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子午流注腕踝针疗法防治化疗所致恶心呕吐的效果研究
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作者 蒋晓芳 何竹 +3 位作者 陈曦 陈莉 李露霞 张倩 《护理管理杂志》 CSCD 2024年第2期180-184,共5页
目的探讨子午流注腕踝针疗法防治化疗所致恶心呕吐的临床效果。方法选取接受静脉化疗的肿瘤患者212例住院患者随机分为观察组107例、对照组105例。对照组采用常规护理方法,观察组在对照组的基础上给予腕踝针干预治疗。观察化疗后所致恶... 目的探讨子午流注腕踝针疗法防治化疗所致恶心呕吐的临床效果。方法选取接受静脉化疗的肿瘤患者212例住院患者随机分为观察组107例、对照组105例。对照组采用常规护理方法,观察组在对照组的基础上给予腕踝针干预治疗。观察化疗后所致恶心呕吐发生率、严重程度、焦虑抑郁、日常生活能力。结果观察组患者化疗后第6天恶心呕吐发生率、严重程度、焦虑抑郁低于对照组(P<0.01),观察组患者化疗后第6天日常生活能力高于对照组(P<0.01)。结论子午流注腕踝针疗法可有效降低化疗所致肿瘤患者恶心呕吐发生率及严重程度,缓解焦虑情绪,提高生存质量具有较好的临床效果。 展开更多
关键词 化疗 恶心 呕吐 子午流注 腕踝针
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超微血管成像技术与多参数磁共振检查在前列腺癌诊断中的应用价值比较
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作者 何竹 张渊 +2 位作者 单君 傅宇 江泉 《影像研究与医学应用》 2024年第12期7-11,共5页
目的:比较超微血管成像(SMI)技术与多参数磁共振(mpMRI)检查对前列腺癌的诊断准确性。方法:选取2022年1月—2023年11月上海市浦东新区人民医院收治的61例可疑前列腺癌患者,均行SMI和mpMRI检查以及经直肠超声(TRUS)引导的系统穿刺+可疑... 目的:比较超微血管成像(SMI)技术与多参数磁共振(mpMRI)检查对前列腺癌的诊断准确性。方法:选取2022年1月—2023年11月上海市浦东新区人民医院收治的61例可疑前列腺癌患者,均行SMI和mpMRI检查以及经直肠超声(TRUS)引导的系统穿刺+可疑病灶的靶向穿刺活检术,以病理结果为金标准,绘制受试者工作特征(ROC)曲线并计算曲线下面积(AUC),评估SMI、mpMRI及SMI联合mpMRI诊断前列腺癌的准确率。结果:61例疑似前列腺癌患者中,病理诊断为前列腺腺癌22例,良性39例。SMI检出23例有异常征象,其中17例病理诊断为恶性,SMI诊断前列腺癌的灵敏度为77.27%、特异度84.62%、阳性预测值73.91%、阴性预测值86.84%、准确率81.97%。mpMRI检出24例有异常征象,其中20例病理诊断为恶性,mpMRI诊断前列腺癌的灵敏度为90.91%、特异度为89.74%、阳性预测值83.33%、阴性预测值94.59%、准确率90.16%。SMI联合mpMRI诊断前列腺癌的灵敏度为95.45%、特异度为79.49%、阳性预测值72.41%、阴性预测值96.88%、准确率85.25%。ROC曲线分析结果显示,SMI、mpMRI及SMI联合mpMRI诊断前列腺癌的AUC分别为0.809(95%CI:0.688~0.931)、0.903(95%CI:0.814~0.993)及0.875(95%CI:0.782~0.968),3种诊断方法比较差异无统计学意义(SMI vs mpMRI,Z=-1.591、P=0.112,SMI vs SMI联合mpMRI,Z=-1.427、P=0.153,mpMRI vs SMI联合mpMRI,Z=0.852、P=0.394)。结论:mpMRI诊断前列腺癌的准确率高于SMI,两者联合应用并精准靶向穿刺可提高前列腺癌的检出率。 展开更多
关键词 前列腺癌 超微血管成像 多参数磁共振 经直肠超声 靶向穿刺
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集成血液净化联合利妥昔单抗治疗抗中性粒细胞胞浆抗体伴抗肾小球基底膜抗体阳性的血管炎患者:一例报告及文献复习
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作者 朱合 徐佳 +4 位作者 尤永珂 宋佚凡 陈利婷 任野萍 王琴 《中华肾病研究电子杂志》 2024年第5期291-295,共5页
抗中性粒细胞胞浆抗体(anti-neutrophil cytoplasmic antibody,ANCA)相关性血管炎(ANCA-associated vasculitis,AAV)、抗肾小球基底膜病(anti-glomerular basement membrane disease,抗GBM病)均为可累及全身多系统的自身免疫性弥漫性小... 抗中性粒细胞胞浆抗体(anti-neutrophil cytoplasmic antibody,ANCA)相关性血管炎(ANCA-associated vasculitis,AAV)、抗肾小球基底膜病(anti-glomerular basement membrane disease,抗GBM病)均为可累及全身多系统的自身免疫性弥漫性小血管炎,肾脏是最常受累的靶器官之一,均可导致新月体性肾小球肾炎,是急进性肾小球肾炎的常见病理类型。两者患病率虽然较低,但起病急、进展快、预后差、死亡率高。 展开更多
关键词 抗中性粒细胞胞浆抗体 利妥昔单抗 急进性肾小球肾炎 小血管炎 血液净化 ANCA 靶器官 预后差
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Insights into Ti doping for stabilizing the Na_(2/3)Fe_(1/3)Mn_(2/3)O_(2)cathode in sodium ion battery 被引量:3
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作者 Tingting Yang Yalan Huang +7 位作者 Jian Zhang he zhu Jincan Ren Tianyi Li Leighanne C.Gallington Si Lan Ligao Yang Qi Liu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第10期542-548,I0013,共8页
Iron-and manganese-based layered metal oxides,as cathodes for sodium ion batteries,have received widespread attention because of the low cost and high specific capacity.However,the Jahn-teller effect of Mn^(3+)ions an... Iron-and manganese-based layered metal oxides,as cathodes for sodium ion batteries,have received widespread attention because of the low cost and high specific capacity.However,the Jahn-teller effect of Mn^(3+)ions and the resulted unstable structure usually lead to continuously capacity decay.Herein,Titanium(Ti)has been successfully doped into Na_(2/3)Fe_(2/3)Mn_(2/3)O_(2)to suppress the Jahn-Teller distortion and improve both cycling and rate performance of sodium ion batteries.In situ high-energy synchrotron X-ray diffraction study shows that Ti-doped compound(Na_(2/3)Fe_(1/3)Mn_(0.57)Ti_(0.1)O_(2))can maintain the single P2 phase without any phase transition during the whole charging/discharging process.Various electrochemical characterizations are also applied to explore the better kinetics of sodium ions transfer in the Na_(2/3)Fe_(1/3)Mn_(0.5)7 Ti_(0.1)O_(2).This work provides a comprehensive insight into the Ti-doping effects on the performance from both structural and electro kinetic perspectives. 展开更多
关键词 Layered transition metal oxides Jahn-Teller effect In situ synchrotron X-ray diffraction Phase transition
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Restoration and protection of brachial plexus injury: hot topics in the last decade 被引量:1
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作者 Kaizhi Zhang Zheng Lv +2 位作者 Jun Liu he zhu Rui Li 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第18期1723-1728,共6页
Brachial plexus injury is frequently induced by injuries, accidents or birth trauma. Upper limb function may be partially or totally lost after injury, or left permanently disabled. With the de- velopment of various m... Brachial plexus injury is frequently induced by injuries, accidents or birth trauma. Upper limb function may be partially or totally lost after injury, or left permanently disabled. With the de- velopment of various medical technologies, different types of interventions are used, but their effectiveness is wide ranging. Many repair methods have phasic characteristics, i.e., repairs are done in different phases. This study explored research progress and hot topic methods for pro- tection after brachial plexus injury, by analyzing 1,797 articles concerning the repair of brachial plexus injuries, published between 2004 and 2013 and indexed by the Science Citation Index database. Results revealed that there are many methods used to repair brachial plexus injury, and their effects are varied. Intervention methods include nerve transfer surgery, electrical stimula- tion, cell transplantation, neurotrophic factor therapy and drug treatment. Therapeutic methods in this field change according to the hot topic of research. 展开更多
关键词 nerve regeneration brachial plexus injury repair NEUROPROTECTION nerve transfer celltransplantation ELECTROACUPUNCTURE neurotrophic factor DRUGS BIBLIOMETRICS neural regeneration
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Short-wavelength infrared InAs/GaSb superlattice hole avalanche photodiode 被引量:1
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作者 Jia-Feng Liu Ning-Tao Zhang +9 位作者 Yan Teng Xiu-Jun Hao Yu Zhao Ying Chen he zhu Hong zhu Qi-Hua Wu Xin Li Bai-Le Chen Yong Huang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第11期469-472,共4页
We demonstrate two short-wavelength infrared avalanche photodiodes based on InAs/GaSb superlattice grown by metal-organic chemical vapor deposition.The difference between the two devices,namely,p+n-n+and p+nn-n+,is th... We demonstrate two short-wavelength infrared avalanche photodiodes based on InAs/GaSb superlattice grown by metal-organic chemical vapor deposition.The difference between the two devices,namely,p+n-n+and p+nn-n+,is that the p+nn-n+device possesses an additional middle-doped layer to separate the multiplication region from the absorption region.By properly controlling the electric field distribution in the p+nn-n+device,an electric field of 906 kV/cm has been achieved,which is 2.6 times higher than that in the p+n-n+device.At a reverse bias of-0.1 V at 77 K,both devices show a 100%cut-off wavelength of 2.25μm.The p+n-n+and p+nn-n+show a dark current density of 1.5×10^-7 A/cm^2 and 1.8×10^-8 A/cm^2,and a peak responsivity about 0.35 A/W and 0.40 A/W at 1.5μm,respectively.A maximum multiplication gain of 55 is achieved in the p+nn-n+device while the value is only less than 2 in the p+n-n+device.Exponential nature of the gain characteristic as a function of reverse bias confirms a single carrier hole dominated impact ionization. 展开更多
关键词 short-wavelength infrared InAs/GaSb superlattice avalanche photodiodes metal-organic chemical vapor deposition
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Effects of Boscalid on the Antioxidant Enzyme System of Adult Zebrafish (Danio rerio)
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作者 Xiaoxia ZANG Mingshan JI +6 位作者 Kai WANG Xiuwei LI Yang ZHANG Xinghai LI Hongzhe TIAN he zhu Fang DU 《Agricultural Science & Technology》 CAS 2017年第2期287-293,共7页
Abstract [Objective] This study was conducted to evaluate the ecotoxicity of boscalid to adult zebrafish (Danio rerio). [Method] The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), ... Abstract [Objective] This study was conducted to evaluate the ecotoxicity of boscalid to adult zebrafish (Danio rerio). [Method] The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), as well as a non-enzymatic antioxidant malondialdehyde (MDA), in the liver were measured 3, 7, 14 and 21 d post exposure (dpe) to 0.02 (1/100 of acute toxicity), 0.036 (monitored concentration), 0.08 (1/20 of acute toxicity), 0.16 (1/10 of acute toxicity) and 0.32 mg/L (1/5 of acute toxicity) boscalid using a semi-static method. [Result] SOD, CAT, POD, GPx and MDA activity in the liver of zebrafish varied with boscalid concentration and exposure time. Boscalid significantly enhanced MDA content at 21 dpe. A significant upregulation of the activity of SOD, CAT, POD and GPx at 7 dpe was observed, suggesting that boscalid resulted in oxidative stress and lipid peroxidation. [Conclusion] These results show that these biomarkers are all appropriate for monitoring oxidative stress and the lipid peroxidation status of fish after exposure to boscalid. Key words Boscalid; Zebrafish; Antioxidant enzyme 展开更多
关键词 BOSCALID ZEBRAFISH Antioxidant enzyme
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抗阿尔兹海默症灯盏乙素苷元衍生物设计、合成及活性研究
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作者 李慧 何筑 +3 位作者 陈娇 李勇军 汤磊 傅晓钟 《化学试剂》 CAS 北大核心 2023年第8期47-56,共10页
基于阿尔兹海默症(AD)发病机制的复杂性,为了开发多功能的抗AD药物,根据多靶点导向配体(Multi-target directed ligands,MTDLs)策略,以灯盏乙素苷元为骨架,通过不同的连接体,连接具有胆碱酯酶抑制作用的N,N-双取代氨基甲酸酯片段和具有... 基于阿尔兹海默症(AD)发病机制的复杂性,为了开发多功能的抗AD药物,根据多靶点导向配体(Multi-target directed ligands,MTDLs)策略,以灯盏乙素苷元为骨架,通过不同的连接体,连接具有胆碱酯酶抑制作用的N,N-双取代氨基甲酸酯片段和具有单胺氧化酶抑制作用的炔丙胺、N-甲基炔丙胺片段,设计并合成9个双靶点抗AD化合物,结构经过1HNMR、13CNMR和ESI-MS鉴定。对目标化合物进行胆碱酯酶和单胺氧化酶的活性测试,其中2-(4-((二甲基氨基甲酰基)氧基)苯基)-5,6-二羟基-4-氧代-4H-色烯-7-基5-(甲基(丙-2-炔-1-基)氨基)-5-氧代戊酸酯对两种酶具有相对较好的抑制活性。酶动力学结果说明该化合物对乙酰胆碱酯酶是混合型抑制。上述化合物不仅对自身和Cu2+诱导的A_(β1-42)聚集具有良好的抑制作用(87.57%和82.22%),而且还能诱导自身和Cu^(2+)诱导的Aβ_(1-42)原纤维的分解(75.01%和77.40%)。该化合物可以进行进一步结构优化和活性测试,为多靶点抗阿尔兹海默症提供候选化合物。 展开更多
关键词 阿尔兹海默症 灯盏乙素苷元 胆碱酯酶 单胺氧化酶 多靶点定向配体
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Towards extreme fast charging of 4.6 V LiCoO_(2) via mitigating high-voltage kinetic hindrance 被引量:2
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作者 Yu Tang Jun Zhao +13 位作者 he zhu Jincan Ren Wei Wang Yongjin Fang Zhiyong Huang Zijia Yin Yalan Huang Binghao Zhang Tingting Yang Tianyi Li Leighanne CGallington Si Lan Yang Ren Qi Liu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第3期13-20,I0001,共9页
High-voltage LiCoO_(2)(LCO) is an attractive cathode for ultra-high energy density lithium-ion batteries(LIBs) in the 3 C markets.However,the sluggish lithium-ion diffusion at high voltage significantly hampers its ra... High-voltage LiCoO_(2)(LCO) is an attractive cathode for ultra-high energy density lithium-ion batteries(LIBs) in the 3 C markets.However,the sluggish lithium-ion diffusion at high voltage significantly hampers its rate capability.Herein,combining experiments with density functional theory(DFT) calculations,we demonstrate that the kinetic limitations can be mitigated by a facial Mg^(2+)+Gd^(3+)co-doping method.The as-prepared LCO shows significantly enhanced Li-ion diffusion mobility at high voltage,making more homogenous Li-ion de/intercalation at a high-rate charge/discharge process.The homogeneity enables the structural stability of LCO at a high-rate current density,inhibiting stress accumulation and irreversible phase transition.When used in combination with a Li metal anode,the doped LCO shows an extreme fast charging(XFC) capability,with a superior high capacity of 193.1 mAh g^(-1)even at the current density of 20 C and high-rate capacity retention of 91.3% after 100 cycles at 5 C.This work provides a new insight to prepare XFC high-voltage LCO cathode materials. 展开更多
关键词 Li-ion battery High-voltage LiCoO_(2) Li-ion diffusion Structural evolution Fast charging
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零相频下离子导体的焦耳加热及其电解反应抑制
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作者 石磊 韩宗益 +4 位作者 冯逸轩 张长庚 张祺 朱贺 朱世平 《Engineering》 SCIE EI CAS CSCD 2023年第6期138-143,M0006,共7页
众所周知,当电流通过导体时,会产生热。虽然我们日常生活和工业中的各种应用都是利用电子导体的加热,但很少有人注意到离子导体在加热方面的潜力。这是因为“不可避免的”电化学反应,这可能导致不必要的导体电解,电极腐蚀和表面污垢。... 众所周知,当电流通过导体时,会产生热。虽然我们日常生活和工业中的各种应用都是利用电子导体的加热,但很少有人注意到离子导体在加热方面的潜力。这是因为“不可避免的”电化学反应,这可能导致不必要的导体电解,电极腐蚀和表面污垢。本文报道了离子导体在没有电化学反应的情况下的焦耳加热。采用零相频率的电来抑制高压下离子导体的电解。用各种离子导体,液体和固体,展示了高效的能量转换,而不需要电化学反应。这种加热方法简单、直接、快速、清洁、均匀,在众多工业和家庭应用中具有巨大的潜力。 展开更多
关键词 电化学反应 离子导体 电子导体 焦耳加热 能量转换 电解反应 加热方法 电极腐蚀
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Strategies for High-quality Development of Greenhouse Vegetables in Zibo City,Shandong Province
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作者 Dongwen SUN he zhu +4 位作者 Bo LI Jiaer XU Xinying YAN Yuxin he Yu SHI 《Asian Agricultural Research》 2023年第12期21-23,共3页
This investigation report got a clear picture of the general situation of the development of greenhouse vegetable industry in Zibo,and found out the existing problems such as frequent harmful weather,few special varie... This investigation report got a clear picture of the general situation of the development of greenhouse vegetable industry in Zibo,and found out the existing problems such as frequent harmful weather,few special varieties and high-grade varieties of greenhouse vegetables,fragmentation of new technology promotion of greenhouse vegetables,low level of intensive seedling raising of vegetables,backward level of facility planting structure and equipment,etc.This paper puts forward the strategies for the future high-quality development of vegetables:promoting the adjustment of vegetable planting structure,rationally arranging vegetables for rotation,strengthening vegetable technical guidance,and innovating vegetable consumption patterns. 展开更多
关键词 GREENHOUSE VEGETABLES High quality STRATEGIES
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基于CanOpen通信的皮带运输机变频控制方案研究
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作者 贺柱 《山西焦煤科技》 CAS 2023年第3期12-15,28,共5页
针对皮带运输机控制系统存在接线复杂、能耗过高、功率失衡的问题,提出基于CanOpen通讯的皮带运输机变频控制方案。在分析皮带运输机结构以及运行工况的基础上,重点分析了核心控制器与变频器之间的CanOpen通讯方案、主从电机的变频控制... 针对皮带运输机控制系统存在接线复杂、能耗过高、功率失衡的问题,提出基于CanOpen通讯的皮带运输机变频控制方案。在分析皮带运输机结构以及运行工况的基础上,重点分析了核心控制器与变频器之间的CanOpen通讯方案、主从电机的变频控制方案以及机头、机尾电机功率平衡方案。最后在山西焦煤西山煤电集团东曲煤矿完成工业性试验。试验结果表明,设计并实现的皮带运输机变频控制系统满足设计要求,提升了皮带运输机的运行效率,达到了节能降耗的目的。 展开更多
关键词 CanOpen通讯 变频控制 功率平衡 状态机 能量消耗 皮带运输机
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藏东南色季拉山不同海拔川滇高山栎叶解剖结构及环境适应性 被引量:9
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作者 郭文文 卓么草 +3 位作者 何竹 任毅华 屈兴乐 方江平 《西南林业大学学报(自然科学)》 CAS 北大核心 2022年第2期33-38,共6页
为探索藏东南色季拉山川滇高山栎叶片解剖结构在海拔梯度上的变化趋势和环境适应性,以藏东南色季拉山11个不同海拔梯度的川滇高山栎叶片为试验材料,采用石蜡切片技术探究川滇高山栎叶片对高寒环境的适应性。结果表明:川滇高山栎叶片为... 为探索藏东南色季拉山川滇高山栎叶片解剖结构在海拔梯度上的变化趋势和环境适应性,以藏东南色季拉山11个不同海拔梯度的川滇高山栎叶片为试验材料,采用石蜡切片技术探究川滇高山栎叶片对高寒环境的适应性。结果表明:川滇高山栎叶片为异面叶,上表皮有明显的角质层,下表皮有表皮毛,栅栏组织细胞2~3层;随着海拔的升高,叶片上下表皮厚度、栅栏组织厚度、海绵组织厚度、叶片厚度呈现增大趋势,而组织结构紧密度、主脉突起度和组织结构疏松度呈现下降趋势;可塑性指数分析表明,川滇高山栎在解剖结构上表现出较小的可塑性,对外界环境的适应能力较弱;相关性分析结果表明,除海绵组织厚度与栅栏组织厚度、组织结构疏松度与组织结构紧密度之间差异不显著以外,其余各指标之间均呈显著相关性。 展开更多
关键词 色季拉山 川滇高山栎 解剖结构 环境适应性
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Prevalence of Cannabis Use around the World:A Systematic Review and Meta-Analysis,2000-2024
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作者 Qianning Wang Zhen Qin +2 位作者 Xing Xing he zhu Zhongwei Jia 《China CDC weekly》 SCIE CSCD 2024年第25期597-604,I0013,I0014,共10页
This study aims to perform a systematic review and meta-analysis on the global prevalence of cannabis use to inform drug prevention strategies,policy-making,and resource allocation.This study initially screened 177,84... This study aims to perform a systematic review and meta-analysis on the global prevalence of cannabis use to inform drug prevention strategies,policy-making,and resource allocation.This study initially screened 177,843 studies published between January 1,2000,and January 15,2024,using peer-reviewed databases including Web of Science,PubMed,Scopus,Embase,and Cochrane Library.Ultimately,595 studies were identified for data extraction,and 39 of these were selected as country-representative studies.Heterogeneity among the selected studies was assessed using the chi-squared test and I2 statistic,while sensitivity analysis was conducted to evaluate the robustness of the results.The prevalence of cannabis use varied between 0.42%and 43.90%across 33 European countries,1.40%to 38.12%across 15 North and South American countries,0.30%to 19.10%across 16 Asian countries,and 1.30%to 48.70%across 18 Oceania and African countries.The pooled prevalence of cannabis use was 12.0%[95%confidence interval(CI):10.0,14.3]in countries where cannabis is legalized,compared to 5.4%(95%CI:4.3,6.9)in non-legalized countries.Our findings indicate that the prevalence of cannabis use has disproportionately increased in most countries with the implementation of medical or recreational cannabis legalization policies and relevant geographic proximity.Increased efforts are needed to monitor newly cannabis-legalized countries and prevent initial use. 展开更多
关键词 PREVENTION LEGAL initially
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One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China
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作者 Jitao Wang Ting Cui +87 位作者 Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang he zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang he Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu zhuang Weidong Wang Qingliang zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei he Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi 《Portal Hypertension & Cirrhosis》 2024年第2期116-123,共8页
Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to in... Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future. 展开更多
关键词 application status hepatic vein pressure gradient questionnaire survey
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小茴香药熨联合穴位按摩预防阿片类药物所致便秘临床研究 被引量:3
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作者 何竹 蒋晓芳 +7 位作者 陈莉 杨茂楠 欧阳婕 宋彦 李露霞 颜丽 陈曦 李灵睿 《四川中医》 2018年第8期206-208,共3页
目的:观察小茴香药熨联合穴位按摩预防阿片类药物所致便秘的护理效果。方法:采用随机数字表将150例使用阿片类药物的恶性肿瘤患者随机分为对照组、观察1组、观察2组各50例。对照组行预防便秘的常规健康指导+口服麻仁胶囊;观察1组在对照... 目的:观察小茴香药熨联合穴位按摩预防阿片类药物所致便秘的护理效果。方法:采用随机数字表将150例使用阿片类药物的恶性肿瘤患者随机分为对照组、观察1组、观察2组各50例。对照组行预防便秘的常规健康指导+口服麻仁胶囊;观察1组在对照组的基础上使用小茴香药熨;观察2组在对照组的基础上使用小茴香药熨联合穴位按摩。观察三组患者首次排便时间、便秘的发生率、排便症状评分。结果:对照组、观察1组、观察2组首次排便时间分别为50.06±38.36h,36.12±26.83h,23.21±16.20h,干预7日后便秘发生率分别为35.4%,16.7%,4.1%,排便症状评分,在排便困难、粪便性状、排便时间、下坠感、排便频率、腹胀方面比较,差异均有统计学意义(P<0.01);观察2组在首次排便时间、便秘的发生率、排便症状评分均优于观察1组,差异有统计学意义(P<0.05)。结论:小茴香药熨联合穴位按摩药穴合用,作用相加,能有效缩短首次排便时间,降低便秘发生率,改善便秘症状,操作简单可行,突出了中医药的特色优势及未病先防的理念,值得在临床推广使用。 展开更多
关键词 癌痛 阿片类药 小茴香药熨联合穴位按摩 便秘
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新农科背景下基于FD-QM标准的“有机化学”在线课程建设 被引量:1
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作者 洪波 陈元晖 +3 位作者 赵淑杰 朱鹤 杨雨东 刘文丛 《吉林省教育学院学报》 2022年第9期77-80,共4页
“新农科”建设的人才培养目标是培养“知农爱农、强农兴农”的新型人才,这对高等农林院校的在线课程建设提出了新要求。FD-QM标准注重“以学为中心”,在关注学生在学习过程中实现知识目标的同时,还关注学生能力目标和素质目标的实现,... “新农科”建设的人才培养目标是培养“知农爱农、强农兴农”的新型人才,这对高等农林院校的在线课程建设提出了新要求。FD-QM标准注重“以学为中心”,在关注学生在学习过程中实现知识目标的同时,还关注学生能力目标和素质目标的实现,符合“新农科”建设对农林人才的需求。吉林农业大学“有机化学”在线开放课程,以FD-QM标准为课程建设的依据,从课程导航、学习目标、学业考评、课程资料、课程活动、课程技术、学习支持、课程制作等方面对课程进行了重新构建,使学生自主学习更加容易,获得更好的学习体验,帮助学生更好地达成学习目标。 展开更多
关键词 新农科 FD-QM标准 在线课程 有机化学
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黄芪甲苷缓解表柔比星相关心脏毒性的动物实验
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作者 栾丽娜 朱裴钦 +5 位作者 何竹 张渊 单君 傅宇 黄燕 江泉 《中国临床医学》 2022年第6期1006-1011,共6页
目的探讨黄芪甲苷对表柔比星相关心脏毒性的心肌保护作用。方法将24只Sprague-Dauley(SD)大鼠随机分为4组,分别为对照组(空白溶剂+生理盐水)、模型组(空白溶剂+表柔比星)、低剂量黄芪甲苷治疗组(15 mg/kg黄芪甲苷+表柔比星)与高剂量黄... 目的探讨黄芪甲苷对表柔比星相关心脏毒性的心肌保护作用。方法将24只Sprague-Dauley(SD)大鼠随机分为4组,分别为对照组(空白溶剂+生理盐水)、模型组(空白溶剂+表柔比星)、低剂量黄芪甲苷治疗组(15 mg/kg黄芪甲苷+表柔比星)与高剂量黄芪甲苷治疗组(75 mg/kg黄芪甲苷+表柔比星),每组6只。用药前及用药后2、4、6周对所有大鼠行超声心动图检查,采用两因素重复测量方差分析评估大鼠心脏收缩功能变化,评价指标包括左室射血分数(left ventricular ejection fraction,LVEF)、三尖瓣环收缩期位移(tricuspid annular plane systolic excursion,TAPSE)及右室面积变化分数(fractional area change,FAC)。用药后6周对所有大鼠心脏取材行Masson染色。结果4组大鼠LVEF不存在组间、时间及组间与时间交互效应。4组大鼠TAPSE存在组间与时间交互效应(P=0.011)。随着时间延长,模型组大鼠TAPSE下降幅度较其余各组显著(P<0.05);TAPSE和FAC在4组间差异均有统计学意义(P<0.001)。模型组大鼠TAPSE和FAC在用药后2周开始下降(P<0.05);低剂量黄芪甲苷治疗组FAC在用药后4周开始下降(P<0.05);高剂量黄芪甲苷治疗组FAC在用药后6周开始下降(P<0.05)。Masson染色显示各组大鼠心肌内不同程度胶原纤维沉积,与右室收缩功能受损程度匹配。结论黄芪甲苷可对抗心肌纤维化、缓解表柔比星相关的心脏毒性,高剂量疗效优于低剂量。 展开更多
关键词 黄芪甲苷 心脏毒性 表柔比星 右室收缩功能
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半导体制冷器在弱散热条件下的制冷性能分析 被引量:5
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作者 李晓辉 廖明建 +1 位作者 贺铸 樊希安 《低温工程》 CAS CSCD 北大核心 2019年第6期32-39,共8页
利用ANSYS Workbench中的热电耦合模块对3款型号半导体制冷器进行建模与数值模拟,并将模拟结果与文献进行对比。基于此模型分析了在热端散热条件受到限制的情况下3款型号半导体制冷器制冷性能的变化规律。研究表明:热端散热条件对功率... 利用ANSYS Workbench中的热电耦合模块对3款型号半导体制冷器进行建模与数值模拟,并将模拟结果与文献进行对比。基于此模型分析了在热端散热条件受到限制的情况下3款型号半导体制冷器制冷性能的变化规律。研究表明:热端散热条件对功率越大的器件影响越显著,在冷端温度为10℃时大功率器件的散热量较小功率器件高出13.8%,热端温度高出7.7℃,其制冷量与制冷系数仅为后者的25.7%和19.7%。将输入电压由12 V减小为9 V后,在相同的散热条件下大功率器件的制冷量增加了2.1 W,增幅达211%,制冷系数增幅达142%。但其性能依然不及其余两款小功率器件。因此,在热端散热条件受到限制时,适当减小器件的输入功率反而可以得到更好的制冷性能,且小功率器件更适合在该场合下使用。在器件的冷端温度高于室温时,大功率器件的热端温度容易过高,影响器件使用寿命甚至烧毁器件。将输入电压由12 V减小为9 V后,大功率器件的制冷量较小功率器件高6.9%。因此,在适当减小输入功率后,大功率器件会更适合冷端温度高于室温的制冷工况。 展开更多
关键词 半导体制冷 数值模拟 散热条件 制冷量 输入功率
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长期施无机磷肥对黄泥土稻田土壤磷库的影响 被引量:5
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作者 许琛 沈素素 +5 位作者 何竹 王宁 周贝贝 沈明星 施林林 薛利红 《农业环境科学学报》 CAS CSCD 北大核心 2022年第11期2506-2514,共9页
本研究选取太湖流域黄泥土长期定位试验田作为研究对象,明确40 a长期施磷对水稻土土壤磷库、磷形态及有效性的影响。结果表明:长期施磷(NPK)处理的土壤总磷和有效磷含量高达589.58 mg·kg^(-1)和51.67 mg·kg^(-1),比不施磷(NK... 本研究选取太湖流域黄泥土长期定位试验田作为研究对象,明确40 a长期施磷对水稻土土壤磷库、磷形态及有效性的影响。结果表明:长期施磷(NPK)处理的土壤总磷和有效磷含量高达589.58 mg·kg^(-1)和51.67 mg·kg^(-1),比不施磷(NK)处理显著增加126.61%和216.41%。两处理无机磷均以Fe-P和Ca-P为主,约占无机磷的69.53%~79.86%,有机磷以活性和中活性有机磷为主。长期施磷使稻田无机磷含量在3个生育期均极显著增加,增幅为170%以上,其中Al-P和Fe-P的含量及相对占比显著提升,Ca-P含量增加但相对含量明显降低,O-P含量变化较小而相对含量降低。长期施磷处理下有机磷含量仅在分蘖期增幅显著(33%),主要表现为活性和中活性有机磷含量显著增加。与分蘖期相比,抽穗期长期施磷处理的Al-P、Fe-P以及高稳定有机磷的相对含量明显下降,Ca-P和中活性有机磷的相对含量上升,而长期不施磷处理表现为Fe-P、O-P以及高稳定有机磷的相对含量下降,Ca-P和中活性有机磷的相对含量上升。Al-P、Fe-P、Ca-P、O-P和中活性有机磷均与有效磷(AP)显著正相关。研究发现:Al-P、Fe-P和Ca-P是黄泥土稻田最主要的有效磷源,土壤缺磷时土壤磷酸酶等对有机磷的活化也是重要的有效磷来源之一;长期施用无机磷肥导致稻田土壤无机磷库累积明显,磷流失风险增加,因此应在保证稻麦高产的前提下合理降低磷肥施入量,充分活化利用土壤中固存的难溶态磷来提高土壤磷素利用率。 展开更多
关键词 长期施磷 稻田 磷形态 磷素有效性
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