Effects of confining pressure and temperature on strength and deformation behavior of frozen saline silty clay

Buildings are always affected by frost heave and thaw settlement in cold regions,even where saline soil is present.This paper describes the triaxial testing results of frozen silty clay with high salt content and examines the in-fluence of confining pressure and temperature on its mechanical characteristics.Conventional triaxial compression tests were conducted under different confining pressures(0.5–7.0 MPa)and temperatures(-6℃,-8℃,-10℃,and-12℃).The test results show that when the confining pressure is less than 1 MPa,the frozen saline silty clay is dominated by brittle behavior with the X-shaped dilatancy failure mode.As the confining pressure increases,the sample gradually transitions from brittle to plastic behavior.The strength of frozen saline silty clay rises first and then decreases with increasing confining pressure.The improved Duncan-Chang hyperbolic model can describe the stress-strain relationship of frozen saline silty clay.And the parabolic strength criterion can be used to describe the strength evolution of frozen saline silty clay.The function relation of strength parameters with temperature is obtained by fitting,and the results of the parabolic strength criterion are in good agreement with the experimental results,especially when confining pressure is less than 5 MPa.Therefore,the study has important guiding significance for design and construction when considering high salinity soil as an engineering material in cold regions.

Thermal influence of ponding and buried warm-oil pipelines on permafrost: a case study of the China-Russia Crude Oil Pipeline

Buried pipelines are widely used for transporting oil in remote cold regions. However, the warm oil can induce considerable thermal influence on the surrounding frozen soils and result in severe maintenance problems. This paper presents a case study of the thermal influence of ponding and buried warm-oil pipelines on permafrost along the China-Russia Crude Oil Pipeline(CRCOP) in Northeast China. Since its operation in 2011, the operation of the warm-oil pipelines has led to rapid warming and thawing of the surrounding permafrost and development of sizable ponding along the pipeline route,which, in return, exacerbates the permafrost degradation. A field study was conducted along a 400-km long segment of the CRCOP in permafrost regions of Northeast China to collect the location and size information of ponding. A two-dimensional heat transfer model coupled with phase change was established to analyze the thermal influence of ponding and the operation of warm-oil pipelines on the surrounding permafrost. In-situ measured ground temperatures from a monitoring site were obtained to validate the numerical model. The simulation results show that ponding accelerates the development of the thaw bulb around the pipeline. The maximum thaw depth below the pipeline increases from 4 m for the case without ponding to 9 m for the case with ponding after 50 years of operation, and ponding directly above the pipe induces the maximum thaw depth. Engineering measures should be adopted to control the size or even eliminate surface water-rich ponding for the long-term performance of buried warm-oil pipelines.

Centrifuge model test on performance of thermosyphon cooled sandbags stabilizing warm oil pipeline buried in permafrost

The thaw settlement of pipeline foundation soils in response to the operation of the first China-Russia Crude Oil Pipeline along the eastern flank of the northern Da Xing'anling Mountains in Northeast China was simulated in a physical model test(with a similitude ratio of 1/73) in a geotechnical centrifuge. Two pipes of a supported and an unsupported section were evaluated over a testing period for simulating 20 years of actual pipeline operation with seasonal cyclically changing oil and ambient temperatures. The results show that pipe settlement of the supported pipe was 45% of settlement of the unsupported pipe. Settlement for the unsupported section was approximately 35% of the thaw bulb depth below the initial pipe elevation, only 30% of that for the supported pipe due to the influence of the supports. The final thaw bulbs extended approximately 3.6 and 1.6 times of the pipe diameter below the unsupported and supported pipe bottom elevations, respectively. The sandbag supports kept frozen during the test period because of cooling effect of the thermosyphons. The maximum bending stress induced over the 20 m span length from bearing of the full cover over the pipe would be equivalent to40% specified minimum yield strength(SMYS). Potential buckling of the pipe should be considered as the ground thaws.This study also offers important data for calibration and validation of numerical simulation models.

Relationship between ponding and topographic factors along the China-Russia Crude Oil Pipeline in permafrost regions

The original landform along the China Russia Crude Oil Pipeline(CRCOP,line 2)was disturbed during installation of pavement for the pipeline.Forest and vegetation coverage is dense,and runoff develops along the pipe.Since the opera tion of the CRCOP(line 2)began in 2018,ponding has appeared on both sides of the pipeline.If there is no drainage,ponding can hardly dissipate,due to the low permeability of the permafrost layer.With the supply of surface flow and the transportation of oil at positive temperatures,ponding promotes an increase in temperature and changes the boundary ther mal conditions of the pipeline.Meanwhile,when the ponding freezes and thaws,frost heave threatens operational safety of the pipeline.Furthermore,the ponding can affect the thermal condition of line 1.In this paper,the distribution of pond ing along the CRCOP was obtained by field investigation.The type and cause of ponding were summarized,and the catch ment and stream order were extracted by the Digital Elevation Model(DEM).According to the statistical results in attri butes for topographic factors,it is known that ponding along the pipeline is relative to elevation,slope,aspect,and the Topographic Wetness Index(TWI).Water easily accumulates at altitudes of 300450 m,slopes within 3°5°,aspect in the northeast or south,TWI within 1316,flow direction in north east south,and flow length within 90150 km.This paper proposes a theoretical basis for the cause and characteristics of ponding along the pipeline.

Application study of the awning measure to obstruct solar radiation in permafrost regions on the Qinghai-Tibet Plateau

With globe warming, road safety will change dramatically, especially within the Qinghai-Tibet Plateau permafrost regions. Because of higher elevation and better almospheric transparency, the Qinghai-Tibet Plateau has stronger radiation than other regions, which can change the daily variation of ground surface temperature on the Plateau. The awning measure （shading board） is one of the actively protected permafrost measures, which was adopted along the Qinghai-Tibet railway and highway and the Qing-Kang Highway in China. Field test results show that embankment surface month mean net radiation is 60-130 W/m2, but the value is below 20 W/m2 under the shading board, and the reducing level of naRn-al net radiation is 80%-90%. The shading board reduced the heat flow entering into the embankment by 80%,90% or more, with heat entering into the soil on the common embankment, but emitting from the embankment under the shading board. At the same time, ground surface temperature under the shading board is 6-8 ℃ lower than the exposed embankment. Test results show that the shading board measure can rapidly and effectively reduce net radiation and heat flow into the embankment, decrease embankment surface and interior temperature, effectively delay increase rate of soil temperature under globe warming, ensure stability and safety of the embankment, and guarantee unblocked road projects in cold and permafrost regions.

Effect of the frozen layer on the stability of cut soil slopes during seasonal freezing and thawing

Research on the stability of soil slopes in seasonally frozen regions has mainly focused on slope failures during the thawing window.There are few studies on slope stability during the freezing window and its subsequent influence on slope failure in the next thawing window.In this paper,soil strength was tested during freezing and thawing to obtain temperature-dependent strength parameters for the simulation of slope stability.Then,the slope's temperature field over an entire year was accurately simulated so that characteristics of the frozen layer could be determined at any time.Based on the above results,the progressive failure modes of frozen soil slopes are discussed.The results show that:1)during the freezing window,depth of the frozen soil layer increases,as does the slope's safety factor,while a yield zone propagates towards the slope shoulder.(2)During the thawing window,the frozen soil layer shrinks in depth while the yield zone continuously expands,which decreases the safety factor.Comprehensive analysis of these results indicate that the frozen layer provides a“toe-locking effect”that increases the safety factor during the freezing window,while it also provides a“dragging effect”that propagates the yield zone towards the slope shoulder.During the thawing window,the“toe-locking effect”gradually diminishes;a continuous sliding surface is formed,which lead to a landslide.The frozen soil layer of the freezing window accelerates the slope sliding in the thawing window.

Extracting water body data based on SDWI and threshold segmentation:A case study in permafrost area surrounding Salt Lake in Hoh Xil,Qinghai-Tibet Plateau,China

There are a large number of lakes,rivers,and other natural water bodies distributed in the permafrost area of the Qinghai-Tibet Plateau(QTP).The changes in water bodies will affect the distribution of water resources in sur-rounding areas and downstream areas,resulting in environmental impact and bringing potential flood disasters,which will induce more serious issues and problems in alpine and high-altitude areas with a fragile habitat(such as the QTP in China).Generally,effective,reasonable,and scientific monitoring of large-scale water bodies can not only document the changes in water bodies intuitively,but also provide important theoretical reference for subsequent environmental impact prediction,and disaster prevention and mitigation in due course of time.The large-scale water extraction technology derived from the optical remote sensing(RS)image is seriously affected by clouds,bringing about large differences among the extracted water result products.Synthetic aperture radar(SAR)RS technology has the unique advantage characteristics of all-weather,all-day,strong penetration,and not being affected by clouds,which is hopeful in extracting water body data,especially for days with cloudy weather.The data extraction of large-scale water bodies based on SAR images can effectively avoid the errors caused by clouds that become prevalent at present.In this paper,the Hoh Xil Salt Lake on the QTP and its surrounding five lakes are taken as the research objects.The 2-scene Sentinel-1 SAR image data covering the whole area on 22 August 2022 was used to verify the feasibility of extracting water body data in permafrost zones.Furthermore,on 22 August 2022,the wealth here was cloudy,which made the optical RS images,e.g.,Sentinel-2 images full of clouds.The results show that:using the Sentinel-1 image and threshold segmentation method to extract water body data is efficient and effective with excellent results in permafrost areas.Concretely,the Sentinel-1 dual-polarized water index(SDWI),calculated by combining dual vertical–vertical(VV)polarized and verti-cal–horizontal(VH)polarized data is a useful index for water extraction and the result is better than each of the VV or VH polarized images.

Inconsistency of changes in uniaxial compressive strength and P-wave velocity of sandstone after temperature treatments

It is generally accepted that the uniaxial compressive strength(UCS)and P-wave velocity of rocks tend to decrease simultaneously with increasing temperature.However,based on a great number of statistical data and systematic analysis of the microstructure variation of rocks with temperature rising and corresponding propagation mechanism of elastic wave,the results show that(1)There are three different trends for the changes of UCS and P-wave velocity of sandstone when heated from room temperature(20C or 25C)to 800C:(i)Both the UCS and P-wave velocity decrease simultaneously;(ii)The UCS increases initially and then decreases,while the P-wave velocity decreases continuously;and(iii)The UCS increases initially and then fluctuates,while the P-wave velocity continuously decreases.(2)The UCS changes at room temperaturee400C,400Ce600C,and 600Ce800C are mainly attributed to the discrepancy of microstructure characteristics and quartz content,the transformation plasticity of clay minerals,and the balance between the thermal cementation and thermal damage,respectively.(3)The inconsistency in the trends of UCS and P-wave velocity changes is caused by the change of quartz content,phase transition of water and certain minerals.

Processes and mechanisms of multi-collapse of loess roads in seasonally frozen ground regions: A review

Usually, the collapsible loess widely distributed across the world can serve as a type of foundation soil that meets its strength requirement after dense compaction and elimination of collapsibility. However, many problems such as cracks and differential settlement still occur in loess roads in the seasonally frozen ground regions after several years of op- eration. Many studies have demonstrated that these secondary or multiple collapses primarily result from the repeated freezing-thawing, wetting-drying, and salinization-desalinization cycles. Therefore, we conducted a research program to （1） monitor the in-situ ground temperatures and water content in certain loess roads to understand their changes, （2） study the effects of freezing-thawing, wetting-drying, and salinization-desalinization cycles on geotechnical properties and micro-fabrics of compacted loess in the laboratory, and （3） develop mitigative measures and examine their engineered effectiveness, i.e., their thermal insulating and water-proofing effects in field and laboratory tests. Our results and advances are reviewed and some further research needs are proposed. These findings more clearly explain the processes and mechanisms of secondary and multiple collapse of loess roads. We also offer references for further study of the weakening mechanisms of similar structural soils.

Definition of failure criterion for frozen soil under directional shear-stress path

A series of directional shear tests on remolded frozen soil was carried out at 10°C by using a hollow cylinder apparatus to study failure criterion under a directional shear-stress path.Directional shear tests were conducted at five shear rates(10,20,30,40,and 50 kPa/min)and five intermediate principal stress coefficients(b=0,0.25,0.5,0.75,and 1),with the mean principal stress(p=4.5 MPa)kept constant.The results show that the torsional strength and the generalized strength both increase with the increase of the shear rates.According to the failure modes of frozen soil under different shear rates,the specimens present obvious plastic failure and shear band;and the torsional shear component dominates the failure modes of hollow cylindrical specimens.A shear rate of 30 kPa/min is chosen as the loading rate in the directional shear tests of frozen soil.The shape of the failure curve in theπplane is dependent on the directional anglesαof the major prin cipal stress.It is reasonable to use the strain-hardening curves to define the deviatoric stress value atγg=15%(generalized shear strain)as the failure criterion of frozen soil under a directional shear-stress path.

Therapeutic Effect and Mechanism of Caulophyllum robustum Maxim Extract on Adjuvant Arthritis Rats

[Objectives]To study the anti-inflammation and anti-swelling effect of Caulophyllum robustum Maxim( CRM) extract on secondary lesions of adjuvant arthritis( AA),associated inflammatory factors of AA rats and mice immune function. [Methods]Rats were divided into high,middle and low dose CRM extract groups( 69. 23,34. 61,17. 31 mg/kg),methotrexate group( 0. 68 mg/kg),triptolide group( 7. 88 mg/kg),model group and normal control group. The AA rat model was induced by intradermal injection of Freund's complete adjuvant( FCA). After the AA model was established successfully,the paw swelling of AA rats was observed and recorded. The levels of interleukin-1β( IL-1β),interleukin-4( IL-4),interleukin-10( IL-10),Tumor Necrosis Factor-α( TNF-α),interleukin 17( IL-17),interferon( IFN-γ),granulocyte colony-stimulating factor( G-CSF) and transforming growth factor( TGF-β) in the serum of AA rats were detected by enzyme-linked immunosorbent assay( ELISA). The spleen was removed and weighed for detecting the drug influence on the immune organs.Impacts were observed by gavage administration at different dosages of 25 mg/kg,50 mg/kg,100 mg/kg for seven days,adopting carbon granules clearance test,delayed-type hypersensitivity induced by dinitrofluorobenzene( DNFB) coupled with flow cytometry evaluating lymphocytes( CD3^+,CD4^+,CD8^+) activation and serolysin test. [Results] Compared with the model group,the joint swelling,spleen index and inflammatory cytokines( IL-1β,IL-4,IL-10,TNF-α,IL-17,IFN-γ,G-CSF,TGF-β) were reduced significantly( P < 0. 05,P < 0. 01). And the activity of CRM was significantly superior to methotrexate and triptergium. Moreover,the results indicated that different dosages of 25 mg/kg,50 mg/kg,100 mg/kg of CRM could significantly reduce the carbon granules clearance index( K) and phagocytic index( a),inhibit the phagocytosis of mononuclear macrophages,reduce the mice swelling extent and inhibit DTH in mice induced by DNFB,decrease the quantity of serum hemolysin. Percentage of CD3^+,CD4^+,and the ratio of CD4^+,CD8^+ notably decreased,whereas CD8^+ obviously increased. Intragastrica dose of 50 mg/kg,100 mg/kg were acknowledged as more objective inhibiting effect compared with a dosage of 25 mg/kg.[Conclusions] Decreasing inflammatory cytokines content,non-specific immune,humoral immune and cellular immune function may be the therapeutic mechanism for rheumatoid arthritis( RA).

A semi-analytical solution for frost heave prediction of clay soil

Frost heave is one of the main freezing problems for construction in permafrost regions.The Konrad-Morgenstern segregation potential（SP） model is being used in practice for frost heave using numerical techniques.However,the heat release from in-situ and migrated water in the freezing zone could result in some numerical instability,so the simulation of frost fringe is not ideal.In this study,a semi-analytical solution is developed for frost heave prediction of clay soil.The prediction results to the two tests with different freezing mode with clay soil agree well with the tested behavior,which indicates the feasibility of the solution.

Diagnosis and treatment of inflammatory breast cancer

Inflammatory breast cancer(IBC)is a rare disease in clinic,with rapid progression and poor prognosis.It is easy to be misdiagnosed in cases of atypical clinical symptoms and imaging findings.Combined with the medical record of IBC in our hospital,the author explores the causes of misdiagnosis of inflammatory breast cancer,based on clinical manifestations,diagnosis,imaging examination,treatment and so on,so as to improve the clinical physicians understanding and diagnosis of this disease.

自组装纳米抗菌肽的设计策略及应用

细菌感染,特别是耐药菌感染,是人类公共卫生的最大威胁之一.与传统抗生素相比,抗菌肽以其多模式作用机制和较低的耐药性风险,展现出显著优势.尽管抗菌肽存在稳定性差、细胞毒性高等问题,限制了其临床应用,但抗菌肽自组装形成纳米结构在很大程度克服了这些限制,并展现出极大的治疗潜力.本综述对抗菌肽自组装纳米材料的设计策略及其在治疗细菌感染方面的应用进行了系统总结,重点介绍了基于两亲性氨基酸非共价力驱动和化学修饰形成自组装抗菌肽的设计方法,最后描述了自组装纳米抗菌肽在腹腔感染、皮肤感染、肺部感染中的治疗潜力,以及在其他领域的应用价值.期望该综述可为该领域的进一步研究提供指导,以促进新型抑菌剂的发展.

Fiber-Optic Displacement Sensor Based on the DBR Fiber Laser

The fiber-optic displacement sensor based on the distributed Bragg reflector fiber laser is proposed, that is, the fiber laser cavity is attached to the measured object, when the measured object is stretched or contracted, and the length of the fiber laser cavity is also stretched or contracted accordingly. In view of the nonlinearity of the fiber-optic displacement sensor, the calibration based on piezoelectric ceramics is applied to improve the linearity of the displacement sensor. Experiment results show that the fiber-optic displacement sensor has a linear response with the nominal working distance of 90 um.