effectively improve the biodegradability of pharmaceutical wastewater.Importantly,this study provides a new vision for constructing single-component photocatalysts with high photocatalytic performance.