The selection of refracturing candidate is one of the most important jobs faced by oilfield engineers. However, due to the complicated multi-parameter relationships and their comprehensive influence, the selection of ...The selection of refracturing candidate is one of the most important jobs faced by oilfield engineers. However, due to the complicated multi-parameter relationships and their comprehensive influence, the selection of refracturing candidate is often very difficult. In this paper, a novel approach combining data analysis techniques and fuzzy clustering was proposed to select refracturing candidate. First, the analysis techniques were used to quantitatively calculate the weight coefficient and determine the key factors. Then, the idealized refracturing well was established by considering the main factors. Fuzzy clustering was applied to evaluate refracturing potential. Finally, reservoirs numerical simulation was used to further evaluate reservoirs energy and material basis of the optimum refracturing candidates. The hybrid method has been successfully applied to a tight oil reservoir in China. The average steady production was 15.8 t/d after refracturing treatment, increasing significantly compared with previous status. The research results can guide the development of tight oil and gas reservoirs effectively.展开更多
No shale-rock physical model has been established in the observation coordinate system.To this end,this paper carried out anisotropic wave velocity tests on shale rock and compared the Thomsen,Daley,and Berryman solut...No shale-rock physical model has been established in the observation coordinate system.To this end,this paper carried out anisotropic wave velocity tests on shale rock and compared the Thomsen,Daley,and Berryman solutions to characterize anisotropic acoustic wave velocity.Finally,the Daley solution was selected.Based on basic rock physical models,such as SCA and DEM methods,and combined with the Daley solution,an anisotropic shale-rock physical model was established in the observation coordinate system and applied in Well B1 in the Luzhou area,Sichuan Basin.Our research conclusions were as follows:1.for the samples from the same core,the P-wave velocities in three directions were in the order VP11>VP45>VP33,shear wave velocity VS11 was the largest,but VS33 and VS45 did not follow the law of Vs33>Vs45 for some samples;2.the Daley solution,which not only considers the accuracy requirements but also has a complete expression of P-,SV-,and SH-waves,is most suitable for characterization of anisotropic wave velocity in this study area;3.the rock physical model constructed in the observation coordinate system has high accuracy,in which the absolute value of the relative error of the P-wave slowness was between 0%and 5.05%(0.55%on average),and that of shear-wave slowness was between 0%and 6.05%(0.59%on average);4.the acoustic waves recorded in Well B1 in the observation coordinate system were very different from those in the constitutive coordinate system.The relative difference of the P-wave was between 6.76%and 30.84%(14.68%on average),and that of the S-wave was between 7.00%and 23.44%(13.99%on average).The acoustic slowness measured in the observation coordinate system,such as in a deviated well or a horizontal well section,must be converted to the constitutive coordinate system before it can be used in subsequent engineering applications;5.the anisotropic shale-rock physical model built in the observation coordinate system proposed in this paper can provide basic data and guidance for subsequent pore pressure prediction,geomechanical modeling,and fracturing stimulation design for deviated and horizontal wells.展开更多
Background： The domestic prevalence of chronic hepatitis B （CHB） in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot（s）ide analogues （NUCs） anti-hepatitis B virus （HBV） therapies ar...Background： The domestic prevalence of chronic hepatitis B （CHB） in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot（s）ide analogues （NUCs） anti-hepatitis B virus （HBV） therapies are widely applied despite the relatively low rate of seroconversion and high risk of drug-resistant mutation. More effective treatments for CHB deserve further explorations. Combined therapy of NUCs plus Chinese herbal medicine （CHM） is widely accepted in China, which is recognized as a prospective alternative approach. The study was primarily designed to confirm the hypothesis that Tiaogan-Yipi Granule （调肝益脾颗粒, TGYP） or Tiaogan-Jianpi-Jiedu Granule （调肝健脾解毒颗粒, TGJPJD） plus entecavir tablet （ETV） was superior over ETV monotherapy in enhancing HBeAg loss rate. Methods： The study was a nationwide, large-scale, multi-center, double-blind, randomized, placebo-controlled trial with a designed duration of 108 weeks. A total of 16 hospitals and 596 eligible Chinese HBeAg positive CHB patients were enrolled from November 2012 to September 2013 and randomly allocated into 2 groups in 1：1 ratio via central randomization system： experimental group （EG） and control group （CG）. Subjects in EG received CM formulae （TGYP or TGJPJD, 50 g per dose, twice daily） plus ETV tablet （or ETV placebo） 0.5 mg per day in the first 24 weeks （stage 1）, and CHM granule plus ETV tablet （0.5 mg per day） from week 25 to 108 （stage 2）. Subjects in CG received CHM Granule placebo plus E＇IV tablet （0.5 mg per day） for 108 weeks throughout the trial. The assessments of primary outcomes （HBV serum markers and HBV-DNA） were conducted by a third-party College of American Pathologists （CAP） qualified laboratory. Adverse effects were observed in the hospitals of recruitment. Discussion： The study was designed to compare the curative effect of CM plus E＇IV and ETV monotherapy in respect of HBeAg loss, which is recognized by the European Association for the Study of the Liver as ＂a valuable endpoint＂. We believe this trial could provide a reliable status for patients＇ ＂joumey＂ towards durable responses after treatment discontinuation. The trial was registered before recruitment on Chinese Clinical trial registry （No. ChiCTR-TRC-12002784, Version 1.0, 2015/12/23）.展开更多
Objective:To compare the circular pathological changes of chronic hepatitis B(CHB)patients according to the tongue diagnosis.Methods:Totally 41 CHB patients with typical white tongue coating(WTC)or yellow tongue coati...Objective:To compare the circular pathological changes of chronic hepatitis B(CHB)patients according to the tongue diagnosis.Methods:Totally 41 CHB patients with typical white tongue coating(WTC)or yellow tongue coating(YTC)were enrolled and 14 healthy volunteers with normal tongue manifestation served as controls.The mRNA expression of peripheral leukocytes was detected by GeneChips,and 9 genes were randomly selected for expression validation.Circular metabolites were detected by gas chromatographymass spectrometry.Biological information was analyzed based on ingenuity pathways analysis or metabolomics database and the integrated networks were constructed by ClueGO.Results:A total of 945 and 716 differentially expressed genes were found in patients with WTC and YTC relative to healthy volunteers respectively.The biological information analysis indicated that CHB patients had obviously increased functions in cell death,apoptosis and necrosis(Z-score 2,P<0.05)and decreased activation in T lymphocytes(Z-score–2,P<0.05),regardless of the tongue manifestation.Compared to patients with WTC,the YTC patients were predicted to be more active in functions related to virus replication(Z-score 2,P<0.05),and the content of circular fatty acids,such as oleic acid(P=0.098)and lauric acid(P=0.035),and citric acid cycle-related metabolites were higher in the YTC patients(P<0.1).The integrated analysis based on differential genes and metabolites indicated that the most difference in the biological function network between the WTC and YTC patients was tumor necrosis factor receptor associated factor 6 mediated-nuclear factor kappa-B activation process.Conclusions:CHB patients with YTC had more severe inflammation and fatty acids metabolism aberrant than patients with WTC.The results facilitate the modern pathological annotation of Chinese medicine tongue diagnosis theory and provide a reference for the interpretation of pharmacological mechanisms of Chinese medicine treatment.展开更多
基金Projects(51204054,51504203)supported by the National Natural Science Foundation of ChinaProject(2016ZX05023-001)supported by the National Science and Technology Major Project of China
文摘The selection of refracturing candidate is one of the most important jobs faced by oilfield engineers. However, due to the complicated multi-parameter relationships and their comprehensive influence, the selection of refracturing candidate is often very difficult. In this paper, a novel approach combining data analysis techniques and fuzzy clustering was proposed to select refracturing candidate. First, the analysis techniques were used to quantitatively calculate the weight coefficient and determine the key factors. Then, the idealized refracturing well was established by considering the main factors. Fuzzy clustering was applied to evaluate refracturing potential. Finally, reservoirs numerical simulation was used to further evaluate reservoirs energy and material basis of the optimum refracturing candidates. The hybrid method has been successfully applied to a tight oil reservoir in China. The average steady production was 15.8 t/d after refracturing treatment, increasing significantly compared with previous status. The research results can guide the development of tight oil and gas reservoirs effectively.
基金supported by the Post Doctoral Project of Southwest Oil and Gas Field Research on Geomechanics and Effective Fracturing Factors of Deep Shale” (No. 20210302-31)the Scientific Research Project of Southwest Oil and Gas Field Branch “Geological Engineering Integration of Well Block Yang101”。
文摘No shale-rock physical model has been established in the observation coordinate system.To this end,this paper carried out anisotropic wave velocity tests on shale rock and compared the Thomsen,Daley,and Berryman solutions to characterize anisotropic acoustic wave velocity.Finally,the Daley solution was selected.Based on basic rock physical models,such as SCA and DEM methods,and combined with the Daley solution,an anisotropic shale-rock physical model was established in the observation coordinate system and applied in Well B1 in the Luzhou area,Sichuan Basin.Our research conclusions were as follows:1.for the samples from the same core,the P-wave velocities in three directions were in the order VP11>VP45>VP33,shear wave velocity VS11 was the largest,but VS33 and VS45 did not follow the law of Vs33>Vs45 for some samples;2.the Daley solution,which not only considers the accuracy requirements but also has a complete expression of P-,SV-,and SH-waves,is most suitable for characterization of anisotropic wave velocity in this study area;3.the rock physical model constructed in the observation coordinate system has high accuracy,in which the absolute value of the relative error of the P-wave slowness was between 0%and 5.05%(0.55%on average),and that of shear-wave slowness was between 0%and 6.05%(0.59%on average);4.the acoustic waves recorded in Well B1 in the observation coordinate system were very different from those in the constitutive coordinate system.The relative difference of the P-wave was between 6.76%and 30.84%(14.68%on average),and that of the S-wave was between 7.00%and 23.44%(13.99%on average).The acoustic slowness measured in the observation coordinate system,such as in a deviated well or a horizontal well section,must be converted to the constitutive coordinate system before it can be used in subsequent engineering applications;5.the anisotropic shale-rock physical model built in the observation coordinate system proposed in this paper can provide basic data and guidance for subsequent pore pressure prediction,geomechanical modeling,and fracturing stimulation design for deviated and horizontal wells.
基金Supported by China National Science and Technology Major Projects 12th 5-year Plan(No.2012ZX10005004)
文摘Background： The domestic prevalence of chronic hepatitis B （CHB） in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot（s）ide analogues （NUCs） anti-hepatitis B virus （HBV） therapies are widely applied despite the relatively low rate of seroconversion and high risk of drug-resistant mutation. More effective treatments for CHB deserve further explorations. Combined therapy of NUCs plus Chinese herbal medicine （CHM） is widely accepted in China, which is recognized as a prospective alternative approach. The study was primarily designed to confirm the hypothesis that Tiaogan-Yipi Granule （调肝益脾颗粒, TGYP） or Tiaogan-Jianpi-Jiedu Granule （调肝健脾解毒颗粒, TGJPJD） plus entecavir tablet （ETV） was superior over ETV monotherapy in enhancing HBeAg loss rate. Methods： The study was a nationwide, large-scale, multi-center, double-blind, randomized, placebo-controlled trial with a designed duration of 108 weeks. A total of 16 hospitals and 596 eligible Chinese HBeAg positive CHB patients were enrolled from November 2012 to September 2013 and randomly allocated into 2 groups in 1：1 ratio via central randomization system： experimental group （EG） and control group （CG）. Subjects in EG received CM formulae （TGYP or TGJPJD, 50 g per dose, twice daily） plus ETV tablet （or ETV placebo） 0.5 mg per day in the first 24 weeks （stage 1）, and CHM granule plus ETV tablet （0.5 mg per day） from week 25 to 108 （stage 2）. Subjects in CG received CHM Granule placebo plus E＇IV tablet （0.5 mg per day） for 108 weeks throughout the trial. The assessments of primary outcomes （HBV serum markers and HBV-DNA） were conducted by a third-party College of American Pathologists （CAP） qualified laboratory. Adverse effects were observed in the hospitals of recruitment. Discussion： The study was designed to compare the curative effect of CM plus E＇IV and ETV monotherapy in respect of HBeAg loss, which is recognized by the European Association for the Study of the Liver as ＂a valuable endpoint＂. We believe this trial could provide a reliable status for patients＇ ＂joumey＂ towards durable responses after treatment discontinuation. The trial was registered before recruitment on Chinese Clinical trial registry （No. ChiCTR-TRC-12002784, Version 1.0, 2015/12/23）.
基金Supported by the National Science and Technology Major Project of China(No.2017ZX09304002)the National Natural Science Foundation of China(No.81830119,81403298)。
文摘Objective:To compare the circular pathological changes of chronic hepatitis B(CHB)patients according to the tongue diagnosis.Methods:Totally 41 CHB patients with typical white tongue coating(WTC)or yellow tongue coating(YTC)were enrolled and 14 healthy volunteers with normal tongue manifestation served as controls.The mRNA expression of peripheral leukocytes was detected by GeneChips,and 9 genes were randomly selected for expression validation.Circular metabolites were detected by gas chromatographymass spectrometry.Biological information was analyzed based on ingenuity pathways analysis or metabolomics database and the integrated networks were constructed by ClueGO.Results:A total of 945 and 716 differentially expressed genes were found in patients with WTC and YTC relative to healthy volunteers respectively.The biological information analysis indicated that CHB patients had obviously increased functions in cell death,apoptosis and necrosis(Z-score 2,P<0.05)and decreased activation in T lymphocytes(Z-score–2,P<0.05),regardless of the tongue manifestation.Compared to patients with WTC,the YTC patients were predicted to be more active in functions related to virus replication(Z-score 2,P<0.05),and the content of circular fatty acids,such as oleic acid(P=0.098)and lauric acid(P=0.035),and citric acid cycle-related metabolites were higher in the YTC patients(P<0.1).The integrated analysis based on differential genes and metabolites indicated that the most difference in the biological function network between the WTC and YTC patients was tumor necrosis factor receptor associated factor 6 mediated-nuclear factor kappa-B activation process.Conclusions:CHB patients with YTC had more severe inflammation and fatty acids metabolism aberrant than patients with WTC.The results facilitate the modern pathological annotation of Chinese medicine tongue diagnosis theory and provide a reference for the interpretation of pharmacological mechanisms of Chinese medicine treatment.
