跟网型永磁同步发电机组相角主动支撑控制策略

永磁同步发电机及全功率变流传动系统相比于双馈异步发电机及部分功率变流传动系统可靠性更高、全生命周期成本更低。本文针对跟网型永磁同步发电机组提出一种相角主动支撑控制策略,在不改变主控制系统的基础上,加入频率变化率-相角反馈环路,在系统负荷突增时放出全功率变流传动系统中间直流环节稳压电容的能量,增大系统惯性以解决高比例新能源电力系统惯性低的问题,并通过DIgSILENT/PowerFactory搭建了仿真平台验证了所提相角主动支撑控制策略的有效性,保证了高比例新能源电力系统的频率稳定。

白芨多糖载纳米粒对肝癌小鼠抗肿瘤活性的实验研究

目的研究白芨多糖载纳米粒对肝癌小鼠的抗肿瘤活性。方法选择60只健康雌性ICR小鼠,复制小鼠肝癌的实体瘤模型,随机分成A、B、C 3组,每组20只。其中,A组注射生理盐水,B组注射紫杉醇溶液,C组注射白芨多糖为载体的紫杉醇纳米粒。连续给药2周后处死各组小鼠,解剖得到肝癌肿瘤,比较各组小鼠的瘤重、瘤体积、抑瘤率、肝脏指数、脾脏指数、胸腺指数等抗肿瘤活性指标。结果 (1)与A组相比,B、C组小鼠的瘤重、瘤体积变小,且C组变小幅度大于B组(P <0.05)。以A组为参照,B组小鼠抑瘤率为16.86%、C组抑瘤率为45.84%,差异有统计学意义(P <0.05),表明白芨多糖载体的紫杉醇纳米粒有较高的抗肿瘤活性。(2)与A组相比,B、C组小鼠肝脏指数降低,且C组降低幅度更大(P <0.05);脾脏指数、胸腺指数升高,且C组升高幅度大于B组(P<0.05)。结论以白芨多糖为载体制备的紫杉醇纳米粒对肝癌有较强的抗肿瘤活性,可减小肝癌小鼠的瘤重、瘤体积,提高抑瘤率,改善携瘤小鼠的肝脏指数、脾脏指数、胸腺指数。白芨多糖可作为难溶性药物载体,有较高的临床应用价值。

Huangqi Guizhi Wuwu Decoction for treating diabetic peripheral neuropathy：a meta-analysis of 16 randomized controlled trials

OBJECTIVE：This meta-analysis was performed to systematically assess the efficacy and safety of the Chinese herbal medicine Huangqi Guizhi Wuwu Decoction（HGWWD） for treating diabetic peripheral neuropathy.DATA SOURCES：Six electronic databases,including the Cochrane Library,MEDLINE database,Chinese Biomedical Database,Chinese National Knowledge Infrastructure Database,Chinese Science and Technique Journals Database,and the Wanfang Database,were search ed on the internet for randomized controlled trials published up until 1 December 2015.The search terms included ＂Chinese herbal medicine＂,＂diabetic peripheral neuropathy＂ and ＂randomized controlled trials＂ in Chinese and in English.DATA SELECTION：We included randomized controlled trials using HGWWD/modified HGWWD for the treatment group,without restriction for the control group.We assessed literature quality in accordance with the Cochrane Review Handbook.A random or a fixed effects model was used to analyze outcomes using Rev Man 5.2 software.OUTCOME MEASURES：The primary outcomes were changes in symptoms and nerve conduction velocities.The secondary outcomeswere fasting blood glucose and hemorheological indexes.RESULTS：Sixteen randomized controlled trials,with a total of 1,173 patients,were included.Meta-analysis revealed that the efficacy of HGWWD for diabetic peripheral neuropathy was significantly superior compared with the control treatment（i.e.,control group）（risk ratio = 0.36,95% confidence interval（CI）：0.29–0.46,Z =8.33,P 〈 0.00001） Compared with the control group,there was an increase in median motor nerve conduction velocity（mean difference（MD） = 3.46,95%CI：1.88–5.04,Z = 4.30,P 〈 0.01） and median sensory nerve conduction velocity（MD = 3.30,95%CI：2.04–4.56,Z = 5.14,P 〈 0.01）.There was also an increase in peroneal motor nerve conduction velocity（MD = 3.22,95%CI：2.45–3.98,Z = 8.21,P 〈 0.01） and peroneal sensory nerve conduction velocity（MD = 3.05,95%CI：2.01–4.09,Z = 5.75,P 〈 0.01） in the treatment groups.No significant difference in fasting blood glucose was found between the treatment groups and the control groups（MD =-0.12,95%CI：-0.42–0.19,Z = 0.76,P = 0.45）.Plasma viscosity was significantly decreased after treatment（MD =-0.11,95%CI：-0.21 to-0.02,Z = 2.30,P = 0.02）.No significant difference in fibrinogen was detectable（MD =-0.53,95%CI：-1.28–0.22,Z = 1.38,P = 0.17）.Four trials reported that treatment groups experienced no adverse reactions.Adverse events were not mentioned in the other 12 trials.No trial reported the incidence of complications,quality of life outcomes,or health economics.CONCLUSION：HGWWD treatment improves diabetic neurologic symptoms and ameliorates nerve conduction velocities.Our study suggests that HGWWD may have significant therapeutic efficacy for the treatment of diabetic peripheral neuropathy.However,the methodological quality of the randomized controlled trials was generally low.Larger and better-designed randomized controlled trials are required to more reliably assess the clinical effectiveness of HGWWD.

肾康丸与依那西普对2型糖尿病大鼠肾脏保护的作用机制

目的观察肾康丸及依那西普对2型糖尿病(T2DM)大鼠肾组织肿瘤坏死因子相关凋亡诱导配体(TRAIL)系统表达的影响,探讨两种药物对肾脏保护的作用机制。方法建立T2DM大鼠模型为模型组(D组),成模后将大鼠随机分为3组:模型对照组(DM组)、肾康丸组(DS组)、依那西普组(DE组);另设正常对照组(C组)。分组干预,全自动生化仪检测尿素氮(BUN)、血肌酐(Scr)及空腹血糖(FBG);ELISA法检测尿微量白蛋白(Uα1-MG)、24 h尿微量白蛋白(24hUm-Alb);Q-RT-PCR法检测治疗后TNF-α、TRAIL、DR4、DcR2在各大鼠肾组织的表达,HE染色法观察大鼠肾组织病理变化。结果 DM组BUN、Scr及FBG上升,与DM组相比,DS组与DE组BUN、Scr、及FBG下降。与C组相比,第4周、第8周DM组大鼠Uα1-MG、24hUm-Alb比其他3组显著升高(P<0.01),肾组织TNF-α、DcR2 mRNA表达显著增强(P<0.01);而TRAIL、DR4 mRNA表达显著减弱(P<0.01),并且DM组大鼠出现了肾脏组织病理损害;DS组及DE组的肾脏病理损害较DM组轻。结论肾康丸与特异性TNF-α拮抗剂依那西普均对T2DM大鼠肾脏有显著保护作用,但两者作用机制不全一致,依那西普主要减少TNF-α表达,减轻炎症反应作用,而肾康丸是通过影响TRAIL系统的表达。

In-plane micro-sized energy storage devices:From device fabrication to integration and intelligent designs

The rapid development of micro-electronics raises the demand of their power sources to be simplified,miniaturized and highly integratable with other electronics on a chip.In-plane Micro-sized energy storage devices(MESDs),which are composed of interdigitated electrodes on a single chip,have aroused particular attentions since they could be easily integrated with other miniaturized electronics,reducing the complexity of overall chip design via removing complex interconnections with bulky power sources.This review highlights the achievements in the device fabrication of in-plane MESDs,as well as their integration and intelligent designs.We also discussed the current challenges and future perspectives for the development of in-plane MESDs.

Dehydration melting of amphibolite at 1.5 GPa and 800–950C:Implications for the Mesozoic potassium-rich adakite in the eastern North China Craton

Mesozoic intermediate-felsic magmatic rocks in the eastern North China Craton commonly show geochemical similarity to adakites.However,the lack of direct constraints from partial melting experiments at high pressures and temperatures fuels a debate over the origin of these rocks.In this work,we performed partial melting experiments at 1.5 GPa and 800–950℃on amphibolite samples collected from the vicinity of the Mesozoic potassium-rich adakitic rocks in the Zhangjiakou area,northern margin of the North China Craton.The experimental melts range from granitic to granodioritic compositions,with SiO_(2)=56.4–72.6 wt.%,Al_(2)O_(3)=16.1–19.3 wt.%,FeO^(*)=2.4–9.6 wt.%,MgO=0.3–2.0 wt.%,CaO=0.6–3.8 wt.%,Na_(2)O=4.7–5.3 wt.%,and K_(2)O=2.6–3.9 wt.%,which are in the ranges of the surrounding Mesozoic potassium-rich adakitic rocks,except for the higher Al_(2)O_(3)contents and the data point at 1.5 GPa and 800℃.Trace element compositions of the melts measured by LA-ICP-MS are rich in Sr(849–1067 ppm)and light rare earth elements(LREEs)and poor in Y(<10.4 ppm)and Yb(<0.88 ppm),and have high Sr/Y(102–221)and(La/Yb)n(27–41)ratios and strongly fractionated rare earth element(REE)patterns,whereas no obvious negative Eu anomalies are observed.The geochemical characteristics show overall similarity to the Mesozoic potassium-rich adakitic rocks in the area,especially adakites with low Mg#,again except for the data point at 1.5 GPa and 800℃.The results suggest that partial melting of amphibolite can produce potassium-rich adakitic rocks with low Mg#in the eastern North China Craton under the experimental conditions of 1.5 GPa and 850–950℃.The experimental restites consist of hornblende(Hbl)+plagioclase(Pl)+garnet(Grt)±clinopyroxene(Cpx),a mineral assemblage significantly different from that of the nearby Hannuoba mafic granulite xenoliths which consist of Cpx+orthopyroxene(Opx)+Pl±Grt.Chemically,the experimental restites contain higher Al_(2)O_(3)but lower MgO and CaO than the Hannuoba mafic granulite xenoliths.We therefore argue that the Hannuoba mafic granulite xenoliths cannot represent the direct products of partial melting of the experimental amphibolite.

Geochemical records of the sediments and their significance in Dongping Lake Area,the lower reach of Yellow River,North China

Dongping Lake area,located in the lower reaches of Yellow River,is an ideal place to study the changes of modern river and lake sedimentary environment.The sediment samples of Dawen River,Yellow River,and Dongping Lake were collected,and the major elements,trace elements and organic matter geochemical composition of the samples were analyzed.Cluster analysis,characteristic element ratio method and graphic method were used to explore the geochemical characteristics of sediments and their environmental implication.The results show that the contents of SiO_(2),Na_(2)O,TiO_(2) and Zr in sediments of Dawen River and Yellow River are relatively high,and the contents of iron and manganese oxides,organic matter,CaO,P2O5 and Sr in lake sediments are relatively high.That reveals the differences of sedimentary environments between the rivers and the lake.The contents of Sr and Zr in Dawen River are affected by the rapid migration of clastic materials in the upstream carbonate source area during the flood season;the δCe,ΣREE and REE’s ratios in the sediments of the Yellow River reflect the influence of the Loess source;and the distribution of elements changes along the flow direction during the flood season.The characteristics of pH,element composition and LREE&HREE fractionation of the lake sediments indicate that the sediment source is complex,and the lake environment is affected by the flood season.The study shows that the geochemical content and its variation characteristics of sediments effectively reveal the sedimentary environment,material composition and characteristics of flood season of rivers and the lake in the study area.

Clinical outcomes and 5-year follow-up results of keratosis pilaris treated by a high concentration of glycolic acid

BACKGROUND Keratosis pilaris is a hereditary abnormal keratosis of the hair follicle orifice.Gray-brown keratotic plugs in the pores and dark red keratotic papules at the openings of hair follicles can be seen,which contain coiled hair and are often accompanied by perifollicular erythema and pigmentation.Glycolic acid can correct the abnormalities of hair follicular duct keratosis and eliminate excessive accumulation of keratinocytes.It also promotes skin metabolism and accelerates the melanin metabolism.The therapeutic effect is related to the glycolic acid concentration.AIM To evaluate the efficacy and safety of a high concentration of glycolic acid in the treatment of keratosis pilaris,and to observe the outcomes at 5-year of follow-up.METHODS Twenty-five participants were recruited and areas with typical keratosis pilaris were selected as testing sites.High concentrations of glycolic acid(50%or 70%)were applied to a circular area(d=8 cm,S=50 cm2)and repeated four times,on days 0,20,40 and 60.Before each treatment and 20 d after the last treatment,on days 0,20,40,60,and 80 and at a 5-year follow-up,The number of follicular keratotic papules were counted and the extent of perifollicular erythema and pigmentation was determined.At the same time,the participants provided subjective evaluations of treatment efficacy and safety.RESULTS Treatment effectiveness was indicated by the percentage of keratotic papules in the test site,on days 20,40,60 and 80,which were 8%,12%,36%,and 60%,respectively.Compared with day 0,each difference was significant(P<0.05).Compared with day 0,differences in melanin content(M)in the skin and skin lightness(L)on days 40,60 and 80,the were statistically significant(P<0.05);skin hemoglobin content(E)on days 60 and 80 was statistically different as compared with before treatment(P<0.05).There were no significant differences in the number of keratotic papules,M,L,and E in 9 participants at the 5-year follow-up compared with before treatment(P>0.05%).CONCLUSION A high concentration of glycolic acid significantly improved skin roughness as well as follicular hyperpigmentation of patients with keratosis pilaris.The treatment was relatively safe,but there was no significant difference at the 5-year follow-up compared to before treatment.

Flexible and tailorable quasi‐solid‐state rechargeable Ag/Zn microbatteries with high performance

The recent boom in flexible and wearable electronics requires their powersources not only to be adequately compact but also could undergo extremedeformation without significant degradation in performance. Here, flexibleand tailorable quasi‐solid‐state microsized Ag/Zn batteries (micro‐AZBs)were designed by combining mask‐assisted spray printing and electrochemicaldeposition strategies. The micro‐AZBs display ultrastable outputvoltage, excellent energy, and power densities, as well as stable cycling performance.Furthermore, the micro‐AZBs with desired shapes can be designedin series or in parallel on a flexible chip to output improved voltage or currentwith the internal connection. More importantly, the microelectrodes could besprayed on various substrates. Flexible micro‐AZBs could be achieved onflexible substrates and tailorable micro‐AZBs are obtained when they arefabricated on clothes. They exhibit stable electrochemical performance evenunder bending or cutting states. The novel design of such quasi‐solid‐statemicro‐AZBs would pave a way for the miniaturization and integration ofenergy storage devices.

基于云服务和人工智能的无人化金属切割远程运维关键技术研发和示范工程

金属型材的切割在我国的基础建设和智能制造领域中占有重要的地位。近年来因劳动力短缺、劳动力成本急剧上升、节能环保要求日益苛刻,传统切割技术和运行模式已无法满足用户提出的新需求。本文基于物联网、云服务、大数据、工业总线、核心部件数字化控制技术,研发和完成了具有自主知识产权的金属切割远程运维系统和示范工程,可显著提高劳动生产效率,减轻劳动强度,改善脏乱差的工作环境,降低对操作人员的技术要求。对我国金属切割领域的无人化工厂建设具有一定的借鉴和参考价值。

疑似系统性红斑狼疮的麻风患者1例及文献复习

麻风病作为古老的三大慢性传染病之一,目前较为少见,本文报道了1例以反复发热和淋巴结肿痛为主要表现,并出现了抗核抗体、抗磷脂抗体、抗β2-GP1-Ab抗体阳性等疑似系统性红斑狼疮(systemic lupus erythematosus,SLE)诊断的麻风患者的诊疗经过,同时对相关文献进行复习。

旁路放风与高硫煤的应用

某5000t/d熟料生产线原、燃材料硫、氯元素含量高,需采用旁路放风系统降低硫、氯元素含量。通过采用经典的Weber法计算了旁路放风量,设置旁路放风量10%的放风系统,放风点设置在窑尾烟室斜坡部正前方。旁路放风量为10%时,热损失不大,排灰量为20g/kg,窑尾结皮减弱,熟料有害成分含量大幅降低,熟料性能改善,技术经济效益可观。

γ-射线分析仪及生料质量控制系统的优势

简述了生料均化系统的设计要求,详细介绍了γ-射线分析仪在生料系统中的应用,γ-射线分析仪彻底解决了"取样代表性"的问题,生料达标率高,简化、优化了均化链,工厂占地面积、设备投入、人员编制大幅减少,生料制备电耗明显降低。

女性领导多重身份双刃剑效应及管理策略研究

随着经济社会的不断发展,女性领导具备多重身份已成为日益突显的趋势。已有研究主要分析了女性领导多重身份带来的身份冲突,而对身份协同的研究还较为欠缺,尤其是在中国文化情境下女性领导多重身份形成的身份冲突和身份协同的“双刃剑”效应研究还几乎是空白。本研究基于已有文献,构建了中国女性领导多重身份双刃剑效应及管理策略的理论模型,提出女性领导多重身份主要包括女性身份、领导身份、工作身份、家庭身份以及社会身份,且多重身份可产生身份冲突和身份协同的“双刃剑”效应。而面对多重身份带来的的冲突和协同,女性领导主要采取区隔策略、整合策略或二者兼有的双元策略,并进而对其领导效能和工作生活平衡带来影响。

Action mechanisms of a new erythrocyte-derived depressing factor

To investigate the action mechanisms of a new erythrocyte-derived depressing factor(EDDF), the focus is placed on the effect of EDDF on both cytosolic and nuclear free calcium (Ca2+) transportation in vascular smooth muscle cell (VSMC), as well as the apoptosis and cell cycle of VSMC of rats. EDDF has been extracted from human erythrocytes. The changes of Ca2+ levels in cytoplasm ([Ca2+],) and nucleus ([Ca2+]n) have been observed using a laser scanning confocal microscope together with fluo-3/AM as a calcium indicator. Flow cytometric technique was used to study the effect of EDDF on cell cycle and apoptosis of VSMC. [Ca2+]j and [Ca2+]n were significantly decreased through several different pathways: ( i) it reduced the Ca2+ influx by blocking L-type voltage-dependent calcium channel (L-VDC) and R-type voltage-dependent calcium channel (R-VDC); (ii) it inhibited the Ca2+ release from inositol 1, 4, 5-trisphosphate (IP3) sensitive calcium store; and (iii) activated Ca2+-ATPase of sarcoplasmic reticulum (

Freestanding reduced graphene oxide/sodium vanadate composite films for flexible aqueous zinc-ion batteries

With the booming development of portable and wearable electronic devices, flexible energy storage devices have attracted great attention. Among various energy storage devices, aqueous zinc ion batteries(ZIBs) are one of the promising candidates due to their low cost, good safety, high energy and power densities. However, the conventional cathodes of aqueous ZIBs were often prepared by mixing active materials with binders and conductive additives and then coating them onto current collectors. The resultant cathodes often suffer from unsatisfied flexibility. Herein, we fabricated freestanding reduced graphene oxide/NaV_3O_8·1.5H_2O(RGO/NVO) composite films with interlinked multilayered architecture by a vacuum filtrating process. Such composite films exhibit excellent mechanical property and high electronic conductivity. Owing to unique architecture, they display a high capacity of 410 mA h g^(-1) and excellent cycling performance up to 2000 cycles with a high capacity retention of 94%. Moreover, RGO/NVO composite films can directly serve as the cathodes of flexible aqueous ZIBs. As a proof of concept,flexible ZIBs were assembled based on the composite films. Impressively, they exhibit stable performance at different bending states, demonstrating great potential application in flexible energy storage devices.

Passivation with crosslinkable diamine yields 0.1 V non-radiative Vloss in inverted perovskite solar cells

Organic-inorganic hybrid perovskite solar cells(PSCs)have attracted continually increasing attention in recent years due to its outstanding photoelectric properties and bright commercial prospect[1–6].So far,the certified power conversion efficiency(PCE)record of PSCs increased up to be 25.2%[7].However,the efficiency for PSCs with inverted structure was generally lower(~22.3%)[8].A major reason for the relatively lower PCE in inverted solar cells was that the achieved open-circuit voltage(V_(oc))was generally lower than that of conventional PSCs based on the same photoactive layers[9–11].

海南黄花梨中1个新的异黄酮类化合物及其酪氨酸酶抑制活性

采用加热回流提取、溶剂萃取、重结晶及正相硅胶、Sephadex LH-20、MCI、HPLC等多种色谱技术,对海南黄花梨干燥枝叶化学成分进行研究,分离得到12个黄酮类化合物。结合NMR、MS等波谱方法对分离得到的化合物进行结构鉴定,分别为6,7,8-三甲氧基-5,4′-二羟基异黄酮(1)、美迪紫檀素(2)、7,2′-二羟基-4′-甲氧基-异黄烷醇(3)、鹰嘴豆芽素A(4)、樱黄素(5)、染料木素(6)、红车轴草素(7)、3-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-4H-chromen-4-one(8)、鸢尾黄素(9)、尼泊尔鸢尾异黄酮(10)、维斯体素(11)和芒柄花黄素(12)。其中化合物1为新的异黄酮类化合物,化合物8为首次从海南黄花梨中分离得到。对分离得到的化合物进行体外酪氨酸酶抑制活性测试显示化合物1~3对酪氨酸酶有抑制作用,在1.0 mmol·L的浓度下,抑制率分别为35.58%、38.63%、51.34%。

Free-standing nitrogen doped graphene/Co(OH)_(2) composite films with superior catalytic activity for aprotic lithium-oxygen batteries

The recent boom in large-scale energy storage system promotes the development of lithium-oxygen batteries because of their high theo retical energy density.However,their applications are still limited by the sluggish kinetic,insoluble discharge product deposition and the undesired parasitic reaction.Herein,the free-standing nitrogen doped reduced graphene oxide/Co(OH)_(2)(NRGO/Co(OH)_(2)) composite films were prepared by a facile hydrothermal method,The NRGO/Co(OH)_(2) composite films display interconnected three-dimensional conductive network,which can not only promote the diffusion of O2 and the transport of electrolyte ions,but also provide abundant storage space for discharge products.Moreover,the introduction of nitrogen-containing functional groups results in improved conductivity and electron adsorption ability,which can facilitate electron transport and enhance the surface catalytic activity.Combining with excellent catalytic performance,the lithium-oxygen batteries with NRGO/Co(OH)_(2) composite film cathodes deliver low charge overpotential and excellent cycling performance.