哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种高度保守的激酶,通过感知和整合细胞环境中的信号来调节生物生长、体内平衡,并在许多细胞的生长过程中发挥着关键作用。自噬是真核生物进化中高度保守的细胞内物质分...哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种高度保守的激酶,通过感知和整合细胞环境中的信号来调节生物生长、体内平衡,并在许多细胞的生长过程中发挥着关键作用。自噬是真核生物进化中高度保守的细胞内物质分解代谢物质循环过程。近年来,遗传学和功能研究表明,mTOR通过自噬途径在骨稳态调节中起着重要作用。作为PI3K/AKT/mTOR信号通路的核心环节,mTOR的激活或抑制对骨髓间充质干细胞/成骨细胞介导的骨形成、成脂分化,以及破骨细胞介导的骨吸收均具有正/负向调节作用。鉴于mTOR在自噬中对骨稳态的重要调控作用,该文就mTOR和自噬与骨稳态之间的联系进行综述,探讨mTOR在骨质疏松中的治疗潜力,以期望为骨质疏松症的治疗提供新的治疗靶点。展开更多
Objective The Hengjian uranium deposit is a typical hydrothermal deposit in the Xiangshan uranium ore field.The uranium mineralization ages of the Xiangshan deposits are poorly constrained,and only a few mineralizatio...Objective The Hengjian uranium deposit is a typical hydrothermal deposit in the Xiangshan uranium ore field.The uranium mineralization ages of the Xiangshan deposits are poorly constrained,and only a few mineralization ages using the pitchblende U–Pb method have been published.These ages are commonly discordant and dispersed for abundant inclusions and an open U–Pb system.Zircon grains after strong hydrothermal alteration are usually characterized by high common Pb contents,and their U–Pb isochron ages recorded the hydrothermal alteration event without interference of common Pb components.The Hengjian gray/grayish-green granite porphyry experienced strong alteration by hydrothermal fluids during the pervasive uranium mineralization in the Xiangshan uranium ore field.Uranium mineralization in the Hengjian deposit may had different stages,and strong hydromicatization alteration occurred at a relatively early stage.Their altered zircon U–Pb isochron ages possibly represent relatively early mineralization age of the Xiangshan uranium deposits.Altered zircon grains from the Hengjian granite porphyry were analyzed using the secondary ion mass spectrometry(SIMS)U-Pb method in this study,and U–Pb isochron ages were measured to constrain the relatively early mineralization age of the Hengjian uranium deposit.展开更多
文摘哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种高度保守的激酶,通过感知和整合细胞环境中的信号来调节生物生长、体内平衡,并在许多细胞的生长过程中发挥着关键作用。自噬是真核生物进化中高度保守的细胞内物质分解代谢物质循环过程。近年来,遗传学和功能研究表明,mTOR通过自噬途径在骨稳态调节中起着重要作用。作为PI3K/AKT/mTOR信号通路的核心环节,mTOR的激活或抑制对骨髓间充质干细胞/成骨细胞介导的骨形成、成脂分化,以及破骨细胞介导的骨吸收均具有正/负向调节作用。鉴于mTOR在自噬中对骨稳态的重要调控作用,该文就mTOR和自噬与骨稳态之间的联系进行综述,探讨mTOR在骨质疏松中的治疗潜力,以期望为骨质疏松症的治疗提供新的治疗靶点。
基金financially supported by the National Key R&D Program of China(Grant No.2017YFC0602600)Project of Nuclear Power Development(No.HXS1403)Project of Core Competency Improvement(No.LTC1605).
文摘Objective The Hengjian uranium deposit is a typical hydrothermal deposit in the Xiangshan uranium ore field.The uranium mineralization ages of the Xiangshan deposits are poorly constrained,and only a few mineralization ages using the pitchblende U–Pb method have been published.These ages are commonly discordant and dispersed for abundant inclusions and an open U–Pb system.Zircon grains after strong hydrothermal alteration are usually characterized by high common Pb contents,and their U–Pb isochron ages recorded the hydrothermal alteration event without interference of common Pb components.The Hengjian gray/grayish-green granite porphyry experienced strong alteration by hydrothermal fluids during the pervasive uranium mineralization in the Xiangshan uranium ore field.Uranium mineralization in the Hengjian deposit may had different stages,and strong hydromicatization alteration occurred at a relatively early stage.Their altered zircon U–Pb isochron ages possibly represent relatively early mineralization age of the Xiangshan uranium deposits.Altered zircon grains from the Hengjian granite porphyry were analyzed using the secondary ion mass spectrometry(SIMS)U-Pb method in this study,and U–Pb isochron ages were measured to constrain the relatively early mineralization age of the Hengjian uranium deposit.
