Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted...Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted of a population-based cross-sectiona subsequent 1-year follow-up study of 171 subjects with the fasting cholesterol of 5.13-8.00 mmol/L. study of 456 plasma total Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol （LDL-c） had a significant and negative association with the erythrocyte membrane n-6：n-3 PUFAs ratio （P for trend=0.019） after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6：n-3 ratio in erythrocyte membrane （△=month 12-month 0）. In the top quartile whose ratios of n-6：n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6：n-3 decreased by an average of 1.13 （-1.07 mmol/L v.s. -0.32 mmol/L）. The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile （P for difference=0.052）. Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.展开更多
运用可视化知识图谱分析,以Web of Science核心合集作为文献来源,梳理孤独症谱系障碍干预研究的热点、趋势。结果表明:孤独症谱系障碍干预研究的载文量经历了1971—1990年的萌芽、1991—2013年的兴起、2014—2024年5月的迅猛发展三个阶...运用可视化知识图谱分析,以Web of Science核心合集作为文献来源,梳理孤独症谱系障碍干预研究的热点、趋势。结果表明:孤独症谱系障碍干预研究的载文量经历了1971—1990年的萌芽、1991—2013年的兴起、2014—2024年5月的迅猛发展三个阶段;研究机构有高校、医院;研究者来自不同学科,有教育学、心理学、医学等;研究热点集中在孤独症谱系障碍干预方法、父母培训、高功能孤独症干预研究三方面;研究趋势从早期关注社交、同伴、社区的单一干预转向对孤独症谱系障碍的核心症状的持续关注;最新的前沿研究集中在基于新技术、新理念的尝试。展开更多
基金supported by research grants from the National Natural Science Foundation of China (30872102)the Diet Nutrition Research & Communication Grant of Danone Institute China (DIC2008‐12)
文摘Objective To investigate the relationships between erythrocyte membrane n-6：n-3 PUFAs ratio and blood lipids and high sensitivity C-reactive protein （hs-CRP）. Methods The Chinese and a observational study consisted of a population-based cross-sectiona subsequent 1-year follow-up study of 171 subjects with the fasting cholesterol of 5.13-8.00 mmol/L. study of 456 plasma total Results In the cross-sectional analysis, plasma low-density lipoprotein cholesterol （LDL-c） had a significant and negative association with the erythrocyte membrane n-6：n-3 PUFAs ratio （P for trend=0.019） after adjusting for sex, age and total PUFA percentage. In the follow-up study, 171 subjects were categorized into quartiles by the changes of n-6：n-3 ratio in erythrocyte membrane （△=month 12-month 0）. In the top quartile whose ratios of n-6：n-3 increased by an average of 1.25 during the follow-up, the LDL-c-lowering extent was 3.3 times of that in the lowest quartile whose ratios of n-6：n-3 decreased by an average of 1.13 （-1.07 mmol/L v.s. -0.32 mmol/L）. The hsCRP decreased by 0.11 mg/dL in the lowest quartile while increasing by 0.10 mg/dL in the top quartile （P for difference=0.052）. Conclusion Our results suggested that the balance between n-6 and n-3 fatty acids may optimize the cardiovascular benefits from dietary PUFAs.
文摘运用可视化知识图谱分析,以Web of Science核心合集作为文献来源,梳理孤独症谱系障碍干预研究的热点、趋势。结果表明:孤独症谱系障碍干预研究的载文量经历了1971—1990年的萌芽、1991—2013年的兴起、2014—2024年5月的迅猛发展三个阶段;研究机构有高校、医院;研究者来自不同学科,有教育学、心理学、医学等;研究热点集中在孤独症谱系障碍干预方法、父母培训、高功能孤独症干预研究三方面;研究趋势从早期关注社交、同伴、社区的单一干预转向对孤独症谱系障碍的核心症状的持续关注;最新的前沿研究集中在基于新技术、新理念的尝试。
