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Thin paints for durable and scalable radiative cooling 被引量:1
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作者 Shanquan Liu fei zhang +3 位作者 Xingyu Chen Hongjie Yan Wei Chen Meijie Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第3期176-182,I0006,共8页
Passive daytime radiative cooling(PDRC) is environment-friendly without energy input by enhancing the coating's solar reflectance(R_(solar)) and thermal emittance(ε_(LWIR)) in the atmosphere's long-wave infra... Passive daytime radiative cooling(PDRC) is environment-friendly without energy input by enhancing the coating's solar reflectance(R_(solar)) and thermal emittance(ε_(LWIR)) in the atmosphere's long-wave infrared transmission window.However,high R_(solar) is usually achieved by increasing the coating's thickness,which not only increases materials' cost but also impairs heat transfer.Additionally,the desired high R_(solar) is vulnerable to dust pollution in the outdoors.In this work,a thin paint was designed by mixing hBN plates,PFOTS,and IPA. R_(solar)=0.963 and ε_(LWIR)=0.927 was achieved at a thickness of 150 μm due to the high backscattering ability of scatters.A high through-plane thermal conductivity(~1.82 W m^(-1) K^(-1)) also can be obtained.In addition,the porous structure coupled with the binder PFOTS resulted in a contact angle of 154°,demonstrating excellent durability under dust contamination.Outdoor experiments showed that the thin paint can obtain a 2.3℃ lower temperature for sub-ambient cooling than the reference PDRC coating in the daytime.Furtherly,the above-ambient heat dissipation performance can be enhanced by spraying the thin paint on a 3D heat sink,which was 15.7℃ lower than the reference 1D structure,demonstrating excellent performance for durable and scalable PDRC applications. 展开更多
关键词 Radiative cooling Heat dissipation Solar reflectance Thermal emittance Contact angle
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The application of the strip-shaped cymba conchae orthosis in the nonsurgical correction of complex auricular deformity 被引量:1
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作者 Huijuan Xu Shaoguang Ding +6 位作者 fei zhang Zhifeng zhang Xiangyu Chen Mingyang Li Haitao Yang Fugen Han Hongjian Liu 《Journal of Otology》 CAS CSCD 2024年第1期24-29,共6页
Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from... Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from 2020 to 2021 for 6 patients who underwent correction using a stripshaped cymba conchae orthosis. The indications, corrective effects, and complications associated with use of the orthosis were analyzed. Results: There were four indications for treatment: cryptotia with helix adhesion;cryptotia with grade I microtia;cryptotia with excessive helix thickness;and auricular deformity beyond the treatment time window(≥6 months). Excellent corrective effects were observed in all 6 patients. Complications occurred in one patient, who recovered after symptomatic treatment. Conclusion: The use of a strip-shaped cymba conchae orthosis alone or combined with a U-shaped helix orthosis presents a feasible approach for correcting complex auricular deformities or deformities beyond the treatment time window in pediatric patients. 展开更多
关键词 Cymba conchae Auricular deformity Cryptotia Nonsurgical correction ORTHOSIS
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Towards the performance limit of catenary meta-optics via field-driven optimization 被引量:1
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作者 Siran Chen Yingli Ha +8 位作者 fei zhang Mingbo Pu Hanlin Bao Mingfeng Xu Yinghui Guo Yue Shen Xiaoliang Ma Xiong Li Xiangang Luo 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第5期33-42,共10页
Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband absorbers.However,the periodic boundary approx... Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband absorbers.However,the periodic boundary approximation without considering aperiodic electromagnetic crosstalk poses challenges for catenary optical devices to reach their performance limits.Here,perfect control of both local geometric and propagation phases is realized through field-driven optimization,in which the field distribution is calculated under real boundary conditions.Different from other optimization methods requiring a mass of iterations,the proposed design method requires less than ten iterations to get the efficiency close to the optimal value.Based on the library of shape-optimized catenary structures,centimeter-scale devices can be designed in ten seconds,with the performance improved by ~15%.Furthermore,this method has the ability to extend catenary-like continuous structures to arbitrary polarization,including both linear and elliptical polarizations,which is difficult to achieve with traditional design methods.It provides a way for the development of catenary optics and serves as a potent tool for constructing high-performance optical devices. 展开更多
关键词 catenary optics catenary structures field-driven optimization
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Ultralow charge-discharge voltage gap of 0.05 V in sunlight-responsive neutral aqueous Zn-air battery
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作者 Zhimin Niu Yan Gao +8 位作者 Tianhui Wu fei zhang Ran Zhao Zijia Chen Yiming Yuan Tifeng Jiao Jianmin Gu Li Lu Desong Wang 《Carbon Energy》 SCIE EI CAS CSCD 2024年第9期172-183,共12页
Rechargeable neutral aqueous zinc-air batteries(ZABs)are a promising type of energy storage device with longer operating life and less corrosiveness compared with conventional alkaline ZABs.However,the neutral ZABs no... Rechargeable neutral aqueous zinc-air batteries(ZABs)are a promising type of energy storage device with longer operating life and less corrosiveness compared with conventional alkaline ZABs.However,the neutral ZABs normally possess poor oxygen evolution reactions(OERs)and oxygen reduction reactions performance,resulting in a large charge–discharge voltage gap and low round-trip efficiency.Herein,we demonstrate a sunlight-assisted strategy for achieving an ultralow voltage gap of 0.05 V in neutral ZABs by using the FeOOH-decorated BiVO4(Fe-BiVO4)as an oxygen catalyst.Under sunlight,the electrons move from the valence band(VB)of Fe-BiVO_(4) to the conduction band producing holes in VB to promote the OER process and hence reduce the overpotential.Meanwhile,the photopotential generated by the Fe-BiVO_(4) compensates a part of the charging potential of neutral ZABs.Accordingly,the energy loss of the battery could be compensated via solar energy,leading to a record-low gap of 0.05 V between the charge and discharge voltage with a high round-trip efficiency of 94%.This work offers a simple but efficient pathway for solar-energy utilization in storage devices,further guiding the design of high energy efficiency of neutral aqueous ZABs. 展开更多
关键词 neutral ZABs oxygen catalytic reactions PHOTOCATALYSIS round-trip efficiency solar energy
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一种用于大视场成像和偏振光谱探测的微型可重构超构光学系统
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作者 fei zhang Minghao Liao +8 位作者 Mingbo Pu Yinghui Guo Lianwei Chen Xiong Li Qiong He Tongtong Kang Xiaoliang Ma Yuan Ke Xiangang Luo 《Engineering》 SCIE EI CAS CSCD 2024年第4期67-73,共7页
Wide-angle imaging and spectral detection play vital roles in tasks such as target tracking,object classification,and anti-camouflage.However,limited by their intrinsically different architectures,as determined by fre... Wide-angle imaging and spectral detection play vital roles in tasks such as target tracking,object classification,and anti-camouflage.However,limited by their intrinsically different architectures,as determined by frequency dispersion requirements,their simultaneous implementation in a shared-aperture system is difficult.Here,we propose a novel concept to realize reconfigurable dual-mode detection based on electrical-control tunable metasurfaces.As a proof-of-concept demonstration,the simultaneous implementation of wide-angle imaging and polarization-spectral detection in a miniature sharedaperture meta-optical system is realized for the first time via the electrical control of cascaded catenary-like metasurfaces.The proposed system supports the imaging(spectral)resolution of approximately 27.8 line-pairs per millimeter(lp·mm^(-1);~80 nm)for an imaging(spectral)mode from 8 to 14 μm.This system also bears a large field of view of about 70°,enabling multi-target recognition in both modes.This work may promote the miniaturization of multifunctional optical systems,including spectrometers and polarization imagers,and illustrates the potential industrial applications of meta-optics in biomedicine,security,space exploration,and more. 展开更多
关键词 Metasurfaces RECONFIGURABLE IMAGING SPECTRAL
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Self-assembly of perovskite nanocrystals:From driving forces to applications
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作者 Yi Li fei zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第1期561-578,I0013,共19页
Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell field.This review ... Self-assembly of metal halide perovskite nanocrystals(NCs)into superlattices can exhibit unique collective properties,which have significant application values in the display,detector,and solar cell field.This review discusses the driving forces behind the self-assembly process of perovskite NCs,and the commonly used self-assembly methods and different self-assembly structures are detailed.Subsequently,we summarize the collective optoelectronic properties and application areas of perovskite superlattice structures.Finally,we conclude with an outlook on the potential issues and future challenges in developing perovskite NCs. 展开更多
关键词 SELF-ASSEMBLY Metal halide perovskite NANOCRYSTALS Driving forces
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Elliptical encirclement control capable of reinforcing performances for UAVs around a dynamic target
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作者 fei zhang Xingling Shao +1 位作者 Yi Xia Wendong zhang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期104-119,共16页
Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external disturbances.However,elliptical encirclement with a time-varying obs... Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external disturbances.However,elliptical encirclement with a time-varying observation radius,may permit a more flexible and high-efficacy enclosing solution,whilst the non-orthogonal property between axial and tangential speed components,non-ignorable environmental perturbations,and strict assignment requirements empower elliptical encircling control to be more challenging,and the relevant investigations are still open.Following this line,an appointed-time elliptical encircling control rule capable of reinforcing circumnavigation performances is developed to enable Unmanned Aerial Vehicles(UAVs)to move along a specified elliptical path within a predetermined reaching time.The remarkable merits of the designed strategy are that the relative distance controlling error can be guaranteed to evolve within specified regions with a designer-specified convergence behavior.Meanwhile,wind perturbations can be online counteracted based on an unknown system dynamics estimator(USDE)with only one regulating parameter and high computational efficiency.Lyapunov tool demonstrates that all involved error variables are ultimately limited,and simulations are implemented to confirm the usability of the suggested control algorithm. 展开更多
关键词 Elliptical encirclement Reinforced performances Wind perturbations UAVS
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Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model
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作者 Baoxiang zhang Wen zhang +5 位作者 fei zhang Chao Ning Mingyang An Ke Yang Lili Tan Qiang zhang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第1期384-393,共10页
Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional sutures.In the present... Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional sutures.In the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as control.The shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after operation.The Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to failure.Gross observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture groups.In the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks postoperatively.The collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous enthesis.In vivo degradation of the magnesium alloy wire was completed within 12 weeks.The results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair. 展开更多
关键词 Rotator cuff repair Mg alloy wire Tendon-bone healing Fibrocartilaginous interface
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The In-Flight Realtime Trigger and Localization Software of GECAM
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作者 Xiao-Yun Zhao Shao-Lin Xiong +86 位作者 Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu zhang Yue Huang Lu Li Xing Wen fei zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第10期11-24,共14页
Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December 10.We developed a multifunctional trigger and localization software operating in the CP... Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December 10.We developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic Box.This onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation system.This paper provides a detailed description of the design and development of the trigger and localization software system for GECAM.It covers the general design,workflow,the main functions,and the algorithms used in the system.The paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation. 展开更多
关键词 telescopes instrumentation:detectors methods:observational
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基于UPLC-Q-TOF/MS及CORT诱导的低分化PC12抑郁细胞模型的柴胡抗抑郁活性成分研究 被引量:5
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作者 于静波 韩越 +5 位作者 周梓洋 牟晴蕊 陈静梅 欧阳煜钦 费璋 王宇红 《世界科学技术-中医药现代化》 CSCD 北大核心 2023年第6期2012-2024,共13页
目的分析鉴定柴胡水提物中的化学成分,探究柴胡抗抑郁活性成分。方法利用超高效液相色谱串联四极杆飞行时间质谱(UPLC-Q-TOF/MS)分析鉴定柴胡水提物中的化学成分。采用皮质酮(CORT)诱导低分化PC12抑郁细胞模型,给予柴胡单体成分预处理P... 目的分析鉴定柴胡水提物中的化学成分,探究柴胡抗抑郁活性成分。方法利用超高效液相色谱串联四极杆飞行时间质谱(UPLC-Q-TOF/MS)分析鉴定柴胡水提物中的化学成分。采用皮质酮(CORT)诱导低分化PC12抑郁细胞模型,给予柴胡单体成分预处理PC12细胞24 h,利用CCK-8试剂盒检测细胞活力;利用乳酸脱氢酶(LDH)试剂盒检测细胞LDH释放率。结果共鉴定出53个化学成分,主要为Ⅰ型、Ⅱ型及Ⅲ型柴胡皂苷类成分。其中,柴胡皂苷A、柴胡皂苷B2、柴胡皂苷C、柴胡皂苷E、柴胡皂苷F和6″-O-乙酰基柴胡皂苷A对柴胡代谢轮廓的贡献度最大,并可增强CORT诱导PC12细胞活力(P<0.05、P<0.01);柴胡皂苷A、柴胡皂苷B2、柴胡皂苷C、柴胡皂苷E、柴胡皂苷F可降低CORT诱导PC12细胞LDH释放率(P<0.05、P<0.01)。结论柴胡皂苷A、柴胡皂苷B2、柴胡皂苷C、柴胡皂苷E、柴胡皂苷F可能为柴胡抗抑郁的主要活性成分,为柴胡质量控制及药效物质基础研究提供依据。 展开更多
关键词 柴胡 抑郁症 液质联用 PC12细胞 活性成分
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Physics-data-driven intelligent optimization for large-aperture metalenses 被引量:5
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作者 Yingli Ha Yu Luo +9 位作者 Mingbo Pu fei zhang Qiong He Jinjin Jin Mingfeng Xu Yinghui Guo Xiaogang Li Xiong Li Xiaoliang Ma Xiangang Luo 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2023年第11期5-15,共11页
Metalenses have gained significant attention and have been widely utilized in optical systems for focusing and imaging,owing to their lightweight,high-integration,and exceptional-flexibility capabilities.Traditional d... Metalenses have gained significant attention and have been widely utilized in optical systems for focusing and imaging,owing to their lightweight,high-integration,and exceptional-flexibility capabilities.Traditional design methods neglect the coupling effect between adjacent meta-atoms,thus harming the practical performance of meta-devices.The existing physical/data-driven optimization algorithms can solve the above problems,but bring significant time costs or require a large number of data-sets.Here,we propose a physics-data-driven method employing an“intelligent optimizer”that enables us to adaptively modify the sizes of the meta-atom according to the sizes of its surrounding ones.The implementation of such a scheme effectively mitigates the undesired impact of local lattice coupling,and the proposed network model works well on thousands of data-sets with a validation loss of 3×10^(−3).Based on the“intelligent optimizer”,a 1-cm-diameter metalens is designed within 3 hours,and the experimental results show that the 1-mm-diameter metalens has a relative focusing efficiency of 93.4%(compared to the ideal focusing efficiency)and a Strehl ratio of 0.94.Compared to previous inverse design method,our method significantly boosts designing efficiency with five orders of magnitude reduction in time.More generally,it may set a new paradigm for devising large-aperture meta-devices. 展开更多
关键词 intelligence method physics-data-driven method inverse design large-aperture metalenses
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An efficient transient gene expression system for protein subcellular localization assay and genome editing in citrus protoplasts 被引量:2
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作者 Wenhui Yang Jiaqin Ren +6 位作者 Wanrong Liu Dan Liu Kaidong Xie fei zhang Pengwei Wang Wenwu Guo Xiaomeng Wu 《Horticultural Plant Journal》 SCIE CAS CSCD 2023年第3期425-436,共12页
Protoplast has been widely used in biotechnologies to circumvent the breeding obstacles in citrus, including long juvenility, polyembryony, and male/female sterility. The protoplast-based transient gene expression sys... Protoplast has been widely used in biotechnologies to circumvent the breeding obstacles in citrus, including long juvenility, polyembryony, and male/female sterility. The protoplast-based transient gene expression system is a powerful tool for gene functional characterization and CRISPR/Cas9 genome editing in higher plants, but it has not been widely used in citrus. In this study, the polyethylene glycol(PEG)-mediated method was optimized for citrus callus protoplast transfection, with an improved transfection efficiency of 68.4%. Consequently, the efficiency of protein subcellular localization assay was increased to 65.8%, through transient expression of the target gene in protoplasts that stably express the fluorescent organelle marker protein. The gene editing frequencies in citrus callus protoplasts reached 14.2% after transient expression of CRISPR/Cas9 constructs. We demonstrated that the intronic polycistronic tRNAgRNA(inPTG) genome editing construct was functional in both the protoplast transient expression system and epicotyl stable transformation system in citrus. With this optimized protoplast transient expression system, we improved the efficiency of protein subcellular localization assay and developed the genome editing system in callus protoplasts, which provides an approach for prompt test of CRISPR vectors. 展开更多
关键词 CITRUS Callus protoplast Transient transfection Subcellular localization Genome editing
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Mixed Cations Enabled Combined Bulk and Interfacial Passivation for Efficient and Stable Perovskite Solar Cells 被引量:2
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作者 Pengfei Wu Shirong Wang +4 位作者 Jin Hyuck Heo Hongli Liu Xihan Chen Xianggao Li fei zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第8期116-127,共12页
Here,we report a mixed GAI and MAI(MGM)treatment method by forming a 2D alternating-cation-interlayer(ACI)phase(n=2)perovskite layer on the 3D perovskite,modulating the bulk and interfacial defects in the perovskite f... Here,we report a mixed GAI and MAI(MGM)treatment method by forming a 2D alternating-cation-interlayer(ACI)phase(n=2)perovskite layer on the 3D perovskite,modulating the bulk and interfacial defects in the perovskite films simultaneously,leading to the suppressed nonradiative recombination,longer lifetime,higher mobility,and reduced trap density.Consequently,the devices’performance is enhanced to 24.5%and 18.7%for 0.12 and 64 cm^(2),respectively.In addition,the MGM treatment can be applied to a wide range of perovskite compositions,including MA-,FA-,MAFA-,and CsFAMA-based lead halide perovskites,making it a general method for preparing efficient perovskite solar cells.Without encapsulation,the treated devices show improved stabilities. 展开更多
关键词 Alternating-cation-interlayer Bulk defects Interfacial passivation Perovskite solar cells
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FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells 被引量:1
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作者 fei zhang Lei Wei +10 位作者 Lei Wang Tao Wang Zhihong Xie Hong Luo Fanchao Li Jian zhang Wentao Dong Gang Liu Qinglin Kang Xuesong Zhu Wuxun Peng 《Bone Research》 SCIE CAS CSCD 2023年第2期398-415,共18页
The specific pathogenesis of steroid-induced osteonecrosis of the femoral head(SONFH)is still not fully understood,and there is currently no effective early cure.Understanding the role and mechanism of long noncoding ... The specific pathogenesis of steroid-induced osteonecrosis of the femoral head(SONFH)is still not fully understood,and there is currently no effective early cure.Understanding the role and mechanism of long noncoding RNAs(lnc RNAs)in the pathogenesis of SONFH will help reveal the pathogenesis of SONFH and provide new targets for its early prevention and treatment.In this study,we first confirmed that glucocorticoid(GC)-induced apoptosis of bone microvascular endothelial cells(BMECs)is a pre-event in the pathogenesis and progression of SONFH.Then,we identified a new lnc RNA in BMECs via lnc RNA/m RNA microarray,termed Fosassociated linc RNA ENSRNOT00000088059.1(FAR591).FAR591 is highly expressed during GC-induced BMEC apoptosis and femoral head necrosis.Knockout of FAR591 effectively blocked the GC-induced apoptosis of BMECs,which then alleviated the damage of GCs to the femoral head microcirculation and inhibited the pathogenesis and progression of SONFH.In contrast,overexpression of FAR591 significantly promoted the GC-induced apoptosis of BMECs,which then aggravated the damage of GCs to the femoral head microcirculation and promoted the pathogenesis and progression of SONFH.Mechanistically,GCs activate the glucocorticoid receptor,which translocates to the nucleus and directly acts on the FAR591 gene promoter to induce FAR591 gene overexpression.Subsequently,FAR591 binds to the Fos gene promoter(–245–51)to form a stable RNA:DNA triplet structure and then recruits TATA-box binding protein associated factor 15 and RNA polymerase II to promote Fos expression through transcriptional activation.Fos activates the mitochondrial apoptotic pathway by regulating the expression of Bcl-2 interacting mediator of cell death(Bim)and P53 upregulated modulator of apoptosis(Puma)to mediate GC-induced apoptosis of BMECs,which leads to femoral head microcirculation dysfunction and femoral head necrosis.In conclusion,these results confirm the mechanistic link between lnc RNAs and the pathogenesis of SONFH,which helps reveal the pathogenesis of SONFH and provides a new target for the early prevention and treatment of SONFH. 展开更多
关键词 PATHOGENESIS prevention inhibited
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Optimization of enrichment and pretreatment of low-activity radium isotopes in the open ocean
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作者 Guiyuan Dai Guizhi Wang +2 位作者 Qing Li Weizhen Jiang fei zhang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第8期171-177,共7页
In the open ocean,radium isotopes are useful tracers of residence time and water-mass mixing.However,limited by the measurement resolution of commonly used gamma counters,the low activity of radium in the open ocean m... In the open ocean,radium isotopes are useful tracers of residence time and water-mass mixing.However,limited by the measurement resolution of commonly used gamma counters,the low activity of radium in the open ocean makes it necessary to enrich radium from large volumes of seawater and pretreat radium-enriched carriers prior to measurements.The commonly applied method of radium enrichment and pretreatment,however,has limitations of uneven coating of MnO_(2)on cartridges,relatively expensive cartridges,time-consuming issues during cartridge-ashing,ash loss during transfer,and changes of gamma counters efficiency caused by different ash weights.To address these issues,in this study we optimized the enrichment and pretreatment of low-activity radium prior to measurements.Firstly,we replaced commonly used acrylic cartridges with cheaper polypropylene cartridges,which took 6 h to be ashed,42 h shorter than for acrylic cartridges.Secondly,MnO_(2)-coated cartridges were prepared with a circulating hot acidic KMnO_(4)solution to ensure homogeneous coating.The radium extraction efficiency of this MnO_(2)-coated cartridge was 20%-61%higher than that prepared by directly immersing cartridges in the solution.The radium delayed coincidence counter efficiency for MnO_(2)-coated cartridge was stable with a moisture content of 0.05-1.Lastly,after ashing cartridges,instead of directly transferring the ash to a measurement vial,a mixture of hydroxylamine hydrochloride and hydrochloric acid was used to completely leach the ash for long-lived radium,followed by coprecipitation by BaSO_(4),to avoid potential loss of ash during transfer and variations in measurement geometry due to different ash weights.And the recovery of long-lived radium pretreatment was 94%-102%,which improved by 11%compared with the common method.In addition,the radium extraction efficiency of the MnO_(2)-coated cartridge varied from 3%to 4%within the in situ pump working flow rate of 4-7 L/min,which fell within the measurement errors. 展开更多
关键词 radium isotopes MnO_(2)-coated cartridge enrichment of Ra pretreatment of MnO_(2)-coated cartridges RaDeCC efficiency extraction efficiency
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SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stabilityviathe PI3K/AKT/GSK3β signaling pathway 被引量:16
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作者 Yue Yuan Yanling Fan +8 位作者 Zicong Gao Xuan Sun He zhang Zhiyong Wang Yanfen Cui Weijie Song Zhaosong Wang fei zhang Ruifang Niu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第3期707-725,共19页
Objective:The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner.Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poo... Objective:The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner.Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.Nevertheless,the mechanistic details of how SHP2 promotes breast cancer progression remain largely undefined.Methods:The relationship between SHP2 expression and the prognosis of patients with breast cancer was investigated by using the TCGA and GEO databases.The expression of SHP2 in breast cancer tissues was analyzed by immunohistochemistry.CRISPR/Cas9 technology was used to generate SHP2-knockout breast cancer cells.Cell-counting kit-8,colony formation,cell cycle,and EdU incorporation assays,as well as a tumor xenograft model were used to examine the function of SHP2 in breast cancer proliferation.Quantitative RT-PCR,western blotting,immunofluorescence staining,and ubiquitination assays were used to explore the molecular mechanism through which SHP2 regulates breast cancer proliferation.Results:High SHP2 expression is correlated with poor prognosis in patients with breast cancer.SHP2 is required for the proliferation of breast cancer cellsin vitro and tumor growthin vivo through regulation of Cyclin D1 abundance,thereby accelerating cell cycle progression.Notably,SHP2 modulates the ubiquitin–proteasome-dependent degradation of Cyclin D1viathe PI3K/AKT/GSK3βsignaling pathway.SHP2 knockout attenuates the activation of PI3K/AKT signaling and causes the dephosphorylation and resultant activation of GSK3β.GSK3βthen mediates phosphorylation of Cyclin D1 at threonine 286,thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin–proteasome system.Conclusions:Our study uncovered the mechanism through which SHP2 regulates breast cancer proliferation.SHP2 may therefore potentially serve as a therapeutic target for breast cancer. 展开更多
关键词 SHP2 breast cancer PROLIFERATION Cyclin D1 GSK3Β PI3K/AKT
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Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization 被引量:21
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作者 Yaxin zhang Mingbo Pu +10 位作者 Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai fei zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo 《Opto-Electronic Advances》 SCIE EI CAS 2022年第11期16-28,共13页
Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths an... Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. 展开更多
关键词 metasurface broadband achromatic crosstalk-free full polarization imaging polarimetry
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Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells 被引量:12
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作者 Xuchen Cao Bowen Liu +8 位作者 Wenfeng Cao Weiran zhang fei zhang Hongmeng Zhao Ran Meng Lin zhang Ruifang Niu Xishan Hao Bin zhang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2013年第2期212-222,共11页
Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer ce... Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluorescent staining and Western blot analysis were employed to detect apoptosis and autophagy, and the role of autophagy was assessed using autophagy inhibitors. Apigenin dose- and time-dependently repressed the proliferation and clonogenic survival of the human breast cancer T47D and MDA-MB-231 cell lines. The death of T47D and MDA-MB-231 cells was due to apoptosis associated with increased levels of Caspase3, PARP cleavage and Bax/Bcl-2 ratios. The results from flow cytometry and fluorescent staining also verified the occurrence of apoptosis. In addition, the apigenin-treated cells exhibited autophagy, as characterized by the appearance of autophagosomes under fluorescence microscopy and the accumulation of acidic vesicular organelles (AVOs) by flow cytometry. Furthermore, the results of the Western blot analysis revealed that the level of LC3-Ⅱ, the processed form of LC3-Ⅰ, was increased. Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage. Similar results were also confirmed by flow cytometry and fluorescence microscopy. These results indicate that apigenin has apoptosis- and autophagy-inducing effects in breast cancer cells. Autophagy plays a cyto-protective role in apigenin-induced apoptosis, and the combination of apigenin and an autophagy inhibitor may be a promising strategy for breast cancer control. 展开更多
关键词 APOPTOSIS AUTOPHAGY APIGENIN breast cancer 3-methyladenine
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TGF-β与细胞内信号通路的交互作用在肿瘤研究中的进展 被引量:10
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作者 冀为 赵元元 +1 位作者 张飞 牛瑞芳 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第15期800-803,共4页
转化生长因子-β(transforming growth factor-β,TGF-β)信号通路在肿瘤发生发展过程中发挥双向调节作用。TGF-β能够抑制上皮细胞的生长、增殖并诱导其凋亡,发挥抑制肿瘤的作用,因此上皮细胞失去对TGF-β抑制增殖的反应是肿瘤发生过... 转化生长因子-β(transforming growth factor-β,TGF-β)信号通路在肿瘤发生发展过程中发挥双向调节作用。TGF-β能够抑制上皮细胞的生长、增殖并诱导其凋亡,发挥抑制肿瘤的作用,因此上皮细胞失去对TGF-β抑制增殖的反应是肿瘤发生过程中的标志性事件。随着肿瘤进展,TGF-β能够促进肿瘤细胞侵袭、转移、耐药以及维持肿瘤干细胞潜能。目前,TGF-β的上述作用转变与其细胞内多条信号通路的交互作用有关,这种交互作用既能减弱或解除TGF-β的增殖抑制和促凋亡作用,又能增强其促进肿瘤进展和恶化的功能。本文主要针对TGF-β在肿瘤进展中与多条细胞内信号通路交互联系的分子机制,以及交互作用对肿瘤发生发展的影响进行综述。 展开更多
关键词 转化生长因子Β 上皮间质转化 信号通路 表皮生长因子受体 磷脂酰肌醇-3-激酶
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Vegetation fractional coverage change in a typical oasis region in Tarim River Watershed based on remote sensing 被引量:12
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作者 fei zhang Tashpolat TIYIP +4 位作者 JianLi DING Mamat SAWUT Verner Carl JOHNSON NigaraTASHPOLAT DongWei GUI 《Journal of Arid Land》 SCIE CSCD 2013年第1期89-101,共13页
Vegetation fractional coverage (VFC) is an important index to describe and evaluate the ecological system. The vegetation index is widely used to monitor vegetation coverage in the field of remote sensing (RS). In... Vegetation fractional coverage (VFC) is an important index to describe and evaluate the ecological system. The vegetation index is widely used to monitor vegetation coverage in the field of remote sensing (RS). In this paper, the author conducted a case study of the delta oasis of Weigan and Kuqa rivers, which is a typical saline area in the Tarim River Watershed. The current study was based on the TM/ETM+ images of 1989, 2001, and 2006, and supported by Geographic Information System (GIS) spatial analysis, vegetation index, and dimidiate pixel model. In addition, VBSl (vegetation, bare soil and shadow indices) suitable for TM/ETM+ irrlages, constructed with FCD (forest canopy density) model principle and put forward by ITTO (International Tropical Timber Organization), was used, and it was applied to estimate the VFC. The estimation accuracy was later prow^n to be up to 83.52%. Further, the study analyzed and appraised the changes in vegetation patterns and revealed a pattern of spatial change in the vegetation coverage of the study area by producing the map of VFC levels in the delta oasis. Forest, grassland, and farmland were the three main land-use types with high and extremely-high coverage, and they played an important role in maintaining the vegetation. The forest area determined the changes of the coverage area, whereas the other two land types affected the directions of change. Therefore, planting trees, protecting grasslands, reclaiming farmlands, and controlling unused lands should be included in a long-term program because of their importance in keeping regional vegetation coverage. Finally, the dynamic variation of VFC in the study area was evaluated according to the quantity and spatial distribution rendered by plant cover diigital images to deeply analyze the reason behind the variation. 展开更多
关键词 vegetation fractional coverage (VFC) VBSI (vegetation bare soil and shadow indices) dimidiate pixel model delta oasis of Weigan and Kuqa rivers
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