Intersection of two rare conditions:Clinical reflection on tuberous sclerosis combined with primary lymphedema

This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis complex(TSC)combined with primary lymphedema(PLE).Additionally,it retrospectively analyzes the data of 16 previously reported cases of children with TSC combined with PLE to summarize the epidemiology,genetic diagnosis,and current main treatments of these patients.The report also speculates on the pathological and physiological mechanisms underlying TSC combined with PLE.TSC combined with PLE is rare;therefore,the report provides a theoretical basis for understanding the pathophysiological mechanisms and treatment options for patients with TSC and PLE.Comprehensive clinical management of TSC is essential due to the diverse and multiorgan nature of its manifestations,often requiring a multidisciplinary approach for newly diagnosed cases.

基于文献计量学BSA在作物育种领域的应用现状与展望

为了解国内外集群分离分析法(bulked segregant analysis,BSA)在作物育种领域的研究现状与前沿动态,客观反映各国家、机构及研究人员在该领域的影响力,本文基于文献计量学分析方法使用文献计量分析软件CiteSpace对WOS(Web of Science)数据库2000~2023年2111项和CNKI(China National Knowledge Infrastructure)数据库2003~2023年446项研究成果进行关键词共现分析、突显词分析、关键词聚类分析、聚类时间线分析及作者共被引分析。结果表明:BSA在作物育种领域应用的研究成果在国内外的发文趋势相同,国内外期刊发文量均逐年上升;在发文量国家排序中,中国排名第一、美国第二、印度第三。在CNKI数据库中华中农业大学的发文量最多,而在WOS数据库中中国农业科学院的发文量最多。国外BSA在作物育种领域应用的文章主要集中在植物科学、农学、园艺学和遗传学等学科,而国内主要集中在作物学、植物保护学、园艺学、生物学等学科;Michlmore RW、Kosambi DD和Li H这3位作者在该领域的影响力最高,而Michlmore RW、Lander ES、Li H这3位作者与其他作者有更密切的联系。国内研究的热点作物和性状分别是水稻(Oryza sativa)、大豆(Glycine max)、玉米(Zea mays L.)和抗病性、株高;国外研究的热点作物和性状分别是水稻、拟南芥(Arabidopsis thaliana)、小麦(Triticum aestivum L.)和抗病性。目前,BSA在国内集中应用于作物目标性状候选基因及作物突变体突变基因的定位和功能验证,而国外则集中应用于作物目标性状基因的精细定位和功能验证及遗传机制的解析。此外,BSA在作物育种领域应用的研究前沿分析表明,未来在该领域热点研究的对象为水稻、花生(Arachis hypogaea L.)、陆地棉(Gossypium hirsutum L.)、作物突变体和作物代谢产物。

Ascertaining the influences of auxiliary qubits on the Einstein–Podolsky–Rosen steering and its directions

Einstein–Podolsky–Rosen(EPR) steering is an example of nontrivial quantum nonlocality and characteristic in the non-classical world.The directivity(or asymmetry) is a fascinating trait of EPR steering,and it is different from other quantum nonlocalities.Here,we consider the strategy in which two atoms compose a two-qubit X state,and the two atoms are owned by Alice and Bob,respectively.The atom of Alice suffers from a reservoir,and the atom of Bob couples with a bit flip channel.The influences of auxiliary qubits on EPR steering and its directions are revealed by means of the entropy uncertainty relation.The results indicate that EPR steering declines with growing time t when adding fewer auxiliary qubits.The EPR steering behaves as damped oscillation when introducing more auxiliary qubits in the strong coupling regime.In the weak coupling regime,the EPR steering monotonously decreases as t increases when coupling auxiliary qubits.The increases in auxiliary qubits are responsible for the fact that the steerability from Alice to Bob(or from Bob to Alice) can be more effectively revealed.Notably,the introductions of more auxiliary qubits can change the situation that steerability from Alice to Bob is certain to a situation in which steerability from Bob to Alice is certain.

Effects of foot reflexology on disease

In this article,we review a recently published article to explore the significance of foot reflexology in modern medical practice.With the advancement of modern medicine,we are increasingly committed to finding the specific physiological mechanisms of foot reflexes to treat diseases,thereby better proving the therapy’s effectiveness.It has been reported that foot reflexes can activate the cerebral cor-tex and organs corresponding to the feet,stimulating blood flow,nutrition and nerves through neural and endocrine regulation to achieve the purpose of treating and preventing diseases and promoting health.The therapy shows unique po-tential and value,and provides a new perspective on integrating traditional me-dicine and modern medicine.

高熔体流动性聚芳酯的合成及性能

通过相转移界面缩聚的方法,将4,4’-二乙基-1,1’-二苯基苯酚(BHPP)和2,2-双(4-羟基苯基)丙烷(BP A)、对苯二甲酰氯(TPC)以及间苯二甲酰氯(IPC)进行共聚,合成了一系列不同酰氯比例的含乙基侧基的聚芳酯(PABAs)。利用核磁共振和傅里叶变换红外光谱对BHPP单体及PABA系列聚芳酯的结构进行了表征。差示扫描量热法和热重分析结果表明,聚合物具有良好的热性能,其玻璃化转变温度(Tg)为183.7~209.9℃,初始分解温度高于436℃。拉伸测试结果表明聚合物薄膜的拉伸强度大于60 MPa,力学性能优异。同时通过流变测试表明所得聚芳酯具有优良的熔体流动性,乙基侧基的引入使其熔融加工性能得到较大提升。

Determination of the available energy values and amino acid digestibility of Flammulina velutipes stem waste and its effects on carcass trait and meat quality fed to growing-finishing pigs

Background:Flammulina velutipes stem waste(FVS)is the by-product of mushroom industry.The objectives of this study were to determine the available energy and amino acid digestibility of FVS fed to pigs,and to evaluate the effects of dietary FVS inclusion on growth performance,biochemical profile of serum,fecal short chain fatty acid(SCFA)concentration,carcass traits,meat quality,intestinal morphology and microflora of pigs.In Exp.1,twelve crossbred barrows with initial body weight(IBW)of 37.48±4.31 kg were randomly allotted to 2 dietary treatments,including a corn basal diet and an experimental diet containing 24.35%FVS.In Exp.2,twelve barrows fitted with an ileal T-cannula(IBW:32.56±1.67 kg)were randomly allotted to 2 dietary treatments,which included a N-free diet and an experimental diet containing 40.0%FVS.In Exp.3,ninety growing pigs(IBW:63.98±6.89 kg)were allotted to 1 of 3 treatment diets for 63 d,including a basal diet and 2 experimental diets with 2.5%and 5%FVS,respectively.Results:The digestible energy(DE)and metabolizable energy(ME)of FVS were 4.58 and 4.06 MJ/kg on dry matter basis,respectively,and the standardized ileal digestibility(SID)of indispensable AAs ranged from 17.50%to 59.47%.Pigs fed diets with 2.5%FVS showed no difference on average daily gain(ADG)and gain to feed ratio(G/F).Although dietary 5%FVS inclusion impaired apparent total tract digestibility(ATTD)of organic matter and gross energy,it elevated the SCFA concentration(P≤0.04)in gut and antioxidant capacity in serum.In addition,dietary FVS inclusion depressed the backfat thickness(P=0.03)in pigs.The longissimus dorsi muscle of pigs fed FVS revealed higher n-3 polyunsaturated fatty acid concentration and optimized fatty acid composition.Dietary 2.5%FVS inclusion also improved the intestinal development and health by increasing the villius height to crypt depth ratio(V/C)in jejunum(P<0.01),and promoting microbial diversity and beneficial microbiota proliferation.Conclusions:It is feasible to include moderate content of FVS as an unconventional fiber ingredient in diet of growingfinishing pigs.

Regeneration of Al-doped LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode material by simulated hydrometallurgy leachate of spent lithium-ion batteries

A uniform Al-doped LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode material was prepared using a coprecipitation method to take advantage of the positive effect of Al on regenerated NCM(Ni,Co,Mn)cathode materials and ameliorate cumbersome and high-cost impurity removal processes during lithium-ion battery recycling.When the Al^(3+) content in the leachate was 1 at.%with respect to the total amount of transition metals(Ni,Co,and Mn),the produced Al-doped NCM cathode material increased concentrations of lattice oxygen and Ni^(2+).The initial specific capacity at 0.1C was 167.4 mA·h/g,with a capacity retention of 79.1%after 400 cycles at 1C.Further,this Al-doped sample showed improved rate performance and a smaller electrochemical impedance.These findings provide a reference for developing industrial processes to resynthesize cathode materials with improved electrochemical performance by incorporating Al^(3+) impurities produced during lithium-ion battery recycling.

基于离子液体的超级电容在3 V及65℃老化条件下的铝碳界面效应

相比于传统乙腈电解液体系的超级电容器,离子液体基超级电容器具有工作窗口电压高,能量密度大,不可燃等优点,适用于碳中和时代清洁但不稳定电力领域的大规模储能。然而,目前的工作主要集中在对纽扣型离子液体-超级电容器的研究上,有关软包式离子液体-超级电容器的长循环寿命评测的报道较少。构建可靠的超级电容器用于长时间测试或在高温下开展加速老化测试,应考虑集流体/电极界面的良好接触,以最小化电荷转移电阻。本文以包覆不同碳层的泡沫铝为集流体,研究了超级电容器新系统中的碳-铝界面效应。通过环氧树脂薄膜碳化得到的均匀无定形碳层,相比通过PVDF粘附石墨烯碳层,赋予了铝相和碳相更强的相互作用。此外,为了充分挖掘大离子尺寸的离子液体电解液的潜力,本文采用介孔碳电极实现离子在介孔间的快速扩散。因此,本工作首次制备了由介孔碳电极、离子液体电解液和覆碳三维泡沫铝集流体组成的新结构软包式超级电容器。以自制的容量为37 F的不同软包式超级电容器件,通过3 V、65℃、500 h加速老化试验,研究了其时间依赖性的电化学性能,包括CV测试、恒流充放电测试、电容值、接触电阻、电化学阻抗谱等。相比石墨烯包覆的泡沫铝基器件,无定形碳层包覆的泡沫铝基器件表现出更高的电容保持率。此外,我们还对ESR进行了等效电路拟合,并深入分析了接触电阻、电荷转移电阻、韦伯电阻,研究了C-Al界面对高能量密度超级电容器的高性能和稳定性的影响。500小时老化测试前后的极片表征证实了上述结果。高温、高压条件使粘附石墨烯碳层的泡沫铝界面结构不可靠。而泡沫铝表面原位包覆的碳层在老化过程中表现出较强的相互作用和稳定的结构。这些坚实的数据为面向高能量密度、高功率密度和长循环寿命,进一步优化高窗口电压超级电容器提供了充足的信息。

大剂量呋塞米持续静脉泵入治疗老年重度心力衰竭患者的疗效分析

目的观察大剂量呋塞米持续静脉泵入对老年重度心力衰竭患者心功能的影响及疗效分析。方法选取2018年3月—2020年5月青岛阜外心血管病医院收治的重度心力衰竭患者50例。采用随机数字表法将患者分为治疗组与对照组,各25例。对照组给予常规药物治疗,治疗组在对照组基础上首次给予呋塞米40 mg/h微量泵入治疗,再以10 mg/h的速度持续静脉泵入200 mg呋塞米,观察两组患者治疗后临床疗效、症状改善时间、心功能指标及不良反应发生情况。结果治疗组临床总有效率高于对照组(P<0.05)。治疗组气促缓解时间、水肿消退时间短于对照组(P<0.05)。治疗组治疗前后左心室射血分数、心率、每搏心输出量及左心室舒张末期内径的差值大于对照组(P<0.05)。治疗组不良反应总发生率低于对照组(P<0.05)。结论大剂量呋塞米持续静脉泵入治疗重度心力衰竭疗效显著,可有效促进患者临床症状的改善,有利于提高心功能,降低药物不良反应,值得临床推广并应用。

Analysis of an improved acquisition method for high-dynamic BOC signal

To reach a compromise between short acquisition time and excellent detection probability for the high-dynamic binary offset carrier (BOC) signal, an overall algorithm based on discrete polynomial-phase transform (DPT) and partial matching filter (PMF)-fast Fourier transform (FFT) algorithm is given. The high order items of received signals are removed by the method of DPT, and the PMF-FFT algorithm is redesigned for the BOC signal. The simulation experiments and theoretical analyses verify that the improved algorithm has attained improvement in acquisition performance. © 2016 Beijing Institute of Aerospace Information.

A case of thyroid emergency with cardiac arrest supported by extracorporeal membrane oxygenation

Dear editor,Thyroid emergency is a rare but potentially life-threatening condition if not recognized early and managed properly.It is usually due to a severe exacerbation of a preexisting thyrotoxicosis,which later leads to decompensation in different organ systems.The treatment of thyroid emergency remains challenging even with the armamentarium of modern intensive care technologies,especially in patients with cardiac

Theory Study and Application of the BP-ANN Method for Power Grid Short-Term Load Forecasting

Aiming at the low accuracy problem of power system short-term load forecasting by traditional methods, a back-propagation artificial neural network （BP-ANN） based method for short-term load forecasting is presented in this paper. The forecast points are related to prophase adjacent data as well as the periodical long-term historical load data. Then the short-term load forecasting model of Shanxi Power Grid （China） based on BP-ANN method and correlation analysis is established. The simulation model matches well with practical power system load, indicating the BP-ANN method is simple and with higher precision and practicality.

Similarities and Differences of Early Pulmonary CT Features of Pneumonia Caused by SARS-CoV-2, SARS-CoV and MERS-CoV: Comparison Based on a Systemic Review

Objective To compare the similarities and differences of early CT manifestations of three types of viral pneumonia induced by SARS-CoV-2(COVID-19),SARS-CoV(SARS)and MERS-CoV(MERS)using a systemic review.Methods Electronic database were searched to identify all original articles and case reports presenting chest CT features for adult patients with COVID-19,SARS and MERS pneumonia respectively.Quality of literature and completeness of presented data were evaluated by consensus reached by three radiologists.Vote-counting method was employed to include cases of each group.Data of patients’manifestations in early chest CT including lesion patterns,distribution of lesions and specific imaging signs for the three groups were extracted and recorded.Data were compared and analyzed using SPSS 22.0.Results A total of 24 studies were included,composing of 10 studies of COVID-19,5 studies of MERS and 9 studies of SARS.The included CT exams were 147,40,and 122 respectively.For the early CT features of the 3 pneumonias,the basic lesion pattern with respect to"mixed ground glass opacity(GGO)and consolidation,GGO mainly,or consolidation mainly"was similar among the 3 groups(χ^2=7.966,P>0.05).There were no significant differences on the lesion distribution(χ^2=13.053,P>0.05)and predominate involvement of the subpleural area of bilateral lower lobes(χ^2=4.809,P>0.05)among the 3 groups.The lesions appeared more focal in COVID-19 pneumonia at early phase(χ^2=23.509,P<0.05).The proportions of crazy-paving pattern(χ^2=23.037,P<0.001),organizing pneumonia pattern(P<0.05)and pleural effusions(P<0.001)in COVID-19 pneumonia were significantly lower than the other two.Although rarely shown in the early CT findings of all three viral pneumonias,the fibrotic changes were more frequent in SARS than COVID-19 and MERS(χ^2=6.275,P<0.05).For other imaging signs,only the MERS pneumonia demonstrated tree-in-buds,cavitation,and its incidence rate of interlobular or intralobular septal thickening presented significantly increased as compared to the other two pneumonia(χ^2=22.412,P<0.05).No pneumothorax,pneumomediastinum and lymphadenopathy was present for each group.Conclusions Imaging findings on early stage of these three coronavirus pneumonias showed similar basic lesion patterns,including GGO and consolidation,bilateral distribution,and predominant involvement of the subpleural area and the lower lobes.Early signs of COVID-19 pneumonia showed less severity of inflammation.Early fibrotic changes appeared in SARS only.MERS had more severe inflammatory changes including cavitation and pleural effusion.The differences may indicate the specific pathophysiological processes for each coronavirus pneumonia.

Dissolution-precipitation mechanism of self-propagating high-temperature synthesis of TiC-Cu cermets

The mechanism of self-propagating high-temperature synthesis （SHS） of TiC-Cu cermets was studied using a combustion front quenching method. Microstructural evolution in the quenched sample was observed using scanning electron microscope （SEM） with energy dispersive X-ray （EDX） spectrometry, and the combustion temperature was measured. The results showed that the combustion reaction started with local formation of Ti-Cu melt and could be described with the dissolution-precipitation mechanism, namely, Ti, Cu, and C particles dissolved into the Ti-Cu solution and TiC particles precipitated in the saturated Ti-Cu-C liquid solution. The local formation of Ti-Cu melt resulted from the solid diffusion between Ti and Cu particles.

Fabrication of segregated poly(arylene sulfide sulfone)/graphene nanoplate composites reinforced by polymer fibers for electromagnetic interference shielding

Poly(arylene sulfide sulfone)/graphene nanoplate(PASS/GNP) composites with segregated structure based on continuous polymer fiber skeletons were fabricated by coating a thin conductive layer on the PASS fibers and then performing compression molding. The formation of a unique segregated conductive network endowed the PASS/GNP composites with high electrical conductivity and excellent electromagnetic interference(EMI) shielding effectiveness(SE), reaching 17.8 S/m and 30.1 d B, respectively, when the content of the GNPs in the conductive layer was 20 wt%. The PASS/GNP composites also exhibited outstanding mechanical properties, which was attributed to the continuous PASS fiber skeletons that could withstand large loads and the strong interfacial interaction between the conductive layers and the PASS fibers that could provide good stress transfer. This approach is suitable for most soluble polymers.

A Thermochromic, Viscoelastic Nacre-like Nanocomposite for the Smart Thermal Management of Planar Electronics

Cutting-edge heat spreaders for soft and planar electronics require not only high thermal conductivity and a certain degree of flexibility but also remarkable self-adhesion without thermal interface materials, elasticity, arbitrary elongation along with soft devices, and smart properties involving thermal self-healing, thermochromism and so on. Nacre-like composites with excellent in-plane heat dissipation are ideal as heat spreaders for thin and planar electronics. However, the intrinsically poor viscoelasticity, i.e., adhesion and elasticity, prevents them from simultaneous self-adhesion and arbitrary elongation along with current flexible devices as well as incurring high interfacial thermal impedance. In this paper, we propose a soft thermochromic composite(STC) membrane with a layered structure, considerable stretchability, high in-plane thermal conductivity(~30 Wm^(-1) K^(-1)), low thermal contact resistance(~12 mm^2 KW^(-1), 4–5 times lower than that of silver paste), strong yet sustainable adhesion forces(~4607 Jm^(-2), 2220 Jm^(-2) greater than that of epoxy paste) and self-healing efficiency. As a self-adhesive heat spreader, it implements efficient cooling of various soft electronics with a temperature drop of 20℃ than the polyimide case. In addition to its self-healing function, the chameleon-like behavior of STC facilitates temperature monitoring by the naked eye, hence enabling smart thermal management.

Synthesis,Characterization and Electromagnetic Studies on Nanocrystalline Co_(0.5)Zn_(0.5)Fe_2O_4 Synthesized by Polyacrylamide Gel

Nanocrystalline Co0.5Zn0.5Fe2O4 ferrite was synthesized by polyacrylamide gel method. The electromagnetic and microwave absorption properties of the ferrite were investigated. The results indicated that calcining temperature of the ferrite had a significant influence on the effective properties of the ferrite. When the calcining temperature was 500, 600 and 700℃, the average size of particles was 10, 30 and 80 nm, respectively. The dielectric loss （ε″） and magnetic loss （μ″） of the ferrite was around 0.65 and 0.29 at 8.2 GHz, respectively. Microwave absorption properties of the ferrites were simultaneously influenced due to the strong correlation between reflection loss and electromagnetic parameters of the ferrite.

Pancake-Like MOF Solid-State Electrolytes with Fast Ion Migration for High-Performance Sodium Battery

Solid-state electrolyte(SSE)of the sodium-ion battery have attracted tremendous attention in the next generation energy storage materials on account of their wide electrochemical window and thermal stability.However,the high interfacial impedance,low ion transference number and complex preparation process restrict the application of SSE.Herein,inspired by the excellent sieving function and high specific surface area of red blood cells,we obtained a solid-like electrolyte(SLE)based on the combination of the pancake-like metal-organic framework(MOF)with liquid electrolyte,possessing a high ionic conductivity of 6.60×10^(-4) S cm^(−1),and excellent sodium metal compatibility.In addition,we investigated the ion restriction effect of MOF’s apertures size and special functional groups,and the ion transference number increased from 0.16 to 0.33.Finally,the assembled Na_(0.44)MnO_(2)//SLE//Na full batteries showed no obvious capacity decrease after 160 cycles.This material design of SLE in our work is an important key to obtain fast ion migration SLE for high-performance sodium-ion batteries.

Perfect pair,scopes unite—laparoscopic-assisted transumbilical gastroscopy for gallbladder-preserving polypectomy:A case report

BACKGROUND Gallbladder polyps are one indication for cholecystectomy,but this procedure carries some disadvantages,including the potential for severe injury and high risk of post-operative complications.Laparoscopy combined with endoscopic surgery is a minimally invasive treatment option.We herein report a young patient with a gallbladder polyp who was successfully discharged from the hospital after laparoscopic-assisted endoscopy.This procedure may offer an alternative in the management of such lesions.CASE SUMMARY A 24-year-old female patient was hospitalized primarily for a gallbladder polyp.Due to the surgical risk associated with cholecystectomy and the low postoperative quality of life,the woman underwent laparoscopic-assisted transumbilical gastroscopy for gallbladder-preserving polypectomy under endotracheal intubation and general anaesthesia.The operation went smoothly.CONCLUSION We conclude laparoscopic-assisted transumbilical gastroscopy for gallbladderpreserving polypectomy is a safe and effective technique for the treatment of gallbladder polyps.

Novel compound heterozygous GPR56 gene mutation in a twin with lissencephaly:A case report

BACKGROUND Lissencephaly(LIS)is a malformation of cortical development with broad gyri,shallow sulci and thickened cortex characterized by developmental delays and seizures.Currently,20 genes have been implicated in LIS.However,GRP56-related LIS has never been reported.GRP56 is considered one of the causative genes for bilateral frontoparietal polymicrogyria.Here,we report a twin infant with LIS and review the relevant literature.The twins both carried the novel compound heterozygous GPR56 mutations.CASE SUMMARY A 5-mo-old female infant was hospitalized due to repeated convulsions for 1 d.The patient had a flat head deformity that manifested as developmental delays and a sudden onset of generalized tonic-clonic seizures at 5 mo without any causes.The electroencephalography was normal.Brain magnetic resonance imaging revealed a simple brain structure with widened and thickened gyri and shallow sulci.The white matter of the brain was significantly reduced.Patchy long T1 and T2 signals could be seen around the ventricles,which were expanded,and the extracerebral space was widened.Genetic testing confirmed that the patient carried the GPR56 gene compound heterozygous mutations c.228delC(p.F76fs)and c.1820_1821delAT(p.H607fs).The unaffected father carried a heterozygous c.1820_1821delAT mutation,and the unaffected mother carried a heterozygous c.228delC mutation.The twin sister carried the same mutations as the proband.The patient was diagnosed with LIS.CONCLUSION This is the first case report of LIS that is likely caused by mutations of the GPR56 gene.