目的观察不同时间点神经元特异性烯醇化酶(NSE)水平对重症社区获得性肺炎(SCAP)患者ICU死亡的预测价值。方法选取2021年6月至2023年6月在河北省人民医院急诊重症监护病房(EICU)住院的74例SCAP患者。患者于入院后12小时内检测血中性粒细...目的观察不同时间点神经元特异性烯醇化酶(NSE)水平对重症社区获得性肺炎(SCAP)患者ICU死亡的预测价值。方法选取2021年6月至2023年6月在河北省人民医院急诊重症监护病房(EICU)住院的74例SCAP患者。患者于入院后12小时内检测血中性粒细胞计数、血肌酐(Scr)、白蛋白(Alb)、降钙素原(PCT)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和白细胞介素6(IL-6)水平。于患者入院后第1天[NSE(day1)]和第4天[NSE(day4)]早晨采集NSE血样进行检验。并根据患者ICU内是否死亡分为生存组(n=57)和死亡组(n=17)。采用多因素logistic回归分析、受试者工作特征(ROC)曲线及曲线下面积(AUC)评价上述参数的预测效果。结果死亡组患者急性生理和慢性健康II评分(APACHE II score)、IL-6水平、中性粒细胞计数、NSE(day1)和NSE(day4)水平高于生存组(P<0.05),氧合指数(PaO_(2)/FiO_(2))明显低于生存组(P<0.05)。APACHE IIscore、IL-6水平、中性粒细胞计数、NSE(day1)和NSE(day4)水平与SCAP患者ICU死亡呈弱的正相关(P<0.05),PaO_(2)/FiO_(2)与患者ICU死亡呈弱的负相关(P<0.05)。多因素logistic回归分析结果显示,APACHE IIscore和NSE(day4)与SCAP患者ICU死亡相关(P<0.05)。APACHE II score和NSE(day4)预测SCAP患者ICU死亡的AUC分别为0.729(95%CI 0.613~0.826)和0.787(95%CI0.676~0.874),两者的AUC差异无统计学意义(P=0.561)。NSE(day4)预测患者ICU死亡的敏感性和特异性分别为57.89%和88.24%(临界值为14.83μg/L)。结论NSE(day4)是SCAP患者ICU死亡的独立预测指标,是评估SCAP患者预后的一个很好的替代选择。展开更多
目的观察心脏收缩力调节(CCM)对心力衰竭(心衰)兔转化生长因子β1(TGFβ1)/Smad/结缔组织生长因子(CTGF)信号通路影响。方法 30只新西兰大白兔经升主动脉根部套扎建立心衰模型,分为假手术组、心衰组、CCM组(心衰模型成功后,给予4周CCM治...目的观察心脏收缩力调节(CCM)对心力衰竭(心衰)兔转化生长因子β1(TGFβ1)/Smad/结缔组织生长因子(CTGF)信号通路影响。方法 30只新西兰大白兔经升主动脉根部套扎建立心衰模型,分为假手术组、心衰组、CCM组(心衰模型成功后,给予4周CCM治疗),每组10只。采用天狼猩红染色法分析心肌组织Ⅰ型及Ⅲ型胶原纤维;比色法测定心肌组织羟脯氨酸含量;蛋白印迹法检测心肌组织TGFβ1、Smad3、Smad7、CTGF蛋白表达水平。结果与假手术组比较,心衰组Ⅰ型和Ⅲ型胶原纤维及羟脯氨酸含量增加(P<0.05),CCM组较心衰组减轻心肌Ⅰ型和Ⅲ型胶原纤维及羟脯氨酸含量[(13.19±5.96)%vs(16.31±7.01)%,(7.39±2.13)%vs(11.57±5.02)%,(0.69±0.05)μg/mg vs(0.98±0.04)μg/mg,P<0.05]。与假手术组比较,心衰组TGFβ1、Smad3、CTGF蛋白表达升高,Smad7蛋白表达下降(P<0.05)。与心衰组比较,CCM组TGFβ1、Smad3、CTGF蛋白表达下调(0.49±0.03 vs 0.67±0.04,0.43±0.06 vs 0.59±0.06,0.45±0.08 vs 0.75±0.09,P<0.05),Smad7蛋白表达上调(0.43±0.08 vs 0.26±0.04,P<0.05)。结论 CCM可下调TGFβ1、Smad3、CTGF蛋白表达,上调Smad7蛋白表达,改善心衰兔心肌纤维化。展开更多
The Dongpu sag is located in the south of the Bohai Bay basin,China,and has abundant oil and gas reserves.To date,there has been no systematic documentation of its geothermal fields.This study measured the rock therma...The Dongpu sag is located in the south of the Bohai Bay basin,China,and has abundant oil and gas reserves.To date,there has been no systematic documentation of its geothermal fields.This study measured the rock thermal conductivity of 324 cores from 47 wells,and calculated rock thermal conductivity for different formations.The geothermal gradient and terrestrial heat flow were calculated for 192 wells on basis of 892 formation-testing data from 523 wells.The results show that the Dongpu sag is characterized by a medium-temperature geothermal field between stable and active tectonic areas,with an average geothermal gradient of 32.0℃/km and terrestrial heat flow of 65.6 mW/m2.The geothermal fields in the Dongpu sag is significantly controlled by the Changyuan,Yellow River,and Lanliao basement faults.They developed in the Paleogene and the Dongying movement occurred at the Dongying Formation depositional period.The geothermal fields distribution has a similar characteristic to the tectonic framework of the Dongpu sag,namely two subsags,one uplift,one steep slope and one gentle slope.The oil and gas distribution is closely associated with the present geothermal fields.The work may provide constraints for reconstructing the thermal history and modeling source rock maturation evolution in the Dongpu sag.展开更多
Owing to the lack o f terrestrial heat flow data, studying lithospheric thermal structure and geodynamics of the Yingen-Ejinaqi Basin in Inner Mongolia is limited. In this paper, the terrestrial heat flow o f the Chag...Owing to the lack o f terrestrial heat flow data, studying lithospheric thermal structure and geodynamics of the Yingen-Ejinaqi Basin in Inner Mongolia is limited. In this paper, the terrestrial heat flow o f the Chagan sag in the YingenEjinaqi Basin were calculated by 193 system steady-state temperature measurements of 4 wells, and newly measuring 62 rock thermal conductivity and 20 heat production rate data on basis o f the original 107 rock thermal conductivity and 70 heat production data. The results show that the average thermal conductivity and heat production rate are 2.11 ±0.28 W/(m.K) and2.42±0.25 nW/m^3 in the Lower Cretaceous o f the Chagan sag. The average geothermal gradient from the Lower Suhongtu 2 Formation to the Suhongtu 1 Fonnation is 37.6 °C/km, and that o f the Bayingebi 2 Formation is 27.4 °C/km. Meanwhile, the average terrestrial heat flow in the Chagan sag is 70.6 mW/m^2. On the above results, it is clear that there is an obvious negative correlation between the thermal conductivity o f the stratum and its geothermal gradient. Moreover, it reveals that there is a geothermal state between tectonically stable and active areas. This work may provide geothermal parameters for further research o f lithospheric thermal structure and geodynamics in the Chagan sag.展开更多
Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164...Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world＇s total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.展开更多
The Silk Road Economic Belt and the 21st-Century Maritime Silk Road Initiative, abbreviated as the Belt and Road Initiative, is a primary development strategy of China＇s future international cooperation. Especially, ...The Silk Road Economic Belt and the 21st-Century Maritime Silk Road Initiative, abbreviated as the Belt and Road Initiative, is a primary development strategy of China＇s future international cooperation. Especially, the energy resource cooperation, including oil and gas resources cooperation, is an important part of this initiative. The Belt and Road has undergone complicated geological evolution, and contains abundant mineral resources such as oil, gas, coal, uranium, iron, copper, gold and manganese ore resources. Among these, Africa holds 7.8% of the world＇s total proven oil reserves. The oil and gas resources in Africa are relatively concentrated, with an overall low exploration degree and small consumption demand. Nigeria and Libya contain the most abundant oil resources in Africa, accounting for 2.2% and 2.9% of the world＇s total reserves, respectively. Nigeria and Algeria hold the richest natural gas resources in Africa, occupying 2.8% and 2.4% of the world＇s total reserves, respectively. Africa＇s oil and gas resources are mainly concentrated in Egypt, Sultan and Western Sahara regions in the northern Africa, and the Gulf of Guinea, Niger River and Congo River area in the western Africa. The Russia--Central Asia area holds rich petroleum resources in Russia, Kazakhstan, Turkmenistan and Uzbekistan. The potential oil and gas areas include the West Siberia Basin, East Siberia Basin and sea continental shelf in Russia, the northern and central Caspian Basin in Kazakhstan, the right bank of the Amu-Darya Basin, the East Karakum uplift and the South Caspian Basin in Turkmenistan, and the Amu-Daria Basin, Fergana Basin, Afghan-Tajik Basin and North Ustyurt Basin in Uzbekistan. The Middle East oil and gas resources are mainly distributed in the Zagros foreland basin and Arabian continental margin basin, and the main oil-producing countries include Saudi Arabia, Iran and Iraq. The Asia Pacific region is a new oil and gas consumption center, with rapid growth of oil and gas demand. In 2012, this region consumed about 33.6% of the world＇s total oil consumption and 18.9% of the world＇s total natural gas consumption, which has been ranked the world＇s largest oil and gas consumption center. The oil and gas resources are concentrated in China, Indosinian, Malaysia, Australia and India. The abundant European proven crude oil reserves are in Norway, Britain and Denmark and also rich natural gas resources in Norway, Holland and Britain. Norway and Britain contain about 77.5% of European proven oil reserves, which accounts for only 0.9% of the world＇s proven reserves. The Europe includes main petroliferous basins of the Voring Basin, Anglo-Dutch Basin, Northwest German Basin, Northeast German-Polish Basin and Carpathian Basin. According to the analysis of source rocks, reservoir rocks, cap rocks and traps for the main petroliferous basins, the potential oil and gas prospecting targets in the Belt and Road are mainly the Zagros Basin and Arabic Platform in the Middle East, the East Barents Sea Basin and the East Siberia Basin in Russia-Central Asia, the Niger Delta Basin, East African rift system and the Australia Northwest Shelf. With the development of oil and gas theory and exploration technology, unconventional petroleum resources will play an increasingly important role in oil and gas industry.展开更多
With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, tradit...With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, traditional metal materials cannot meet the functional requirements. Consequently, ＂three rare mineral resources＂, regarded as the best altemative for current and future new industries, have received much attention among industrial circles and have become a new focus during the present geological prospecting in China.展开更多
文摘目的观察不同时间点神经元特异性烯醇化酶(NSE)水平对重症社区获得性肺炎(SCAP)患者ICU死亡的预测价值。方法选取2021年6月至2023年6月在河北省人民医院急诊重症监护病房(EICU)住院的74例SCAP患者。患者于入院后12小时内检测血中性粒细胞计数、血肌酐(Scr)、白蛋白(Alb)、降钙素原(PCT)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和白细胞介素6(IL-6)水平。于患者入院后第1天[NSE(day1)]和第4天[NSE(day4)]早晨采集NSE血样进行检验。并根据患者ICU内是否死亡分为生存组(n=57)和死亡组(n=17)。采用多因素logistic回归分析、受试者工作特征(ROC)曲线及曲线下面积(AUC)评价上述参数的预测效果。结果死亡组患者急性生理和慢性健康II评分(APACHE II score)、IL-6水平、中性粒细胞计数、NSE(day1)和NSE(day4)水平高于生存组(P<0.05),氧合指数(PaO_(2)/FiO_(2))明显低于生存组(P<0.05)。APACHE IIscore、IL-6水平、中性粒细胞计数、NSE(day1)和NSE(day4)水平与SCAP患者ICU死亡呈弱的正相关(P<0.05),PaO_(2)/FiO_(2)与患者ICU死亡呈弱的负相关(P<0.05)。多因素logistic回归分析结果显示,APACHE IIscore和NSE(day4)与SCAP患者ICU死亡相关(P<0.05)。APACHE II score和NSE(day4)预测SCAP患者ICU死亡的AUC分别为0.729(95%CI 0.613~0.826)和0.787(95%CI0.676~0.874),两者的AUC差异无统计学意义(P=0.561)。NSE(day4)预测患者ICU死亡的敏感性和特异性分别为57.89%和88.24%(临界值为14.83μg/L)。结论NSE(day4)是SCAP患者ICU死亡的独立预测指标,是评估SCAP患者预后的一个很好的替代选择。
文摘目的观察心脏收缩力调节(CCM)对心力衰竭(心衰)兔转化生长因子β1(TGFβ1)/Smad/结缔组织生长因子(CTGF)信号通路影响。方法 30只新西兰大白兔经升主动脉根部套扎建立心衰模型,分为假手术组、心衰组、CCM组(心衰模型成功后,给予4周CCM治疗),每组10只。采用天狼猩红染色法分析心肌组织Ⅰ型及Ⅲ型胶原纤维;比色法测定心肌组织羟脯氨酸含量;蛋白印迹法检测心肌组织TGFβ1、Smad3、Smad7、CTGF蛋白表达水平。结果与假手术组比较,心衰组Ⅰ型和Ⅲ型胶原纤维及羟脯氨酸含量增加(P<0.05),CCM组较心衰组减轻心肌Ⅰ型和Ⅲ型胶原纤维及羟脯氨酸含量[(13.19±5.96)%vs(16.31±7.01)%,(7.39±2.13)%vs(11.57±5.02)%,(0.69±0.05)μg/mg vs(0.98±0.04)μg/mg,P<0.05]。与假手术组比较,心衰组TGFβ1、Smad3、CTGF蛋白表达升高,Smad7蛋白表达下降(P<0.05)。与心衰组比较,CCM组TGFβ1、Smad3、CTGF蛋白表达下调(0.49±0.03 vs 0.67±0.04,0.43±0.06 vs 0.59±0.06,0.45±0.08 vs 0.75±0.09,P<0.05),Smad7蛋白表达上调(0.43±0.08 vs 0.26±0.04,P<0.05)。结论 CCM可下调TGFβ1、Smad3、CTGF蛋白表达,上调Smad7蛋白表达,改善心衰兔心肌纤维化。
基金granted by the Key Project of the National Natural Science Foundation of China (Grant Nos. 41125010, 91114202, 90914006)the key state science and technology projects (Grant No: 2011ZX05006-004)the National Basic Research Program of China (Grant No: 2011CB201100)
文摘The Dongpu sag is located in the south of the Bohai Bay basin,China,and has abundant oil and gas reserves.To date,there has been no systematic documentation of its geothermal fields.This study measured the rock thermal conductivity of 324 cores from 47 wells,and calculated rock thermal conductivity for different formations.The geothermal gradient and terrestrial heat flow were calculated for 192 wells on basis of 892 formation-testing data from 523 wells.The results show that the Dongpu sag is characterized by a medium-temperature geothermal field between stable and active tectonic areas,with an average geothermal gradient of 32.0℃/km and terrestrial heat flow of 65.6 mW/m2.The geothermal fields in the Dongpu sag is significantly controlled by the Changyuan,Yellow River,and Lanliao basement faults.They developed in the Paleogene and the Dongying movement occurred at the Dongying Formation depositional period.The geothermal fields distribution has a similar characteristic to the tectonic framework of the Dongpu sag,namely two subsags,one uplift,one steep slope and one gentle slope.The oil and gas distribution is closely associated with the present geothermal fields.The work may provide constraints for reconstructing the thermal history and modeling source rock maturation evolution in the Dongpu sag.
基金funded by the National Natural Science Foundation of China (grant no. 41374089, 41402219)the Foundation of the Geoscience Young Science Foundation of Liu Baojun (Grant No. DMSM2017003)+1 种基金the Sichuan Science & Technology Foundation (Grant No. 2016JQ0043)the State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum, Beijing (Grant No. PRP/open-1705)
文摘Owing to the lack o f terrestrial heat flow data, studying lithospheric thermal structure and geodynamics of the Yingen-Ejinaqi Basin in Inner Mongolia is limited. In this paper, the terrestrial heat flow o f the Chagan sag in the YingenEjinaqi Basin were calculated by 193 system steady-state temperature measurements of 4 wells, and newly measuring 62 rock thermal conductivity and 20 heat production rate data on basis o f the original 107 rock thermal conductivity and 70 heat production data. The results show that the average thermal conductivity and heat production rate are 2.11 ±0.28 W/(m.K) and2.42±0.25 nW/m^3 in the Lower Cretaceous o f the Chagan sag. The average geothermal gradient from the Lower Suhongtu 2 Formation to the Suhongtu 1 Fonnation is 37.6 °C/km, and that o f the Bayingebi 2 Formation is 27.4 °C/km. Meanwhile, the average terrestrial heat flow in the Chagan sag is 70.6 mW/m^2. On the above results, it is clear that there is an obvious negative correlation between the thermal conductivity o f the stratum and its geothermal gradient. Moreover, it reveals that there is a geothermal state between tectonically stable and active areas. This work may provide geothermal parameters for further research o f lithospheric thermal structure and geodynamics in the Chagan sag.
文摘Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world＇s total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.
基金financially supported by the National Natural Science Foundation of China(grant No.41402219)
文摘The Silk Road Economic Belt and the 21st-Century Maritime Silk Road Initiative, abbreviated as the Belt and Road Initiative, is a primary development strategy of China＇s future international cooperation. Especially, the energy resource cooperation, including oil and gas resources cooperation, is an important part of this initiative. The Belt and Road has undergone complicated geological evolution, and contains abundant mineral resources such as oil, gas, coal, uranium, iron, copper, gold and manganese ore resources. Among these, Africa holds 7.8% of the world＇s total proven oil reserves. The oil and gas resources in Africa are relatively concentrated, with an overall low exploration degree and small consumption demand. Nigeria and Libya contain the most abundant oil resources in Africa, accounting for 2.2% and 2.9% of the world＇s total reserves, respectively. Nigeria and Algeria hold the richest natural gas resources in Africa, occupying 2.8% and 2.4% of the world＇s total reserves, respectively. Africa＇s oil and gas resources are mainly concentrated in Egypt, Sultan and Western Sahara regions in the northern Africa, and the Gulf of Guinea, Niger River and Congo River area in the western Africa. The Russia--Central Asia area holds rich petroleum resources in Russia, Kazakhstan, Turkmenistan and Uzbekistan. The potential oil and gas areas include the West Siberia Basin, East Siberia Basin and sea continental shelf in Russia, the northern and central Caspian Basin in Kazakhstan, the right bank of the Amu-Darya Basin, the East Karakum uplift and the South Caspian Basin in Turkmenistan, and the Amu-Daria Basin, Fergana Basin, Afghan-Tajik Basin and North Ustyurt Basin in Uzbekistan. The Middle East oil and gas resources are mainly distributed in the Zagros foreland basin and Arabian continental margin basin, and the main oil-producing countries include Saudi Arabia, Iran and Iraq. The Asia Pacific region is a new oil and gas consumption center, with rapid growth of oil and gas demand. In 2012, this region consumed about 33.6% of the world＇s total oil consumption and 18.9% of the world＇s total natural gas consumption, which has been ranked the world＇s largest oil and gas consumption center. The oil and gas resources are concentrated in China, Indosinian, Malaysia, Australia and India. The abundant European proven crude oil reserves are in Norway, Britain and Denmark and also rich natural gas resources in Norway, Holland and Britain. Norway and Britain contain about 77.5% of European proven oil reserves, which accounts for only 0.9% of the world＇s proven reserves. The Europe includes main petroliferous basins of the Voring Basin, Anglo-Dutch Basin, Northwest German Basin, Northeast German-Polish Basin and Carpathian Basin. According to the analysis of source rocks, reservoir rocks, cap rocks and traps for the main petroliferous basins, the potential oil and gas prospecting targets in the Belt and Road are mainly the Zagros Basin and Arabic Platform in the Middle East, the East Barents Sea Basin and the East Siberia Basin in Russia-Central Asia, the Niger Delta Basin, East African rift system and the Australia Northwest Shelf. With the development of oil and gas theory and exploration technology, unconventional petroleum resources will play an increasingly important role in oil and gas industry.
文摘With the global rise of industries of the new-generation information technology, energy conservation and environmental protection, biotechnology, high-end manufacturing, new materials and clean-energy vehicles, traditional metal materials cannot meet the functional requirements. Consequently, ＂three rare mineral resources＂, regarded as the best altemative for current and future new industries, have received much attention among industrial circles and have become a new focus during the present geological prospecting in China.
