Inspired by natural photosynthesis,fabricating high-performance S-scheme heterojunction is regarded as a successful tactic to address energy and environmental issues.Herein,NH_(2)-MIL-125(Ti)/Zn_(0.5)Cd_(0.5)S/NiS(NMT...Inspired by natural photosynthesis,fabricating high-performance S-scheme heterojunction is regarded as a successful tactic to address energy and environmental issues.Herein,NH_(2)-MIL-125(Ti)/Zn_(0.5)Cd_(0.5)S/NiS(NMT/ZCS/NiS)S-scheme heterojunction with interfacial coordination bonds is successfully synthesized through in-situ solvothermal strategy.Notably,the optimal NMT/ZCS/NiS S-scheme heterojunction exhibits comparable photocatalytic H_(2)evolution(PHE)rate of about 14876.7μmol h^(−1)g^(−1)with apparent quantum yield of 24.2%at 420 nm,which is significantly higher than that of recently reported MOFs-based photocatalysts.The interfacial coordination bonds(Zn–N,Cd–N,and Ni–N bonds)accelerate the separation and transfer of photogenerated charges,and the NiS as cocatalyst can provide more catalytically active sites,which synergistically improve the photocatalytic performance.Moreover,theoretical calculation results display that the construction of NMT/ZCS/NiS S-scheme heterojunction also optimize the binding energy of active site-adsorbed hydrogen atoms to enable fast adsorption and desorption.Photoassisted Kelvin probe force microscopy,in-situ irradiation X-ray photoelectron spectroscopy,femtosecond transient absorption spectroscopy,and theoretical calculations provide sufficient evidence of the S-scheme charge migration mechanism.This work offers unique viewpoints for simultaneously accelerating the charge dynamics and optimizing the binding strength between the active sites and hydrogen adsorbates over S-scheme heterojunction.展开更多
Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing ...Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC.展开更多
目的:基于数据挖掘和网络药理学研究夏玉清教授治疗肺癌的用药规律。方法:收集2020年9月—2023年11月夏玉清教授于中国中医科学院望京医院门诊采用中药治疗肺癌的病例,采用古今医案云平台(V2.3.7)录入和分析数据,包括用药频次、关联分...目的:基于数据挖掘和网络药理学研究夏玉清教授治疗肺癌的用药规律。方法:收集2020年9月—2023年11月夏玉清教授于中国中医科学院望京医院门诊采用中药治疗肺癌的病例,采用古今医案云平台(V2.3.7)录入和分析数据,包括用药频次、关联分析、聚类分析等;采用TCMSP、UniProt、GeneCards等数据库,通过网络药理学方法分析药物成分、靶基因和潜在作用机制;采用古今医案云平台(V2.3.7)的大数据分析模块,对用药频率、归经、性质、中医证候、用药规律等进行统计学分析。结果:共收集病例102例,筛选中药处方343首,涉及中药130种,用药总频次为9470次。其中高频中药16味;关联规则分析得到高频次的中药组合如半枝莲-白花蛇舌草、金银花-半枝莲;聚类分析获得4个聚类组合。对紫花地丁、干鱼腥草、紫菀、桔梗、浙贝母聚类组合进行分析,共得到40个药物活性成分及181个对应靶基因。获得1811个肺癌靶点基因,124个药物-疾病靶点共有基因,27个核心靶点。对124个共有基因进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,获得GO 3种类别,KEGG通路174个。结论:夏玉清教授治疗肺癌的组方用药原则多以健脾益肺、清热解毒、燥湿化痰为主,随症加减。其用药反映了肺癌病机的复杂性,体现了夏玉清教授治疗肺癌注重气虚、阴虚、热毒、痰湿、瘀血等多种病理因素,临证时在正气亏虚、热毒蕴结的核心病机上坚持扶正祛邪、攻补兼施的治疗原则。展开更多
Blasting operations,which are crucial to open-pit mine production due to their simplicity and efficiency,require precise control through accurate vibration velocity calculations.The conventional Sadowski formula mainl...Blasting operations,which are crucial to open-pit mine production due to their simplicity and efficiency,require precise control through accurate vibration velocity calculations.The conventional Sadowski formula mainly focuses on blast center distance but neglects the amplification effect of blasting vibration waves by terraced terrain,from which the calculated blasting vibration velocities are smaller than the actual values,affecting the safety of the project.To address this issue,our model introduces the influences of slope and time into Sadowski formula to measure safety through blast vibration displacement.In the northern section of the open-pit quartz mine in Jinchang City,Gansu Province,China,the data of a continuous blasting slope project are referred to.Our findings reveal a noticeable vibration amplification effect during blasting when a multi-stage slope platform undergoes a sudden cross-sectional change near the upper overhanging surface.The amplification vibration coefficient increases with height,while vibration waves within rocks decrease from bottom to top.Conversely,platforms without distinct crosssectional changes exhibit no pronounced amplification during blasting.In addition,the vibration intensity decreases with distance as the rock height difference change propagates.The results obtained by the proposed blast vibration displacement equation incorporating slope shape influence closely agree with real-world scenarios.According to Pearson correlation coefficient(PPMCC)analysis,the average accuracy rate of our model is 88.84%,which exceeds the conventional Sadowski formula(46.92%).展开更多
Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality...Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality.It is essential to understand the underlying printability of different material combinations based on an adapted process.Here,the printability disparities of two common and attractive material combinations(nickel-and iron-based alloys)are evaluated at the macro and micro levels via laser directed energy deposition(DED).The deposition processes were captured using in situ high-speed imaging,and the dissimilarities in melt pool features and track morphology were quantitatively investigated within specific process windows.Moreover,the microstructure diversity of the tracks and blocks processed with varied material pairs was comparatively elaborated and,complemented with the informative multi-physics modeling,the presented non-uniformity in mechanical properties(microhardness)among the heterogeneous material pairs was rationalized.The differences in melt flow induced by the unlike thermophysical properties of the material pairs and the resulting element intermixing and localized re-alloying during solidification dominate the presented dissimilarity in printability among the material combinations.This work provides an in-depth understanding of the phenomenological differences in the deposition of dissimilar materials and aims to guide more reliable DED forming of bimetallic parts.展开更多
A dual-arm nursing robot can gently lift patients and transfer them between a bed and a wheelchair.With its lightweight design,high load-bearing capacity,and smooth surface,the coupled-drive joint is particularly well...A dual-arm nursing robot can gently lift patients and transfer them between a bed and a wheelchair.With its lightweight design,high load-bearing capacity,and smooth surface,the coupled-drive joint is particularly well suited for these robots.However,the coupled nature of the joint disrupts the direct linear relationship between the input and output torques,posing challenges for dynamic modeling and practical applications.This study investigated the transmission mechanism of this joint and employed the Lagrangian method to construct a dynamic model of its internal dynamics.Building on this foundation,the Newton-Euler method was used to develop a dynamic model for the entire robotic arm.A continuously differentiable friction model was incorporated to reduce the vibrations caused by speed transitions to zero.An experimental method was designed to compensate for gravity,inertia,and modeling errors to identify the parameters of the friction model.This method establishes a mapping relationship between the friction force and motor current.In addition,a Fourier series-based excitation trajectory was developed to facilitate the identification of the dynamic model parameters of the robotic arm.Trajectory tracking experiments were conducted during the experimental validation phase,demonstrating the high accuracy of the dynamic model and the parameter identification method for the robotic arm.This study presents a dynamic modeling and parameter identification method for coupled-drive joint robotic arms,thereby establishing a foundation for motion control in humanoid nursing robots.展开更多
Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,m...Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic function.While the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains uncertain.This study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and inflammation.Methods Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were assessed.RNA sequencing was utilized to analyze differential gene expression and identify potential therapeutic targets.In vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 cells.Cell viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and ELISA.Protein expression levels were determined by Western blotting analysis.The investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein levels.Results The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in cardiomyocytes.Furthermore,JPQHF downregulated the expression of myocardial JunB/c-Fos,which was upregulated in both diabetic rats and high glucose-treated H9c2 cells.Conclusion The JPQH formula holds promise in mitigating diabetic myocardial apoptosis and inflammation in cardiomyocytes by inhibiting JunB/c-Fos expression through suppressing the MAPK(p38 and ERK1/2)pathway.展开更多
In the application of aerial target recognition,on the one hand,the recognition error produced by the single measurement of the sensor is relatively large due to the impact of noise.On the other hand,it is difficult t...In the application of aerial target recognition,on the one hand,the recognition error produced by the single measurement of the sensor is relatively large due to the impact of noise.On the other hand,it is difficult to apply machine learning methods to improve the intelligence and recognition effect due to few or no actual measurement samples.Aiming at these problems,an aerial target recognition algorithm based on self-attention and Long Short-Term Memory Network(LSTM)is proposed.LSTM can effectively extract temporal dependencies.The attention mechanism calculates the weight of each input element and applies the weight to the hidden state of the LSTM,thereby adjusting the LSTM’s attention to the input.This combination retains the learning ability of LSTM and introduces the advantages of the attention mechanism,making the model have stronger feature extraction ability and adaptability when processing sequence data.In addition,based on the prior information of the multidimensional characteristics of the target,the three-point estimation method is adopted to simulate an aerial target recognition dataset to train the recognition model.The experimental results show that the proposed algorithm achieves more than 91%recognition accuracy,lower false alarm rate and higher robustness compared with the multi-attribute decision-making(MADM)based on fuzzy numbers.展开更多
BACKGROUND： Inevitable warm ischemia time before organ procurement aggravates posttransplantation ischemia- reperfusion injury. Endoplasmic reticulum （ER） stress is involved in ischemia-reperfusion injury, but its ...BACKGROUND： Inevitable warm ischemia time before organ procurement aggravates posttransplantation ischemia- reperfusion injury. Endoplasmic reticulum （ER） stress is involved in ischemia-reperfusion injury, but its role in donation after cardiac death （DCD） liver transplantation is not clear and the effect of ER stress inhibitors, tauroursodeoxycholic acid （TUDCA） and 4-phenyl butyric acid （PBA）, on the prognosis of recipient of DCD liver transplantation remains unclear. METHODS： Male Sprague-Dawley rats （8-10 weeks） were randomly divided into control group： liver grafts without warm ischemia were implanted; DCD group： warm ischemia time of the liver grafts was 60 minutes; TUDCA and PBA groups： based on the DCD group, donors were intraperitoneally injected with TUDCA or PBA 30 minutes before the organ procurements. Serum aminotransferase levels, oxidative stress activation and expression of ER stress signal molecules were evaluated. Pathological examinations were performed. The survivals of the recipients in each group were compared for 14 days.RESULTS： Compared with the control group, DCD rats had significantly higher levels of serum aminotransferase at 6 hours, 1 day and 3 days after operation （P〈0.01, 0.01 and 0.05, respectively） and oxidative indices （P〈0.01 for both malondialdehyde and 8-hydroxy deoxyguanosine）, more severe liver damage （P〈0.01） and up-regulated ER stress signal expressions （P〈0.01 for GRP78, phos-eIF2al, CHOP, ATF-4, ATF-6, PERK, XBP-1 and pro-caspase-12）. All recipients died within 3 days after liver transplantation. Administration of TUDCA or PBA significantly decreased aminotransferase levels （P〈0.05）, increased superoxide dismutase activities （P〈0.01）, alleviated liver damage （P〈0.01）, down-regulated ER stress signal expressions （P〈0.01） and improved postoperative survivals （P〈0.01）. CONCLUSIONS： ER stress was involved with DCD liver trans- plantation in rats. Preoperative intraperitoneally injection of TUDCA or PBA protected ER stress and improved prognosis.展开更多
As the scale of residual oil treatment increases and cleaner production improves in China,slurry bubble column reactors face many challenges and opportunities for residual oil hydrogenation technology.The internals de...As the scale of residual oil treatment increases and cleaner production improves in China,slurry bubble column reactors face many challenges and opportunities for residual oil hydrogenation technology.The internals development is critical to adapt the long-term stable operation.In this paper,the volumetric mass transfer coefficient,gas holdup and bubble size in a gas-liquid up-flow column are studied with two kinds of internals.The gas holdup and volumetric mass transfer coefficient increase by 120% and 42% when the fractal dimension of bubbles increases from 0.56 to 2.56,respectively.The enhanced mass transfer processing may improve the coke suppression ability in the slurry reactor for residual oil treatment.The results can be useful for the exploration of reacting conditions,scale-up strategies,and oil adaptability.This work is valuable for the design of reactor systems and technological processes.展开更多
An increasing number of palaeo-climatic records have been reported to identify the Holocene climate history in the arid Xinjiang region of northwest China. However, few studies have fully considered the internal linka...An increasing number of palaeo-climatic records have been reported to identify the Holocene climate history in the arid Xinjiang region of northwest China. However, few studies have fully considered the internal linkages within the regional climate system, which may limit our understanding of the forcing mechanisms of Holocene climate change in this region. Here, we systematically consider three major issues of the moisture/precipitation, temperature and near-surface wind relevant to the Holocene climate history of Xinjiang. First, despite there still has debated for the Holocene moisture evolution in this region, more climatic reconstructions from lake sediments, loess, sand-dunes and peats support a long-term regional wetting trend. Second, temperature records from ice cores, peats and stalagmites demonstrate a long-term winter warming trend during the Holocene in middle-to high-latitudes of Asia. Third, recent studies of aeolian sedimentary sequences reveal that the near-surface winds in winter gradually weakened during the Holocene, whereas the winter mid-latitude Westerlies strengthened in the Tienshan Mountains. Based on this evidence, in the arid Xinjiang region we propose an early to middle Holocene relatively cold and dry interval, with strong near-surface winds;and a warmer, wetter interval with weaker near-surface winds in the middle to late Holocene during winter. Additionally,we develop a conceptual model to explain the pattern of Holocene climate changes in this region.From the early to the late Holocene, the increasing atmospheric COcontent and winter insolation,and the shrinking of high-latitude continental ice-sheets, resulted in increasing winter temperatures in middle to high latitudes in the Northern Hemisphere. Subsequently, the increased winter temperature strengthened the winter mid-latitude Westerlies and weakened the Siberian high-pressure system,which caused an increase in winter precipitation and a decrease in near-surface wind strength. This scenario is strongly supported by evidence from geological records, climate simulation results, and modern reanalysis data. Our hypothesis highlights the important contribution of winter temperature in driving the Holocene climatic evolution of the arid Xinjiang region, and it implies that the socio-economic development and water resources security of this region will face serious challenges presented by the increasing winter temperature in the future.展开更多
In this study, surface air temperature from 75 meteorological stations above 3000 m on the Tibetan Plateau are applied for evaluation of the European Centre for Medium-Range Weather Forecasts(ECMWF) third-generation r...In this study, surface air temperature from 75 meteorological stations above 3000 m on the Tibetan Plateau are applied for evaluation of the European Centre for Medium-Range Weather Forecasts(ECMWF) third-generation reanalysis product ERA-Interim in the period of 1979-2010. High correlations ranging from 0.973 to 0.999 indicate that ERA-Interim could capture the annual cycle very well. However, an average root-meansquare error(rmse) of 3.7°C for all stations reveals that ERA-Interim could not be applied directly for the individual sites. The biases can be mainly attributed to the altitude differences between ERA-Interim grid points and stations. An elevation correction method based on monthly lapse rates is limited to reduce the bias for all stations. Generally, ERA-Interim captured the Plateau-Wide annual and seasonal climatologies very well. The spatial variance is highly related to the topographic features of the TP. The temperature increases significantly(10°C- 15°C) from the western to the eastern Tibetan Plateau for all seasons, in particular during winter and summer. A significant warming trend(0.49°C/decade) is found over the entire Tibetan Plateau using station time series from 1979-2010. ERA-Interim captures the annual warming trend with an increase rate of 0.33°C /decade very well. The observation data and ERA-Interim data both showed the largest warming trends in winter with values of 0.67°C/decade and 0.41°C/decade, respectively. We conclude that in general ERA-Interim captures the temperature trends very well and ERA-Interim is reliable for climate change investigation over the Tibetan Plateau under the premise of cautious interpretation.展开更多
Zinc supplementation can help maintain learning and memory function in rodents. In this study, we hypothesized that zinc supplementation could antagonize the neurotoxicity induced by aluminum in rats. Animals were fed...Zinc supplementation can help maintain learning and memory function in rodents. In this study, we hypothesized that zinc supplementation could antagonize the neurotoxicity induced by aluminum in rats. Animals were fed a diet containing different doses of zinc （50, 100, 200 mg/kg） for 9 weeks, and orally administered aluminum chloride （300 mg/kg daily） from the third week for 7 consecutive weeks. Open-field behavioral test results showed that the number of rearings in the group given the 100 mg/kg zinc supplement was significantly increased compared with the group given the 50 mg/kg zinc supplement. Malondialdehyde content in the cerebrum was significantly decreased, while dopamine and 5-hydroxytryptamine levels were increased in the groups given the diet sup- plemented with 100 and 200 mg/kg zinc, compared with the group given the diet supplemented with 50 mg/kg zinc. The acetylcholinesterase activity in the cerebrum was significantly decreased in the group given the 100 mg/kg zinc supplement. Hematoxylin-eosin staining revealed evident patho- logical damage in the hippocampus of rats in the group given the diet supplemented with 50 mg/kg zinc, but the damage was attenuated in the groups given the diet supplemented with 100 and 200 mg/kg zinc. Our findings suggest that zinc is a potential neuroprotective agent against alumi-num-induced neurotoxicity in rats, and the optimal dosages are 100 and 200 mg/kg.展开更多
Silicon monoxide(SiO) has been considered as one of the most promising anode materials for next generation highenergy-density Li-ion batteries(LiBs) thanks to its high theoretical capacity. However, the poor intrinsic...Silicon monoxide(SiO) has been considered as one of the most promising anode materials for next generation highenergy-density Li-ion batteries(LiBs) thanks to its high theoretical capacity. However, the poor intrinsic electronic conductivity and large volume change during lithium intercalation/de-intercalation restrict its practical applications. Fabrication of SiO/C composites is an effective way to overcome these problems. Herein, a series of micro-sized SiO@C/graphite(Si0@C/G) composite anode materials, with designed capacity of 600 mAh·g-1, are successfully prepared through a pitch pyrolysis reaction method. The electrochemical performance of SiO@C/G composite anodes with different carbon coating contents of 5 wt%, 10 wt%, 15 wt%, and 35 wt% is investigated. The results show that the SiO@C/G composite with15-wt% carbon coating content exhibits the best cycle performance, with a high capacity retention of 90.7% at 25℃ and90.1% at 45 0 C after 100 cycles in full cells with LiNi0.5Co0.2Mn0.3O2 as cathodes. The scanning electron microscope(SEM) and electrochemistry impedance spectroscopy(EIS) results suggest that a moderate carbon coating layer can promote the formation of stable SEI film, which is favorable for maintaining good interfacial conductivity and thus enhancing the cycling stability of SiO electrode.展开更多
文摘Inspired by natural photosynthesis,fabricating high-performance S-scheme heterojunction is regarded as a successful tactic to address energy and environmental issues.Herein,NH_(2)-MIL-125(Ti)/Zn_(0.5)Cd_(0.5)S/NiS(NMT/ZCS/NiS)S-scheme heterojunction with interfacial coordination bonds is successfully synthesized through in-situ solvothermal strategy.Notably,the optimal NMT/ZCS/NiS S-scheme heterojunction exhibits comparable photocatalytic H_(2)evolution(PHE)rate of about 14876.7μmol h^(−1)g^(−1)with apparent quantum yield of 24.2%at 420 nm,which is significantly higher than that of recently reported MOFs-based photocatalysts.The interfacial coordination bonds(Zn–N,Cd–N,and Ni–N bonds)accelerate the separation and transfer of photogenerated charges,and the NiS as cocatalyst can provide more catalytically active sites,which synergistically improve the photocatalytic performance.Moreover,theoretical calculation results display that the construction of NMT/ZCS/NiS S-scheme heterojunction also optimize the binding energy of active site-adsorbed hydrogen atoms to enable fast adsorption and desorption.Photoassisted Kelvin probe force microscopy,in-situ irradiation X-ray photoelectron spectroscopy,femtosecond transient absorption spectroscopy,and theoretical calculations provide sufficient evidence of the S-scheme charge migration mechanism.This work offers unique viewpoints for simultaneously accelerating the charge dynamics and optimizing the binding strength between the active sites and hydrogen adsorbates over S-scheme heterojunction.
基金supported by the National Natural Science Foundation of China (Grant No. 12074321)the Young Science and Technology Talents Development Project of Guizhou Provincial Education Department (Grant No. QJH-KY [2022]012)+2 种基金the Fundamental Research Funds for the Central Universities (Grant No. SWU020019)the Natural Science Foundation of Chongqing (Grant No. cstc2020jcyjmsxmx0648)the Chongqing Graduate Student Research Innovation Project (Grant No. CYB22119)。
文摘Achieving highly-efficient and stable perovskite solar cells(PSCs) with a simplified structure remains challenging, despite the tremendous potential for reducing preparation cost and facile processability by removing hole transport layer(HTL). In this work, eco-friendly glucose(Gl) as an interface modifier for HTL-free narrow bandgap tin-lead(Sn-Pb) PSCs is proposed. Gl not only enhances the wettability of the indium tin oxide to promote perovskite heterogeneous nucleation on substrate, but also realizes defect passivation by interacting with uncoordinated Pb^(2+) and Sn^(2+) in perovskite films. As a result, the quality of the perovskite films has been significantly improved, accompanied by reduced defects of bottom interface and optimized energy level structure of device, leading to an efficiency increase and a less nonradiative voltage loss of 0.102 V(for a bandgap of ~1.26 eV). Consequently, the optimized PSC delivers an unprecedented efficiency over 21% with high open-circuit voltage and enhanced stability, outperforming the control device. This work demonstrates a cost-effective approach to develop simplified structure high efficiency HTL-free Sn-Pb PSC.
文摘目的:基于数据挖掘和网络药理学研究夏玉清教授治疗肺癌的用药规律。方法:收集2020年9月—2023年11月夏玉清教授于中国中医科学院望京医院门诊采用中药治疗肺癌的病例,采用古今医案云平台(V2.3.7)录入和分析数据,包括用药频次、关联分析、聚类分析等;采用TCMSP、UniProt、GeneCards等数据库,通过网络药理学方法分析药物成分、靶基因和潜在作用机制;采用古今医案云平台(V2.3.7)的大数据分析模块,对用药频率、归经、性质、中医证候、用药规律等进行统计学分析。结果:共收集病例102例,筛选中药处方343首,涉及中药130种,用药总频次为9470次。其中高频中药16味;关联规则分析得到高频次的中药组合如半枝莲-白花蛇舌草、金银花-半枝莲;聚类分析获得4个聚类组合。对紫花地丁、干鱼腥草、紫菀、桔梗、浙贝母聚类组合进行分析,共得到40个药物活性成分及181个对应靶基因。获得1811个肺癌靶点基因,124个药物-疾病靶点共有基因,27个核心靶点。对124个共有基因进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,获得GO 3种类别,KEGG通路174个。结论:夏玉清教授治疗肺癌的组方用药原则多以健脾益肺、清热解毒、燥湿化痰为主,随症加减。其用药反映了肺癌病机的复杂性,体现了夏玉清教授治疗肺癌注重气虚、阴虚、热毒、痰湿、瘀血等多种病理因素,临证时在正气亏虚、热毒蕴结的核心病机上坚持扶正祛邪、攻补兼施的治疗原则。
文摘Blasting operations,which are crucial to open-pit mine production due to their simplicity and efficiency,require precise control through accurate vibration velocity calculations.The conventional Sadowski formula mainly focuses on blast center distance but neglects the amplification effect of blasting vibration waves by terraced terrain,from which the calculated blasting vibration velocities are smaller than the actual values,affecting the safety of the project.To address this issue,our model introduces the influences of slope and time into Sadowski formula to measure safety through blast vibration displacement.In the northern section of the open-pit quartz mine in Jinchang City,Gansu Province,China,the data of a continuous blasting slope project are referred to.Our findings reveal a noticeable vibration amplification effect during blasting when a multi-stage slope platform undergoes a sudden cross-sectional change near the upper overhanging surface.The amplification vibration coefficient increases with height,while vibration waves within rocks decrease from bottom to top.Conversely,platforms without distinct crosssectional changes exhibit no pronounced amplification during blasting.In addition,the vibration intensity decreases with distance as the rock height difference change propagates.The results obtained by the proposed blast vibration displacement equation incorporating slope shape influence closely agree with real-world scenarios.According to Pearson correlation coefficient(PPMCC)analysis,the average accuracy rate of our model is 88.84%,which exceeds the conventional Sadowski formula(46.92%).
基金supported by the National Natural Science Foundation of China(51975112,52375412)Fundamental Research Funds for Central Universities(N2203011)。
文摘Additive manufacturing provides achievability for the fabrication of bimetallic and multi-material structures;however,the material compatibility and bondability directly affect the parts’formability and final quality.It is essential to understand the underlying printability of different material combinations based on an adapted process.Here,the printability disparities of two common and attractive material combinations(nickel-and iron-based alloys)are evaluated at the macro and micro levels via laser directed energy deposition(DED).The deposition processes were captured using in situ high-speed imaging,and the dissimilarities in melt pool features and track morphology were quantitatively investigated within specific process windows.Moreover,the microstructure diversity of the tracks and blocks processed with varied material pairs was comparatively elaborated and,complemented with the informative multi-physics modeling,the presented non-uniformity in mechanical properties(microhardness)among the heterogeneous material pairs was rationalized.The differences in melt flow induced by the unlike thermophysical properties of the material pairs and the resulting element intermixing and localized re-alloying during solidification dominate the presented dissimilarity in printability among the material combinations.This work provides an in-depth understanding of the phenomenological differences in the deposition of dissimilar materials and aims to guide more reliable DED forming of bimetallic parts.
基金Supported by Shanghai Municipal Science and Technology Program (Grant No.21511101701)National Key Research and Development Program of China (Grant No.2021YFC0122704)。
文摘A dual-arm nursing robot can gently lift patients and transfer them between a bed and a wheelchair.With its lightweight design,high load-bearing capacity,and smooth surface,the coupled-drive joint is particularly well suited for these robots.However,the coupled nature of the joint disrupts the direct linear relationship between the input and output torques,posing challenges for dynamic modeling and practical applications.This study investigated the transmission mechanism of this joint and employed the Lagrangian method to construct a dynamic model of its internal dynamics.Building on this foundation,the Newton-Euler method was used to develop a dynamic model for the entire robotic arm.A continuously differentiable friction model was incorporated to reduce the vibrations caused by speed transitions to zero.An experimental method was designed to compensate for gravity,inertia,and modeling errors to identify the parameters of the friction model.This method establishes a mapping relationship between the friction force and motor current.In addition,a Fourier series-based excitation trajectory was developed to facilitate the identification of the dynamic model parameters of the robotic arm.Trajectory tracking experiments were conducted during the experimental validation phase,demonstrating the high accuracy of the dynamic model and the parameter identification method for the robotic arm.This study presents a dynamic modeling and parameter identification method for coupled-drive joint robotic arms,thereby establishing a foundation for motion control in humanoid nursing robots.
基金supported by grants from the National Natural Science Foundation of China(No.81874434 and No.81804053)Yangtze River Delta Traditional Chinese Medicine Endocrinology and Metabolic Disease Specialist Alliance(No.ZY2021-2023-0302).
文摘Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic function.While the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains uncertain.This study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and inflammation.Methods Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were assessed.RNA sequencing was utilized to analyze differential gene expression and identify potential therapeutic targets.In vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 cells.Cell viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and ELISA.Protein expression levels were determined by Western blotting analysis.The investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein levels.Results The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in cardiomyocytes.Furthermore,JPQHF downregulated the expression of myocardial JunB/c-Fos,which was upregulated in both diabetic rats and high glucose-treated H9c2 cells.Conclusion The JPQH formula holds promise in mitigating diabetic myocardial apoptosis and inflammation in cardiomyocytes by inhibiting JunB/c-Fos expression through suppressing the MAPK(p38 and ERK1/2)pathway.
文摘In the application of aerial target recognition,on the one hand,the recognition error produced by the single measurement of the sensor is relatively large due to the impact of noise.On the other hand,it is difficult to apply machine learning methods to improve the intelligence and recognition effect due to few or no actual measurement samples.Aiming at these problems,an aerial target recognition algorithm based on self-attention and Long Short-Term Memory Network(LSTM)is proposed.LSTM can effectively extract temporal dependencies.The attention mechanism calculates the weight of each input element and applies the weight to the hidden state of the LSTM,thereby adjusting the LSTM’s attention to the input.This combination retains the learning ability of LSTM and introduces the advantages of the attention mechanism,making the model have stronger feature extraction ability and adaptability when processing sequence data.In addition,based on the prior information of the multidimensional characteristics of the target,the three-point estimation method is adopted to simulate an aerial target recognition dataset to train the recognition model.The experimental results show that the proposed algorithm achieves more than 91%recognition accuracy,lower false alarm rate and higher robustness compared with the multi-attribute decision-making(MADM)based on fuzzy numbers.
基金supported by a grant from the National Natural Science Foundation of China (81273262)
文摘BACKGROUND： Inevitable warm ischemia time before organ procurement aggravates posttransplantation ischemia- reperfusion injury. Endoplasmic reticulum （ER） stress is involved in ischemia-reperfusion injury, but its role in donation after cardiac death （DCD） liver transplantation is not clear and the effect of ER stress inhibitors, tauroursodeoxycholic acid （TUDCA） and 4-phenyl butyric acid （PBA）, on the prognosis of recipient of DCD liver transplantation remains unclear. METHODS： Male Sprague-Dawley rats （8-10 weeks） were randomly divided into control group： liver grafts without warm ischemia were implanted; DCD group： warm ischemia time of the liver grafts was 60 minutes; TUDCA and PBA groups： based on the DCD group, donors were intraperitoneally injected with TUDCA or PBA 30 minutes before the organ procurements. Serum aminotransferase levels, oxidative stress activation and expression of ER stress signal molecules were evaluated. Pathological examinations were performed. The survivals of the recipients in each group were compared for 14 days.RESULTS： Compared with the control group, DCD rats had significantly higher levels of serum aminotransferase at 6 hours, 1 day and 3 days after operation （P〈0.01, 0.01 and 0.05, respectively） and oxidative indices （P〈0.01 for both malondialdehyde and 8-hydroxy deoxyguanosine）, more severe liver damage （P〈0.01） and up-regulated ER stress signal expressions （P〈0.01 for GRP78, phos-eIF2al, CHOP, ATF-4, ATF-6, PERK, XBP-1 and pro-caspase-12）. All recipients died within 3 days after liver transplantation. Administration of TUDCA or PBA significantly decreased aminotransferase levels （P〈0.05）, increased superoxide dismutase activities （P〈0.01）, alleviated liver damage （P〈0.01）, down-regulated ER stress signal expressions （P〈0.01） and improved postoperative survivals （P〈0.01）. CONCLUSIONS： ER stress was involved with DCD liver trans- plantation in rats. Preoperative intraperitoneally injection of TUDCA or PBA protected ER stress and improved prognosis.
基金the National Natural Science Foundation of China(51678238,51722806,51608325,21908057)National Key R&D Program of China(2018YFC1802704,2018YFC1801904)+1 种基金China Postdoctoral Science Foundation funded project(2018M641942)Shanghai Sailing Program(19YF1411800)for financial support.
文摘As the scale of residual oil treatment increases and cleaner production improves in China,slurry bubble column reactors face many challenges and opportunities for residual oil hydrogenation technology.The internals development is critical to adapt the long-term stable operation.In this paper,the volumetric mass transfer coefficient,gas holdup and bubble size in a gas-liquid up-flow column are studied with two kinds of internals.The gas holdup and volumetric mass transfer coefficient increase by 120% and 42% when the fractal dimension of bubbles increases from 0.56 to 2.56,respectively.The enhanced mass transfer processing may improve the coke suppression ability in the slurry reactor for residual oil treatment.The results can be useful for the exploration of reacting conditions,scale-up strategies,and oil adaptability.This work is valuable for the design of reactor systems and technological processes.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) (Grant No. 2019QZKK0602)the National Natural Science Foundation of China (Grant Nos. 41401046, 42067049)+1 种基金the Education Science and technology Innovation project of Gansu Province (2021QB-118)the Jiangxi Provincial Natural Science Foundation (Grant No. 20202BABL213035)。
文摘An increasing number of palaeo-climatic records have been reported to identify the Holocene climate history in the arid Xinjiang region of northwest China. However, few studies have fully considered the internal linkages within the regional climate system, which may limit our understanding of the forcing mechanisms of Holocene climate change in this region. Here, we systematically consider three major issues of the moisture/precipitation, temperature and near-surface wind relevant to the Holocene climate history of Xinjiang. First, despite there still has debated for the Holocene moisture evolution in this region, more climatic reconstructions from lake sediments, loess, sand-dunes and peats support a long-term regional wetting trend. Second, temperature records from ice cores, peats and stalagmites demonstrate a long-term winter warming trend during the Holocene in middle-to high-latitudes of Asia. Third, recent studies of aeolian sedimentary sequences reveal that the near-surface winds in winter gradually weakened during the Holocene, whereas the winter mid-latitude Westerlies strengthened in the Tienshan Mountains. Based on this evidence, in the arid Xinjiang region we propose an early to middle Holocene relatively cold and dry interval, with strong near-surface winds;and a warmer, wetter interval with weaker near-surface winds in the middle to late Holocene during winter. Additionally,we develop a conceptual model to explain the pattern of Holocene climate changes in this region.From the early to the late Holocene, the increasing atmospheric COcontent and winter insolation,and the shrinking of high-latitude continental ice-sheets, resulted in increasing winter temperatures in middle to high latitudes in the Northern Hemisphere. Subsequently, the increased winter temperature strengthened the winter mid-latitude Westerlies and weakened the Siberian high-pressure system,which caused an increase in winter precipitation and a decrease in near-surface wind strength. This scenario is strongly supported by evidence from geological records, climate simulation results, and modern reanalysis data. Our hypothesis highlights the important contribution of winter temperature in driving the Holocene climatic evolution of the arid Xinjiang region, and it implies that the socio-economic development and water resources security of this region will face serious challenges presented by the increasing winter temperature in the future.
基金funded by Fujian Bureau of Surveying,Mapping and Geoinformation(Grant No.2013S17)Natural Science Foundation of China(Grant No.71373130)+2 种基金Non-Profit Research Projects of Fujian Province,China(Grant No2013R04)Key Project of the Department of Science and Technology of Fujian Province,China(Grant No.2012Y4001)supported by the ECMWF’s public web server(http://apps.ecmwf.int/datasets/)
文摘In this study, surface air temperature from 75 meteorological stations above 3000 m on the Tibetan Plateau are applied for evaluation of the European Centre for Medium-Range Weather Forecasts(ECMWF) third-generation reanalysis product ERA-Interim in the period of 1979-2010. High correlations ranging from 0.973 to 0.999 indicate that ERA-Interim could capture the annual cycle very well. However, an average root-meansquare error(rmse) of 3.7°C for all stations reveals that ERA-Interim could not be applied directly for the individual sites. The biases can be mainly attributed to the altitude differences between ERA-Interim grid points and stations. An elevation correction method based on monthly lapse rates is limited to reduce the bias for all stations. Generally, ERA-Interim captured the Plateau-Wide annual and seasonal climatologies very well. The spatial variance is highly related to the topographic features of the TP. The temperature increases significantly(10°C- 15°C) from the western to the eastern Tibetan Plateau for all seasons, in particular during winter and summer. A significant warming trend(0.49°C/decade) is found over the entire Tibetan Plateau using station time series from 1979-2010. ERA-Interim captures the annual warming trend with an increase rate of 0.33°C /decade very well. The observation data and ERA-Interim data both showed the largest warming trends in winter with values of 0.67°C/decade and 0.41°C/decade, respectively. We conclude that in general ERA-Interim captures the temperature trends very well and ERA-Interim is reliable for climate change investigation over the Tibetan Plateau under the premise of cautious interpretation.
基金was funded by the National Nature Science Foundation of China,No.30872098,30901185the National Nature Science Foundation of Tianjin,No.05YFJMJC 05500the Medical Science and Technology Project of Chinese PLA,No.13QNP069.
文摘Zinc supplementation can help maintain learning and memory function in rodents. In this study, we hypothesized that zinc supplementation could antagonize the neurotoxicity induced by aluminum in rats. Animals were fed a diet containing different doses of zinc （50, 100, 200 mg/kg） for 9 weeks, and orally administered aluminum chloride （300 mg/kg daily） from the third week for 7 consecutive weeks. Open-field behavioral test results showed that the number of rearings in the group given the 100 mg/kg zinc supplement was significantly increased compared with the group given the 50 mg/kg zinc supplement. Malondialdehyde content in the cerebrum was significantly decreased, while dopamine and 5-hydroxytryptamine levels were increased in the groups given the diet sup- plemented with 100 and 200 mg/kg zinc, compared with the group given the diet supplemented with 50 mg/kg zinc. The acetylcholinesterase activity in the cerebrum was significantly decreased in the group given the 100 mg/kg zinc supplement. Hematoxylin-eosin staining revealed evident patho- logical damage in the hippocampus of rats in the group given the diet supplemented with 50 mg/kg zinc, but the damage was attenuated in the groups given the diet supplemented with 100 and 200 mg/kg zinc. Our findings suggest that zinc is a potential neuroprotective agent against alumi-num-induced neurotoxicity in rats, and the optimal dosages are 100 and 200 mg/kg.
基金Project supported by the State Grid Technology Project,China(study on the mechanism and characterization of lithium dendrite growth in lithium ion batteries,Project No.DG71-17-010)the National Key Research and Development Program of China(Grant No.2017YFB0102004)the National Natural Science Foundation of China(Grant No.51822211)
文摘Silicon monoxide(SiO) has been considered as one of the most promising anode materials for next generation highenergy-density Li-ion batteries(LiBs) thanks to its high theoretical capacity. However, the poor intrinsic electronic conductivity and large volume change during lithium intercalation/de-intercalation restrict its practical applications. Fabrication of SiO/C composites is an effective way to overcome these problems. Herein, a series of micro-sized SiO@C/graphite(Si0@C/G) composite anode materials, with designed capacity of 600 mAh·g-1, are successfully prepared through a pitch pyrolysis reaction method. The electrochemical performance of SiO@C/G composite anodes with different carbon coating contents of 5 wt%, 10 wt%, 15 wt%, and 35 wt% is investigated. The results show that the SiO@C/G composite with15-wt% carbon coating content exhibits the best cycle performance, with a high capacity retention of 90.7% at 25℃ and90.1% at 45 0 C after 100 cycles in full cells with LiNi0.5Co0.2Mn0.3O2 as cathodes. The scanning electron microscope(SEM) and electrochemistry impedance spectroscopy(EIS) results suggest that a moderate carbon coating layer can promote the formation of stable SEI film, which is favorable for maintaining good interfacial conductivity and thus enhancing the cycling stability of SiO electrode.
