Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate t...Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.展开更多
The urban agglomeration in the middle reaches of the Yangtze River(UAMRYR)is a key area to promote the central region rise and the green development of the Yangtze River Economic Belt.In this paper,an evaluation index...The urban agglomeration in the middle reaches of the Yangtze River(UAMRYR)is a key area to promote the central region rise and the green development of the Yangtze River Economic Belt.In this paper,an evaluation index system was comprehensively constructed for the green development level of the UAMRYR from five aspects:resource utilization,green environment,green economy,green life,and support mechanisms.Entropy weight-TOPSIS method and multivariate statistical method,including spatial autocorrelation analysis and geographic detectors,were used to analyze the regional differences and influencing factors of the green development level of the UAMRYR from 2008 to 2018.The results showed that:(1)the overall green development level of the UAMRYR showed a fluctuating upward trend from 2008 to 2018,among which the provincial capital cities such as Wuhan,Changsha,and Nanchang,as well as the cities covered by the Poyang Lake urban agglomeration had relatively higher green development levels.(2)The green development level of the 31 cities in the UAMRYR showed insignificant spatial heterogeneity within the study period.Compared with other areas,the green development levels varied greatly among the regions of the Wuhan metropolitan area,which was a typical high-low aggregation type.(3)Green economy,green life,and support mechanisms were the highly influential aspects of the green development of the UAMRYR,and the main influencing factors were the total value added of secondary and tertiary industries,urbanization rate,and fixed asset investment.The explanatory power of the interaction of influencing factors on the green development of the UAMRYR was greater than that of a single factor.This study is intended to provide a reference for the green transformation development and the coordinated development of the“resources-environment-economy”in the UAMRYR.展开更多
基金supported by grants from the National Natural Science Foundation of China (No. 81901042)the Sichuan Science and Technology Program (No. 2022NSFSC1384)International Team for Implantology (No. 1477_2020)。
文摘Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral tissues.Magnesium has been proved to promote bone healing under normal conditions.Here,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic status.We generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased angiogenesis.We then developed Mg-coating implants with hydrothermal synthesis.These implants successfully improved the vascularization and osseointegration in diabetic status.Mechanically,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia.Altogether,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA23040304)the National Natural Science Foundation of China(Grant Nos.41890822&42101043)。
文摘The urban agglomeration in the middle reaches of the Yangtze River(UAMRYR)is a key area to promote the central region rise and the green development of the Yangtze River Economic Belt.In this paper,an evaluation index system was comprehensively constructed for the green development level of the UAMRYR from five aspects:resource utilization,green environment,green economy,green life,and support mechanisms.Entropy weight-TOPSIS method and multivariate statistical method,including spatial autocorrelation analysis and geographic detectors,were used to analyze the regional differences and influencing factors of the green development level of the UAMRYR from 2008 to 2018.The results showed that:(1)the overall green development level of the UAMRYR showed a fluctuating upward trend from 2008 to 2018,among which the provincial capital cities such as Wuhan,Changsha,and Nanchang,as well as the cities covered by the Poyang Lake urban agglomeration had relatively higher green development levels.(2)The green development level of the 31 cities in the UAMRYR showed insignificant spatial heterogeneity within the study period.Compared with other areas,the green development levels varied greatly among the regions of the Wuhan metropolitan area,which was a typical high-low aggregation type.(3)Green economy,green life,and support mechanisms were the highly influential aspects of the green development of the UAMRYR,and the main influencing factors were the total value added of secondary and tertiary industries,urbanization rate,and fixed asset investment.The explanatory power of the interaction of influencing factors on the green development of the UAMRYR was greater than that of a single factor.This study is intended to provide a reference for the green transformation development and the coordinated development of the“resources-environment-economy”in the UAMRYR.
