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不同地区粉煤灰合成防渗材料的渗透性能分析
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作者 马喆 方樟 +1 位作者 孙晓庆 郝洋 《化工管理》 2024年第12期35-37,41,共4页
粉煤灰由于具有良好的火山灰效应和微集料效应可以应用在混凝土中,以提高混凝土的渗透性能。通过采集白城和吉林热电厂的粉煤灰进行合成防渗材料实验,研究不同地区粉煤灰与氯化钠掺和料配比,以确定防渗性能最优的掺和比,并分析不同地区... 粉煤灰由于具有良好的火山灰效应和微集料效应可以应用在混凝土中,以提高混凝土的渗透性能。通过采集白城和吉林热电厂的粉煤灰进行合成防渗材料实验,研究不同地区粉煤灰与氯化钠掺和料配比,以确定防渗性能最优的掺和比,并分析不同地区粉煤灰聚合物渗透性能影响因素。研究表明,相同条件下,水力除灰方式不同,粉煤灰含水量不同,粉煤灰含水率越高,相对密度越小,防渗性能越好。 展开更多
关键词 粉煤灰 掺和比 防渗聚合物 渗透性能
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Reproductive cycle of Ophiopholis mirabilis (Echinodermata: Ophiuroidea) in Zhangzi Island area, northern Yellow Sea
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作者 Nan YU Song SUN +1 位作者 Guangtao zhang fang zhang 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2021年第1期173-184,共12页
Ophiopholis mirabilis is a common species with a high population density on the western coasts of the northern Pacifi c Ocean.The number of O.mirabilis has been increasing recently in the scallop aquaculture zone(the ... Ophiopholis mirabilis is a common species with a high population density on the western coasts of the northern Pacifi c Ocean.The number of O.mirabilis has been increasing recently in the scallop aquaculture zone(the Zhangzi Island area,northern Yellow Sea)in China.To explore the mechanism of its population variation,the reproductive cycle of O.mirabilis was investigated in this area(39°04′N;122°51′E)from February 2017 through January 2018 and determined by the monthly gonad index(GI),histological examinations of the gonads and the oocyte size-frequency distribution.O.mirabilis had a clear annual reproductive cycle that was synchronous between males and females.Sea temperature and food availability played important roles in O.mirabilis reproduction.The GI value was less reliable for determining reproductive activity in O.mirabilis because the nutritive tissues within the gonads may be utilized to synthesize gametes,leading to a decrease in GI during maturation.The histological results also show that abundant nutritive phagocytes were present in the gonads of O.mirabilis,which,together with the germ cells,aff ected the weight of the gonads.In addition,the mature oocytes of O.mirabilis were relatively small(75–150μm),indicating that the larval development was planktotrophic.This study provided insights into the reproductive patterns and biology of O.mirabilis and is an essential basis for the quantity control of this species in aquaculture areas. 展开更多
关键词 reproductive biology OPHIUROIDEA the northern Pacifi c Ocean Ophiopholis mirabilis
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Characteristics of the anti-dementia drug system of Zisu Fang preparations based on pharmacokinetic and pharmacodynamic analysis
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作者 Jianye Quan Shujuan Yang +5 位作者 fang zhang Li Tan Jing Kong Yanyan Jiang Rendi Sun Renbing Shi 《Journal of Traditional Chinese Medical Sciences》 2017年第2期207-215,共9页
Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu Fang preparations and additionally analysis the anti-dementia drug system characteristics.Methods:A PK-PD-drug i... Objectives:To investigate the pharmacokinetics (PK) and pharmacodynamics (PD)of index components of Zisu Fang preparations and additionally analysis the anti-dementia drug system characteristics.Methods:A PK-PD-drug interaction (DI) method was applied to determine the characteristics of index components of Zisu Fong preparations in vivo.Results:In the PK study,maximum plasma concentration,area under the plasma concentration-time curve,and mean residence time of index components of Zisu Fang preparations were higher in the memory-deficit model group than in the control group.This suggested that the index components of Zisu Fang preparations had an affinity for the state of dementia in this model.In the PD study,at the peak time points of anti-dementia efficacy (0.17 h and 1 h),the plasma concentrations of index components of Zisu Fang preparations reached the first or second largest plasma concentration peak or were close to the plasma concentration peak,and showed positive correlation between these two peaks,indicating that the index components of Zisu Fang synergistically exerted an anti-dementia effect.According to the association analysis of PK-PD-DI,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA were the main active ingredients of the anti-dementia drug system of Zisu Fang preparations in vivo,but were only efficacious against dementia when all five components were present at a specific concentration and proportion.Conclusions:Based on the PK and PD correlation analysis,baicalin,rosmarinic acid,salvianolic acid B,matrine,and tanshinone ⅡA are the main active ingredients of Zisu Fang preparations with regard to its anti-dementia effects,and represent the basic characteristics of drug system:natures,synergy,and affinity. 展开更多
关键词 Index components Pharmacokinetics PHARMACODYNAMICS CHARACTERISTICS of anti-dementia DRUG SYSTEM
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影响心肌血流下降的因素及其价值研究
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作者 蔡文怡 方章 +5 位作者 施建伷 卜菊 陈丽梅 赵中强 周宁天 李殿富 《医学研究与战创伤救治》 CAS 北大核心 2024年第3期287-291,共5页
目的探讨传统单光子发射计算机断层成像(SPECT)获取的心肌灌注显像、半定量参数以及冠脉造影结果、临床参数对心肌缺血的影响。方法回顾性分析2022年6月至2022年10月在南京医科大学第一附属医院(江苏省人民医院)完成CZT-SPECT检查的116... 目的探讨传统单光子发射计算机断层成像(SPECT)获取的心肌灌注显像、半定量参数以及冠脉造影结果、临床参数对心肌缺血的影响。方法回顾性分析2022年6月至2022年10月在南京医科大学第一附属医院(江苏省人民医院)完成CZT-SPECT检查的116例临床疑似或确诊的冠心病患者临床资料,最终纳入39例患者。以三支主要冠脉区域心肌血流储备功能<2.1作为心肌缺血的诊断标准,绘制冠脉狭窄程度、区域负荷灌注积分(SS)、静息灌注积分(RS)和灌注积分差(DS)诊断心肌缺血的ROC曲线以获得最佳截断值和相应的诊断效能,通过逐步回归法建立预测模型,绘制ROC曲线。结果共计117支主要血管,其中判定为心肌缺血的有36支(30.77%)。冠脉狭窄程度、SS、RS和DS诊断心肌缺血的ROC曲线最佳截断值分别为53%、3.5、1.5、1.5,准确性分别为75.2%、74.4%、70.9%、72.6%,ROC曲线的AUC及95%CI分别为0.78(0.68~0.87)、0.64(0.53~0.74)、0.58(0.49~0.66)、0.65(0.55~0.75)。冠脉狭窄程度、血管区域心肌灌注显像、SS、RS和DS等单因素有意义的指标联合预测心肌缺血的ROC曲线的AUC及95%CI为0.79(0.69~0.88)。逐步回归法踢除变量后,最终模型预测心肌缺血的ROC曲线的AUC及95%CI为0.84(0.76~0.92)。结论SPECT心肌灌注显像中SS>3.5、DS>1.5、RS>1.5对预测心肌缺血有一定的意义,联合多个指标(冠脉造影结果、SS、DS、RS、心肌灌注显像)预测显著提高了对心肌缺血的诊断价值。 展开更多
关键词 冠心病 冠状动脉血流储备 碲锌镉 单光子发射计算机断层成像 心肌灌注显像
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Esophageal cancer screening,early detection and treatment:Current insights and future directions 被引量:3
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作者 Hong-Tao Qu Qing Li +7 位作者 Liang Hao Yan-Jing Ni Wen-Yu Luan Zhe Yang Xiao-Dong Chen Tong-Tong zhang Yan-Dong Miao fang zhang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1180-1191,共12页
Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival rates.According to the 2020 global cancer statistics,there were approximately ... Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival rates.According to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 deaths.The 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and distribution.Squamous cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local population.Conversely,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United States.The role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of controversy.The effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated topic.The variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer diagnoses.In areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive treatments.These techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal functionality.Early screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer. 展开更多
关键词 Esophageal cancer SCREENING Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection
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集成X射线、TEM和STM的晶体学教学尝试
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作者 马宏伟 张芳 +3 位作者 艾惠 张妞 彭绍春 李晖 《大学化学》 CAS 2024年第3期5-17,共13页
以Si晶体为例,介绍了一种结合X-射线、电子显微学和扫描隧道显微技术进行晶体学教学的尝试。主要是从基本原理、实验技术、实验结果等方面建立不同方法之间的联系,也说明其区别。目的是使学生能依据基本的晶体学原理、概念和数据,理解... 以Si晶体为例,介绍了一种结合X-射线、电子显微学和扫描隧道显微技术进行晶体学教学的尝试。主要是从基本原理、实验技术、实验结果等方面建立不同方法之间的联系,也说明其区别。目的是使学生能依据基本的晶体学原理、概念和数据,理解不同的晶体结构分析和表征方法提供的晶体学信息之间的区别和联系,达到融会贯通的效果。 展开更多
关键词 晶体学 教学 X-射线 TEM STM
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吉林省镇赉县农业井灌“以电折水”系数研究初探
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作者 刘毅强 王楠 +1 位作者 王蕾 方樟 《东北水利水电》 2024年第9期53-55,共3页
针对吉林省农业机电井数目庞大、用水计量监测难度大等问题,本文以白城市镇赉县为例,引入“以电折水”方法计量农业用水。通过测定农业井抽水耗费的电量和水量,初步确定镇赉县的“以电折水”折算系数。折算系数的大小受不同多因素的综... 针对吉林省农业机电井数目庞大、用水计量监测难度大等问题,本文以白城市镇赉县为例,引入“以电折水”方法计量农业用水。通过测定农业井抽水耗费的电量和水量,初步确定镇赉县的“以电折水”折算系数。折算系数的大小受不同多因素的综合影响,镇赉县各地区折算系数差异较大,西北部地势高处系数最小,东部与南部冲积平原系数最大,中部漫岗地系数处于平均水平。 展开更多
关键词 “以电折水”系数 农业灌溉 吉林省 镇赉县
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Experimental clearance rate and intraguild predation of jellyfish Cyanea nozakii
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作者 Pengpeng WANG fang zhang +1 位作者 Song SUN Shuguo LÜ 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期128-140,共13页
Cyanea nozakii,a common jellyfish distributed in offshore China,has a complex trophic relationship with other zooplankton groups.However,few studies have reported the predation rates and prey selection patterns of C.n... Cyanea nozakii,a common jellyfish distributed in offshore China,has a complex trophic relationship with other zooplankton groups.However,few studies have reported the predation rates and prey selection patterns of C.nozakii medusae on different prey items.Research is also lacking on the intraguild predation of Aurelia coerulea(another common bloom jellyfish in offshore China)by C.nozakii.To address the knowledge gaps,the clearance rates of C.nozakii for different prey items,including copepods(small<1000μm and large>1000μm),fish larvae,and gelatinous prey(hydromedusae,A.coerulea ephyrae,and chaetognaths),were measured.The influence of predator size on the clearance rate was also determined.Additionally,we examined the intraguild predation of C.nozakii on A.coerulea medusae.The clearance rates of C.nozakii varied widely with prey organisms,being independent of prey concentrations.Gelatinous organisms,except for chaetognaths,were captured with considerably high efficiency,followed by fish larvae and copepods,indicating the preferential prey selection of gelatinous organisms by C.nozakii.The clearance rate increased linearly with the cross-sectional area of C.nozakii.Body size in medusae may,to some extents,underpin their capacity to capture more prey by increasing the encounter rate and capture success through ontogeny.C.nozakii preyed voraciously on A.coerulea in high feeding efficiency,but the clearance rate decreased with increasing A.coerulea(as prey)size.This phenomenon of intraguild predation suggests a speculative hypothesis of potential population regulation of A.coerulea by C.nozakii.The information regarding the feeding ecology of C.nozakii reported in this study is important for understanding plankton dynamics in marine ecosystems with extensive occurrences of this jellyfish. 展开更多
关键词 SCYPHOMEDUSAE predation rate gelatinous organisms prey selection feeding mechanism
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Distribution,abundance,and realized niches of meroplankton by two different mesh size nets during spring 2017 in the Southern Yellow Sea,China
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作者 Shuangyan zhang fang zhang +3 位作者 Xiaoxia SUN Dongjie GUO Jianfeng WANG Song SUN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第5期1540-1556,共17页
Meroplankton play a crucial role in both benthic and pelagic ecosystems.Existing quantitative research on estimating the quantities of meroplankton groups is both underrepresented and inaccurate.To investigate and eva... Meroplankton play a crucial role in both benthic and pelagic ecosystems.Existing quantitative research on estimating the quantities of meroplankton groups is both underrepresented and inaccurate.To investigate and evaluate the influence of varying mesh sizes(505 and 160μm)on the sampling efficiency of meroplankton,we conducted an examination using two commonly used plankton nets during the spring season in the Southern Yellow Sea(SYS).Our study revealed a total of 12 meroplankton groups,with 9 groups identified in the 505-μm mesh nets and 11 groups in the 160-μm mesh nets.The results demonstrated the superior collection efficiency of the 160-μm net compared to the 505-μm net across the majority of meroplankton groups.Furthermore,we focused on exploring the abundance,distribution patterns,and realized niches of meroplankton collected by the two mesh size nets,and observed that the distribution of meroplankton closely resembled the distribution of possible benthic adults in the SYS.Correlation analysis of the six dominant groups collected in the 160-μm mesh nets revealed that seawater temperature and salinity emerged as the key environmental factors driving variations in meroplankton abundance within the SYS.This study also found that a smaller mesh size net does not necessarily capture meroplankton more comprehensively.A comprehensive understanding of the ecological characteristics of meroplankton requires the combination of two types of nets for research.Our research significantly advances our understanding of the quantification,abundance,and distribution of meroplankton,serving as a valuable contribution to the broader landscape of detailed quantitative meroplankton studies. 展开更多
关键词 meroplankton plankton net mesh size collection efficiency distribution characteristic realized niches
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A data-adaptive network design for the regional gravity field modelling using spherical radial basis functions
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作者 fang zhang Huanling Liu Hanjiang Wen 《Geodesy and Geodynamics》 EI CSCD 2024年第6期627-634,共8页
A high-precision regional gravity field model is significant in various geodesy applications.In the field of modelling regional gravity fields,the spherical radial basis functions(SRBFs)approach has recently gained wi... A high-precision regional gravity field model is significant in various geodesy applications.In the field of modelling regional gravity fields,the spherical radial basis functions(SRBFs)approach has recently gained widespread attention,while the modelling precision is primarily influenced by the base function network.In this study,we propose a method for constructing a data-adaptive network of SRBFs using a modified Hierarchical Density-Based Spatial Clustering of Applications with Noise(HDBSCAN)algorithm,and the performance of the algorithm is verified by the observed gravity data in the Auvergne area.Furthermore,the turning point method is used to optimize the bandwidth of the basis function spectrum,which satisfies the demand for both high-precision gravity field and quasi-geoid modelling simultaneously.Numerical experimental results indicate that our algorithm has an accuracy of about 1.58 mGal in constructing the gravity field model and about 0.03 m in the regional quasi-geoid model.Compared to the existing methods,the number of SRBFs used for modelling has been reduced by 15.8%,and the time cost to determine the centre positions of SRBFs has been saved by 12.5%.Hence,the modified HDBSCAN algorithm presented here is a suitable design method for constructing the SRBF data adaptive network. 展开更多
关键词 Regional gravity field modelling Spherical radial basis functions Poisson kernel function HDBSCAN clustering algorithm
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Minerals in edible insects:a review of content and potential for sustainable sourcing
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作者 Mingxing Lu Chenxu Zhu +4 位作者 Sergiy Smetana Ming Zhao Haibo zhang fang zhang Yuzhou Du 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期65-74,共10页
In response to the rapid increase in world population and subsequent demands for food,edible insects represent an alternative food source for humans that is rich in proteins,amino acids and minerals.Entomophagy is a t... In response to the rapid increase in world population and subsequent demands for food,edible insects represent an alternative food source for humans that is rich in proteins,amino acids and minerals.Entomophagy is a tradition in many countries including China and Thailand,and edible insects have attracted a lot of attention in Western World due to their suitable nutrient composition,high mineral content(e.g.,Fe,Zn,Ca,Mg)and potential use as a supplement in human diet.In this study,we surveyed mineral content in seven insect orders and 67 species of mass produced and wild-harvested edible insects.The total content of essential elements in edible insects was very high in Tenebrio molitor,Bombyx mori,and Zonocerus variegatus.The heavy metal content(summarized for eight species)was below the maximum limit allowed for safe consumption.Sustainable supply of minerals derived from insect biomass is complicated due to the high variations of mineral content in insects and the potential of its change due to processing. 展开更多
关键词 Edible insects MINERALS NUTRITION Food safety SUSTAINABILITY
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基于WOE与PCA的油田钻井区地下水脆弱性研究 被引量:1
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作者 李霞 方樟 +2 位作者 江世雄 马喆 李立军 《节水灌溉》 北大核心 2019年第8期84-89,共6页
油田钻井的选址必须尽量减少其对地下水及周边环境的影响。以伊通县油田钻井选址为例,利用主成分因子分析法(PCA)和证据权重法(WOE)对研究区分别进行了地下水脆弱性评价。在地下水固有脆弱性基础上,增加土地利用方式、河流距离及河流密... 油田钻井的选址必须尽量减少其对地下水及周边环境的影响。以伊通县油田钻井选址为例,利用主成分因子分析法(PCA)和证据权重法(WOE)对研究区分别进行了地下水脆弱性评价。在地下水固有脆弱性基础上,增加土地利用方式、河流距离及河流密度3个指标,建立了地下水脆弱性评价指标体系,利用硝酸盐浓度评价与验证,并通过ROC曲线比较其评价性能,AUC值分别为0.73和0.80,则WOE的评价性能较优。利用ArcGIS对评价结果进行可视化,结果表明,脆弱性较低的面积占研究区的25.57%,脆弱性中等、较高的区域占69.85%,研究区油田钻井选址尽量避免东北部漫滩、一级阶地、河流及水库影响范围。该研究对于WOE应用到地下水脆弱性评价具有参考价值,为油田钻井选址提供依据。 展开更多
关键词 伊通县水源地 脆弱性评价 PCA WOE 评价指标体系
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病因相关肠易激综合征动物模型研究进展 被引量:10
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作者 张方 翁志军 +6 位作者 吴璐一 包春辉 杨玲 赵敏 吴焕淦 刘慧荣 周次利 《世界华人消化杂志》 CAS 2018年第30期1772-1777,共6页
肠易激综合征(irritable bowel syndrome, IBS)属于慢性功能性肠道疾病,其发病率在全球范围内呈逐年上升趋势.目前病因和发病机制尚不完全明确,较为公认的病因包括内脏高敏感、肠道感染、精神心理、胃肠激素、肠道菌群紊乱、基因遗传等... 肠易激综合征(irritable bowel syndrome, IBS)属于慢性功能性肠道疾病,其发病率在全球范围内呈逐年上升趋势.目前病因和发病机制尚不完全明确,较为公认的病因包括内脏高敏感、肠道感染、精神心理、胃肠激素、肠道菌群紊乱、基因遗传等因素.因此,研究者研发了多种与IBS病因相关的动物模型,取得了重大研究进展并普遍应用于基础实验研究.本文概括总结了目前与IBS病因相关的国内外通用的动物模型的制作方法,以期为IBS基础研究的动物模型选择提供参考. 展开更多
关键词 肠易激综合征 内脏高敏感 病因 动物模型
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石河子地区儿童眼外伤的致伤原因和致盲因素分析 被引量:7
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作者 张芳 孟新丹 +2 位作者 李军 张培莉 杨炜 《国际眼科杂志》 CAS 北大核心 2019年第4期636-640,共5页
目的:研究儿童眼外伤致伤原因及致盲分析,提出防治措施。方法:收集163例眼外伤患者(14岁以下)的年龄、性别、致伤物、眼别、眼外伤分类、并发症,并比较治疗前后的视力,采用OTS评分比较与预后视力是否相关。结果:眼外伤男女比为3.79∶1;... 目的:研究儿童眼外伤致伤原因及致盲分析,提出防治措施。方法:收集163例眼外伤患者(14岁以下)的年龄、性别、致伤物、眼别、眼外伤分类、并发症,并比较治疗前后的视力,采用OTS评分比较与预后视力是否相关。结果:眼外伤男女比为3.79∶1;学龄儿童7~10岁最多见;就诊时间≤24h内最多见。性质主要为闭合性眼外伤;受伤原因主要为跌倒撞击伤;类型主要是钝挫伤;受伤环境多发于居民区及附近;最常见并发症为前房积血、外伤性白内障。将入院视力按≥0.05分组,其中就诊时间、外伤性质、并发症、受伤类别、手术有差异,并发症为独立影响因素[OR=2.708,95%CI(1.285~5.705)];将治疗后视力是否提高分组,其中性别、年龄、就诊时间、外伤性质、并发症有差异,性别、年龄、就诊时间为独立影响因素,就诊时间的OR值为2.895,95%CI(1.296~6.465)。结论:眼外伤是儿童主要致盲性眼病之一,但预防可以降低绝大多数眼外伤的发生。 展开更多
关键词 眼外伤 儿童 致盲 回归分析
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常见泪腺上皮性肿瘤中EGFL7的表达及其与血管生成和细胞增殖活性的相关性研究 被引量:3
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作者 邢其棋 张芳 +1 位作者 刘栋 刘夫玲 《国际眼科杂志》 CAS 北大核心 2020年第7期1139-1142,共4页
目的:检测常见泪腺上皮性肿瘤中类表皮生长因子结构域7(EGFL7)、微血管密度(MVD)、Ki67的表达,探究EGFL7与MVD、Ki67之间的相互关系。方法:应用免疫组化法,对10例正常泪腺组织(取自因炎性假瘤、Mikulicz病等良性泪腺肿瘤切除后,标本中... 目的:检测常见泪腺上皮性肿瘤中类表皮生长因子结构域7(EGFL7)、微血管密度(MVD)、Ki67的表达,探究EGFL7与MVD、Ki67之间的相互关系。方法:应用免疫组化法,对10例正常泪腺组织(取自因炎性假瘤、Mikulicz病等良性泪腺肿瘤切除后,标本中的部分正常泪腺组织)、20例泪腺多形性腺瘤、12例多形性腺癌、14例腺样囊性癌组织中的EGFL7蛋白、Ki67进行检测,并应用CD34标记计数MVD。结果:EGFL7主要在泪腺多形性腺癌、腺样囊性癌的肿瘤细胞的细胞浆中表达,免疫组化染色结果显示,在正常泪腺组织中EGFL7无阳性表达,泪腺多形性腺瘤组织中EGFL7的阳性率为5%(1/20),泪腺多形性腺癌中EGFL7的阳性表达率83%(10/12),泪腺腺样囊性癌中EGFL7的阳性表达率为86%(12/14),两种恶性肿瘤中的表达率明显高于多形性腺瘤和正常泪腺组织(P<0.001)。CD34可使肿瘤微血管染色呈棕黄色的单个或成簇细胞群。在泪腺多形性腺癌(32.58±14.46)及腺样囊性癌(43.43±4.60)中CD34的表达明显高于多形性腺瘤(4.20±1.19)(P<0.001);Ki67在具有增殖活性的细胞核呈棕褐色着色,在泪腺多形性腺癌(44.83±13.68)及腺样囊性癌(26.29±8.44)中Ki67的表达明显高于多形性腺瘤(2.80±3.14)及正常组织(0.40±0.70)(P<0.001)。在两种恶性肿瘤中EGFL7的表达分别与MVD、Ki67呈明显正相关(rs=0.897,P<0.001;rs=0.837,P<0.001)。结论:EGFL7在泪腺上皮性肿瘤中的表达与MVD、Ki67呈正相关性,提示EGFL7不仅在泪腺上皮性肿瘤血管生成中起重要作用,而且参与泪腺上皮性肿瘤的增殖。 展开更多
关键词 泪腺上皮性肿瘤 类表皮生长因子结构域7 微血管密度 增殖
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燃煤电厂贮灰场土壤重金属污染及健康风险评价 被引量:12
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作者 刘柱光 方樟 丁小凡 《生态环境学报》 CSCD 北大核心 2021年第9期1916-1922,共7页
燃煤电厂贮灰场堆积了大量的粉煤灰,而粉煤灰中蕴含的重金属可能会威胁到人类健康。为查明燃煤电厂贮灰场土壤重金属污染状况及对人体健康风险问题,以吉林省某燃煤电厂贮灰场及其周边地区为研究区,采集20个土壤样品进行主要重金属含量... 燃煤电厂贮灰场堆积了大量的粉煤灰,而粉煤灰中蕴含的重金属可能会威胁到人类健康。为查明燃煤电厂贮灰场土壤重金属污染状况及对人体健康风险问题,以吉林省某燃煤电厂贮灰场及其周边地区为研究区,采集20个土壤样品进行主要重金属含量的分析。应用污染负荷指数法(PLI)评价研究区重金属污染水平,采用US EPA模型进行贮灰场重金属健康风险评价。研究区土壤Cr、Ni、Cu、Cd、Pb平均含量高于土壤环境背景值,其中Cd的平均含量是背景值的11倍,并且其含量均高于《土壤环境质量标准》(GB 15618—2018)的风险筛选值,Cd在研究区土壤中有明显的富集。土壤重金属含量分析结果显示,灰水渗漏和粉煤灰飞灰飘散是贮灰场粉煤灰重金属迁移的主要方式。土壤重金属变异系数排序为:Ni>Cu>As>Zn>Pb>36%>Cd>Cr>15%,Cd、Cr属于中度变异,贮灰场粉煤灰是其主要污染来源,Ni、Cu、As、Zn、Pb属于高度变异,除了贮灰场影响因素外,人类活动也是其重要来源。污染负荷指数法的评价结果显示,贮灰场及其西北侧灰坝下落差最大处部分土壤处于中度污染,其他采样点土壤处于轻度污染。土壤污染主要源于灰坝处灰水渗漏,受盛行风影响较小,研究区总体处于轻度污染。人体健康风险评价结果显示,经口摄入是重金属暴露风险的主要途径,研究区土壤重金属存在的非致癌和致癌风险,儿童均高于成人,7种重金属元素对成人与儿童不存在非致癌风险;Cr、Cd、As对成人和儿童均存在可接受的致癌风险,其中Cr是主要的致癌因子,应针对Cr开展必要的治理措施。 展开更多
关键词 燃煤电厂 贮灰场 土壤 重金属 健康风险 污染负荷指数
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基于人为开采响应的小尺度地下水可持续性评价--以吉林省大安市为例 被引量:1
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作者 丁小凡 方樟 +2 位作者 高晗 刘柱光 李继森 《南水北调与水利科技(中英文)》 CAS 北大核心 2021年第6期1175-1183,共9页
为充分利用地表数据、小尺度考虑时空变异性评价地下水的可持续性,提出基于人为开采响应的地下水可持续性指标(artificial mining response-based groundwater sustainability index,AGSI),采用熵权TOPSIS(technique for order preferen... 为充分利用地表数据、小尺度考虑时空变异性评价地下水的可持续性,提出基于人为开采响应的地下水可持续性指标(artificial mining response-based groundwater sustainability index,AGSI),采用熵权TOPSIS(technique for order preferenceby similarity to ideal solution)法确定地下水人为开采程度,并通过分解系数将人为开采对地下水系统施加的压力分解至各监测井,进而与地下水响应状态关联。以大安市为研究区,使用Mann-Kendall检验法和Sen′s slope变化趋势分析法验证评价结果的准确性。结果表明:2008—2017年研究区地下水可持续性受到破坏的风险由潜水向承压水转移,而各含水层间、层内的地下水可持续性分布差异表明调控地下水开采布局是大安市未来地下水管理工作的重点;研究区地下水可持续性演变过程可被水位趋势分析结果验证,AGSI法强调了人工开采的作用效果,有助于更好地理解人类活动与地下水资源的相互作用过程,为评估地下水可持续性提供新思路。 展开更多
关键词 人为开采 地下水响应 小尺度 可持续性评价 大安市
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丝素溶液的瞬时凝胶化 被引量:2
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作者 沈旖云 孙姗 +1 位作者 张芳 卢神州 《材料科学》 2013年第5期187-191,共5页
蛋白质溶液具有凝胶化趋势,其中丝素蛋白的凝胶化在常温下需要十几天的时间。本文提出了一种促使丝素蛋白瞬时凝胶化的方法,该方法能够促使丝素蛋白水凝胶瞬时形成。SEM分析显示该水凝胶内部为疏松多孔的三维交联网状无规则卷曲结构,且... 蛋白质溶液具有凝胶化趋势,其中丝素蛋白的凝胶化在常温下需要十几天的时间。本文提出了一种促使丝素蛋白瞬时凝胶化的方法,该方法能够促使丝素蛋白水凝胶瞬时形成。SEM分析显示该水凝胶内部为疏松多孔的三维交联网状无规则卷曲结构,且有很多微球状的结构交联在一起。利用X衍射、红外光谱等手段进行检测,结果显示丝素蛋白分子快速凝胶化过程中,其分子结构基本保持无规卷曲不变。该瞬时凝胶化的丝素水凝胶具有一定的力学性能和保水性能,可以用于化妆品以及组织工程材料。 展开更多
关键词 丝素蛋白 瞬时凝胶化 水凝胶 结构
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Economic burden of irritable bowel syndrome in China 被引量:40
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作者 fang zhang Wei Xiang +1 位作者 Chun-yan Li Shu-Chuen Li 《World Journal of Gastroenterology》 SCIE CAS 2016年第47期10450-10460,共11页
AIM To estimate annual direct and indirect costs for patients diagnosed with irritable bowel syndrome(IBS) and subtypes.METHODS Patients completed a standardized questionnaire concerning usage of healthcare resources,... AIM To estimate annual direct and indirect costs for patients diagnosed with irritable bowel syndrome(IBS) and subtypes.METHODS Patients completed a standardized questionnaire concerning usage of healthcare resources, travel costs, meals, and productivity loss of patients when seeking treatment for IBS. Total annual costs per patient were calculated as the sum of direct(including medical and nonmedical) and indirect costs. Total annual costs per patient among various IBS subtypes were compared. Analysis of variance and bootstrapped independent sample t-tests were performed to determine differences between groups after controlling for IBS subtypes.RESULTS A total of 105 IBS patients(64.80% female), mean age of 57.12 years ± 10.31 years), mean disease duration of 4.31 years ± 5.40 years, were included. Total annual costs per patient were estimated as CNy18262.84(USD2933.08). Inpatient and outpatient healthcare use were major cost drivers, accounting for 46.41%and 23.36% of total annual costs, respectively. Productivity loss accounted for 25.32% of total annual costs. The proportions of direct and indirect costs were similarto published studies in other countries. Nationally, the total costs of managing IBS would amount to CNy123.83 billion(USD1.99 billion). Among the IBS subtypes, total annual costs per patient of IBS-M was highest at CNy18891.18(USD3034). Furthermore, there was significant difference in productivity loss among IBS subtypes(P = 0.031).CONCLUSION IBS imposes a huge economic burden on patients and healthcare systems, which could account for 3.3% of the total healthcare budget for the entire Chinese nation. More than two-thirds of total annual costs of IBS consist of inpatient and outpatient healthcare use. Among the subtypes, IBS-M patients appear to have the greatest economic burden but require further confirmation. 展开更多
关键词 Irritable bowel syndrome Burden of illness Direct and indirect medical and nonmedical costs Irritable bowel syndrome subtype Productivity loss
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C/EBPα regulates SIRT1 expression during adipogenesis 被引量:8
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作者 Qihuang Jin fang zhang +4 位作者 Tingting Yan Zhen Liu Chunxi Wang Xinjian Ge Qiwei Zhai 《Cell Research》 SCIE CAS CSCD 2010年第4期470-479,共10页
SIRT1 plays an important role in adipogenesis, but how SIRT1 is regulated in adipogenesis is largely unknown. In this study, we show that both SIRT1 protein and mRNA levels were increased along with CCAAT/enhancer-bin... SIRT1 plays an important role in adipogenesis, but how SIRT1 is regulated in adipogenesis is largely unknown. In this study, we show that both SIRT1 protein and mRNA levels were increased along with CCAAT/enhancer-binding protein a (C/EBPa) during adipocyte differentiation. C/EBPa, but not C/EBPap30, activated SIRT1 promoter in both HeLa cells and 3T3-L1 preadipocytes. Furthermore, C/EBPa upregulated SIRT1 mRNA and protein levels in HeLa cells and increased SIRT1 expression in a p53-independent manner in Soas2 cells. In preadipocytes, ectopic expression of C/EBPa upregulated SIRT1 protein level and knockdown of C/EBPa led to the decrease of SIRTI pro- tein level. Moreover, by promoter deletion analysis, gel shift assay and chromatin immunoprecipitation, we found that C/EBPa bound to the SIRT1 promoter at a consensus C/EBPα binding site. These data demonstrate that C/ EBPα regulates SIRT1 expression during adipogenesis by directly binding to the SIRT1 promoter. 展开更多
关键词 SIRT1 C/EBPΑ ADIPOGENESIS transcriptional regulation OBESITY
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