姜黄素是从中药姜科姜黄属植物姜黄(Curcuma longa L.)的根茎中提取的活性分子。研究表明,姜黄素药理活性广泛,具有良好的抗病毒、抗肿瘤、降血糖、抗氧化、抗炎、抗肝纤维化、抗骨质疏松等药理作用。且药用价值高,在医药领域中发展潜...姜黄素是从中药姜科姜黄属植物姜黄(Curcuma longa L.)的根茎中提取的活性分子。研究表明,姜黄素药理活性广泛,具有良好的抗病毒、抗肿瘤、降血糖、抗氧化、抗炎、抗肝纤维化、抗骨质疏松等药理作用。且药用价值高,在医药领域中发展潜力大。因此本文通过对姜黄素生物活性以及作用机制的研究进展进行综述,并着重介绍姜黄素在发挥药理作用过程中涉及的潜在靶点及重要分子信号通路,为姜黄素的临床应用提供科学依据。展开更多
Based on effective field method,the dynamic effective elastic modulus of polymer matrix composites embedded with dense piezoelectric nano-fibers is obtained,and the interacting effect of piezoelectric surfaces/interfa...Based on effective field method,the dynamic effective elastic modulus of polymer matrix composites embedded with dense piezoelectric nano-fibers is obtained,and the interacting effect of piezoelectric surfaces/interfaces around the nano-fibers is considered.The multiple scattering effects of harmonic anti-plane shear waves between the piezoelectric nano-fibers with surface/interface are averaged by effective field method.To analyze the interacting results among the random nano-fibers,the problem of two typical piezoelectric nano-fibers is introduced by employing the addition theorem of Bessel functions.Through numerical calculations,the influence of the distance between the randomly distributed piezoelectric nano-fibers under different surface/interface parameters is analyzed.The effect of piezoelectric property of surface/interface on the effective shear modulus under different volume fractions is also examined.Comparison with the simplified cases is given to validate this dynamic electro-elastic model.展开更多
文摘姜黄素是从中药姜科姜黄属植物姜黄(Curcuma longa L.)的根茎中提取的活性分子。研究表明,姜黄素药理活性广泛,具有良好的抗病毒、抗肿瘤、降血糖、抗氧化、抗炎、抗肝纤维化、抗骨质疏松等药理作用。且药用价值高,在医药领域中发展潜力大。因此本文通过对姜黄素生物活性以及作用机制的研究进展进行综述,并着重介绍姜黄素在发挥药理作用过程中涉及的潜在靶点及重要分子信号通路,为姜黄素的临床应用提供科学依据。
基金supported by the National Natural Science Foundation of China(Grant Nos.11172185 and 11272222)the Natural Science Foundation for Outstanding Young Researcher in Hebei Province of China(Grant No.A201410015)+1 种基金the National Key Basic Research Program of China(Grant No.2012CB723300)the Training Program for Leading Talent in University Innovative Research Team in Hebei Province(Grant No.LJRC006)
文摘Based on effective field method,the dynamic effective elastic modulus of polymer matrix composites embedded with dense piezoelectric nano-fibers is obtained,and the interacting effect of piezoelectric surfaces/interfaces around the nano-fibers is considered.The multiple scattering effects of harmonic anti-plane shear waves between the piezoelectric nano-fibers with surface/interface are averaged by effective field method.To analyze the interacting results among the random nano-fibers,the problem of two typical piezoelectric nano-fibers is introduced by employing the addition theorem of Bessel functions.Through numerical calculations,the influence of the distance between the randomly distributed piezoelectric nano-fibers under different surface/interface parameters is analyzed.The effect of piezoelectric property of surface/interface on the effective shear modulus under different volume fractions is also examined.Comparison with the simplified cases is given to validate this dynamic electro-elastic model.