AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological myopia.METHODS:This was a prospective non-randomized series case study.Fourteen...AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological myopia.METHODS:This was a prospective non-randomized series case study.Fourteen eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this study.All cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas tamponade.These cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were analyzed.RESULTS:All cases were successfully performed the surgery and the postoperative follow-up was completed.After surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence tomography.The reattachment of retina was achieved in all 6 eyes(100%,6/6)with MHRD.BCVA was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all cases.CONCLUSION:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary study.And it can effectively improve the visual function of patients.This new technique offers meaningful new ideas for treating refractory MH in pathological myopia.展开更多
The major constraint on the performance of orthogonal frequency division multiplexing （OFDM） based underwater acoustic （UWA） communication is to keep subcarriers orthogonal. In this paper, Doppler estimation and t...The major constraint on the performance of orthogonal frequency division multiplexing （OFDM） based underwater acoustic （UWA） communication is to keep subcarriers orthogonal. In this paper, Doppler estimation and the respective compensation technique along with various diversity techniques were deliberated for OFDM-based systems best suited for underwater wireless information exchange. In practice, for mobile communication, adjustment and tuning of transducers in order to get spatial diversity is extremely difficult. Considering the relatively low coherence bandwidth in UWA, the frequency diversity design with the Doppler compensation function was elaborated here. The outfield experiments of mobile underwater acoustic communication （UWAC） based on OFDM were carried out with 0.17 bit/（s-Hz） spectral efficiency. The validity and the dependability of the scheme were also analyzed.展开更多
AIM:To evaluate the therapeutic effect of amniotic membrane(AM)for covering high myopic macular hole associated with retinal detachment following failed primary surgery.METHODS:Seventeen eyes of 17 patients whose axia...AIM:To evaluate the therapeutic effect of amniotic membrane(AM)for covering high myopic macular hole associated with retinal detachment following failed primary surgery.METHODS:Seventeen eyes of 17 patients whose axial length was more than 29 mm suffered from macular hole(MH)or MH associated with retinal detachment(RD),and had previously surgery of pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling and silicone oil(SO)tamponade.Half a year after the surgery,optical coherence tomography(OCT)showed that MH did not heal in all 17 eyes and RD was still maintained in 13 eyes of these 17 eyes.We performed SO removal combined with AM covering on macular area and C3 F8 tamponade,and phacoemulsification combined with intraocular lens implantation simultaneously cataract eyes.We followed up these patients for one year.RESULTS:In all 17 eyes,SO was removed successfully,MHs were healed and RDs were reattached.One eye(5.89%,1/17)had AM shifted half a month after surgery and underwent a second surgery to adjust the position of the AM and supplement C3 F8.After surgery,the visual acuity(VA)improved in 15 eyes(88.24%,15/17),no change in two eyes(11.76%,2/17).No serious complications occurred in all eyes.CONCLUSION:AM covering is helpful to rescue the previous failure surgery of high myopic MH.展开更多
Objective:To analyze the dynamic expression of Wnt family member 5A(Wingless-type MMTV integration Wnt site family,member 5a)in murine hair cycle and its inhibitory effects on follicle in vivo.Methods:Situ hybridizati...Objective:To analyze the dynamic expression of Wnt family member 5A(Wingless-type MMTV integration Wnt site family,member 5a)in murine hair cycle and its inhibitory effects on follicle in vivo.Methods:Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages,and Ad-Wnt5a was injected after defeathering to observe the hair follicle growth in vivo.Results:The Wnt5a mRNA was expressed at birth,and was firstly increased then decreased along with the progress of the hair cycle.It reached the peak in advanced stage of growth cycle(P<0.05).Rhoa andβ-catenin expression levels were significantly decreased in three groups.Rac2 expression was significantly up-regulated,and the expression level of Wnt5a,Shh and Frizzled2 was increased,but less significantly than group 2.Conclusions:The expression of Wnt5a mRNA is consistent with change of murine follicle cycle,and has obvious inhibitory effects on the growth of hair follicle in vivo,indicating that it is antagonistic to Wnts pathway and interferes the growth of follicle together.展开更多
To study the parameter estimating effects of a free-floating tumbling space target,the extended Kalman filter(EKF)scheme is utilized with different high-nonlinear translational and rotational coupled kinematic&dyn...To study the parameter estimating effects of a free-floating tumbling space target,the extended Kalman filter(EKF)scheme is utilized with different high-nonlinear translational and rotational coupled kinematic&dynamic models on the LIDAR measurements.Applying the aforementioned models and measurements results in the situation where one single state can be estimated differently with varying accuracies since the EKFs based on different models have different observabilities.In the proposed EKFs,the traditional quaternions based kinematics and dynamics and the dual vector quaternions(DVQ)based kinematics and dynamics are used for the modeling of the relative motions between a chaser satellite and an uncooperative target.In the non-contact estimating scenarios,only highly nonlinear relative attitude and range measurements:the grapple fixture on the target measured from the chaser satellite via vision-based sensors,can be used.By evaluating the results of the EKFs,the observability properties of each EKF are studied analytically and numerically with the the Observability Gramian matrices(OG)and the standard deviations for every estimated parameters.The analysis of observability perform intensive studies and reveal the intrinsic factors that affect the accuracy and stability of the parameters estimation of an uncooperative space target.Finally,the analytical and numerical results show the optimal composition of the kinematic&dynamic models and measurements.展开更多
AIM： To appraise the effect of treatment for diabetic macular edema（DME） in proliferative stage with sufficient panrentinal photocoagulation（PRP） therapy and intravitreal injections（IV） Conbercept and posterior...AIM： To appraise the effect of treatment for diabetic macular edema（DME） in proliferative stage with sufficient panrentinal photocoagulation（PRP） therapy and intravitreal injections（IV） Conbercept and posterior subtenon＇s triamcinolone acetonide（STTA） sequential therapy.METHODS： This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment. Group A were treated with IVConbercept 0.5 mg for one month in the 1^st phase. Group B were treated with STTA 40 mg（twice per two weeks）. The interventions were exchanged in the second phase（2mo） between the two groups. In the third phase（3-6mo） no other treatment was given. Best corrected visual acuity（BCVA）, central macular thickness（CMT） measured by OCT and complications were compared.RESULTS： After phase I： in Group A, BCVA improved from 0.201±0.17 to 0.37±0.24（F=5.88, P=0.004）. CMT changed from 449±155.10 to 304.1±84.70 μm（F=14.9, P〈0.01）. In Group B, BCVA changed from 0.195±0.19 to 0.26±0.20（F=0.76, P=0.41） while CMT changed from 463.82±152.92 to 366.00±115.40 μm（F=3.70, P〈0.03）. The improvement of BCVA was better in Group A（P〈0.05）. After phase II： in Group A, BCVA raised to 0.47±0.27（F=0.26, P〈0.01）, CMT reduced to 260.67±62.97 μm（F=-188.3, P〈0.01）; in Group B, BCVA raised to 0.51±0.26（F=0.31, P〈0.01）, CMT reduced to 261.93±50.15 μm（F=-201.9, P〈0.01）. But there were no difference between two groups（P〉0.05）. After phase III： in Group A, BCVA maintained 0.42±0.25（F=0.22, P=0.001）, CMT maintained 267.8±58.34 μm,（F=-0.27, P〈0.01）; in Group B, BCVA was 0.47±0.25（F=-0.27, P〈0.01）, CMT was 272.71±49.16 μm（F=-191.1, P〈0.01）. No serious complications happened in all phases.CONCLUSION： PRP＋Conbercept is better than PRP＋STTA in DME with proliferative stage but PRP＋Conbercept＋STTA sequential therapy may be a wiser choice for persistent effectiveness on anatomical as well as functional status.展开更多
AIM：To examine possible differences in clinical outcomes between sub-threshold micro-pulse diode laser photocoagulation（SDM） and traditional modified Early Treatment Diabetic Retinopathy Study（mETDRS）treatment pr...AIM：To examine possible differences in clinical outcomes between sub-threshold micro-pulse diode laser photocoagulation（SDM） and traditional modified Early Treatment Diabetic Retinopathy Study（mETDRS）treatment protocol in diabetic macuiar edema（DME）.METHODS：A comprehensive literature search using the Cochrane Collaboration methodology to identify RCTs comparing SDM with mETDRS for DME.The participants were type Ⅰ or type Ⅱ diabetes mellitus with clinically significant macuiar edema treated by SDM from previously reported randomized controlled trials（RCTs）.The primary outcome measures were the changes in the best corrected visual acuity（BCVA） and the central macuiar thickness（CMT） as measured by optical coherence tomography（OCT）.The secondary outcomes were the contrast sensitivity and the damages of the retina.RESULTS：Seven studies were identified and analyzed for comparing SDM（215 eyes） with mETDRS（210 eyes）for DME.There were no statistical differences in the BCVA after treatment between the SDM and mETDRS based on the follow-up：3mo（MD,-0.02;95% Cl,-0.12 to 0.09;P=0.77）,6mo（MD,-0.02;95% Cl,-0.12 to 0.09;P=0.75）,12mo（MD,-0.05;95% Cl,-0.17 to 0.07;P=0.40）.Likewise,there were no statistical differences in the CMT after treatment between the SDM and mETDRS in 3mo（MD,-9.92;95% Cl,-28.69 to 8.85;P=0.30）,6mo（MD,-11.37;95% Cl,-29.65 to 6.91;P=0.22）,12mo（MD,8.44;95% Cl,-29.89 to 46.77;P=0.67）.Three RCTs suggested that SDM laser results in good preservation of contrast sensitivity as mETDRS,in two different followup evaluations：3mo（MD,0.05;95% Cl,0 to 0.09;P=0.04） and 6mo（MD,0.02;95% Cl,-0.10 to 0.14;P=0.78）.Two RCTs showed that the SDM laser treatment did less retinal damage than that mETDRS did（OR,0.05;95% Cl,0.02 to 0.13;P〈0.01）.CONCLUSION：SDM laser photocoagulation shows an equally good effect on visual acuity,contrast sensitivity,and reduction of DME as compared to conventional mETDRS protocol with less retinal damage.展开更多
High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose...High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose zone is primarily generated by the external solar radiation energy,and evapotranspiration is contingent on the consumption of vadose heat,the intensity of evapotranspiration is associated with the intensity of solar radiation and the heat budget in the vadose zone.However,the spatial and temporal variation of heat budget and thermodynamic transfer process of the vadose zone in the frigid region are not clear,which hinders the revelation of the dynamic mechanism of evapotranspiration in the vadose zone in the frigid region.With the moisture content of the vadose zone in the alpine regions being the research object,the paper conducts in-situ geothermal observation tests,takes meteorological characteristics into consideration,and adopts the method of geothermal gradient and numerical computation to analyse the temporal and spatial variation rule of heat budget and thermodynamic transmission process of the vadose zone in the high and cold regions.The results show there is a positive correlation between air temperature,ground temperature,and water content of the vadose zone in both thawing and freezing periods.According to the change law of geothermal gradient,the thermodynamic transfer process of the vadose zone has four stages:slow exothermic heating,fast endothermic melting,slow endothermic cooling,and fast exothermic freezing.From the surface down,the moisture freezing rate of the vadose zone is slightly higher than the melting rate.This is of great significance for understanding the evapotranspiration dynamic process of the vadose zone and protecting and rebuilding the ecological and geological environment in the high and cold regions.展开更多
Traditional underwater acoustic communication networks(UACNs)generally use omnidirectional transmission technology that causes a large number of data-packet collisions,thus resulting in low network throughput and high...Traditional underwater acoustic communication networks(UACNs)generally use omnidirectional transmission technology that causes a large number of data-packet collisions,thus resulting in low network throughput and high end-to-end delays.Compared with omnidirectional transmission technology,directional technology only sends and receives data packets in a specified direction.This can significantly reduce the probability of collisions and improve network performance.However,it also causes a deafness problem,which occurs when the sending node sends a data packet to the receiving node but the receiving node is unable to reply to the sender,because its antenna beam is closed.To resolve this issue,this study proposes a collision classification media access control(CC-MAC)protocol for UACNs.With this protocol,the underwater acoustic channel is divided into two subchannels,and the nodes transmit corresponding data types on them.The sending node can estimate the current status of the receiving node(i.e.,no collision,normal collision,deafness)according to the type of the data packet received and the sub-channel it arrived on,and it can choose correct options to improve network efficiency.Finally,we verify the performance of CC-MAC via simulations,showing that the protocol achieved higher network throughput and lower end-toend delays.展开更多
Objective: To investigate the mid-and long-term clinical effects of tricuspid valvuloplasty with the implantation of an artificial plastic ring.Methods: Data of 677 patients who had functional tricuspid regurgitation ...Objective: To investigate the mid-and long-term clinical effects of tricuspid valvuloplasty with the implantation of an artificial plastic ring.Methods: Data of 677 patients who had functional tricuspid regurgitation and left cardiac valve disease and underwent tricuspid valvuloplasty and left cardiac valve surgery were retrospectively.Among these patients, 353 underwent simple suture annuloplasty(group A) while the rest 324 patients underwent artificial plastic ring annuloplasty(group B).The two-year and more-than-two-year clinical and ultrasonocardiograph(UCG) follow-up data of the two groups were obtained and compared.Results: A total of 600 patients(88.6%) completed the long-term follow-up(more than two years).The two-year follow-up showed no significant difference in the incidence of mild tricuspid regurgitation between the two groups(82.2% vs.92.7%, P=0.37).However, there were significantly more cases that developed into moderate to severe tricuspid regurgitation in group A than in group B(17.8% vs.7.3%, P=0.031).The long-term follow-up revealed that the recurrence rate of tricuspid regurgitation in group B was significantly lower than that in group A(11.0% vs.25.0%, P=0.029), and the ratio of cases developing into moderate to severe tricuspid regurgitation in group A was significantly higher than that in group B(28.9% vs.9.9%, P=0.007).The comparison between the two intra-group time segments showed that the development of tricuspid regurgitation in group A was significantly increased(28.9% vs.17.8%, P=0.022), but in group B it was relatively stable(9.9% vs.7.3%, P=0.52).Conclusions: Artificial ring annuloplasty is associated with significantly less tricuspid regurgitation than simple suture annuloplasty.展开更多
The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a ...The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a combination of Electrical Resistivity Tomography(ERT), Induced Polarization(IP) and Surface Nuclear Magnetic Resonance(SNMR) methods were used in this study. By conducting a comprehensive analysis, the characteristics of water-bearing structure in vertical and groundwater distribution in horizontal were detected;and the influence of the groundwater on plateau and landslides was also identified. The results indicate that the groundwater occurs in the loess aquifer with a three-layer structure in vertical.Horizontally, the aquifer has a unified water table over the plateau, with a low water level in the north and high one in the south. The high resistivity bedrock uplift belt in the middle of the plateau forms a watershed,with the north side of the uplift belt being a relatively stable slope area with stable water content and fewer geological disasters. In contrast, the south side of the uplift belt is a disaster-prone region with vertical fissures well developed in the loess aquifers. The southern landslides are characterized by the interphase distribution of high and low electrical resistivity. The infiltration and discharge of groundwater result in the formation of a collapse belt in the low resistivity water-bearing structure of landslide, which causes the entire block with high resistivity and stable bedrock to slide. There was a newly formed landslide in a larger range at the landslide' s trailing edge. This study provides a scientific basis for the study of landslides mechanisms and disaster prevention by identifying the distribution characteristics of groundwater and analyzing its influence from a geophysical perspective in Heifangtai.展开更多
Dear Editor,Qiao et al[1]have published"Amniotic membrane for covering high myopic macular hole associated with retinal detachment following failed primary surgery".This prospective non-control case study pr...Dear Editor,Qiao et al[1]have published"Amniotic membrane for covering high myopic macular hole associated with retinal detachment following failed primary surgery".This prospective non-control case study presents the efficacy and the safety of amniotic membrane(AM)for covering high myopic macular hole(MH)associated with retinal detachment(RD)following failed primary surgery.They explained that they improved the technique published by Caporossi et al[2],with a new technique using a covering AM rather than an AM plug.Indeed,it is interesting to discuss about surgical techniques using this adjuvant to close complex MHs.Whatever the adjuvant,the question of to fill or not fill the MH"is still unsolved.展开更多
Independent light propagation through one or multiple modes is commonly considered as a basic demand for mode manipulation in few-mode fiber(FMF)-or multimode fiber(MMF)-based optical systems such as transmission link...Independent light propagation through one or multiple modes is commonly considered as a basic demand for mode manipulation in few-mode fiber(FMF)-or multimode fiber(MMF)-based optical systems such as transmission links,optical fiber lasers,or distributed optical fiber sensors.However,the insertion of doped-fiber amplifiers always kills the entire effort by inducing significant modal crosstalk.In this paper,we propose the design of doped-fiber amplifiers in FMF-based systems adopting identical multiple-ring-core(MRC)index profiles for both passive and doped fibers to achieve low modal crosstalk.We develop the direct-glass-transition(DGT)modified chemical vapor deposition(MCVD)processing for precise fabrication of few-mode erbium-doped fibers(FM-EDFs)with MRC profiles of both refractive index and erbium-ion doping distribution.Then,a few-mode erbium-doped-fiber amplifier(FM-EDFA)with a maximum gain of 26.08 dB and differential modal gain(DMG)of 2.3 dB is realized based on fabricated FM-EDF matched with a transmission FMF supporting four linearly polarized(LP)modes.With the insertion of the FM-EDFA,60+60 km simultaneous LP_(01)∕LP_(11)∕LP_(21)∕LP_(02)transmission without inter-modal multiple-input multiple-output digital signal processing(MIMO-DSP)is successfully demonstrated.The proposed design of low-modal-crosstalk doped-fiber amplifiers provides,to our knowledge,new insights into mode manipulation methods in various applications.展开更多
We propose a joint look-up-table(LUT)-based nonlinear predistortion and digital resolution enhancement scheme to achieve high-speed and low-cost optical interconnects using low-resolution digital-to-analog converters(...We propose a joint look-up-table(LUT)-based nonlinear predistortion and digital resolution enhancement scheme to achieve high-speed and low-cost optical interconnects using low-resolution digital-to-analog converters(DACs).The LUT-based predistortion is employed to mitigate the patterndependent effect(PDE)of a semiconductor optical amplifier(SOA),while the digital resolution enhancer(DRE)is utilized to shape the quantization noise,lowering the requirement for the resolution of DAC.We experimentally demonstrate O-band intensity modulation and direct detection(IM/DD)transmission of 124-GBd 4∕6-level pulse-amplitude modulation ePAMT-4∕6 and 112-GBd PAM-8 signals over a 2-km standard single-mode fiber(SSMF)with 3∕3.5∕4-bit DACs.In the case of 40-km SSMF transmission with an SOAbased preamplifier,124-GBd on-off-keying(OOK)/PAM-3/PAM-4 signals are successfully transmitted with 1.5∕2∕3-bit DACs.To the best of our knowledge,we have achieved the highest net data rates of 235.3-Gb∕s PAM-4,289.7-Gb∕s PAM-6,and 294.7 Gb∕s PAM-8 signals over 2-km SSMF,as well as 117.6-Gb∕s OOK,173.8-Gb∕s PAM-3,and−231.8 Gb∕s PAM-4 signals over 40-km SSMF,employing low-resolution DACs.The experimental results reveal that the joint LUT-based predistortion and DRE effectively mitigate the PDE and improve the signal-to-quantization noise ratio by shaping the noise.The proposed scheme can provide a powerful solution for low-cost IM/DD optical interconnects beyond 200 Gb∕s.展开更多
The Antarctic Ice Sheet(AIS)has been losing ice mass and contributing to the rise in the global sea-level(GSL)for the last 4 decades,as quantified by using satellite observations.We developed a framework for implement...The Antarctic Ice Sheet(AIS)has been losing ice mass and contributing to the rise in the global sea-level(GSL)for the last 4 decades,as quantified by using satellite observations.We developed a framework for implementing the state-of-the-art input-output(IO)method that has the advantage of explicit estimation of the mass balance of individual glaciers,basins and the continent.We estimated the mass balance of the AIS from 2013 to 2018 using improved observations and updated datasets recently made available,including annual ice flow velocity maps from the Inter-mission Time Series of Land Ice Velocity and Elevation(ITS_LIVE)dataset,the Bed Machine and the Princess Elizabeth Land(PEL)Earth System Science Data(ESSD)datasets,and the surface mass balance from the RACMO 2.3 system.For example,using the improved ice thickness data,the proposed method for ice discharge estimation enables a 10%reduction of uncertainty in ice discharge.During the period of 2013–2018,an ice discharge acceleration of 6.9±6.5 Gt yr^(–2)in West Antarctica(WA)was detected,which contributed significantly to the estimated mass loss of~1069 Gt(–178.2±108.9 Gt yr^(–1))in the AIS.On the other hand,Queen Maud Land,East Antarctica(EA),showed clearly a mass gain rate of 56.0±10.0 Gt yr^(–1)due to the regional increase in surface mass balance.Our results extended the estimation period by 3 years in comparison to the published study using the same annual velocity maps from the ITS_LIVE dataset.Furthermore,our results,along with those from other studies using the IO method,reassures the acceleration of recent mass loss in WA and Wilkes Land in EA,which are caused by glacier thinning and ice shelf basal melting.Compared with the long-term mass balance record since 1979,our results suggest that the mass loss in AIS accelerated in the last decade.The developed framework can be modified for mass balance estimation of the AIS or for other ice sheets by using velocity maps from other satellite data or from different periods.展开更多
基金Supported by Medical Research Project of Sichuan(No.S23090).
文摘AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological myopia.METHODS:This was a prospective non-randomized series case study.Fourteen eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this study.All cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas tamponade.These cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were analyzed.RESULTS:All cases were successfully performed the surgery and the postoperative follow-up was completed.After surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence tomography.The reattachment of retina was achieved in all 6 eyes(100%,6/6)with MHRD.BCVA was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all cases.CONCLUSION:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary study.And it can effectively improve the visual function of patients.This new technique offers meaningful new ideas for treating refractory MH in pathological myopia.
基金Supported by the National High Technology Research and Development Program of China (2009AA093601-2)the National Defense Foundation Research (B2420110007)
文摘The major constraint on the performance of orthogonal frequency division multiplexing （OFDM） based underwater acoustic （UWA） communication is to keep subcarriers orthogonal. In this paper, Doppler estimation and the respective compensation technique along with various diversity techniques were deliberated for OFDM-based systems best suited for underwater wireless information exchange. In practice, for mobile communication, adjustment and tuning of transducers in order to get spatial diversity is extremely difficult. Considering the relatively low coherence bandwidth in UWA, the frequency diversity design with the Doppler compensation function was elaborated here. The outfield experiments of mobile underwater acoustic communication （UWAC） based on OFDM were carried out with 0.17 bit/（s-Hz） spectral efficiency. The validity and the dependability of the scheme were also analyzed.
基金Medical Research Project of Sichuan Province(No.S20018)。
文摘AIM:To evaluate the therapeutic effect of amniotic membrane(AM)for covering high myopic macular hole associated with retinal detachment following failed primary surgery.METHODS:Seventeen eyes of 17 patients whose axial length was more than 29 mm suffered from macular hole(MH)or MH associated with retinal detachment(RD),and had previously surgery of pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling and silicone oil(SO)tamponade.Half a year after the surgery,optical coherence tomography(OCT)showed that MH did not heal in all 17 eyes and RD was still maintained in 13 eyes of these 17 eyes.We performed SO removal combined with AM covering on macular area and C3 F8 tamponade,and phacoemulsification combined with intraocular lens implantation simultaneously cataract eyes.We followed up these patients for one year.RESULTS:In all 17 eyes,SO was removed successfully,MHs were healed and RDs were reattached.One eye(5.89%,1/17)had AM shifted half a month after surgery and underwent a second surgery to adjust the position of the AM and supplement C3 F8.After surgery,the visual acuity(VA)improved in 15 eyes(88.24%,15/17),no change in two eyes(11.76%,2/17).No serious complications occurred in all eyes.CONCLUSION:AM covering is helpful to rescue the previous failure surgery of high myopic MH.
基金supported by Zhejiang University Medical Key Funds(No201028382)
文摘Objective:To analyze the dynamic expression of Wnt family member 5A(Wingless-type MMTV integration Wnt site family,member 5a)in murine hair cycle and its inhibitory effects on follicle in vivo.Methods:Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages,and Ad-Wnt5a was injected after defeathering to observe the hair follicle growth in vivo.Results:The Wnt5a mRNA was expressed at birth,and was firstly increased then decreased along with the progress of the hair cycle.It reached the peak in advanced stage of growth cycle(P<0.05).Rhoa andβ-catenin expression levels were significantly decreased in three groups.Rac2 expression was significantly up-regulated,and the expression level of Wnt5a,Shh and Frizzled2 was increased,but less significantly than group 2.Conclusions:The expression of Wnt5a mRNA is consistent with change of murine follicle cycle,and has obvious inhibitory effects on the growth of hair follicle in vivo,indicating that it is antagonistic to Wnts pathway and interferes the growth of follicle together.
文摘To study the parameter estimating effects of a free-floating tumbling space target,the extended Kalman filter(EKF)scheme is utilized with different high-nonlinear translational and rotational coupled kinematic&dynamic models on the LIDAR measurements.Applying the aforementioned models and measurements results in the situation where one single state can be estimated differently with varying accuracies since the EKFs based on different models have different observabilities.In the proposed EKFs,the traditional quaternions based kinematics and dynamics and the dual vector quaternions(DVQ)based kinematics and dynamics are used for the modeling of the relative motions between a chaser satellite and an uncooperative target.In the non-contact estimating scenarios,only highly nonlinear relative attitude and range measurements:the grapple fixture on the target measured from the chaser satellite via vision-based sensors,can be used.By evaluating the results of the EKFs,the observability properties of each EKF are studied analytically and numerically with the the Observability Gramian matrices(OG)and the standard deviations for every estimated parameters.The analysis of observability perform intensive studies and reveal the intrinsic factors that affect the accuracy and stability of the parameters estimation of an uncooperative space target.Finally,the analytical and numerical results show the optimal composition of the kinematic&dynamic models and measurements.
基金Supported by the Health and Family Planning Commission of Sichuan Province(No:17PJ536)
文摘AIM： To appraise the effect of treatment for diabetic macular edema（DME） in proliferative stage with sufficient panrentinal photocoagulation（PRP） therapy and intravitreal injections（IV） Conbercept and posterior subtenon＇s triamcinolone acetonide（STTA） sequential therapy.METHODS： This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment. Group A were treated with IVConbercept 0.5 mg for one month in the 1^st phase. Group B were treated with STTA 40 mg（twice per two weeks）. The interventions were exchanged in the second phase（2mo） between the two groups. In the third phase（3-6mo） no other treatment was given. Best corrected visual acuity（BCVA）, central macular thickness（CMT） measured by OCT and complications were compared.RESULTS： After phase I： in Group A, BCVA improved from 0.201±0.17 to 0.37±0.24（F=5.88, P=0.004）. CMT changed from 449±155.10 to 304.1±84.70 μm（F=14.9, P〈0.01）. In Group B, BCVA changed from 0.195±0.19 to 0.26±0.20（F=0.76, P=0.41） while CMT changed from 463.82±152.92 to 366.00±115.40 μm（F=3.70, P〈0.03）. The improvement of BCVA was better in Group A（P〈0.05）. After phase II： in Group A, BCVA raised to 0.47±0.27（F=0.26, P〈0.01）, CMT reduced to 260.67±62.97 μm（F=-188.3, P〈0.01）; in Group B, BCVA raised to 0.51±0.26（F=0.31, P〈0.01）, CMT reduced to 261.93±50.15 μm（F=-201.9, P〈0.01）. But there were no difference between two groups（P〉0.05）. After phase III： in Group A, BCVA maintained 0.42±0.25（F=0.22, P=0.001）, CMT maintained 267.8±58.34 μm,（F=-0.27, P〈0.01）; in Group B, BCVA was 0.47±0.25（F=-0.27, P〈0.01）, CMT was 272.71±49.16 μm（F=-191.1, P〈0.01）. No serious complications happened in all phases.CONCLUSION： PRP＋Conbercept is better than PRP＋STTA in DME with proliferative stage but PRP＋Conbercept＋STTA sequential therapy may be a wiser choice for persistent effectiveness on anatomical as well as functional status.
文摘AIM：To examine possible differences in clinical outcomes between sub-threshold micro-pulse diode laser photocoagulation（SDM） and traditional modified Early Treatment Diabetic Retinopathy Study（mETDRS）treatment protocol in diabetic macuiar edema（DME）.METHODS：A comprehensive literature search using the Cochrane Collaboration methodology to identify RCTs comparing SDM with mETDRS for DME.The participants were type Ⅰ or type Ⅱ diabetes mellitus with clinically significant macuiar edema treated by SDM from previously reported randomized controlled trials（RCTs）.The primary outcome measures were the changes in the best corrected visual acuity（BCVA） and the central macuiar thickness（CMT） as measured by optical coherence tomography（OCT）.The secondary outcomes were the contrast sensitivity and the damages of the retina.RESULTS：Seven studies were identified and analyzed for comparing SDM（215 eyes） with mETDRS（210 eyes）for DME.There were no statistical differences in the BCVA after treatment between the SDM and mETDRS based on the follow-up：3mo（MD,-0.02;95% Cl,-0.12 to 0.09;P=0.77）,6mo（MD,-0.02;95% Cl,-0.12 to 0.09;P=0.75）,12mo（MD,-0.05;95% Cl,-0.17 to 0.07;P=0.40）.Likewise,there were no statistical differences in the CMT after treatment between the SDM and mETDRS in 3mo（MD,-9.92;95% Cl,-28.69 to 8.85;P=0.30）,6mo（MD,-11.37;95% Cl,-29.65 to 6.91;P=0.22）,12mo（MD,8.44;95% Cl,-29.89 to 46.77;P=0.67）.Three RCTs suggested that SDM laser results in good preservation of contrast sensitivity as mETDRS,in two different followup evaluations：3mo（MD,0.05;95% Cl,0 to 0.09;P=0.04） and 6mo（MD,0.02;95% Cl,-0.10 to 0.14;P=0.78）.Two RCTs showed that the SDM laser treatment did less retinal damage than that mETDRS did（OR,0.05;95% Cl,0.02 to 0.13;P〈0.01）.CONCLUSION：SDM laser photocoagulation shows an equally good effect on visual acuity,contrast sensitivity,and reduction of DME as compared to conventional mETDRS protocol with less retinal damage.
基金Science Foundation of China(41877199)the Key Research and Development Program of Shaanxi Province(2021ZDLSF05-01)+3 种基金the Key Scientific and Technological Innovation Team of Groundwater Hydrological Process and Supergene Ecology in Arid Regions of Shaanxi Province(2019TD-040)the Key Research and Development Program of Shaanxi(2022SF-327)the Science and Technology Program of Inner Mongolia Autonomous Region(2021GG0198)the Project of China Geological Survey(1212011220224,DD20221751,DD20211393,DD20190504).
文摘High altitude,cold and dry climate,strong solar radiation,and high evapotranspiration intensity have created an extremely fragile ecological and geological environment on the Tibet Plateau.Since the heat in the vadose zone is primarily generated by the external solar radiation energy,and evapotranspiration is contingent on the consumption of vadose heat,the intensity of evapotranspiration is associated with the intensity of solar radiation and the heat budget in the vadose zone.However,the spatial and temporal variation of heat budget and thermodynamic transfer process of the vadose zone in the frigid region are not clear,which hinders the revelation of the dynamic mechanism of evapotranspiration in the vadose zone in the frigid region.With the moisture content of the vadose zone in the alpine regions being the research object,the paper conducts in-situ geothermal observation tests,takes meteorological characteristics into consideration,and adopts the method of geothermal gradient and numerical computation to analyse the temporal and spatial variation rule of heat budget and thermodynamic transmission process of the vadose zone in the high and cold regions.The results show there is a positive correlation between air temperature,ground temperature,and water content of the vadose zone in both thawing and freezing periods.According to the change law of geothermal gradient,the thermodynamic transfer process of the vadose zone has four stages:slow exothermic heating,fast endothermic melting,slow endothermic cooling,and fast exothermic freezing.From the surface down,the moisture freezing rate of the vadose zone is slightly higher than the melting rate.This is of great significance for understanding the evapotranspiration dynamic process of the vadose zone and protecting and rebuilding the ecological and geological environment in the high and cold regions.
基金This work was supported by the National Key Research and Development Program of China(No.2018YFC0308500)National Natural Science Foundation of China(Nos.61901273,11774074,61771152,U1806201 and 11974090)+1 种基金Natural Science Foundation of Heilongjiang Province of China(No.YQ2019F002)Acoustic Science and Technology Laboratory,Science and Technology on Underwater Information and Control Laboratory,and by the Young Elite Scientists Sponsorship by CAST.
文摘Traditional underwater acoustic communication networks(UACNs)generally use omnidirectional transmission technology that causes a large number of data-packet collisions,thus resulting in low network throughput and high end-to-end delays.Compared with omnidirectional transmission technology,directional technology only sends and receives data packets in a specified direction.This can significantly reduce the probability of collisions and improve network performance.However,it also causes a deafness problem,which occurs when the sending node sends a data packet to the receiving node but the receiving node is unable to reply to the sender,because its antenna beam is closed.To resolve this issue,this study proposes a collision classification media access control(CC-MAC)protocol for UACNs.With this protocol,the underwater acoustic channel is divided into two subchannels,and the nodes transmit corresponding data types on them.The sending node can estimate the current status of the receiving node(i.e.,no collision,normal collision,deafness)according to the type of the data packet received and the sub-channel it arrived on,and it can choose correct options to improve network efficiency.Finally,we verify the performance of CC-MAC via simulations,showing that the protocol achieved higher network throughput and lower end-toend delays.
文摘Objective: To investigate the mid-and long-term clinical effects of tricuspid valvuloplasty with the implantation of an artificial plastic ring.Methods: Data of 677 patients who had functional tricuspid regurgitation and left cardiac valve disease and underwent tricuspid valvuloplasty and left cardiac valve surgery were retrospectively.Among these patients, 353 underwent simple suture annuloplasty(group A) while the rest 324 patients underwent artificial plastic ring annuloplasty(group B).The two-year and more-than-two-year clinical and ultrasonocardiograph(UCG) follow-up data of the two groups were obtained and compared.Results: A total of 600 patients(88.6%) completed the long-term follow-up(more than two years).The two-year follow-up showed no significant difference in the incidence of mild tricuspid regurgitation between the two groups(82.2% vs.92.7%, P=0.37).However, there were significantly more cases that developed into moderate to severe tricuspid regurgitation in group A than in group B(17.8% vs.7.3%, P=0.031).The long-term follow-up revealed that the recurrence rate of tricuspid regurgitation in group B was significantly lower than that in group A(11.0% vs.25.0%, P=0.029), and the ratio of cases developing into moderate to severe tricuspid regurgitation in group A was significantly higher than that in group B(28.9% vs.9.9%, P=0.007).The comparison between the two intra-group time segments showed that the development of tricuspid regurgitation in group A was significantly increased(28.9% vs.17.8%, P=0.022), but in group B it was relatively stable(9.9% vs.7.3%, P=0.52).Conclusions: Artificial ring annuloplasty is associated with significantly less tricuspid regurgitation than simple suture annuloplasty.
基金supported and funded by the National Natural Science Foundation of China (Grant No: 42177346, 52009103)the Key Laboratory for Groundwater and Ecology in Arid and Semi-arid Areasthe China Geological Survey project (No: DD20190296)。
文摘The occurrence of landslides in Heifangtai plateau is primarily caused by the rise in water levels due to irrigation. To accurately understand the distribution of groundwater and its impact on the landslide hazard, a combination of Electrical Resistivity Tomography(ERT), Induced Polarization(IP) and Surface Nuclear Magnetic Resonance(SNMR) methods were used in this study. By conducting a comprehensive analysis, the characteristics of water-bearing structure in vertical and groundwater distribution in horizontal were detected;and the influence of the groundwater on plateau and landslides was also identified. The results indicate that the groundwater occurs in the loess aquifer with a three-layer structure in vertical.Horizontally, the aquifer has a unified water table over the plateau, with a low water level in the north and high one in the south. The high resistivity bedrock uplift belt in the middle of the plateau forms a watershed,with the north side of the uplift belt being a relatively stable slope area with stable water content and fewer geological disasters. In contrast, the south side of the uplift belt is a disaster-prone region with vertical fissures well developed in the loess aquifers. The southern landslides are characterized by the interphase distribution of high and low electrical resistivity. The infiltration and discharge of groundwater result in the formation of a collapse belt in the low resistivity water-bearing structure of landslide, which causes the entire block with high resistivity and stable bedrock to slide. There was a newly formed landslide in a larger range at the landslide' s trailing edge. This study provides a scientific basis for the study of landslides mechanisms and disaster prevention by identifying the distribution characteristics of groundwater and analyzing its influence from a geophysical perspective in Heifangtai.
文摘Dear Editor,Qiao et al[1]have published"Amniotic membrane for covering high myopic macular hole associated with retinal detachment following failed primary surgery".This prospective non-control case study presents the efficacy and the safety of amniotic membrane(AM)for covering high myopic macular hole(MH)associated with retinal detachment(RD)following failed primary surgery.They explained that they improved the technique published by Caporossi et al[2],with a new technique using a covering AM rather than an AM plug.Indeed,it is interesting to discuss about surgical techniques using this adjuvant to close complex MHs.Whatever the adjuvant,the question of to fill or not fill the MH"is still unsolved.
基金Pengcheng Zili Project(PCL2023A04)National Natural Science Foundation of China(62101009,U20A20160)。
文摘Independent light propagation through one or multiple modes is commonly considered as a basic demand for mode manipulation in few-mode fiber(FMF)-or multimode fiber(MMF)-based optical systems such as transmission links,optical fiber lasers,or distributed optical fiber sensors.However,the insertion of doped-fiber amplifiers always kills the entire effort by inducing significant modal crosstalk.In this paper,we propose the design of doped-fiber amplifiers in FMF-based systems adopting identical multiple-ring-core(MRC)index profiles for both passive and doped fibers to achieve low modal crosstalk.We develop the direct-glass-transition(DGT)modified chemical vapor deposition(MCVD)processing for precise fabrication of few-mode erbium-doped fibers(FM-EDFs)with MRC profiles of both refractive index and erbium-ion doping distribution.Then,a few-mode erbium-doped-fiber amplifier(FM-EDFA)with a maximum gain of 26.08 dB and differential modal gain(DMG)of 2.3 dB is realized based on fabricated FM-EDF matched with a transmission FMF supporting four linearly polarized(LP)modes.With the insertion of the FM-EDFA,60+60 km simultaneous LP_(01)∕LP_(11)∕LP_(21)∕LP_(02)transmission without inter-modal multiple-input multiple-output digital signal processing(MIMO-DSP)is successfully demonstrated.The proposed design of low-modal-crosstalk doped-fiber amplifiers provides,to our knowledge,new insights into mode manipulation methods in various applications.
基金supported by the National Key R&D Program of China(Grant No.2020YFB1806400)the China Scholarship Council(Grant No.202306230183)the National Natural Science Foundation of China(Grant Nos.62271305 and 62001287).
文摘We propose a joint look-up-table(LUT)-based nonlinear predistortion and digital resolution enhancement scheme to achieve high-speed and low-cost optical interconnects using low-resolution digital-to-analog converters(DACs).The LUT-based predistortion is employed to mitigate the patterndependent effect(PDE)of a semiconductor optical amplifier(SOA),while the digital resolution enhancer(DRE)is utilized to shape the quantization noise,lowering the requirement for the resolution of DAC.We experimentally demonstrate O-band intensity modulation and direct detection(IM/DD)transmission of 124-GBd 4∕6-level pulse-amplitude modulation ePAMT-4∕6 and 112-GBd PAM-8 signals over a 2-km standard single-mode fiber(SSMF)with 3∕3.5∕4-bit DACs.In the case of 40-km SSMF transmission with an SOAbased preamplifier,124-GBd on-off-keying(OOK)/PAM-3/PAM-4 signals are successfully transmitted with 1.5∕2∕3-bit DACs.To the best of our knowledge,we have achieved the highest net data rates of 235.3-Gb∕s PAM-4,289.7-Gb∕s PAM-6,and 294.7 Gb∕s PAM-8 signals over 2-km SSMF,as well as 117.6-Gb∕s OOK,173.8-Gb∕s PAM-3,and−231.8 Gb∕s PAM-4 signals over 40-km SSMF,employing low-resolution DACs.The experimental results reveal that the joint LUT-based predistortion and DRE effectively mitigate the PDE and improve the signal-to-quantization noise ratio by shaping the noise.The proposed scheme can provide a powerful solution for low-cost IM/DD optical interconnects beyond 200 Gb∕s.
基金supported by the National Key Research&Development Program of China(Grant No.2017YFA0603102)the National Natural Science Foundation of China(Grant Nos.41730102,41771471,41941006&4201101408)+1 种基金the Shanghai Science and Technology Development Funds(Grant No.21ZR1469700)supported by the Central University Research Fund。
文摘The Antarctic Ice Sheet(AIS)has been losing ice mass and contributing to the rise in the global sea-level(GSL)for the last 4 decades,as quantified by using satellite observations.We developed a framework for implementing the state-of-the-art input-output(IO)method that has the advantage of explicit estimation of the mass balance of individual glaciers,basins and the continent.We estimated the mass balance of the AIS from 2013 to 2018 using improved observations and updated datasets recently made available,including annual ice flow velocity maps from the Inter-mission Time Series of Land Ice Velocity and Elevation(ITS_LIVE)dataset,the Bed Machine and the Princess Elizabeth Land(PEL)Earth System Science Data(ESSD)datasets,and the surface mass balance from the RACMO 2.3 system.For example,using the improved ice thickness data,the proposed method for ice discharge estimation enables a 10%reduction of uncertainty in ice discharge.During the period of 2013–2018,an ice discharge acceleration of 6.9±6.5 Gt yr^(–2)in West Antarctica(WA)was detected,which contributed significantly to the estimated mass loss of~1069 Gt(–178.2±108.9 Gt yr^(–1))in the AIS.On the other hand,Queen Maud Land,East Antarctica(EA),showed clearly a mass gain rate of 56.0±10.0 Gt yr^(–1)due to the regional increase in surface mass balance.Our results extended the estimation period by 3 years in comparison to the published study using the same annual velocity maps from the ITS_LIVE dataset.Furthermore,our results,along with those from other studies using the IO method,reassures the acceleration of recent mass loss in WA and Wilkes Land in EA,which are caused by glacier thinning and ice shelf basal melting.Compared with the long-term mass balance record since 1979,our results suggest that the mass loss in AIS accelerated in the last decade.The developed framework can be modified for mass balance estimation of the AIS or for other ice sheets by using velocity maps from other satellite data or from different periods.
