Purpose: To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study (OHTS). Methods: 436 participants
Purpose: Most research studies in glaucoma screening focus on the discriminatory ability of the screening instrument In the community, glaucoma screening is also designed to educate and encourage participants to have ...Purpose: Most research studies in glaucoma screening focus on the discriminatory ability of the screening instrument In the community, glaucoma screening is also designed to educate and encourage participants to have eye exams. This study was performed to investigate whether an abnormal result with Frequency Doubling Technology (FDT) perimetry encourages participants展开更多
Objective:To assess endothelin B receptor(ETbR)expression in human glaucomatous optic nerves and the spatial relationship between ETbR and astrocytes.Methods:Twenty-six eyes from 16 glaucoma patients and 10 normal con...Objective:To assess endothelin B receptor(ETbR)expression in human glaucomatous optic nerves and the spatial relationship between ETbR and astrocytes.Methods:Twenty-six eyes from 16 glaucoma patients and 10 normal control subjects were immunohistochemically labeled with antibodies to ETbR.The immunoreactivity was quantified and compared between normal and glaucomatous eyes with an image analysis system.Tissues were also double-labeled for ETbR and astrocytes.In addition,the optic nerve of a monkey with regional degeneration induced by laser coagulation was examined with the same techniques.Results:The frequency of positive ETbR immunoreactivity was higher in human glaucomatous optic nerves as comparedwith age-matched controls(9/16 vs 1/10,P=.02).The ETbR immunoreactivity colocalized with astrocytic processes andwas quantitatively higher in the glaucomatous eyes(P=.02).In the monkey,the regions of degeneration showed increased ETbR associated with reactive astrocytes and was highest at the borders between normal areas and degeneration.Conclusion:Increased ETbR immunoreactivity in diseased optic nerves and its association with astrocytes suggest that the glia-endothelin system may be involved in the pathologic mechanisms of neuronal degeneration.Clinical Relevance:The study supports the clinical observation of endothelin involvement in glaucoma and provides direct evidence that the endothelin system is associated with glaucomatous pathologic abnormalities.展开更多
文摘Purpose: To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study (OHTS). Methods: 436 participants
文摘Purpose: Most research studies in glaucoma screening focus on the discriminatory ability of the screening instrument In the community, glaucoma screening is also designed to educate and encourage participants to have eye exams. This study was performed to investigate whether an abnormal result with Frequency Doubling Technology (FDT) perimetry encourages participants
文摘Objective:To assess endothelin B receptor(ETbR)expression in human glaucomatous optic nerves and the spatial relationship between ETbR and astrocytes.Methods:Twenty-six eyes from 16 glaucoma patients and 10 normal control subjects were immunohistochemically labeled with antibodies to ETbR.The immunoreactivity was quantified and compared between normal and glaucomatous eyes with an image analysis system.Tissues were also double-labeled for ETbR and astrocytes.In addition,the optic nerve of a monkey with regional degeneration induced by laser coagulation was examined with the same techniques.Results:The frequency of positive ETbR immunoreactivity was higher in human glaucomatous optic nerves as comparedwith age-matched controls(9/16 vs 1/10,P=.02).The ETbR immunoreactivity colocalized with astrocytic processes andwas quantitatively higher in the glaucomatous eyes(P=.02).In the monkey,the regions of degeneration showed increased ETbR associated with reactive astrocytes and was highest at the borders between normal areas and degeneration.Conclusion:Increased ETbR immunoreactivity in diseased optic nerves and its association with astrocytes suggest that the glia-endothelin system may be involved in the pathologic mechanisms of neuronal degeneration.Clinical Relevance:The study supports the clinical observation of endothelin involvement in glaucoma and provides direct evidence that the endothelin system is associated with glaucomatous pathologic abnormalities.
