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Regulating interfacial chemistry and kinetic behaviors of F/Mo co-doping Ni-rich layered oxide cathode for long-cycling lithium-ion batteries over-20°C-60°C
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作者 Siqi Guan lin Tao +9 位作者 Pei Tang Ruopian Fang Huize Wu Nan Piao Huicong Yang Guangjian Hu Xin Geng lixiang li Baigang An feng li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第7期449-457,共9页
Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature condit... Ni-rich layered oxide cathodes have shown promise for high-energy lithium-ion batteries(LIBs)but are usually limited to mild environments because of their rapid performance degradation under extreme temperature conditions(below0°C and above 50 °C).Here,we report the design of F/Mo co-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(FMNCM)cathode for high-performance LIBs from-20 to 60°C.F^(-) doping with high electronegativity into the cathode surface is found to enhance the stability of surface lattice structure and protect the interface from side reactions with the electrolyte by generating a LiF-rich surface layer.Concurrently,the Mo^(6+) doping suppresses phase transition,which blocks Li^(+)/Ni^(2+) mixing,and stabilizes lithium-ion diffusion pathway.Remarkably,the FMNCM cathode demonstrates excellent cycling stability at a high cutoff voltage of 4.4 V,even at 60°C,maintaining 90.6%capacity retention at 3 C after 150 cycles.Additionally,at temperatures as low as-20°C,it retains 77.1%of its room temperature capacity,achieving an impressive 97.5%capacity retention after 500 cycles.Such stable operation under wide temperatures has been further validated in practical Ah-level pouch-cells.This study sheds light on both fundamental mechanisms and practical implications for the design of advanced cathode materials for wide-temperature LIBs,presenting a promising path towards high-energy and long-cycling LIBs with temperatureadaptability. 展开更多
关键词 Anion-cation co-doping Wide temperature operation Ni-richlayered cathode Phase transition Surface/interface
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Molecular-level proton acceptor boosts oxygen evolution catalysis to enable efficient industrial-scale water splitting
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作者 Yaobin Wang Qian Lu +7 位作者 Xinlei Ge feng li Le Chen Zhihui Zhang Zhengping Fu Yalin Lu Yang Song Yunfei Bu 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第2期344-355,共12页
Industrial water splitting has long been suppressed by the sluggish kinetics of the oxygen evolution reaction(OER),which requires a catalyst to be efficient.Herein,we propose a molecular-level proton acceptor strategy... Industrial water splitting has long been suppressed by the sluggish kinetics of the oxygen evolution reaction(OER),which requires a catalyst to be efficient.Herein,we propose a molecular-level proton acceptor strategy to produce an efficient OER catalyst that can boost industrial-scale water splitting.Molecular-level phosphate(-PO_(4))group is introduced to modify the surface of PrBa_(0.5)Ca_(0.5)Co_(2)O_(5)+δ(PBCC).The achieved catalyst(PO_(4)-PBCC)exhibits significantly enhanced catalytic performance in alkaline media.Based on the X-ray absorption spectroscopy results and density functional theory(DFT)calculations,the PO_(4)on the surface,which is regarded as the Lewis base,is the key factor to overcome the kinetic limitation of the proton transfer process during the OER.The use of the catalyst in a membrane electrode assembly(MEA)is further evaluated for industrial-scale water splitting,and it only needs a low voltage of 1.66 V to achieve a large current density of 1 A cm^(-2).This work provides a new molecular-level strategy to develop highly efficient OER electrocatalysts for industrial applications. 展开更多
关键词 Oxygen evolution reaction NANOFIBER Water splitting Proton acceptor PEROVSKITE
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Weak Fault Feature Extraction of the Rotating Machinery Using Flexible Analytic Wavelet Transform and Nonlinear Quantum Permutation Entropy
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作者 lili Bai Wenhui li +3 位作者 He Ren feng li TaoYan lirong Chen 《Computers, Materials & Continua》 SCIE EI 2024年第6期4513-4531,共19页
Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extrac... Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform(FAWT)with Nonlinear Quantum Permutation Entropy.FAWT,leveraging fractional orders and arbitrary scaling and translation factors,exhibits superior translational invariance and adjustable fundamental oscillatory characteristics.This flexibility enables FAWT to provide well-suited wavelet shapes,effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults.In our approach,gearbox vibration signals undergo FAWT to obtain sub-bands.Quantum theory is then introduced into permutation entropy to propose Nonlinear Quantum Permutation Entropy,a feature that more accurately characterizes the operational state of vibration simulation signals.The nonlinear quantum permutation entropy extracted from sub-bands is utilized to characterize the operating state of rotating machinery.A comprehensive analysis of vibration signals from rolling bearings and gearboxes validates the feasibility of the proposed method.Comparative assessments with parameters derived from traditional permutation entropy,sample entropy,wavelet transform(WT),and empirical mode decomposition(EMD)underscore the superior effectiveness of this approach in fault detection and classification for rotating machinery. 展开更多
关键词 Rotating machinery quantum theory nonlinear quantum permutation entropy Flexible Analytic Wavelet Transform(FAWT) feature extraction
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Conceptual design of the tail research experiment at the Space Plasma Environment Research Facility(SPERF-TREX)
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作者 肖青梅 毛傲华 +8 位作者 何向磊 邹继同 杨肖易 孙萌萌 李丰 汤鹏飞 周田春 王晓钢 the SPERF Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第8期44-49,共6页
The Space Plasma Environment Research Facility(SPERF)for ground simulation of the space plasma environment is a key component of the Space Environment Simulation Research Infrastructure(SESRI),a major national science... The Space Plasma Environment Research Facility(SPERF)for ground simulation of the space plasma environment is a key component of the Space Environment Simulation Research Infrastructure(SESRI),a major national science and technology infrastructure for fundamental research.It is designed to investigate outstanding issues in the space plasma environment,such as energetic particle acceleration,transport,and interaction with electromagnetic waves,as well as magnetic reconnection processes,in magnetospheric plasmas.The Tail-Research EXperiment(TREX)is part of the SPERF for laboratory studies of space physics relevant to magnetic reconnection,dipolarization and hydromagnetic wave excitation in the magnetotail.SPERFTREX is designed to carry out three types of experiments:the tail plasmoid for magnetic reconnection,dipolarization front formation,and magnetohydrodynamic waves excited by highspeed plasma jets.In this paper,the scientific goals and three scenarios of SPERF-TREX for typical processes in space plasmas are presented,and experimental plans for SPERF-TREX are also reviewed,together with the plasma sources applied to generate the plasma with the desired parameters and various magnetic configurations. 展开更多
关键词 SPERF-TREX wave-particle interaction magnetic reconnection DIPOLARIZATION
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A Lightweight UAV Visual Obstacle Avoidance Algorithm Based on Improved YOLOv8
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作者 Zongdong Du Xuefeng feng +2 位作者 feng li Qinglong Xian Zhenhong Jia 《Computers, Materials & Continua》 SCIE EI 2024年第11期2607-2627,共21页
The importance of unmanned aerial vehicle(UAV)obstacle avoidance algorithms lies in their ability to ensure flight safety and collision avoidance,thereby protecting people and property.We propose UAD-YOLOv8,a lightwei... The importance of unmanned aerial vehicle(UAV)obstacle avoidance algorithms lies in their ability to ensure flight safety and collision avoidance,thereby protecting people and property.We propose UAD-YOLOv8,a lightweight YOLOv8-based obstacle detection algorithm optimized for UAV obstacle avoidance.The algorithm enhances the detection capability for small and irregular obstacles by removing the P5 feature layer and introducing deformable convolution v2(DCNv2)to optimize the cross stage partial bottleneck with 2 convolutions and fusion(C2f)module.Additionally,it reduces the model’s parameter count and computational load by constructing the unite ghost and depth-wise separable convolution(UGDConv)series of lightweight convolutions and a lightweight detection head.Based on this,we designed a visual obstacle avoidance algorithm that can improve the obstacle avoidance performance of UAVs in different environments.In particular,we propose an adaptive distance detection algorithm based on obstacle attributes to solve the ranging problem for multiple types and irregular obstacles to further enhance the UAV’s obstacle avoidance capability.To verify the effectiveness of the algorithm,the UAV obstacle detection(UAD)dataset was created.The experimental results show that UAD-YOLOv8 improves mAP50 by 3.4%and reduces GFLOPs by 34.5%compared to YOLOv8n while reducing the number of parameters by 77.4%and the model size by 73%.These improvements significantly enhance the UAV’s obstacle avoidance performance in complex environments,demonstrating its wide range of applications. 展开更多
关键词 Unmanned aerial vehicle obstacle detection obstacle avoidance algorithm
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Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrinαvβ3 expression with a targeted molecular imaging modality
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作者 Xiao-Quan Huang ling Wu +7 位作者 Chun-Yan Xue Chen-Yi Rao Qing-Qing Fang Ying Chen Cao Xie Sheng-Xiang Rao Shi-Yao Chen feng li 《World Journal of Hepatology》 2024年第11期1290-1305,共16页
BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently unavailable.AIM To develop an integrinαvβ3-targeted m... BACKGROUND Non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH),an inflammatory subtype of non-alcoholic fatty liver disease(NAFLD),are currently unavailable.AIM To develop an integrinαvβ3-targeted molecular imaging modality to differentiate NASH.METHODS Integrinαvβ3 expression was assessed in Human LO2 hepatocytes Scultured with palmitic and oleic acids(FFA).Hepatic integrinαvβ3 expression was analyzed in rabbits fed a high-fat diet(HFD)and in rats fed a high-fat,high-carbohydrate diet(HFCD).After synthesis,cyclic arginine-glycine-aspartic acid peptide(cRGD)was labeled with gadolinium(Gd)and used as a contrast agent in magnetic resonance imaging(MRI)performed on mice fed with HFCD.RESULTS Integrinαvβ3 was markedly expressed on FFA-cultured hepatocytes,unlike the control hepatocytes.Hepatic integrinαvβ3 expression significantly increased in both HFD-fed rabbits and HFCD-fed rats as simple fatty liver(FL)progressed to steatohepatitis.The distribution of integrinαvβ3 in the liver of NASH cases largely overlapped with albumin-positive staining areas.In comparison to mice with simple FL,the relative liver MRI-T1 signal value at 60 minutes post-injection of Gd-labeled cRGD was significantly increased in mice with steatohepatitis(P<0.05),showing a positive correlation with the NAFLD activity score(r=0.945;P<0.01).Hepatic integrinαvβ3 expression was significantly upregulated during NASH development,with hepatocytes being the primary cells expressing integrinαvβ3.CONCLUSION After using Gd-labeled cRGD as a tracer,NASH was successfully distinguished by visualizing hepatic integrinαvβ3 expression with MRI. 展开更多
关键词 Non-alcoholic steatohepatitis Cyclic peptides Magnetic resonance imaging Non-invasive diagnosis Hepatic integrinαvβ3
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Bird’s-eye view of recycled solid wastes in road engineering
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作者 Zhuangzhuang liu Tengteng feng +5 位作者 Xingyi Zhu Jie Gao Kui Hu Meng Guo Fan Gu feng li 《Journal of Road Engineering》 2024年第2期93-150,共58页
Recent trends in road engineering have explored the potential of incorporating recycled solid wastes into infrastructures that including pavements,bridges,tunnels,and accessory structures.The utilization of solid wast... Recent trends in road engineering have explored the potential of incorporating recycled solid wastes into infrastructures that including pavements,bridges,tunnels,and accessory structures.The utilization of solid wastes is expected to offer sustainable solutions to waste recycling while enhancing the performance of roads.This review provides an extensive analysis of the recycling of three main types of solid wastes for road engineering purposes:industrial solid waste,infrastructure solid waste,and municipal life solid waste.Industrial solid wastes suitable for road engineering generally include coal gangue,fly ash,blast furnace slag,silica fume,and steel slag,etc.Infrastructure solid wastes recycled in road engineering primarily consist of construction&demolition waste,reclaimed asphalt pavements,and recycled cement concrete.Furthermore,recent exploration has extended to the utilization of municipal life solid wastes,such as incinerated bottom ash,glass waste,electronics waste,plastic waste,and rubber waste in road engineering applications.These recycled solid wastes are categorized into solid waste aggregates,solid waste cements,and solid waste fillers,each playing distinct roles in road infrastructure.Roles of solid waste acting aggregates,cements,and fillers in road infrastructures were fully investigated,including their pozzolanic properties,integration effects to virgin materials,modification or enhancement solutions,engineering performances.Utilization of these materials not only addresses the challenge of waste management but also offers environmental benefits aiming carbon neutral and contributes to sustainable infrastructure development.However,challenges such as variability in material properties,environmental impact mitigation,secondary pollution to environment by leaching,and concerns regarding long-term performance need to be further addressed.Despite these challenges,the recycled solid wastes hold immense potential in revolutionizing road construction practices and fostering environmental stewardship.This review delves into a bird’seye view of the utilization of recycled solid wastes in road engineering,highlighting advances,benefits,challenges,and future prospects. 展开更多
关键词 Road engineering Industrial solid waste Infrastructure solid waste Municipal life waste Recycled materials
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Review of China's policy and management system for the paid use of sea area Feng 被引量:1
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作者 feng li Zenglei Xi Xiangbo liang 《Chinese Journal of Population,Resources and Environment》 2019年第1期58-66,共9页
As a carrier to develop various marine resources, sea area is regulated as a kind of important resources through legislation by many coastal countries with a management system for the paid use of sea area. Since the e... As a carrier to develop various marine resources, sea area is regulated as a kind of important resources through legislation by many coastal countries with a management system for the paid use of sea area. Since the early 1990s, China has begun to implement the paid use and formed an institutional system comprised of three levels after developing it for more than two decades. From 2002 to 2015, the Chinese Government transferred the use right of sea area of 33,910 km2 by paid use and levied a total of 75.89 billion CNY (11.328 billion US dollars) of sea area use payment. Apart from this, the Government has gained rich experience in operating and managing the compensable use of sea area. After retrospectively analyzing the development history of paid use of China’s sea area, the research presents an institutional structure and the implementation of the management system for the paid use of sea area and the main problems therein. On this basis, management policies and feasible policy suggestions are proposed. Research results from this study can provide available references for other developing countries and emerging economies to apply and improve native management system for the paid use of sea area. 展开更多
关键词 PAID USE SEA area POLICY management system China
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基于多视图表征的虚假新闻检测 被引量:1
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作者 张新有 孙峰 +1 位作者 冯力 邢焕来 《信息网络安全》 CSCD 北大核心 2024年第3期438-448,共11页
社交网络已经成为人们日常生活中获取和分享信息的主要渠道,同时也为虚假新闻的传播提供了捷径。如今,针对网络虚假新闻的检测问题受到学术界的广泛关注,但目前的检测方法缺乏基于新闻多个视角的深度探索或忽视了新闻中不同信息传播方... 社交网络已经成为人们日常生活中获取和分享信息的主要渠道,同时也为虚假新闻的传播提供了捷径。如今,针对网络虚假新闻的检测问题受到学术界的广泛关注,但目前的检测方法缺乏基于新闻多个视角的深度探索或忽视了新闻中不同信息传播方向不同的问题,有待改进。文章提出一种基于新闻内容、用户信息和新闻传播3种视角的多视图表征和检测的模型MVRFD(Multi-View Representations for Fake News Detection),为虚假新闻检测任务提供更全面的视角。首先,利用协同注意力机制表征新闻内容中的多模态信息,使用具有不同方向的图神经网络聚合新闻传播过程中的用户信息和观点信息;然后,利用双协同注意力机制实现多个视角间的信息交互;最后,将新闻内容特征和新闻上下文特征进行融合。在公开数据集上的实验结果表明,文章所提出的模型实现了96.7%的准确率和96.8%的F1值,优于主流的文本处理模型以及基于单视角的检测模型。 展开更多
关键词 虚假新闻检测 图神经网络 多模态表征 注意力机制 多视图表征
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Lyophilized recombinant human brain natriuretic peptide for chronic heart failure:Effects on cardiac function and inflammation 被引量:6
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作者 feng li Hao li +2 位作者 Rong Luo Jia-Bao Pei Xue-Ying Yu 《World Journal of Clinical Cases》 SCIE 2023年第26期6066-6072,共7页
BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and inflammation.Standard therapy for CHF has limitations,prompting the exploration of alternative t... BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and inflammation.Standard therapy for CHF has limitations,prompting the exploration of alternative treatments.Recombinant human brain natriuretic peptide(BNP)has emerged as a potential therapy,with evidence suggesting that it can improve cardiac function and reduce inflammation in patients with CHF.However,further research is required to determine the efficacy and safety of lyophilized recombinant human BNP in CHF patients and its impact on microinflammatory status.This study aimed to investigate the effects of lyophilized recombinant human BNP therapy on CHF patients’cardiac function and microinflammatory status.AIM To investigate the effects of freeze-dried recombinant human BNP therapy on cardiac function and microinflammatory status in patients with CHF.METHODS In total,102 CHF patients admitted to our hospital from January 2021 to January 2022 were randomly assigned to control and observation groups(n=51 patients/group).The control patients were treated with standard HF therapy for 3 d,whereas the observational patients were injected with the recombinant human BNP for 3 d.Clinical efficacy,inflammatory factor levels,myocardial damage,cardiac function before and after the treatment,and adverse reactions during treatment were compared between the two groups.RESULTS The overall clinical efficacy was higher in the observation group than in the control group.Compared with baseline,serum hypersensitive C-reactive protein,N-terminal proBNP,and troponin I level,and physical,emotional,social,and economic scores were lower in both groups after treatment,with greater reductions in levels and scores noted in the observation group than in the control group.The overall incidence of adverse reactions in the observation group was not significantly different compared with that in the control group(P>0.05).CONCLUSION Freeze-dried recombinant human BNP therapy can improve heart function and enhance microinflammatory status,thereby improving overall quality of life without any obvious side effects.This therapy is safe and reliable. 展开更多
关键词 Chronic heart failure Lyophilized recombinant human brain natriuretic peptide Cardiac function Microinflammatory state
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应用临床教学五步法进行形成性评价提升住院医师医患沟通能力 被引量:3
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作者 冯黎 周鸿雁 +4 位作者 申存周 赖蓉 王海燕 孙逊沙 冯慧宇 《中国毕业后医学教育》 2024年第1期67-70,共4页
目的研究应用临床教学五步法进行形成性评价提升住院医师医患沟通能力。方法采用自身对照的队列研究方法,由参与研究的指导医师对自愿纳入研究的住院医师进行5次关于医患沟通技能的形成性评价,每次均应用临床教学五步法进行反馈指导。... 目的研究应用临床教学五步法进行形成性评价提升住院医师医患沟通能力。方法采用自身对照的队列研究方法,由参与研究的指导医师对自愿纳入研究的住院医师进行5次关于医患沟通技能的形成性评价,每次均应用临床教学五步法进行反馈指导。对形成性评价前后住院医师的自评和他评结果进行对比分析。结果21名住院医师纳入研究。第5次形成性评价得分(90.00±2.47)分与第1次得分(61.24±9.86)分相比,差异有统计学意义(P<0.01)。18名住院医师完成自评问卷,结果提示,应用临床教学五步法进行形成性评价后,住院医师更注意在沟通前了解患方的社会文化背景,并据此拟定不同沟通策略。在沟通中,住院医师更注意观察患者的表情和语气的变化,主动询问患者的理解程度、治疗期望和意愿(P<0.05)。结论应用教学五步法进行形成性评价可有效提升住院医师医患沟通能力。 展开更多
关键词 形成性评价 临床教学五步法 医患沟通 胜任力 住院医师规范化培训
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特厚煤层小煤柱沿空掘巷支护技术研究 被引量:1
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作者 冯丽 王华 《煤炭技术》 CAS 2024年第1期66-69,共4页
小煤柱沿空掘巷过程中易出现巷道围岩变形大、局部鼓出等现象,针对这一问题,采用理论分析、数值模拟、工程类比的方法,对巷道基本顶破断方式进行了判断,并采用数值模拟分析不同宽度下煤柱的应力及位移变化规律,初步确定了煤柱留设宽度为... 小煤柱沿空掘巷过程中易出现巷道围岩变形大、局部鼓出等现象,针对这一问题,采用理论分析、数值模拟、工程类比的方法,对巷道基本顶破断方式进行了判断,并采用数值模拟分析不同宽度下煤柱的应力及位移变化规律,初步确定了煤柱留设宽度为8 m;对比邻近矿井的沿空掘巷案例,采用工程类比法最终确定了煤柱宽度,并对巷道支护方案进行设计,现场应用效果良好。 展开更多
关键词 特厚煤层 小煤柱 沿空掘巷 支护技术
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茯苓酸对慢性肾衰竭大鼠肾功能及纤维化的影响机制
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作者 彭斌 冯雪 +6 位作者 冯立 熊玮 胡溪 朱双益 肖阳 陈芳 高智 《中国药房》 CAS 北大核心 2024年第12期1489-1494,共6页
目的 基于Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路探讨茯苓酸(PA)对慢性肾衰竭(CRF)大鼠肾功能、纤维化的影响及潜在机制。方法 以雄性SD大鼠为对象,以5/6肾切除术建立CRF大鼠模型,将造模成功的大鼠分... 目的 基于Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路探讨茯苓酸(PA)对慢性肾衰竭(CRF)大鼠肾功能、纤维化的影响及潜在机制。方法 以雄性SD大鼠为对象,以5/6肾切除术建立CRF大鼠模型,将造模成功的大鼠分为模型组,PA低、中、高剂量组(5、10、20 mg/kg PA)和PA高剂量+ROCK通路激活剂溶血磷脂酸(LPA)组(20 mg/kg PA+1 mg/kg LPA),每组15只;另取15只大鼠仅切口暴露肾脏但不切除,作为假手术组。各药物组大鼠灌胃和/或尾静脉注射相应药液,每天1次,连续12周。实验期间,观察各组大鼠一般情况;末次给药后,检测各组大鼠的血清肾功能指标(血尿素氮、血清肌酐、尿酸)水平,观察其肾组织病理学改变,并进行肾小管损伤评分和肾纤维化区域面积量化,检测其肾组织中氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]、炎症因子(肿瘤坏死因子α、白细胞介素1β、白细胞介素6)水平,结缔组织生长因子(CTGF)、Ⅰ型胶原(collagenⅠ)阳性表达率,以及通路相关蛋白(RhoA、ROCK1)、纤维化相关蛋白(转化生长因子β1、裸角质层同源物2、α-平滑肌肌动蛋白)表达水平。结果 与假手术组比较,模型组大鼠饮食减少,体型瘦小,精神萎靡且反应迟钝,肾小球减少、萎缩,肾小管扩张且结构杂乱,间质可见大量炎症细胞浸润;其血清肾功能指标水平,肾小管损伤评分、肾纤维化面积占比、肾组织MDA和炎症因子水平、CTGF和collagenⅠ阳性表达率、通路相关蛋白和纤维化相关蛋白的表达水平均显著升高,SOD水平显著降低(P<0.05)。与模型组比较,PA各剂量组大鼠的一般情况和肾组织病理损伤均有不同程度好转,上述各定量指标均显著改善,且呈剂量依赖性(P<0.05)。LPA可显著逆转PA对上述指标的改善作用(P<0.05)。结论 PA能改善CRF大鼠肾功能并减轻肾组织纤维化,上述作用可能与抑制RhoA/ROCK信号通路的激活有关。 展开更多
关键词 茯苓酸 慢性肾衰竭 肾功能 纤维化 RhoA/ROCK信号通路
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黄芪多糖对腹膜透析大鼠腹膜纤维化和血管生成的影响及机制
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作者 冯雪 彭斌 +4 位作者 冯立 朱双益 胡溪 熊玮 高智 《中国药房》 CAS 北大核心 2024年第6期712-717,共6页
目的探讨黄芪多糖(APS)对腹膜透析(PD)大鼠腹膜纤维化和血管生成的影响及机制。方法将大鼠分为正常对照组(Control组)、模型组(PD组)、70 mg/kgAPS组(APS-L组)、140 mg/kgAPS组(APS-H组)、140 mg/kgAPS+40 mg/kg缺氧诱导因子1α(HIF-1α... 目的探讨黄芪多糖(APS)对腹膜透析(PD)大鼠腹膜纤维化和血管生成的影响及机制。方法将大鼠分为正常对照组(Control组)、模型组(PD组)、70 mg/kgAPS组(APS-L组)、140 mg/kgAPS组(APS-H组)、140 mg/kgAPS+40 mg/kg缺氧诱导因子1α(HIF-1α)激动剂DMOG组(APS-H+DMOG组),每组12只。后4组大鼠构建PD大鼠模型。各给药组大鼠灌胃相应剂量的APS及腹腔注射相应剂量的DMOG,Control组和PD组大鼠灌胃等体积生理盐水,每天给药1次,连续4周。末次给药后,检测大鼠腹膜超滤量(UF)、葡萄糖转运量(MTG)和血清中肌酐(Scr)、尿素氮(BUN)水平;观察腹膜组织病理学变化和纤维化情况(腹膜厚度和胶原纤维沉积占比);检测腹膜组织微血管密度和α-平滑肌肌动蛋白(α-SMA)、层粘连蛋白(LN)、HIF-1α、血管内皮生长因子(VEGF)蛋白表达水平。结果与Control组比较,PD组大鼠间皮细胞结构疏松,腹膜间皮细胞脱落,炎症细胞浸润,腹膜厚度和胶原纤维沉积占比均显著增加(P<0.05);MTG,血清中Scr、BUN水平,腹膜组织微血管密度和α-SMA、LN、HIF-1α、VEGF蛋白表达水平均显著升高,而UF显著降低(P<0.05);与PD组比较,APS-L组、APS-H组大鼠上述指标均显著改善(P<0.05),其中APS-H组改善效果优于APS-L组(P<0.05);与APS-H组比较,APS-H+DMOG组大鼠上述指标变化均逆转(P<0.05)。结论APS可以通过抑制HIF-1α/VEGF信号通路来抑制PD大鼠腹膜纤维化及血管新生。 展开更多
关键词 黄芪多糖 缺氧诱导因子-1α/血管内皮生长因子信号通路 腹膜透析 腹膜纤维化 血管生成
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月球空间天气探测与研究进展
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作者 罗冰显 张贤国 +23 位作者 孙天然 白先勇 韦飞 林瑞淋 李磊 张珅毅 孔令高 王馨悦 谢良海 彭松武 唐斌斌 张颖洁 徐秋予 冷双 冯鹏远 苏杨 甘为群 封莉 田晖 陈林杰 颜毅华 宋永亮 刘四清 邓元勇 《深空探测学报(中英文)》 CSCD 北大核心 2024年第2期159-168,共10页
稳定的天体地质构造、与地球合适的距离、无稠密大气和全球磁场,使得月球成为日地月空间天气监测和研究的天然优良实验室。回顾了国内外月球空间天气探测和研究进展,梳理了月球空间天气关键科学问题及预报应用问题,提出了建立月球空间... 稳定的天体地质构造、与地球合适的距离、无稠密大气和全球磁场,使得月球成为日地月空间天气监测和研究的天然优良实验室。回顾了国内外月球空间天气探测和研究进展,梳理了月球空间天气关键科学问题及预报应用问题,提出了建立月球空间天气监测站的构想,明确了监测站具体科学目标,并介绍了监测站三大系统构成及相互关系,包括监测系统、科学研究系统以及建模与预报系统。建立月球空间天气监测站对研究太阳爆发活动、日地月耦合关系以及月球局地环境的变化具有重要的科学意义,也有利于促进月球空间天气建模和预报技术的发展,提升未来月球科研探索任务空间环境保障能力。 展开更多
关键词 月球空间天气 月球空间天气探测和研究 月球空间天气监测站 月球空间天气预报
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贝母素乙调节RhoA/ROCK信号通路对膝骨关节炎大鼠软骨损伤的影响
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作者 彭博文 冯立 覃剑 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第7期980-984,共5页
目的 探讨贝母素乙调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对膝骨关节炎(knee osteoarthritis, KOA)大鼠软骨损伤的影响。方法 以碘乙酸钠(MIA)法制备KOA大鼠模型,随机分为模型组、贝母素乙(3.5 mg/kg)组... 目的 探讨贝母素乙调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对膝骨关节炎(knee osteoarthritis, KOA)大鼠软骨损伤的影响。方法 以碘乙酸钠(MIA)法制备KOA大鼠模型,随机分为模型组、贝母素乙(3.5 mg/kg)组、贝母素乙(3.5 mg/kg)+LPA(RhoA激活剂,1 mg/kg)组,每组10只,另选10只大鼠为对照组。机械刺激法和热辐射法检测大鼠膝关节疼痛症状;检测大鼠关节肿胀度、膝关节宽度并以步态评分评测其关节功能;透射电镜检测大鼠膝关节软骨细胞超微结构;TUNEL染色检测大鼠关节软骨细胞凋亡比;酶联免疫吸附(ELISA)法检测大鼠血清和关节液促炎因子白细胞介素(IL)-18、单核细胞趋化蛋白1(MCP-1)水平;免疫印迹检测各组大鼠关节软骨组织凋亡(Cleaved caspase-3、Bax)和RhoA/ROCK通路相关蛋白表达。结果 贝母素乙可降低KOA大鼠关节肿胀度、膝关节宽度、步态评分、软骨细胞凋亡比、血清及关节液IL-18、MCP-1水平、软骨组织Cleaved caspase-3、Bax、RhoA、ROCK1、ROCK1蛋白表达,升高机械痛阈值、热痛阈值(P<0.05);LPA可减弱贝母素乙对KOA大鼠关节软骨损伤的改善作用。结论 贝母素乙可通过抑制RhoA/ROCK信号激活而抑制KOA大鼠关节炎症反应和关节软骨细胞凋亡,减轻软骨损伤。 展开更多
关键词 贝母素乙 RhoA/ROCK 膝骨关节炎 软骨损伤 信号通路
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云南部分地区畜禽肉中沙门氏菌的污染状况及其耐药性
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作者 高斌 任凌洁 +2 位作者 冯励 朱静静 黄艾祥 《云南农业大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第4期63-69,共7页
【目的】了解云南省部分地区生鲜畜禽肉中沙门氏菌(Salmonella)的污染及其耐药情况。【方法】采集生鲜畜禽肉样164份,对沙门氏菌分离培养后,运用基质辅助激光解吸电离飞行时间质谱技术进行鉴定;采用玻片凝集法分析沙门氏菌血清型,并通... 【目的】了解云南省部分地区生鲜畜禽肉中沙门氏菌(Salmonella)的污染及其耐药情况。【方法】采集生鲜畜禽肉样164份,对沙门氏菌分离培养后,运用基质辅助激光解吸电离飞行时间质谱技术进行鉴定;采用玻片凝集法分析沙门氏菌血清型,并通过脉冲场凝胶电泳(pulsed field gel electrophoresis,PFGE)进行分子分型和聚类分析;再用药敏检测板(微量肉汤稀释法)对沙门氏菌进行14种抗生素药敏试验。【结果】164份样品中,有12份样品检出沙门氏菌19株,总检出率为7.32%;分属于5个血清群,B群最多(10株,占52.60%);主要血清型包括鼠伤寒沙门氏菌5株、圣保罗沙门氏菌3株、甲型副伤寒沙门氏菌2株和鸭沙门氏菌2株。15株沙门氏菌PFGE分型产生14条不同的带型,表明畜禽肉中的少数沙门氏菌存在地域聚集,且存在交叉污染。19株沙门氏菌中有17株对抗生素耐药,多重耐药率为68.42%。【结论】生鲜畜禽肉中沙门氏菌检出率较高,呈现多重血清型,存在地域交叉污染,且耐药情况较为严重,需加强生肉制品卫生管理及抗生素使用管理。 展开更多
关键词 食品安全 畜禽肉 沙门氏菌 耐药性
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来华留学生在线医学课程英文习题库的构建思路
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作者 蒋玲 周嘉 +2 位作者 李燕 冯丽 韦秋文 《广西医学》 CAS 2024年第7期1125-1128,共4页
随着全球化进程的不断深入,国际医学教育蓬勃发展。在此背景下,来华学习医学专业的留学生人数持续增长,我国医学教育面临新的挑战。英文教学是来华留学生接受专业教育的主要形式,如何满足来华留学生教育需求、提高英文教学质量成为教育... 随着全球化进程的不断深入,国际医学教育蓬勃发展。在此背景下,来华学习医学专业的留学生人数持续增长,我国医学教育面临新的挑战。英文教学是来华留学生接受专业教育的主要形式,如何满足来华留学生教育需求、提高英文教学质量成为教育界关注的热点。在线习题库是一种现代化的教学辅助工具,可有效地帮助学生巩固专业知识和提高实践技能,有助于提升教学质量。本文从课程目标的确立、英文习题的编写、跨文化教育内容的融入、现代教育技术的应用、习题质量的评估与保障、数据驱动的持续改进等方面对在线医学课程英文习题库的构建思路进行探讨,旨在为构建高质量的针对来华留学生的在线医学课程英文习题库提供参考。 展开更多
关键词 医学教育 在线英文习题库 医学课程 来华留学生 教育国际化
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白地黑花瓷黑彩的仿制及呈色研究
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作者 王芬 赵馨怡 +3 位作者 朱建锋 罗宏杰 冯篱 任肇 《中国陶瓷》 CAS CSCD 北大核心 2024年第10期68-79,共12页
白地黑花瓷是先民创造性以低品位原料生产的一类绘画装饰瓷,在我国北方地区广为烧造,今天仍然有广泛的市场。其中的黑彩,多选自当地的贫铁矿烧成,但外观受多种因素影响。采用考古实验法,通过古瓷样品的测试分析,确定黑彩的组成与施彩工... 白地黑花瓷是先民创造性以低品位原料生产的一类绘画装饰瓷,在我国北方地区广为烧造,今天仍然有广泛的市场。其中的黑彩,多选自当地的贫铁矿烧成,但外观受多种因素影响。采用考古实验法,通过古瓷样品的测试分析,确定黑彩的组成与施彩工艺。后选用耀州窑陈炉当地制瓷原料,在电窑中以中性气氛烧成,仿烧了耀州窑白地黑花瓷黑彩;采用X射线荧光光谱仪(XRF)、色度仪、超景深显微镜、X射线衍射仪(XRD)、显微共聚焦激光拉曼光谱仪(Raman)等测试分析探讨了烧成温度、彩料的Fe_(2)O_(3)含量、施釉厚度等黑彩呈色的影响。对比发现,仿烧样品基本达到明代白地黑花瓷黑彩的效果。研究结果有助于深入探讨耀州窑白地黑花瓷的地方特色的形成因素,为进一步认知古代白地黑花瓷的科学内涵及地域特色建立理论与实验基础。 展开更多
关键词 白地黑花瓷 制备工艺 耀州窑 化学组成 呈色机理
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布地奈德联合鼻内镜手术治疗慢性泪囊炎
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作者 齐智伟 谭小波 +3 位作者 袁玉洁 关利莹 封莉 苏锐锋 《河北医科大学学报》 CAS 2024年第4期468-471,共4页
目的探讨布地奈德鼻喷雾剂联合鼻内镜手术治疗慢性泪囊炎的效果。方法将慢性泪囊炎患者80例(80眼)纳入前瞻性单盲研究,随机分为布地奈德组(40例)和对照组(40例)。所有患者均接受鼻内镜下鼻腔泪囊吻合术。布地奈德组应用布地奈德鼻喷雾... 目的探讨布地奈德鼻喷雾剂联合鼻内镜手术治疗慢性泪囊炎的效果。方法将慢性泪囊炎患者80例(80眼)纳入前瞻性单盲研究,随机分为布地奈德组(40例)和对照组(40例)。所有患者均接受鼻内镜下鼻腔泪囊吻合术。布地奈德组应用布地奈德鼻喷雾剂喷鼻3个月,对照组应用生理性海水喷鼻3个月。比较2组手术疗效、Lund-Kenndey评分和并发症发生情况。结果随访6个月时,布地奈德组疗效优于对照组(P<0.05)。术后3个月时,2组Lund-Kenndey评分低于术前,布地奈德组Lund-Kenndey评分低于对照组(P<0.05)。布地奈德组并发症发生率低于对照组(5%vs.20%,P<0.05)。结论鼻内镜下鼻腔泪囊吻合术后应用布地奈德鼻喷剂治疗慢性泪囊炎安全有效,手术成功率更高、术后出现吻合口粘连、肉芽肿的概率更小,且不增加术后感染的风险。 展开更多
关键词 泪囊炎 布地奈德 泪囊鼻腔吻合术
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