The presence of horizontal layered rocks in tunnel engineering significantly impacts the stability and strength of the surrounding rock mass,leading to floor heave in the tunnel.This study focused on preparing layered...The presence of horizontal layered rocks in tunnel engineering significantly impacts the stability and strength of the surrounding rock mass,leading to floor heave in the tunnel.This study focused on preparing layered specimens of rock-like material with varying thickness to investigate the failure behaviors of tunnel floors.The results indicate that thin-layered rock mass exhibits weak interlayer bonding,causing rock layers near the surface to buckle and break upwards when subjected to horizontal squeezing.With an increase in the layer thickness,a transition in failure mode occurs from upward buckling to shear failure along the plane,leading to a noticeable reduction in floor heave deformation.The primary cause of significant deformation in floor heave is upward buckling failure.To address this issue,the study proposes the installation of a partition wall in the middle of the floor to mitigate heave deformation of the rock layers.The results demonstrate that the partition wall has a considerable stabilizing effect on the floor,reducing the zone of buckling failure and minimizing floor heave deformation.It is crucial for the partition wall to be sufficiently high to prevent buckling failure and ensure stability.Through simulation calculations on an engineering example,it is confirmed that implementing a partition wall can effectively reduce floor heave and enhance the stability of tunnel floor.展开更多
基金supported by the Key Program of National Natural Science Foundation of China(No.U23A202579)the National Natural Science Foundation of China(No.42277187,42007276,41972297)the Natural Science Foundation of Hebei Province(No.D2021202002)。
文摘The presence of horizontal layered rocks in tunnel engineering significantly impacts the stability and strength of the surrounding rock mass,leading to floor heave in the tunnel.This study focused on preparing layered specimens of rock-like material with varying thickness to investigate the failure behaviors of tunnel floors.The results indicate that thin-layered rock mass exhibits weak interlayer bonding,causing rock layers near the surface to buckle and break upwards when subjected to horizontal squeezing.With an increase in the layer thickness,a transition in failure mode occurs from upward buckling to shear failure along the plane,leading to a noticeable reduction in floor heave deformation.The primary cause of significant deformation in floor heave is upward buckling failure.To address this issue,the study proposes the installation of a partition wall in the middle of the floor to mitigate heave deformation of the rock layers.The results demonstrate that the partition wall has a considerable stabilizing effect on the floor,reducing the zone of buckling failure and minimizing floor heave deformation.It is crucial for the partition wall to be sufficiently high to prevent buckling failure and ensure stability.Through simulation calculations on an engineering example,it is confirmed that implementing a partition wall can effectively reduce floor heave and enhance the stability of tunnel floor.
文摘目的:基于加权基因共表达网络分析(weighted gene co-expression network analysis,WGCNA)联合网络药理学方法探讨益髓生血胶囊治疗肝细胞癌(hepatocellular carcinoma,HCC)的分子机制,筛选肝细胞癌潜在预后标志物。方法:采用中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)筛选益髓生血胶囊有效成分对应靶点;从TCGA数据库下载HCC及癌旁组织基因芯片,通过“Limma”包筛选差异基因;使用WGCNA包通过TCGA数据库中HCC的基因表达数据图谱构建基因共表达网络,筛选与临床性状相关基因模块;对益髓生血胶囊调控基因、HCC差异基因、模块基因取交集;使用Cytoscape构建药物-靶点-疾病网络,对交集基因进行基因本体论(gene ontology,Go)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析;使用STRING数据库构建交集基因间的蛋白-蛋白互作(protein-protein interactions,PPI)网络;根据最大团中心性(maximal clique centrality,MCC)评分对前10个基因与HCC的预后进行探索,进一步分析以获得HCC潜在标志物。结果:共获得益髓生血胶囊438个有效成分对应靶点;从TCGA数据库共获得374个肿瘤样本和50个正常样本,Limma包共筛选出2703个差异基因;WGCNA筛选出1922个与正常组织相关的基因,交集基因共26个,主要富集于细胞衰老、细胞周期、乙肝、p53信号通路、多种癌症、IL-17等信号通路;26个交集基因中,7个基因的高表达与肝癌患者的较差总生存率(overall survival,OS)/无病生存率(disease free survival,DFS)具有显著差异(P<0.05)。结论:益髓生血胶囊治疗HCC的作用机制复杂,主要涉及细胞衰老、细胞周期、乙肝、p53信号通路、多种癌症、IL-17等信号通路,其主要作用成分可能与榭皮素、木草素、芦荟大黄素、芒柄花素等有关。BIRC5、CCNA2、CCNB1、CDK1、CHEK1、E2F1、TOP2A等7个基因可能为HCC的潜在预后生物标志物。
