The Lomagundi-Jatuli Event(LJE)refers to the significant positive carbon isotope excursion in seawater constituents that occurred immediately after the increase in atmospheric oxygen content during the Paleoproterozoi...The Lomagundi-Jatuli Event(LJE)refers to the significant positive carbon isotope excursion in seawater constituents that occurred immediately after the increase in atmospheric oxygen content during the Paleoproterozoic(2.22-2.06 Ga).Theδ^(13)C values of 46 dolostone samples collected from the Paleoproterozoic Yongjingshao Formation varied in the range of 0.05‰-4.95‰(V-PDB;maximum:4.95‰)in this study,which may be related to the multicellular eukaryotes in the Liangshan Formation in the Yimen Group.They are much higher than theδ^(13)C values of marine carbonates(-1.16‰on average).Theδ^(13)C values of other formations in the Paleoproterozoic Yimen Group are negative.The notable positive carbon isotope anomalies of the Yongjingshao Formation indicate the response to the LJE at the southwestern margin of the Yangtze Block,which is reported for the first time.Furthermore,they are comparable to theδ^(13)C values of carbonates in the Dashiling Formation of the Hutuo Group in the Wutaishan area in the North China Craton,the Wuzhiling Formation of the Songshan Group in the Xiong'er area,Henan Province,and the Dashiqiao Formation of the Liaohe Group in the Guanmenshan area,Liaoning Province.Therefore,it can be further concluded that the LJE is a global event.This study reveals that LJE occurred in Central Yunnan at 2.15-2.10 Ga,lasting for about 50 Ma.The macro-columnar,bean-shaped,and microfilament fossils and reticular ultramicrofossils of multicellular eukaryotes in this period were discovered in the Liangshan Formation of the Yimen Group.They are the direct cause for the LJE and are also the oldest paleontological fossils ever found.The major events successively occurring in the early stage of the Earth include the Great Oxygenation Event(first occurrence),the global Superiortype banded iron formations(BIFs),the Huronian glaciation,the Great Oxygenation Event(second occurrence),the explosion of multicellular eukaryotes,the positive carbon isotope excursion,and the global anoxic and selenium-rich sedimentary event.The authors think that the North China Craton and the Yangtze Craton were possibly in different tectonic locations of the same continental block during the Proterozoic.展开更多
Heterophylly is regard as an important adaptive mechanism in response to different environments within plants.However,the genetic mechanisms responsible for heterophylly in woody plants are still poorly understood.Her...Heterophylly is regard as an important adaptive mechanism in response to different environments within plants.However,the genetic mechanisms responsible for heterophylly in woody plants are still poorly understood.Herein,the divergence of heterophyllous leaves was investigated at morphogenesis and using microdissection and physiological indexes in paper mulberry,and the genetic basis of heterophylly was further revealed combined with genome-wide association study(GWAS),transcriptome analysis and weighted gene coexpression network analysis(WGCNA).Our results revealed that the flavonoid content and antioxidant activity increased gradually from the entire leaf to the palmatisect leaf,while the hormone content and net photosynthetic rate decreased.Through GWAS and transcriptome analysis,a total of 98 candidate genes and 2338 differentially expressed genes associated with heterophylly were identified.Importantly,we uncovered critical variations in the candidate genes Bp07g0981(WOX)and Bp07g0920(HHO),along with significant differences in haplotypes and expression levels among heterophyllous leaves.Our results also suggested that the genes involved in hormone signaling pathways,antioxidant activity,and f lavonoid metabolism might be closely related to the heterophylly of paper mulberry,which could account for the physiological data.Indeed,CR-wox mutant lines showed significant changes in leaf phenotypes,and differential expression profile analysis also highlighted the expression of genes related to phytohormones and transcription factors.Together,the genetic variations and candidate genes detected in this study provide novel insights into the genetic mechanism of heterophylly,and would improve the understanding of eco-adaptability in heterophyllous woody plants.展开更多
Objective To investigate the value of in vivo proton magnetic resonance spectroscopy (MRS) in the assessment of hepatocelhilar carcinoma (HCC) and monitor its metabolic change shortly after transcatheter arterial ...Objective To investigate the value of in vivo proton magnetic resonance spectroscopy (MRS) in the assessment of hepatocelhilar carcinoma (HCC) and monitor its metabolic change shortly after transcatheter arterial chemoembolization (TACE). Mothoda In this prospective study, 28 consecutive patients with large HCC ( ≥3 cm in diameter) confirmed by fine needle aspiration biopsy were recruited. The ^1H MRS of all hepatic lesions and some uninvolved liver parenchyma were performed with 1.5T whole body MR scanner. Among them, 15 cases were evaluated again about one week after TACE. The main metabolites such as choline and lipid before and after interventional therapy were measured to assess the early response of the tumor. The technical success rate of IH MRS in liver was high (33/41, 80% ), closely related to breath motion, location of lesion, and size of voxeL In spectra, the choline compound peak of HCC elevated compared with uninvolved liver parenchyma. After TACE, both the amplitude and the area of choline resonance peak significantly descended ( choline-to-lipid ratios from 0.352±0. 080 to 0. 167±0. 030, P = 0. 026; from 0. 205±0. 060 to 0. 070±0. 020, P = 0. 042, respectively ) ; yet lipid resonance peak ascended. Conclusions In vivo tH MRS is technically feasible for the evaluation of large focal hepatic lesions, however, the reproducibility and stability are not as good as routine MR scan. IH MRS can monitor the early stage metabolic changes of HCC after TACE but limitation like quantification still exists.展开更多
AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (T...AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS: Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated with TACE. Diffusion-weighted imaging (DWI) with various b values was performed using the same protocol before and 3 d after treatment with TACE. ADC values and CNR of each tumor pre- and post-treatment with different b factors were analyzed. Correlation between ADC values and extent of necrosis in histological specimens was analyzed by a Pearson's correlation test.RESULTS: The quality of diffusion-weighted images diminished as the b value increased. A substantial decrease in the mean lesion-to-liver CNR was observed on both pre- and post-treatment DW images, the largest difference in CNR pre- and post-treatment was manifested at a b value of 1000 s/mm^2 (P = 0.036 ). The effect of therapy on diffusion early after treatment was shown by a significant increase in ADCs (P = 0.007), especially with large b factors (≥ 600 s/mm^2). The mean percentage of necrotic cells present within the tumor was 76.3%-97.5%. A significant positive correlation was found between ADC values and the extent of necrosis with all b values except for b200, a higher relative coefficient between ADC values and percentage of necrosis was found on DWI with bl000 and b2000 (P = 0.002 and 0.006, respectively). CONCLUSION: An increasing b value of up to 600 s/mm^2 would increase ADC contrast pre- and post-treatment, but decrease image quality. Taking into account both CNR and ADC measurement, diffusion-weighted imaging obtained with a b value of 1000 s/mm^2 is recommended for monitoring early hepatic tumor response to TACE.展开更多
AIM: To investigate the hemodynamic changes in a precancerous lesion model of hepatocellular carcinoma (HCC). METHODS: Hemodynamic changes in 18 Wistar rats were studied with non-invasive magnetic resonance (MR) perfu...AIM: To investigate the hemodynamic changes in a precancerous lesion model of hepatocellular carcinoma (HCC). METHODS: Hemodynamic changes in 18 Wistar rats were studied with non-invasive magnetic resonance (MR) perfusion. The changes induced by diethylnitrosamine (DEN) developed into liver nodular lesions due to hepatic cirrhosis during the progression of carcinogenesis. The MR perfusion data [positive enhancement integral (PEI)] were compared between the nodular lesions corresponding well with MR images and pathology and their surrounding hepatic parenchyma. RESULTS: A total of 46 nodules were located by MR imaging and autopsy, including 22 dysplastic nodules (DN), 9 regenerative nodules (RN), 10 early HCCs and 5 overt HCCs. Among the 22 DNs, 6 were low-grade DN (lGDN) and 16 were high-grade DN (HGDN). The average PEI of RN, DN, early and overt HCC was 205.67 ± 31.17, 161.94 ± 20.74, 226.09 ± 34.83, 491.86 ± 44.61 respectively, and their liver parenchyma nearby was 204.84 ± 70.19. Comparison of the blood perfusion index between each RN and its surrounding hepatic parenchyma showed no statistically significant difference (P = 0.06). There were significant differences in DN (P = 0.02). During the late hepatic arterial phase, the perfusion curve in DN declined. DN had an iso-signal intensity at the early hepatic arterial phase and a low signal intensity at the portal venous phase. Of the 10early HCCs, 4 demonstrated less blood perfusion and 6 displayed minimally increased blood flow compared to the surrounding parenchyma. Five HCCs showed significantly increased blood supply compared to the surrounding parenchyma (P = 0.02). CONCLUSION: Non-invasive MR perfusion can detect changes in blood supply of precancerous lesions.展开更多
AIM: To assess Magnetic resonance colonography with fat enema as a method for detection of colorectal neoplasm.METHODS: Consecutive twenty-two patients underwent MR colonography with fat enema before colonoscopy. Tl...AIM: To assess Magnetic resonance colonography with fat enema as a method for detection of colorectal neoplasm.METHODS: Consecutive twenty-two patients underwent MR colonography with fat enema before colonoscopy. Tl-weighted three-dimensional fast spoiled gradient- echo with inversion recovery sequence was acquired with the patient in the supine position before and 75 s after Gadopentetate Dimelumine administration. Where by, pre and post MR coronal images were obtained with a single breath hold for about 20 s to cover the entire colon. The quality of MR colonographs and patients' tolerance to fat contrast medium was investigated. Colorectal neoplasms identified by MR colonography were compared with those identified on colonoscopy and sensitivity of detecting the lesions was calculated accordingly.RESULTS: MR colonography with fat enema was well tolerated without sedation and analgesia. 120 out of 132 (90.9%) colonic segments were well distended and only 1 (0.8%) colonic segment was poor distension. After contrast enhancement scan, mean contrast-to-noise ratio (CNR) value between the normal colonic wall and lumen was 18.5 ± 2.9 while mean CNR value between colorectal neoplasm and lumen was 20.2± 3.1. By Magnetic resonance colonography, 26 of 35 neoplasms (sensitivity 74.3%) were detected. However, sensitivity of MRC was 95.5% (21 of 22) for neoplasm larger than 10 mm and 55.6% (5 of 9) for 5-10 mm neoplasm.CONCLUSION: MR colonography with fat enema and Tl-weighted three-dimensional fast spoiled gradientecho with inversion recovery sequence is feasible in detecting colorectal neoplasm larger than 10 mm.展开更多
It has been an intense debate on the exact boundary between Ediacaran and Cambrian in the southwest Yangtze Block.The calibration of this critical boundary has a remarkable influence on the further investigation of th...It has been an intense debate on the exact boundary between Ediacaran and Cambrian in the southwest Yangtze Block.The calibration of this critical boundary has a remarkable influence on the further investigation of the break-up of the Rodinia Supercontinent,the early life evolution,and the mechanism of the phosphorite deposit.Ediacaran and Cambrian strata and fossils are widely distributed in Anning,Yunnan Province in China.In recent years,the Xiaowaitoushan Member from the Lower Yuhucun Formation has been studied.Through this interval with continuous collections,the first appearance datums(FADs)of the protoconodont(Fomitchella cf.inchoate Yang et He,Protohertzina cf.anabarica Missarzhevsky)and globular embryos fossil(Olivooides sp.)earlier than these in the Lower Cambrian strata of the Meishucun Formation were discovered.This discovery indicates that the Xiaowaitoushan Member has included more FADs than the previously discovered single FAD of Anabarites primitivus Qian et Jiang,and the Ediacaran–Cambrian boundary in southwest China should be replaced below the Point“A”of the Meishucun Formation in Yunnan Province.The Point“B”of the Meishucun Formation is younger than the suggested age 541 Ma of the Ediacaran–Cambrian boundary and can no longer reference the Global Boundary Stratotype Section and Point(GSSP)correlation in southwest China.It can be suggested based on the previous stratigraphy and palaeontology studies from northern Sichuan and southern Shaanxi and the FAD of the globular embryos fossils that the Ediacaran‒Cambrian boundary in the southwest Yangtze Block should be placed at the base of the Xiaowaitoushan Member;other phosphorite strata refer to Xiaowaitoushan Member.The discovery of the FADs of the shelly fossils in the Xiaowaitoushan Member provides new evidence for the global correlation of the Ediacaran–Cambrian boundary in the southwest Yangtze Block.The conodont discoloration index(CAI)of the specimens in Anning is between 2 and 3,which indicates that the organic matter in Xiaowaitoushan Member is matured and has high potential to form a shale gas reservoir.展开更多
During the Late Neoproterozoic and Early Cambrian,a series of paleogeographic and paleoecological events occurred associated with deglaciations and the evolution of life.The appearance of fossils representing diverse ...During the Late Neoproterozoic and Early Cambrian,a series of paleogeographic and paleoecological events occurred associated with deglaciations and the evolution of life.The appearance of fossils representing diverse phyla,novel body plans and complex ecologies in Ediacaran and Cambrian sedimentary successions has sparked diverse hypotheses about potential drivers for the radiation of early animals during this interval.Recently,new macroscopic fossils of carbonaceous compressions with unique features have been found in Anning,Yunnan,China.The fossils’bodies are ribbon-shaped and bilaterally symmetric,with dense longitudinal features and transversal features.The fossils occur 0.68 m below a bentonite interlayer which has been dated 535.2±1.7 Ma by Ri-xiang Zhu and his team in 2009.The relatively simply morphology of these fossils,coupled with a lack of preserved internal structures challenge efforts taxonomically identify the precursor organism and definitively ally it to a living group.However,the symmetry and unusual features of the body are analogous to members of Platyzoa.The presence of ribbon-shaped fossils in the Zhongyicun Member in Anning indicates that these organisms were at least a locally significant component of Cambrian seafloor ecosystems,and may hold important implications for our understanding of the early evolution of Bilateria.展开更多
A low voltage circuit breaker(LVCB)is an important piece of protection equipment which will switch off the fault current in a power system.The moving contact of a low voltage circuit breaker with a higher rated curren...A low voltage circuit breaker(LVCB)is an important piece of protection equipment which will switch off the fault current in a power system.The moving contact of a low voltage circuit breaker with a higher rated current consists of two parallel contacts.Therefore,the convection effect on the air arc evolution process in a two parallel contact system is analyzed.A threedimensional(3 D)magneto–hydro–dynamic(MHD)model of arc simulation is built.In this model,the anode consists of two parallel contacts and a bonding conductor.A nonlinear voltage–current density characteristic is employed to represent the near-anode and near-cathode voltage.The current density,arc voltage and currents through every contact are obtained.The influence of convection and conduction on the arc evolution process are quantitatively calculated.The displacements of the arc roots are obtained and the asymmetry of the arc root motion is analyzed.The arc evolution process of a two parallel contact system is preliminarily revealed.展开更多
Optical metasurfaces are two-dimensional arrays of nano-scatterers that modify optical wavefronts at subwavelength spatial resolution.They achieve the effect of focusing through phase control under a subwavelength sca...Optical metasurfaces are two-dimensional arrays of nano-scatterers that modify optical wavefronts at subwavelength spatial resolution.They achieve the effect of focusing through phase control under a subwavelength scale,and are called metalenses.They are poised to revolutionize optics by enabling complex low-cost systems.However,there are severe monochromatic aberrations in the metasurfaces.In this paper,the coma of the long-wave infrared optical system is eliminated through a single-layer metasurface.By changing the phase function,this metalens has a numerical aperture of 0.89,a focal length of 150μm and a field of view of 120°(0.4@60 line pairs/mm)that enables diffraction-limited monochromatic imaging along the focal plane at a wavelength of 10.6μm.The designed metasurface maintains a favorable value of the modulation transfer function at different angles.This equipment can be widely used in imaging and industrial processing.展开更多
Quantum sensing has been receiving researcher's attention these years due to its ultrahigh sensitivity and precision. However, the bandwidth of the sensors may be low, thus limiting the scope of their practical ap...Quantum sensing has been receiving researcher's attention these years due to its ultrahigh sensitivity and precision. However, the bandwidth of the sensors may be low, thus limiting the scope of their practical applications. The low-bandwidth problem is conquered by feedback control methods, which are widely utilized in classic control fields. Based on a quantum harmonic oscillator model operating near the resonant point, the bandwidth and sensitivity of the quantum sensor are analyzed. The results give two important conclusions: (a) the bandwidth and sensitivity are two incompatible performance parameters of the sensor, so there must be a trade-off between bandwidth and sensitivity in practical applications;(b) the quantum white noise affects the signal to be detected in a non-white form due to the feedback control.展开更多
Once the metalenses are fabricated,the functions of most metalenses are invariable.The tunability and reconfigurability are useful and cost-saving for metalenses in realistic applications.We demonstrate this tunabilit...Once the metalenses are fabricated,the functions of most metalenses are invariable.The tunability and reconfigurability are useful and cost-saving for metalenses in realistic applications.We demonstrate this tunability here via a novel hybrid metalens with the strategic placement of an ultra-thin VO;layer.The hybrid metalens is capable of dynamically modulating the focusing intensity of transmitted light at a wavelength of 1550 nm,and demonstrate a 42.28%focusing efficiency of the incident light and 70.01%modulation efficiency.The hybrid metalens’optothermal simulations show an optothermal conversion process of dynamic focusing,and a maximum laser density of 1.76×10^(3)W/cm^(2) can be handled at an ambient temperature lower than 330 K.The hybrid metalens proposed in this work,a light-dose sensitive tunable smart metalens that can protect other instruments/systems or materials from being damaged,has its specific applications such as in anti-satellite blinding,bio-imaging,etc.展开更多
Magnetic exchange interactions(MEIs) define networks of coupled magnetic moments and lead to a surprisingly rich variety of their magnetic properties. Typically MEIs can be estimated by fitting experimental results.Un...Magnetic exchange interactions(MEIs) define networks of coupled magnetic moments and lead to a surprisingly rich variety of their magnetic properties. Typically MEIs can be estimated by fitting experimental results.Unfortunately, how many MEIs need to be included in the fitting process for a material is unclear a priori,which limits the results obtained by these conventional methods. Based on linear spin-wave theory but without performing matrix diagonalization, we show that for a general quadratic spin Hamiltonian, there is a simple relation between the Fourier transform of MEIs and the sum of square of magnon energies(SSME). We further show that according to the real-space distance range within which MEIs are considered relevant, one can obtain the corresponding relationships between SSME in momentum space. By directly utilizing these characteristics and the experimental magnon energies at only a few high-symmetry k points in the Brillouin zone, one can obtain strong constraints about the range of exchange path beyond which MEIs can be safely neglected. Our methodology is also generally applicable for other Hamiltonian with quadratic Fermi or Boson operators.展开更多
Macroalga Gesinella,a carbonaceous compression,is found in the upper part of Doushantuo Formation(Ediacaran)in the Yangtze Platform of South China.Morphologically,it is composed of a thallus(including an oval or oblon...Macroalga Gesinella,a carbonaceous compression,is found in the upper part of Doushantuo Formation(Ediacaran)in the Yangtze Platform of South China.Morphologically,it is composed of a thallus(including an oval or oblong lamina and a short-rod-like stipe)and a holdfast(including a cone-shaped rhizome and many filamentous rhizoids).The cone-shaped rhizome connects with the stipe and the long rhizoids grew on the rhizome,meaning that the rhizome grew downwards and inserted into the sediment,while the rhizoids grew in the gaps between the sediment grains to anchor its body on the seafloor.On the lamina,branching and/or unbranching filaments are regularly distributed,so that the oval or oblong lamina can be interpreted as a sac-like body that has been compressed.The filaments on the lamina extend from the three-dimensionally preserved stipe,suggesting that the short-rod-like stipe may have been flexible to support the sac-like body in the water column.With tissue and organ differentiations,Gesinella can be regarded as a eukaryotic macroalga and a high-level metaphyte.Based on measurement and analysis of 108 specimens,the Ediacaran macroalga Gesinella from South China can be divided into three stages:juvenile stage(<3 mm maximum width)identified with difficulty,adult stage(3e10 mm maximum width)interpreted to have grown upwards for sunlight,and senescent stage(>10 mm maximum width)that grew sideways.展开更多
基金financially supported by the project entitled 1∶50000 Regional Geological Survey of Samaki,Yinmin,Guicheng,and Shugu Sheets in Yunnan Province(D201905)organized by the Land and Resources Department of Yunnan ProvinceTraining Object Project of technological innovation talents in Yunnan Province(202205AD160073)+2 种基金the project entitled“1∶50000 Regional Geological Survey of Dazhuang,Fabiao,Ditu,and Dianzhong Sheets in Yunnan Province”(S53A00722001048-007)“Joint Foundation Project between Yunnan Science and Technology Department and Yunnan University”(CY21624103)the project entitled“Area Summary and Service Product Development of Regional Geological Surveys in Yunnan Province”initiated by the China Geological Survey(121201102000150012-02)。
文摘The Lomagundi-Jatuli Event(LJE)refers to the significant positive carbon isotope excursion in seawater constituents that occurred immediately after the increase in atmospheric oxygen content during the Paleoproterozoic(2.22-2.06 Ga).Theδ^(13)C values of 46 dolostone samples collected from the Paleoproterozoic Yongjingshao Formation varied in the range of 0.05‰-4.95‰(V-PDB;maximum:4.95‰)in this study,which may be related to the multicellular eukaryotes in the Liangshan Formation in the Yimen Group.They are much higher than theδ^(13)C values of marine carbonates(-1.16‰on average).Theδ^(13)C values of other formations in the Paleoproterozoic Yimen Group are negative.The notable positive carbon isotope anomalies of the Yongjingshao Formation indicate the response to the LJE at the southwestern margin of the Yangtze Block,which is reported for the first time.Furthermore,they are comparable to theδ^(13)C values of carbonates in the Dashiling Formation of the Hutuo Group in the Wutaishan area in the North China Craton,the Wuzhiling Formation of the Songshan Group in the Xiong'er area,Henan Province,and the Dashiqiao Formation of the Liaohe Group in the Guanmenshan area,Liaoning Province.Therefore,it can be further concluded that the LJE is a global event.This study reveals that LJE occurred in Central Yunnan at 2.15-2.10 Ga,lasting for about 50 Ma.The macro-columnar,bean-shaped,and microfilament fossils and reticular ultramicrofossils of multicellular eukaryotes in this period were discovered in the Liangshan Formation of the Yimen Group.They are the direct cause for the LJE and are also the oldest paleontological fossils ever found.The major events successively occurring in the early stage of the Earth include the Great Oxygenation Event(first occurrence),the global Superiortype banded iron formations(BIFs),the Huronian glaciation,the Great Oxygenation Event(second occurrence),the explosion of multicellular eukaryotes,the positive carbon isotope excursion,and the global anoxic and selenium-rich sedimentary event.The authors think that the North China Craton and the Yangtze Craton were possibly in different tectonic locations of the same continental block during the Proterozoic.
基金supported by the National Natural Science Foundation of China(31770360,32070358)the National Key Research and Development Program of China(2021YFD1000100).
文摘Heterophylly is regard as an important adaptive mechanism in response to different environments within plants.However,the genetic mechanisms responsible for heterophylly in woody plants are still poorly understood.Herein,the divergence of heterophyllous leaves was investigated at morphogenesis and using microdissection and physiological indexes in paper mulberry,and the genetic basis of heterophylly was further revealed combined with genome-wide association study(GWAS),transcriptome analysis and weighted gene coexpression network analysis(WGCNA).Our results revealed that the flavonoid content and antioxidant activity increased gradually from the entire leaf to the palmatisect leaf,while the hormone content and net photosynthetic rate decreased.Through GWAS and transcriptome analysis,a total of 98 candidate genes and 2338 differentially expressed genes associated with heterophylly were identified.Importantly,we uncovered critical variations in the candidate genes Bp07g0981(WOX)and Bp07g0920(HHO),along with significant differences in haplotypes and expression levels among heterophyllous leaves.Our results also suggested that the genes involved in hormone signaling pathways,antioxidant activity,and f lavonoid metabolism might be closely related to the heterophylly of paper mulberry,which could account for the physiological data.Indeed,CR-wox mutant lines showed significant changes in leaf phenotypes,and differential expression profile analysis also highlighted the expression of genes related to phytohormones and transcription factors.Together,the genetic variations and candidate genes detected in this study provide novel insights into the genetic mechanism of heterophylly,and would improve the understanding of eco-adaptability in heterophyllous woody plants.
基金Supported by National Natural Sciences Foundation of China(30470503)
文摘Objective To investigate the value of in vivo proton magnetic resonance spectroscopy (MRS) in the assessment of hepatocelhilar carcinoma (HCC) and monitor its metabolic change shortly after transcatheter arterial chemoembolization (TACE). Mothoda In this prospective study, 28 consecutive patients with large HCC ( ≥3 cm in diameter) confirmed by fine needle aspiration biopsy were recruited. The ^1H MRS of all hepatic lesions and some uninvolved liver parenchyma were performed with 1.5T whole body MR scanner. Among them, 15 cases were evaluated again about one week after TACE. The main metabolites such as choline and lipid before and after interventional therapy were measured to assess the early response of the tumor. The technical success rate of IH MRS in liver was high (33/41, 80% ), closely related to breath motion, location of lesion, and size of voxeL In spectra, the choline compound peak of HCC elevated compared with uninvolved liver parenchyma. After TACE, both the amplitude and the area of choline resonance peak significantly descended ( choline-to-lipid ratios from 0.352±0. 080 to 0. 167±0. 030, P = 0. 026; from 0. 205±0. 060 to 0. 070±0. 020, P = 0. 042, respectively ) ; yet lipid resonance peak ascended. Conclusions In vivo tH MRS is technically feasible for the evaluation of large focal hepatic lesions, however, the reproducibility and stability are not as good as routine MR scan. IH MRS can monitor the early stage metabolic changes of HCC after TACE but limitation like quantification still exists.
基金The National Natural Science Foundation of China, NO. 30470503The Key Program of Shanghai Science and Technology Commission, NO. 04JC14074The Foundation of Shanghai Educational commission, NO. 03J405037
文摘AIM: To explore the diffusion gradient b-factor that optimizes both apparent diffusion coefficient (ADC) measurement and contrast-to-noise (CNR) for assessing tumor response to transarterial chemoembolization (TACE) in a rabbit model. METHODS: Twelve New Zealand white rabbits bearing VX2 tumors in the liver were treated with TACE. Diffusion-weighted imaging (DWI) with various b values was performed using the same protocol before and 3 d after treatment with TACE. ADC values and CNR of each tumor pre- and post-treatment with different b factors were analyzed. Correlation between ADC values and extent of necrosis in histological specimens was analyzed by a Pearson's correlation test.RESULTS: The quality of diffusion-weighted images diminished as the b value increased. A substantial decrease in the mean lesion-to-liver CNR was observed on both pre- and post-treatment DW images, the largest difference in CNR pre- and post-treatment was manifested at a b value of 1000 s/mm^2 (P = 0.036 ). The effect of therapy on diffusion early after treatment was shown by a significant increase in ADCs (P = 0.007), especially with large b factors (≥ 600 s/mm^2). The mean percentage of necrotic cells present within the tumor was 76.3%-97.5%. A significant positive correlation was found between ADC values and the extent of necrosis with all b values except for b200, a higher relative coefficient between ADC values and percentage of necrosis was found on DWI with bl000 and b2000 (P = 0.002 and 0.006, respectively). CONCLUSION: An increasing b value of up to 600 s/mm^2 would increase ADC contrast pre- and post-treatment, but decrease image quality. Taking into account both CNR and ADC measurement, diffusion-weighted imaging obtained with a b value of 1000 s/mm^2 is recommended for monitoring early hepatic tumor response to TACE.
基金the grants from Foundation of Ministry of Public Health of China, No. 20011420National Natural Science Foundation of China, No. 30470503
文摘AIM: To investigate the hemodynamic changes in a precancerous lesion model of hepatocellular carcinoma (HCC). METHODS: Hemodynamic changes in 18 Wistar rats were studied with non-invasive magnetic resonance (MR) perfusion. The changes induced by diethylnitrosamine (DEN) developed into liver nodular lesions due to hepatic cirrhosis during the progression of carcinogenesis. The MR perfusion data [positive enhancement integral (PEI)] were compared between the nodular lesions corresponding well with MR images and pathology and their surrounding hepatic parenchyma. RESULTS: A total of 46 nodules were located by MR imaging and autopsy, including 22 dysplastic nodules (DN), 9 regenerative nodules (RN), 10 early HCCs and 5 overt HCCs. Among the 22 DNs, 6 were low-grade DN (lGDN) and 16 were high-grade DN (HGDN). The average PEI of RN, DN, early and overt HCC was 205.67 ± 31.17, 161.94 ± 20.74, 226.09 ± 34.83, 491.86 ± 44.61 respectively, and their liver parenchyma nearby was 204.84 ± 70.19. Comparison of the blood perfusion index between each RN and its surrounding hepatic parenchyma showed no statistically significant difference (P = 0.06). There were significant differences in DN (P = 0.02). During the late hepatic arterial phase, the perfusion curve in DN declined. DN had an iso-signal intensity at the early hepatic arterial phase and a low signal intensity at the portal venous phase. Of the 10early HCCs, 4 demonstrated less blood perfusion and 6 displayed minimally increased blood flow compared to the surrounding parenchyma. Five HCCs showed significantly increased blood supply compared to the surrounding parenchyma (P = 0.02). CONCLUSION: Non-invasive MR perfusion can detect changes in blood supply of precancerous lesions.
基金Supported by the Developing Research Programs of Science Technology Commission Foundation of Shanghai,No.34958038
文摘AIM: To assess Magnetic resonance colonography with fat enema as a method for detection of colorectal neoplasm.METHODS: Consecutive twenty-two patients underwent MR colonography with fat enema before colonoscopy. Tl-weighted three-dimensional fast spoiled gradient- echo with inversion recovery sequence was acquired with the patient in the supine position before and 75 s after Gadopentetate Dimelumine administration. Where by, pre and post MR coronal images were obtained with a single breath hold for about 20 s to cover the entire colon. The quality of MR colonographs and patients' tolerance to fat contrast medium was investigated. Colorectal neoplasms identified by MR colonography were compared with those identified on colonoscopy and sensitivity of detecting the lesions was calculated accordingly.RESULTS: MR colonography with fat enema was well tolerated without sedation and analgesia. 120 out of 132 (90.9%) colonic segments were well distended and only 1 (0.8%) colonic segment was poor distension. After contrast enhancement scan, mean contrast-to-noise ratio (CNR) value between the normal colonic wall and lumen was 18.5 ± 2.9 while mean CNR value between colorectal neoplasm and lumen was 20.2± 3.1. By Magnetic resonance colonography, 26 of 35 neoplasms (sensitivity 74.3%) were detected. However, sensitivity of MRC was 95.5% (21 of 22) for neoplasm larger than 10 mm and 55.6% (5 of 9) for 5-10 mm neoplasm.CONCLUSION: MR colonography with fat enema and Tl-weighted three-dimensional fast spoiled gradientecho with inversion recovery sequence is feasible in detecting colorectal neoplasm larger than 10 mm.
基金The authors appreciate the comments given by the reviewers and editors.The work was financially supported by projects of“1∶50000 Regional Geological Survey of Samaki,Yinmin,Guicheng”and“Shugu Sheets in Yunnan Province by Land and Resources Department of Yunnan Province”(D201905)project of“1∶50000 Regional Geological Survey of Erjie,Yimen,Mingyihe,and Shangpubei Sheets in Yunnan Province”(DD20160017)“Regional Geological Survey Area Summary and Service Product Development in Yunnan Province”by China Geological Survey(121201102000150012-02,DD20190008)).
文摘It has been an intense debate on the exact boundary between Ediacaran and Cambrian in the southwest Yangtze Block.The calibration of this critical boundary has a remarkable influence on the further investigation of the break-up of the Rodinia Supercontinent,the early life evolution,and the mechanism of the phosphorite deposit.Ediacaran and Cambrian strata and fossils are widely distributed in Anning,Yunnan Province in China.In recent years,the Xiaowaitoushan Member from the Lower Yuhucun Formation has been studied.Through this interval with continuous collections,the first appearance datums(FADs)of the protoconodont(Fomitchella cf.inchoate Yang et He,Protohertzina cf.anabarica Missarzhevsky)and globular embryos fossil(Olivooides sp.)earlier than these in the Lower Cambrian strata of the Meishucun Formation were discovered.This discovery indicates that the Xiaowaitoushan Member has included more FADs than the previously discovered single FAD of Anabarites primitivus Qian et Jiang,and the Ediacaran–Cambrian boundary in southwest China should be replaced below the Point“A”of the Meishucun Formation in Yunnan Province.The Point“B”of the Meishucun Formation is younger than the suggested age 541 Ma of the Ediacaran–Cambrian boundary and can no longer reference the Global Boundary Stratotype Section and Point(GSSP)correlation in southwest China.It can be suggested based on the previous stratigraphy and palaeontology studies from northern Sichuan and southern Shaanxi and the FAD of the globular embryos fossils that the Ediacaran‒Cambrian boundary in the southwest Yangtze Block should be placed at the base of the Xiaowaitoushan Member;other phosphorite strata refer to Xiaowaitoushan Member.The discovery of the FADs of the shelly fossils in the Xiaowaitoushan Member provides new evidence for the global correlation of the Ediacaran–Cambrian boundary in the southwest Yangtze Block.The conodont discoloration index(CAI)of the specimens in Anning is between 2 and 3,which indicates that the organic matter in Xiaowaitoushan Member is matured and has high potential to form a shale gas reservoir.
基金The authors thank the China Geological Survey(DD20190008)the National Natural Science Foundation of China(41574024,41662003)programmes for supporting the project.
文摘During the Late Neoproterozoic and Early Cambrian,a series of paleogeographic and paleoecological events occurred associated with deglaciations and the evolution of life.The appearance of fossils representing diverse phyla,novel body plans and complex ecologies in Ediacaran and Cambrian sedimentary successions has sparked diverse hypotheses about potential drivers for the radiation of early animals during this interval.Recently,new macroscopic fossils of carbonaceous compressions with unique features have been found in Anning,Yunnan,China.The fossils’bodies are ribbon-shaped and bilaterally symmetric,with dense longitudinal features and transversal features.The fossils occur 0.68 m below a bentonite interlayer which has been dated 535.2±1.7 Ma by Ri-xiang Zhu and his team in 2009.The relatively simply morphology of these fossils,coupled with a lack of preserved internal structures challenge efforts taxonomically identify the precursor organism and definitively ally it to a living group.However,the symmetry and unusual features of the body are analogous to members of Platyzoa.The presence of ribbon-shaped fossils in the Zhongyicun Member in Anning indicates that these organisms were at least a locally significant component of Cambrian seafloor ecosystems,and may hold important implications for our understanding of the early evolution of Bilateria.
基金supported by the Natural Science Foundation of Shaanxi Province of China(No.2017ZDJC-16)Shenzhen Power Supply Co.Ltd(No.SZKJXM20170480).
文摘A low voltage circuit breaker(LVCB)is an important piece of protection equipment which will switch off the fault current in a power system.The moving contact of a low voltage circuit breaker with a higher rated current consists of two parallel contacts.Therefore,the convection effect on the air arc evolution process in a two parallel contact system is analyzed.A threedimensional(3 D)magneto–hydro–dynamic(MHD)model of arc simulation is built.In this model,the anode consists of two parallel contacts and a bonding conductor.A nonlinear voltage–current density characteristic is employed to represent the near-anode and near-cathode voltage.The current density,arc voltage and currents through every contact are obtained.The influence of convection and conduction on the arc evolution process are quantitatively calculated.The displacements of the arc roots are obtained and the asymmetry of the arc root motion is analyzed.The arc evolution process of a two parallel contact system is preliminarily revealed.
基金the National Natural Science Foundation of China(Grant No.61875087)Innovation and Development Foundation of China Academy of Engineering Physics(Grant No.CX20200021)。
文摘Optical metasurfaces are two-dimensional arrays of nano-scatterers that modify optical wavefronts at subwavelength spatial resolution.They achieve the effect of focusing through phase control under a subwavelength scale,and are called metalenses.They are poised to revolutionize optics by enabling complex low-cost systems.However,there are severe monochromatic aberrations in the metasurfaces.In this paper,the coma of the long-wave infrared optical system is eliminated through a single-layer metasurface.By changing the phase function,this metalens has a numerical aperture of 0.89,a focal length of 150μm and a field of view of 120°(0.4@60 line pairs/mm)that enables diffraction-limited monochromatic imaging along the focal plane at a wavelength of 10.6μm.The designed metasurface maintains a favorable value of the modulation transfer function at different angles.This equipment can be widely used in imaging and industrial processing.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11534002, U1930402, and U1930403).
文摘Quantum sensing has been receiving researcher's attention these years due to its ultrahigh sensitivity and precision. However, the bandwidth of the sensors may be low, thus limiting the scope of their practical applications. The low-bandwidth problem is conquered by feedback control methods, which are widely utilized in classic control fields. Based on a quantum harmonic oscillator model operating near the resonant point, the bandwidth and sensitivity of the quantum sensor are analyzed. The results give two important conclusions: (a) the bandwidth and sensitivity are two incompatible performance parameters of the sensor, so there must be a trade-off between bandwidth and sensitivity in practical applications;(b) the quantum white noise affects the signal to be detected in a non-white form due to the feedback control.
基金Project supported by the National Natural Science Foundation of China(Grant No.61875087)the Innovation and Development Foundation of China Academy of Engineering Physics(Grant No.CX20200020)。
文摘Once the metalenses are fabricated,the functions of most metalenses are invariable.The tunability and reconfigurability are useful and cost-saving for metalenses in realistic applications.We demonstrate this tunability here via a novel hybrid metalens with the strategic placement of an ultra-thin VO;layer.The hybrid metalens is capable of dynamically modulating the focusing intensity of transmitted light at a wavelength of 1550 nm,and demonstrate a 42.28%focusing efficiency of the incident light and 70.01%modulation efficiency.The hybrid metalens’optothermal simulations show an optothermal conversion process of dynamic focusing,and a maximum laser density of 1.76×10^(3)W/cm^(2) can be handled at an ambient temperature lower than 330 K.The hybrid metalens proposed in this work,a light-dose sensitive tunable smart metalens that can protect other instruments/systems or materials from being damaged,has its specific applications such as in anti-satellite blinding,bio-imaging,etc.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 11834006, 12004170, and 12104215)the Natural Science Foundation of Jiangsu Province,China (Grant No. BK20200326)+1 种基金the Excellent Programme in Nanjing Universitythe support from the Tencent Foundation through the XPLORER PRIZE。
文摘Magnetic exchange interactions(MEIs) define networks of coupled magnetic moments and lead to a surprisingly rich variety of their magnetic properties. Typically MEIs can be estimated by fitting experimental results.Unfortunately, how many MEIs need to be included in the fitting process for a material is unclear a priori,which limits the results obtained by these conventional methods. Based on linear spin-wave theory but without performing matrix diagonalization, we show that for a general quadratic spin Hamiltonian, there is a simple relation between the Fourier transform of MEIs and the sum of square of magnon energies(SSME). We further show that according to the real-space distance range within which MEIs are considered relevant, one can obtain the corresponding relationships between SSME in momentum space. By directly utilizing these characteristics and the experimental magnon energies at only a few high-symmetry k points in the Brillouin zone, one can obtain strong constraints about the range of exchange path beyond which MEIs can be safely neglected. Our methodology is also generally applicable for other Hamiltonian with quadratic Fermi or Boson operators.
基金supported by the National Natural Science Foundation of China(Grant No.41762001 and 42172035)the Science and Technology Project of Guizhou Province,China(Grant No.2021-4001)the China Geological Survey(compilation of international geomaps through cooperation of China,Russia and Mongolia,DD20221648).
文摘Macroalga Gesinella,a carbonaceous compression,is found in the upper part of Doushantuo Formation(Ediacaran)in the Yangtze Platform of South China.Morphologically,it is composed of a thallus(including an oval or oblong lamina and a short-rod-like stipe)and a holdfast(including a cone-shaped rhizome and many filamentous rhizoids).The cone-shaped rhizome connects with the stipe and the long rhizoids grew on the rhizome,meaning that the rhizome grew downwards and inserted into the sediment,while the rhizoids grew in the gaps between the sediment grains to anchor its body on the seafloor.On the lamina,branching and/or unbranching filaments are regularly distributed,so that the oval or oblong lamina can be interpreted as a sac-like body that has been compressed.The filaments on the lamina extend from the three-dimensionally preserved stipe,suggesting that the short-rod-like stipe may have been flexible to support the sac-like body in the water column.With tissue and organ differentiations,Gesinella can be regarded as a eukaryotic macroalga and a high-level metaphyte.Based on measurement and analysis of 108 specimens,the Ediacaran macroalga Gesinella from South China can be divided into three stages:juvenile stage(<3 mm maximum width)identified with difficulty,adult stage(3e10 mm maximum width)interpreted to have grown upwards for sunlight,and senescent stage(>10 mm maximum width)that grew sideways.