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Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses
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作者 fang ruan Wen-Jun Kong +4 位作者 Qian Fan Hong-Wei Dong Wei Zhang Wen-Bin Wei Ying Jie 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第5期822-830,共9页
AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 patients.METHODS:A cross-sectional observational design was used.Totally 123 eligible adults(46.34%of men,age range,18-... AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 patients.METHODS:A cross-sectional observational design was used.Totally 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,2022.Ocular Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this study.RESULTS:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression. 展开更多
关键词 COVID-19 dry eye disease recurrent infection mental health
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弥漫性中线胶质瘤H3K27改变型的影像特征
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作者 方阮 任彦 张家文 《中国医学计算机成像杂志》 CSCD 北大核心 2024年第1期1-5,共5页
目的:总结分析脑弥漫性中线胶质瘤H3K27改变型的CT和MRI影像学特征,以提高对本病的认识。方法:回顾性分析89例经手术病理诊断为脑弥漫性中线胶质瘤伴H3K27改变型患者的临床和影像学资料。结果:32例(36.0%)位于丘脑,36例(40.4%)位于脑干... 目的:总结分析脑弥漫性中线胶质瘤H3K27改变型的CT和MRI影像学特征,以提高对本病的认识。方法:回顾性分析89例经手术病理诊断为脑弥漫性中线胶质瘤伴H3K27改变型患者的临床和影像学资料。结果:32例(36.0%)位于丘脑,36例(40.4%)位于脑干,其余位于脊髓、松果体、第三脑室、第四脑室、桥臂、小脑、基底节区;66例(74.2%)形态规则,边界较清;75例(91.5%)无或轻度瘤周水肿。肿瘤实性部分CT平扫呈等低-稍高密度,磁共振T1WI呈等-稍低信号,T2WI呈等-稍高或高信号;29例(32.6%)伴不同程度囊变或坏死,6例伴出血,7例伴点状或边缘线样钙化。46例行弥散加权成像(DWI)检查,28例(60.9%)无或轻度受限,18例(39.1%)局部明显受限;30例行磁共振波谱(MRS)检查,28例(93.3%)呈高代谢改变。86例行MRI增强,50例(58.1%)呈局部花环状高强化,22例(25.6%)为整体轻度/无强化,12例(14.0%)呈局部斑片或结节状明显高强化,2例为整体不均匀明显强化。肿瘤易包绕邻近血管,“基底动脉包绕征”最常见(18例);29例(32.6%)可见“增粗血管进入征”;脑干病灶中10例(27.8%)可见“虎纹征”。结论:脑弥漫性中线胶质瘤H3K27M改变型具有一定的影像学特征,有助于术前准确诊断。 展开更多
关键词 弥漫性中线胶质瘤 计算机体层成像 磁共振成像 影像特征
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Subconjunctival conbercept for the treatment of corneal neovascularization
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作者 Cun Sun fang ruan +2 位作者 Shang Li Jian-Qiang Zhang Ying Jie 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第6期871-875,共5页
·AIM:To investigate the effectiveness and safety of subconjunctival injection of conbercept in the treatment of corneal neovascularization(CNV).·METHODS:The data on 10 consecutively recruited patients with C... ·AIM:To investigate the effectiveness and safety of subconjunctival injection of conbercept in the treatment of corneal neovascularization(CNV).·METHODS:The data on 10 consecutively recruited patients with CNV who received a subconjunctival conbercept(1 mg)once,and measured the area,length,and diameter of neovascularization before and after(1d,1,2wk,and 1mo)treatment as well as the occurrence of systemic and ocular complications after treatment were analyzed.·RESULTS:There was a statistically significant reduction in the area of CNV one day after treatment(mean±SD:38.46±11.36 mm^(2)),compared with before treatment(42.46±12.80 mm^(2),P<0.01).There was also a statistically significant reduction in the length(3.86±1.80 mm vs 4.64±1.77 mm,P<0.01)and diameter(0.044±0.022 vs 0.060±0.026,P<0.05)of CNV,one week after treatment comparing to before treatment.The reduction in all three parameters was maximized at two weeks after treatment(area:29.49±8.83 mm^(2),P<0.001;length:3.50±1.88 mm,P<0.001;and diameter:0.038±0.017 mm,P<0.01).No severe systemic or ocular complication was observed during the study.·CONCLUSION:During the observation period of onemonth,subconjunctival injection of conbercept is an effective and safe method for the reduction of CNV.It may be effective as a preoperative drug for neovascular corneal transplantation. 展开更多
关键词 KEYWORDS:corneal neovascularization conbercept anti-vascular endothelial growth factor subconjunctival injection
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肾上腺腺瘤样瘤1例 被引量:1
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作者 刘啸峰 方阮 王文娟 《医学影像学杂志》 2022年第4期566-566,571,共2页
患者男,63岁。体检发现肾上腺肿块,曾有全身乏力史,余无其他异常。CT检查:左肾上腺一类圆形囊性肿块,界清壁薄,密度均匀,CT值约13 HU,增强囊壁中度延迟强化(图1~3);MRI:均匀水样长T_(1)长T_(2)信号,T_(2)内见线样低信号分隔,增强囊壁及... 患者男,63岁。体检发现肾上腺肿块,曾有全身乏力史,余无其他异常。CT检查:左肾上腺一类圆形囊性肿块,界清壁薄,密度均匀,CT值约13 HU,增强囊壁中度延迟强化(图1~3);MRI:均匀水样长T_(1)长T_(2)信号,T_(2)内见线样低信号分隔,增强囊壁及分隔中度延迟强化(图4~7)。全麻下腹腔镜左肾上腺肿瘤切除,肉眼观:肿物最大径约4 cm,界清,囊性灰白色,周边少许黄色肾上腺及脂肪组织。 展开更多
关键词 肾上腺腺瘤样瘤 磁共振成像 体层摄影术 X线计算机
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A Study of Animated Transition in Similarity-Based Tiled Image Layout
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作者 Huan Zhang Jun Tao +1 位作者 fang ruan Chaoli Wang 《Tsinghua Science and Technology》 SCIE EI CAS 2013年第2期157-170,共14页
For many information visualization applications, showing the transition when interacting with the data is critically important as it can help users better perceive the changes and understand the underlying data. In th... For many information visualization applications, showing the transition when interacting with the data is critically important as it can help users better perceive the changes and understand the underlying data. In this paper, we investigate the effectiveness of animated transition in a tiled image layout where the spiral arrangement of the images is based on their similarity. Three aspects of animated transition are considered, including animation steps, animation actions, and flying paths. Exploring and weighting the advantages and disadvantages of different methods for each aspect and in conjunction with the characteristics of the spiral image layout, we present an integrated solution, called AniMap, for animating the transition from an old layout to a new layout when a different image is selected as the query image. We show the effectiveness of our animated transition solution by demonstrating experimental results and conducting a comparative user study. 展开更多
关键词 animated transition image layout large image collections user study
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