Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (...Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.展开更多
目的对胃肠道肿瘤患者肠外营养治疗通路护理管理的证据进行检索、评价和汇总。方法根据6S[System(计算机决策支持系统)、Summaries(专题证据汇总)、Synopses of syntheses(系统评价摘要)、Syntheses(系统评价)、Synopses of studies(原...目的对胃肠道肿瘤患者肠外营养治疗通路护理管理的证据进行检索、评价和汇总。方法根据6S[System(计算机决策支持系统)、Summaries(专题证据汇总)、Synopses of syntheses(系统评价摘要)、Syntheses(系统评价)、Synopses of studies(原始研究摘要)、Studies(原始研究)]模型系统检索国内外胃肠道肿瘤患者营养治疗通路管理文献,检索时限为2011年1月至2023年1月,双人评价文献质量后进行证据总结。结果共纳入指南7篇,专家共识8篇,法律法规2篇,系统评价3篇,共形成团队建设、通路选择、置管前中后预防、营养液配置与应用、拔管时机、并发症预防与处理、患者教育、通路质量监测8个方面47条证据。结论胃肠道肿瘤患者肠外营养治疗通路护理管理证据科学、合理,可为临床医护人员实施营养治疗通路护理管理提供参考依据。展开更多
文摘Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rates worldwide. In the various treatment methods for HCC, the lack of cancer cell specificity and the development of multidrug resistance (MDR) are two major obstacles in the treatment of HCC. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump that can reduce the accumulation of drugs in cells and make cancer cells acquire drug resistance. D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) can inhibit the activity of ATP-dependent P-gp and serves as an effective excipient for overcoming tumor multidrug resistance (MDR). TPGS has been approved by the FDA as a safe adjuvant and is widely used in drug delivery systems. The biological and physicochemical properties of TPGS provide multiple advantages for its application in drug delivery, such as high biocompatibility, enhanced drug solubility, improved drug permeation, and selective antitumor activity. In recent years, more and more studies have found that using TPGS-modified nanomaterials to load chemotherapy drugs to treat tumors can effectively reverse the drug resistance of tumors, including HCC. This review summarizes and discusses the role of TPGS in reversing tumor drug resistance and the therapeutic effects of TPGS-based drugs on drug-resistant HCC.
文摘目的对胃肠道肿瘤患者肠外营养治疗通路护理管理的证据进行检索、评价和汇总。方法根据6S[System(计算机决策支持系统)、Summaries(专题证据汇总)、Synopses of syntheses(系统评价摘要)、Syntheses(系统评价)、Synopses of studies(原始研究摘要)、Studies(原始研究)]模型系统检索国内外胃肠道肿瘤患者营养治疗通路管理文献,检索时限为2011年1月至2023年1月,双人评价文献质量后进行证据总结。结果共纳入指南7篇,专家共识8篇,法律法规2篇,系统评价3篇,共形成团队建设、通路选择、置管前中后预防、营养液配置与应用、拔管时机、并发症预防与处理、患者教育、通路质量监测8个方面47条证据。结论胃肠道肿瘤患者肠外营养治疗通路护理管理证据科学、合理,可为临床医护人员实施营养治疗通路护理管理提供参考依据。
