Today’s link prediction methods are based on the network structure using a single-channel approach for prediction,and there is a lack of link prediction algorithms constructed from a multichannel approach,which makes...Today’s link prediction methods are based on the network structure using a single-channel approach for prediction,and there is a lack of link prediction algorithms constructed from a multichannel approach,which makes the features monotonous and noncomplementary.To address this problem,this paper proposes a link prediction algorithm based on multichannel structure modelling(MCLP).First,the network is sampled three times to construct its three subgraph structures.Second,the node representation vectors of the network are learned separately for each subgraph on a single channel.Then,the three node representation vectors are combined,and the similarity matrix is calculated for the combined vectors.Finally,the performance of the MCLP algorithm is evaluated by calculating the AUC using the similarity matrix and conducting multiple experiments on three citation network datasets.The experimental results show that the proposed link prediction algorithm has an AUC of 98.92%,which is better than the performance of the 24 link prediction comparison algorithms used in this paper.The experimental results sufficiently prove that the MCLP algorithm can effectively extract the relationships between network nodes,and confirm its effectiveness and feasibility.展开更多
Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact material.Elucidating the anti-arc erosion mechanism of the MAX phase is crucial for furt...Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact material.Elucidating the anti-arc erosion mechanism of the MAX phase is crucial for further improving performance,but it is not well-understood.In this study,Ag/Ti_(3)AlC_(2) electrical contact material was synthesized by powder metallurgy and examined by nanoindentation techniques such as constant loading rate indentation,creep testing,and continuous stiffness measurements.Our results indicated a gradual degradation in the nano-mechanical properties of the Ti_(3)AlC_(2) reinforcing phase with increasing arc erosion times,although the rate of this degradation appeared to decelerate over arc erosion times.Specifically,continuous stiffness measurements highlighted the uneven mechanical properties within Ti_(3)AlC_(2),attributing this heterogeneity to the phase’s decomposition.During the early(1-100 times)and intermediate(100-1000 times)stages of arc erosion,the decline in the nano-mechanical properties of Ti_(3)AlC_(2) was primarily ascribed to the decomposition of Ti_(3)AlC_(2) and limited surface oxidation.During the later stage of arc erosion(1000-6200 times),the inner region of Ti_(3)AlC_(2) also sustained arc damage,but a thick oxide layer formed on its surface,enhancing the mechanical properties and overall arc erosion resistance of the Ag/Ti_(3)AlC_(2).展开更多
Bone is a common organ affected by metastasis in various advanced cancers,including lung,breast,prostate,colorectal,and melanoma.Once a patient is diagnosed with bone metastasis,the patient’s quality of life and over...Bone is a common organ affected by metastasis in various advanced cancers,including lung,breast,prostate,colorectal,and melanoma.Once a patient is diagnosed with bone metastasis,the patient’s quality of life and overall survival are significantly reduced owing to a wide range ofmorbidities and the increasing difficulty of treatment.Many studies have shown that bone metastasis is closely related to bone microenvironment,especially bone immune microenvironment.However,the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear.Here,we described the changes in various immune cells during bone metastasis and discussed their related mechanisms.Osteoblasts,adipocytes,and other non-immune cells closely related to bone metastasis were also included.This review also summarized the existing treatment methods and potential therapeutic targets,and provided insights for future studies of cancer bone metastasis.展开更多
基金This article was supported by the National Key Research and Development Program of China(No.2020YFC1523300)the Innovation Platform Construction Project of Qinghai Province(2022-ZJ-T02).
文摘Today’s link prediction methods are based on the network structure using a single-channel approach for prediction,and there is a lack of link prediction algorithms constructed from a multichannel approach,which makes the features monotonous and noncomplementary.To address this problem,this paper proposes a link prediction algorithm based on multichannel structure modelling(MCLP).First,the network is sampled three times to construct its three subgraph structures.Second,the node representation vectors of the network are learned separately for each subgraph on a single channel.Then,the three node representation vectors are combined,and the similarity matrix is calculated for the combined vectors.Finally,the performance of the MCLP algorithm is evaluated by calculating the AUC using the similarity matrix and conducting multiple experiments on three citation network datasets.The experimental results show that the proposed link prediction algorithm has an AUC of 98.92%,which is better than the performance of the 24 link prediction comparison algorithms used in this paper.The experimental results sufficiently prove that the MCLP algorithm can effectively extract the relationships between network nodes,and confirm its effectiveness and feasibility.
基金supported by the National Natural Science Foundation of China(52101064,52171033)Jiangsu Planned Projects for Postdoctoral Research Funds(2020Z158)Natural Science Foundation of Jiangsu Province(BK20220627).
文摘Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact material.Elucidating the anti-arc erosion mechanism of the MAX phase is crucial for further improving performance,but it is not well-understood.In this study,Ag/Ti_(3)AlC_(2) electrical contact material was synthesized by powder metallurgy and examined by nanoindentation techniques such as constant loading rate indentation,creep testing,and continuous stiffness measurements.Our results indicated a gradual degradation in the nano-mechanical properties of the Ti_(3)AlC_(2) reinforcing phase with increasing arc erosion times,although the rate of this degradation appeared to decelerate over arc erosion times.Specifically,continuous stiffness measurements highlighted the uneven mechanical properties within Ti_(3)AlC_(2),attributing this heterogeneity to the phase’s decomposition.During the early(1-100 times)and intermediate(100-1000 times)stages of arc erosion,the decline in the nano-mechanical properties of Ti_(3)AlC_(2) was primarily ascribed to the decomposition of Ti_(3)AlC_(2) and limited surface oxidation.During the later stage of arc erosion(1000-6200 times),the inner region of Ti_(3)AlC_(2) also sustained arc damage,but a thick oxide layer formed on its surface,enhancing the mechanical properties and overall arc erosion resistance of the Ag/Ti_(3)AlC_(2).
基金National Natural Science Foundation of China,Grant/Award Numbers:82173089,82073332,82073142Natural Science Foundation of Zhejiang Province,Grant/Award Numbers:LY21H100004,LY19H160050+1 种基金Medical Science and Technology Project of Zhejiang Province,Grant/Award Number:2021RC063Chinese Society of Clinical Oncology,Grant/Award Numbers:Y-2020Sciclone/ms-0099,Y-2019Sciclone-019。
文摘Bone is a common organ affected by metastasis in various advanced cancers,including lung,breast,prostate,colorectal,and melanoma.Once a patient is diagnosed with bone metastasis,the patient’s quality of life and overall survival are significantly reduced owing to a wide range ofmorbidities and the increasing difficulty of treatment.Many studies have shown that bone metastasis is closely related to bone microenvironment,especially bone immune microenvironment.However,the effects of various immune cells in the bone microenvironment on bone metastasis remain unclear.Here,we described the changes in various immune cells during bone metastasis and discussed their related mechanisms.Osteoblasts,adipocytes,and other non-immune cells closely related to bone metastasis were also included.This review also summarized the existing treatment methods and potential therapeutic targets,and provided insights for future studies of cancer bone metastasis.