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Current Situation and Suggestions of Decorative Fishery Development in Hainan Province
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作者 Xi ZHANG Ning YANG hai huang 《Asian Agricultural Research》 2013年第9期36-38,共3页
Decorative fishery is an important part of recreational fisheries,Hainan has the potential to develop decorative fishery.In this paper,on the basis of the deep-going survey on the current situation of decorative fishe... Decorative fishery is an important part of recreational fisheries,Hainan has the potential to develop decorative fishery.In this paper,on the basis of the deep-going survey on the current situation of decorative fishery development in Hainan,the main questions of decorative fish cultivation and market were discussed.At the same time,many suggestions were brought up,such as exploiting the biological resources of Hainan Island,strengthening scientific research efforts,introducing new varieties of ornamental species,strengthening industrial guidance and market management,etc.,which will benefit the rational utilization of tropical biological resources and increase the whole competitive advantage of decorative fishery in Hainan Province. 展开更多
关键词 HAINAN DECORATIVE FISHERY CURRENT SITUATION Sugges
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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial
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作者 Xiangjun Li Chunyan Li +5 位作者 hai huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期923-928,共6页
The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic mac... The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0). 展开更多
关键词 choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity
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Proppant transport in rough fracture networks using supercritical CO_(2)
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作者 Yong Zheng Meng-Meng Zhou +6 位作者 Ergun Kuru Bin Wang Jun Ni Bing Yang Ke Hu hai huang hai-Zhu Wang 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期1852-1864,共13页
Proppant transport within fractures is one of the most critical tasks in oil,gas and geothermal reservoir stimulation,as it largely determines the ultimate performance of the operating well.Proppant transport in rough... Proppant transport within fractures is one of the most critical tasks in oil,gas and geothermal reservoir stimulation,as it largely determines the ultimate performance of the operating well.Proppant transport in rough fracture networks is still a relatively new area of research and the associated transport mechanisms are still unclear.In this study,representative parameters of rough fracture surfaces formed by supercritical CO_(2) fracturing were used to generate a rough fracture network model based on a spectral synthesis method.Computational fluid dynamics(CFD)coupled with the discrete element method(DEM)was used to study proppant transport in this rough fracture network.To reveal the turning transport mechanism of proppants into branching fractures at the intersections of rough fracture networks,a comparison was made with the behavior within smooth fracture networks,and the effect of key pumping parameters on the proppant placement in a secondary fracture was analyzed.The results show that the transport behavior of proppant in rough fracture networks is very different from that of the one in the smooth fracture networks.The turning transport mechanisms of proppant into secondary fractures in rough fracture networks are gravity-driven sliding,high velocity fluid suspension,and fracture structure induction.Under the same injection conditions,supercritical CO_(2)with high flow Reynolds number still has a weaker ability to transport proppant into secondary fractures than water.Thickening of the supercritical CO_(2)needs to be increased beyond a certain value to have a significant effect on proppant carrying,and under the temperature and pressure conditions of this paper,it needs to be increased more than 20 times(about 0.94 m Pa s).Increasing the injection velocity and decreasing the proppant concentration facilitates the entry of proppant into the branching fractures,which in turn results in a larger stimulated reservoir volume.The results help to understand the proppant transport and placement process in rough fracture networks formed by reservoir stimulation,and provide a theoretical reference for the optimization of proppant pumping parameters in hydraulic fracturing. 展开更多
关键词 Reservoir stimulation CCUS Rough fracture network Supercritical CO_(2) Proppanttransport
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Privacy-Preserving Federated Deep Learning Diagnostic Method for Multi-Stage Diseases
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作者 Jinbo Yang hai huang +2 位作者 Lailai Yin Jiaxing Qu Wanjuan Xie 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期3085-3099,共15页
Diagnosing multi-stage diseases typically requires doctors to consider multiple data sources,including clinical symptoms,physical signs,biochemical test results,imaging findings,pathological examination data,and even ... Diagnosing multi-stage diseases typically requires doctors to consider multiple data sources,including clinical symptoms,physical signs,biochemical test results,imaging findings,pathological examination data,and even genetic data.When applying machine learning modeling to predict and diagnose multi-stage diseases,several challenges need to be addressed.Firstly,the model needs to handle multimodal data,as the data used by doctors for diagnosis includes image data,natural language data,and structured data.Secondly,privacy of patients’data needs to be protected,as these data contain the most sensitive and private information.Lastly,considering the practicality of the model,the computational requirements should not be too high.To address these challenges,this paper proposes a privacy-preserving federated deep learning diagnostic method for multi-stage diseases.This method improves the forward and backward propagation processes of deep neural network modeling algorithms and introduces a homomorphic encryption step to design a federated modeling algorithm without the need for an arbiter.It also utilizes dedicated integrated circuits to implement the hardware Paillier algorithm,providing accelerated support for homomorphic encryption in modeling.Finally,this paper designs and conducts experiments to evaluate the proposed solution.The experimental results show that in privacy-preserving federated deep learning diagnostic modeling,the method in this paper achieves the same modeling performance as ordinary modeling without privacy protection,and has higher modeling speed compared to similar algorithms. 展开更多
关键词 Vertical federation homomorphic encryption deep neural network intelligent diagnosis machine learning and big data
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胆囊并发胆总管结石患者的微创外科治疗研究 被引量:7
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作者 金海敏 黄海 +1 位作者 李晓文 李晔 《中国内镜杂志》 2018年第7期62-66,共5页
目的探究胆囊并发胆总管结石患者的微创外科治疗。方法选取2013年1月-2018年1月该院收治的92例胆囊并发胆总管结石患者为研究对象,采用随机数字表法将患者分为对照组(n=46)和观察组(n=46)。两组患者中存在胰腺炎的患者先行控制腹膜炎,... 目的探究胆囊并发胆总管结石患者的微创外科治疗。方法选取2013年1月-2018年1月该院收治的92例胆囊并发胆总管结石患者为研究对象,采用随机数字表法将患者分为对照组(n=46)和观察组(n=46)。两组患者中存在胰腺炎的患者先行控制腹膜炎,对照组患者行腹腔镜胆囊切除术(LC)联合胆总管探查取石术(LCBDE),观察组患者行十二指肠乳头括约肌切开取石术(EST),术后3 d行LC治疗。比较两组患者围术期情况、费用情况和并发症情况。结果两组患者均未出现中转开腹手术情况,观察组患者的手术时间、止痛药使用率、住院时间均低于对照组患者,耗材费用和住院总费用多于对照组患者,差异具有统计学意义(P<0.05);两组患者的术中出血量、术后排气时间和手术费用比较差异无统计学意义(P>0.05)。观察组患者各项并发症总发生率为6.51%低于对照组患者的19.53%,差异具有统计学意义(P<0.05)。结论胆囊并发胆总管结石患者控制腹膜炎后行EST+LC治疗较LC+LCBDE治疗能够缩短手术时间,减轻术后疼痛,降低并发症发生率,缩短住院时间,但所需费用较高。 展开更多
关键词 胆囊并发胆总管结石 腹腔镜胆囊切除术 十二指肠乳头括约肌切开取石术 胆总管探查取石术
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EX-PRESS引流钉植入术联合康柏西普及PRP治疗新生血管性青光眼 被引量:2
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作者 黄海 郑炜 《国际眼科杂志》 CAS 北大核心 2020年第11期2008-2011,共4页
目的:评价EX-PRESS房水引流钉植入术联合玻璃体内注射康柏西普及全视网膜光凝(PRP)治疗新生血管性青光眼的临床疗效。方法:回顾性分析2015-01/2018-05在我院符合纳入标准的新生血管性青光眼患者21例21眼,术前均先行康柏西普玻璃体内注射... 目的:评价EX-PRESS房水引流钉植入术联合玻璃体内注射康柏西普及全视网膜光凝(PRP)治疗新生血管性青光眼的临床疗效。方法:回顾性分析2015-01/2018-05在我院符合纳入标准的新生血管性青光眼患者21例21眼,术前均先行康柏西普玻璃体内注射,5~10d虹膜新生血管消退后接受EX-PRESS房水引流钉植入术,2~3wk后行全视网膜光凝术,术后随访12mo观察眼压、视力、虹膜新生血管复发率、术后并发症情况。结果:患者引流钉植入术前术后不同时间眼压比较,差异有统计学意义(F=18.513,P<0.05)。引流钉植入术前和术后视力比较,差异有统计学意义(P=0.008)。至末次随访时,手术完全成功18眼(86%),条件成功2眼(9%),总手术成功率95%。虹膜新生血管复发1眼(5%),术后浅前房1眼(5%)、高眼压5眼(24%)。结论:康柏西普注射玻璃体后行EX-PRESS房水引流钉植入术再联合PRP可有效降低新生血管性青光眼的眼压。 展开更多
关键词 新生血管性青光眼 EX-PRESS引流钉 眼压
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右美托咪定预处理联合后处理对心肌缺血再灌注损伤的影响 被引量:21
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作者 黄海 刘玉杰 +3 位作者 冯璐 李志军 刘玲 于泳浩 《中国现代医学杂志》 CAS 2019年第7期102-107,共6页
目的观察右美托咪定预处理联合后处理对心肌缺血再灌注损伤的保护作用。方法选取天津医科大学总医院120例心脏瓣膜置换术患者。随机分为3组,右美托咪定预处理组(pre D组)、右美托咪定后处理组(pos D组)及右美托咪定预处理联合后处理组(p... 目的观察右美托咪定预处理联合后处理对心肌缺血再灌注损伤的保护作用。方法选取天津医科大学总医院120例心脏瓣膜置换术患者。随机分为3组,右美托咪定预处理组(pre D组)、右美托咪定后处理组(pos D组)及右美托咪定预处理联合后处理组(pre-pos D组),每组40例。pre D组和pre-pos D组于阻断主动脉前30 min静脉输注右美托咪定1μg/kg,posD组输注等容量生理盐水;pos D组和pre-pos D组于开放主动脉前30 min灌注液中加入右美托咪定0.2~1.0μg/kg进行心脏灌注,pre D组灌注液中加入等容量生理盐水。观察麻醉诱导前5 min(T_0)、开放主动脉后15 min(T_1)、体外心肺转流(CPB)结束时(T_2)、术后4 h(T_3)、术后16 h(T_4)、术后36 h(T_5)、术后72 h(T_6)的心率(HR)、平均动脉压(MAP)及术中脑电双频指数(BIS)的变化,记录心脏复跳时间和心脏复跳情况,记录3组前并行循环时间(T_(pre))、主动脉阻断时间(T_(ab))及后并行循环时间(T_(pos))。检测各时间点血浆肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、血清心肌肌钙蛋白(cTn I)浓度及肌酸激酶同工酶(CK-MB)活性。结果不同时间点3组HR、MAP值差异无统计学意义(P>0.05)。T_1~T_6时pre-posD组血浆TNF-α浓度低于preD和posD组(P<0.05)。T_2~T_6时pre-posD组血浆IL-6浓度低于preD组和posD组(P<0.05)。T_1~T_6时pre-posD组血浆CK-MB活性弱于preD组和posD组(P<0.05)。结论右美托咪定预处理联合后处理较单纯的预处理或单纯的后处理能更有效地抑制炎症因子的产生和释放,具有更好的心肌保护功能。 展开更多
关键词 心肌再灌注损伤 右美托咪定/麻醉药 缺血预处理 心肌 缺血后处理
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白内障患者术前术中细菌培养及药物干预研究 被引量:4
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作者 黄海 管怀进 +1 位作者 董业峰 唐义权 《国际眼科杂志》 CAS 北大核心 2021年第8期1461-1464,共4页
目的:研究年龄相关性白内障患者睑缘(睫毛根部睑板腺开口处)和结膜囊应用不同抗生素滴眼液滴眼及不同结膜囊冲洗液冲洗结膜囊后的灭菌效果。方法:选取2015-01/11在我院拟行白内障超声乳化手术的年龄相关性白内障患者216例216眼随机分成A... 目的:研究年龄相关性白内障患者睑缘(睫毛根部睑板腺开口处)和结膜囊应用不同抗生素滴眼液滴眼及不同结膜囊冲洗液冲洗结膜囊后的灭菌效果。方法:选取2015-01/11在我院拟行白内障超声乳化手术的年龄相关性白内障患者216例216眼随机分成A(72眼)、B(72眼)、C(72眼)三组,术前分别采用3g/L妥布霉素滴眼液、5g/L左氧氟沙星滴眼液及上述两种滴眼液点眼;再随机分为莫西沙星组(110眼)和聚维酮碘组(106眼),分别于术野常规消毒后手术正式开始前使用1.6g/L莫西沙星和5g/L聚维酮碘冲洗结膜囊。分别于入院未用药前、手术未消毒前及结膜囊冲洗后采集术眼睑缘和结膜囊标本,术毕采集结膜囊标本并抽取前房水进行常规细菌培养及药敏试验。结果:白内障患者术前睑缘、结膜囊细菌培养阳性率分别为86.6%、25.0%。A、B、C组患者应用不同抗生素滴眼液点眼前后睑缘细菌培养阳性率分别为86.1%和36.1%、84.7%和31.9%、88.9%和30.6%;结膜囊细菌培养阳性率分别为25.0%和11.1%、26.4%和11.1%、23.6%和8.3%。采用莫西沙星和聚维酮碘组进行结膜囊冲洗前后睑缘细菌培养的阳性率分别为33.6%和10.9%、32.1%和10.4%;结膜囊细菌培养的阳性率分别为10.0%和0、10.4%和0。结论:白内障术前联合使用3g/L妥布霉素和5g/L左氧氟沙星滴眼液点眼清洁睑缘和结膜囊效果更佳,5g/L聚维酮碘和1.6g/L莫西沙星均可作为白内障术前结膜囊冲洗液使用。 展开更多
关键词 结膜囊 细菌培养 眼内炎 抗生素 聚维酮碘
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Plant fertility defects induced by the enhanced expression of microRNA167 被引量:35
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作者 Peng Ru Lin Xu +1 位作者 Hong Ma hai huang 《Cell Research》 SCIE CAS CSCD 2006年第5期457-465,共9页
The plant hormone auxin plays a critical role in regulating plant growth and development. Recent advances have been made in the understanding of auxin response pathways, primarily by the characterization of auxin resp... The plant hormone auxin plays a critical role in regulating plant growth and development. Recent advances have been made in the understanding of auxin response pathways, primarily by the characterization of auxin response mutants in Arabidopsis. In addition, microRNAs (miRNAs) have been shown to be critical regulators of genes important for normal plant development and physiology. However, little is known about possible interactions between miRNAs and hormonal signaling during normal development. Here we show that an Arabidopsis microRNA, miR167, which has a complementary sequence to a portion of the A UXINRESPONSE FACTOR6 (ARF6) and ARF8 mRNAs, can cause transcript degradation for ARF8, but not for ARF6. We report phenotypic characterizations of 35S::MIR167b transgenic lines, and show that severe 35S::MIR167b transgenic lines had phenotypes similar to those of an arf6 arf8 double mutant. The transgenic phenotypes suggest that miR167 may repress ARF6 at the level of translation. We demonstrate that the transgenic plants are defective in all four whods of floral organs. In the transgenic flowers, filaments were abnormally short, anthers could not properly release pollen, and pollen grains did not germinate. Our results provide an important link between the miRNA-mediated regulatory pathway of gene expression and the auxin signaling network promoting plant reproductive development. 展开更多
关键词 ARABIDOPSIS auxin response factor microRNA167 floral organ pollen germination
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Identification and genetic mapping of four novel genes that regulate leaf development in Arabidopsis 被引量:53
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作者 SUN YUE WEI ZHANG +3 位作者 FENG LING LI YING LI GUO TIAN LEI LIU hai huang 《Cell Research》 SCIE CAS CSCD 2000年第4期325-335,共11页
Molecular and genetic characterizations of mutants have led to a better understanding of many developmental processes in the model system Arabidopsis thaliana. However, the leaf development that is specific to plants ... Molecular and genetic characterizations of mutants have led to a better understanding of many developmental processes in the model system Arabidopsis thaliana. However, the leaf development that is specific to plants has been little studied. With the aim of contributing to the genetic dissection of leaf development, we have performed a large-scare screening for mutants with abnormal leaves. Among a great number of leaf mutants we have generated by T-DNA and transposon tagging and ethylmethae sulfonate (EMS) mutagenesis, four independent mutant lines have been identified and studied genetically. Phenotypes of these mutant lines represent the defects of four novel nuclear genes designated LL1 (LOTUS LEAF 1), LL2 (LOTUS LEAF 2), URO (UPRIGHT ROSETTE), and EIL (ENVIRONT CONDITION INDUCED LESION). The phenotypic analysis indicates that these genes play important roles during leaf development. FOr the further genetic analysis of these genes and the map-based cloning of LL1 and LL2, we have mapped these genes to chromosome regions with an efficient and rapid mapping method. 展开更多
关键词 ARABIDOPSIS leaf mutant leaf development genetic mappin
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Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue 被引量:12
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作者 Xiao-Yu Lu Xiao-Hong Ding +3 位作者 Li-Jun Zhong Hong Xia Xiao-Dong Chen hai huang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2013年第1期79-81,共3页
Objective:To investigate the mechanism of expression and significance of vascular endothelial growth factor(VEGF) and p53 in degenerate intervertebral disc tissue.Methods:Pathological sections collected from 156 patie... Objective:To investigate the mechanism of expression and significance of vascular endothelial growth factor(VEGF) and p53 in degenerate intervertebral disc tissue.Methods:Pathological sections collected from 156 patienls with lumbar disc herniation after surgery were tested by immunohistochemistry method,for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.Results:98 cases(62.8%) with vascular infiltration phenomenon are found,and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97%(92/156);co-expression rate is 53.2%(83/l56);the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration;there is a close relationship of VEGF with p53.Conclusions:VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue,working together in neovascularization and infiltration,and accelerating intervertebral disc tissue degeneration. 展开更多
关键词 INTERVERTEBRAL disc IMMUNOHISTOCHEMISTRY VEGF P53
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Performance comparison of novel chemical agents in improving oil recovery from tight sands through spontaneous imbibition 被引量:5
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作者 hai huang Tayfun Babadagli +1 位作者 Xin Chen Huazhou Andy Li 《Petroleum Science》 SCIE CAS CSCD 2020年第2期409-418,共10页
Tight sands are abundant in nanopores leading to a high capillary pressure and normally a low fluid injectivity.As such,spontaneous imbibition might be an effective mechanism for improving oil recovery from tight sand... Tight sands are abundant in nanopores leading to a high capillary pressure and normally a low fluid injectivity.As such,spontaneous imbibition might be an effective mechanism for improving oil recovery from tight sands after fracturing.The chemical agents added to the injected water can alter the interfacial properties,which could help further enhance the oil recovery by spontaneous imbibition.This study explores the possibility of using novel chemicals to enhance oil recovery from tight sands via spontaneous imbibition.We experimentally examine the effects of more than ten different chemical agents on spontaneous imbibition,including a cationic surfactant(C12 TAB),two anionic surfactants(0242 and 0342),an ionic liquid(BMMIM BF4),a high pH solution(NaBO2),and a series of house-made deep eutectic solvents(DES3-7,9,11,and 14).The interfacial tensions(IFT)between oil phase and some chemical solutions are also determined.Experimental results indicate that both the ionic liquid and cationic surfactant used in this study are detrimental to spontaneous imbibition and decrease the oil recovery from tight sands,even though cationic surfactant significantly decreases the oil-water IFT while ionic liquid does not.The high pH NaBO2 solution does not demonstrate significant effect on oil recovery improvement and IFT reduction.The anionic surfactants(O242 and O342)are effective in enhancing oil recovery from tight sands through oil-water IFT reduction and emulsification effects.The DESs drive the rock surface to be more water-wet,and a specific formulation(DES9)leads to much improvement on oil recovery under counter-current imbibition condition.This preliminary study would provide some knowledge about how to optimize the selection of chemicals for improving oil recovery from tight reservoirs. 展开更多
关键词 SPONTANEOUS IMBIBITION NOVEL chemical agent Water FLOODING TIGHT SANDS
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Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients 被引量:5
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作者 Xingsheng Hu Dongyong Yang +15 位作者 Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao hai huang Qian Chu Chengping Hu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第3期556-564,共9页
Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cance... Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. 展开更多
关键词 GERMLINE BRCA MUTATIONS NON-SMALL cell lung cancer PREVALENCE BRCA1 BRCA2
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Model Based Adaptive Control and Disturbance Compensation for Underwater Vehicles 被引量:6
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作者 hai huang Guo-Cheng Zhang +3 位作者 Ji-Yong Li Qiang Zhang Jin-Yu Xu Hong-De Qin 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2018年第1期114-126,共13页
Underwater vehicles are being emphasized as highly integrated and intelligent devices for a significant number of oceanic operations. However, their precise operation is usually hindered by disturbances from a tether ... Underwater vehicles are being emphasized as highly integrated and intelligent devices for a significant number of oceanic operations. However, their precise operation is usually hindered by disturbances from a tether or manipulator because their propellers are unable to realize a stable suspension. A dynamic multi-body model-based adaptive controller was designed to allow the controller of the vehicle to observe and compensate for disturbances from a tether or manipulator. Disturbances, including those from a tether or manipulator, are deduced for the observation of the controller. An analysis of a tether disturbance covers the conditions of the surface, the underwater area, and the vehicle end point. Interactions between the vehicle and manipulator are mainly composed of coupling forces and restoring moments.To verify the robustness of the controller, path-following experiments on a streamlined autonomous underwater vehicle experiencing various disturbances were conducted in Song Hua Lake in China. Furthermore,path-following experiments for a tethered open frame remote operated vehicle were verified for accurate cruising with a controller and an observer, and vehicle and manipulator coordinate motion control during the simulation and experiments verified the effectiveness of the controller and observer for underwater operation. This study provides instructions for the control of an underwater vehicle experiencing disturbances from a tether or manipulator. 展开更多
关键词 Underwater vehicle Adaptive control Disturbance observer Multi-body dynamic model
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基于人工智能的多Agent协同辩证逻辑推理方法
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作者 黄海 桂起权 《逻辑学研究》 CSSCI 2023年第5期81-96,共16页
为消除Agent内部信念冲突,实现多Agent的协同运行,利用人工智能技术,设计多Agent协同的论辩式辩证逻辑推理方法。根据Agent的组成结构以及多Agent之间的通信方式,建立多Agent协同模型。在该模型下,利用人工智能技术,求解多Agent协同任务... 为消除Agent内部信念冲突,实现多Agent的协同运行,利用人工智能技术,设计多Agent协同的论辩式辩证逻辑推理方法。根据Agent的组成结构以及多Agent之间的通信方式,建立多Agent协同模型。在该模型下,利用人工智能技术,求解多Agent协同任务,消解Agent间冲突。通过计算识别出微小变化会导致系统行为重大变化的关键变量,找到推理依据,在推理论据和规则的支持下,实现多Agent协同的论辩式辩证逻辑推理。实验结果表明,设计论辩式辩证逻辑推理方法的加速率提高了1.4,多Agent之间的协同程度提高了4.12,同时抵制恶意节点的成功率提升了12.6%,具有更好的应用效果。 展开更多
关键词 人工智能 多AGENT协同 论辩式辩证逻辑 逻辑推理
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Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer 被引量:1
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作者 Qiong Wang Zean Li +10 位作者 Jin Yang Shirong Peng Qianghua Zhou Kai Yao Wenli Cai Zhongqiu Xie Fujun Qin Hui Li Xu Chen Kaiwen Li hai huang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2022年第8期1193-1210,共18页
Objective:To explore the genetic changes in the progression of castration-resistant prostate cancer(CRPC)and neuroendocrine prostate cancer(NEPC)and the reason why these cancers resist existing therapies.Methods:We em... Objective:To explore the genetic changes in the progression of castration-resistant prostate cancer(CRPC)and neuroendocrine prostate cancer(NEPC)and the reason why these cancers resist existing therapies.Methods:We employed our CRPC cell line microarray and other CRPC or NEPC datasets to screen the target gene NEIL3.Lentiviral transfection and RNA interference were used to construct overexpression and knockdown cell lines.Cell and animal models of radiotherapy were established by using a medical electron linear accelerator.Flow cytometry was used to detect apoptosis or cell cycle progression.Western blot and qPCR were used to detect changes in the protein and RNA levels.Results:TCGA and clinical patient datasets indicated that NEIL3 was downregulated in CRPC and NEPC cell lines,and NEIL3 was correlated with a high Gleason score but a good prognosis.Further functional studies demonstrated that NEIL3 had no effect on the proliferation and migration of PCa cells.However,cell and animal radiotherapy models revealed that NEIL3 could facilitate the radiotherapy sensitivity of PCa cells,while loss of NEIL3 activated radiotherapy resistance.Mechanistically,we found that NEIL3 negatively regulated the expression of ATR,and higher NEIL3 expression repressed the ATR/CHK1 pathway,thus regulating the cell cycle.Conclusions:We demonstrated that NEIL3 may serve as a diagnostic or therapeutic target for therapy-resistant patients. 展开更多
关键词 CRPC NEIL3 NEPC prostate cancer radiotherapy resistance
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The Water Quality Evaluation in Balihe Lake Based on Principal Component Analysis 被引量:2
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作者 Lei Zhang Meifang Zhong +2 位作者 Yixin Xu Zhongyu Wang hai huang 《Journal of Geoscience and Environment Protection》 2019年第8期38-48,共11页
The water pollution situation in Balihe Lake, the biggest tributary of Shaying River Basin in Anhui Province, China, has brought a huge pressure on the improvement of water quality in Huai River. On October 16th, 2017... The water pollution situation in Balihe Lake, the biggest tributary of Shaying River Basin in Anhui Province, China, has brought a huge pressure on the improvement of water quality in Huai River. On October 16th, 2017, 11 major pollution indexes were observed at 15 sampling points in Balihe Lake. Based on the data experimentally measured, the water quality in Balihe Lake was analyzed utilizing the Principal Component Analysis (PCA) of SPSS. The result suggested that the major components were oxygenated pollutants, water eutrophication pollutants and ammonia nitrogen, in which oxygenated pollutants played a dominant role. In addition, the upper part of Balihe Lake suffered serious situation and needed a focus on oxygenated pollutants. 展开更多
关键词 Balihe LAKE WATER QUALITY Principal COMPONENT Analysis ENVIRONMENTAL PROTECTION
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Content Feature Extraction-based Hybrid Recommendation for Mobile Application Services 被引量:1
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作者 Chao Ma YinggangSun +3 位作者 Zhenguo Yang hai huang Dongyang Zhan Jiaxing Qu 《Computers, Materials & Continua》 SCIE EI 2022年第6期6201-6217,共17页
The number of mobile application services is showing an explosive growth trend,which makes it difficult for users to determine which ones are of interest.Especially,the new mobile application services are emerge conti... The number of mobile application services is showing an explosive growth trend,which makes it difficult for users to determine which ones are of interest.Especially,the new mobile application services are emerge continuously,most of them have not be rated when they need to be recommended to users.This is the typical problem of cold start in the field of collaborative filtering recommendation.This problem may makes it difficult for users to locate and acquire the services that they actually want,and the accuracy and novelty of service recommendations are also difficult to satisfy users.To solve this problem,a hybrid recommendation method for mobile application services based on content feature extraction is proposed in this paper.First,the proposed method in this paper extracts service content features through Natural Language Processing technologies such as word segmentation,part-of-speech tagging,and dependency parsing.It improves the accuracy of describing service attributes and the rationality of the method of calculating service similarity.Then,a language representation model called Bidirectional Encoder Representation from Transformers(BERT)is used to vectorize the content feature text,and an improved weighted word mover’s distance algorithm based on Term Frequency-Inverse Document Frequency(TFIDF-WMD)is used to calculate the similarity of mobile application services.Finally,the recommendation process is completed by combining the item-based collaborative filtering recommendation algorithm.The experimental results show that by using the proposed hybrid recommendation method presented in this paper,the cold start problem is alleviated to a certain extent,and the accuracy of the recommendation result has been significantly improved. 展开更多
关键词 Service recommendation cold start feature extraction natural language processing word mover’s distance
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Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients 被引量:1
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作者 Xingsheng Hu Dongyong Yang +15 位作者 Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao hai huang Qian Chu Chengping Hu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2020年第2期F0003-F0003,共1页
In the published article1,the affiliation for the first author,Xingshcng Hu,is"Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences",we would like to update it to"Departmen... In the published article1,the affiliation for the first author,Xingshcng Hu,is"Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences",we would like to update it to"Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China".We apologize for the errors and for any confusion it may have caused. 展开更多
关键词 Cancer Medical CLINICAL
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高温形状记忆聚酰亚胺的合成 被引量:2
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作者 杜淏霖 朱文慧 +3 位作者 黄海 李冰 肖鑫礼 李欣 《大学化学》 CAS 2022年第5期104-112,共9页
作为一种典型的智能材料,形状记忆聚酰亚胺(Shape Memory Polyimide,SMPI)因其优异的高温形状记忆效应和做功能力,在航空航天和智能光电等尖端领域展示了广阔的应用前景。本实验通过设计一种简单、有效的装置实现无水无氧条件,以1,3-双... 作为一种典型的智能材料,形状记忆聚酰亚胺(Shape Memory Polyimide,SMPI)因其优异的高温形状记忆效应和做功能力,在航空航天和智能光电等尖端领域展示了广阔的应用前景。本实验通过设计一种简单、有效的装置实现无水无氧条件,以1,3-双(3-氨基苯氧基)苯与4,4’-氧代双邻苯二甲酸酐为原料合成聚酰胺酸前驱体,采用梯度升温法制得SMPI。通过凝胶色谱、红外光谱、动态热机械分析和热重分析等方法对产物进行表征。所得SMPI呈现优异的形状记忆效应,高温下可推翻超过自身重量11.93倍的金属板,具有良好的做功能力。本实验涵盖了高分子化学合成、产物结构表征、力学性能测试及应用,具有较强的综合性;此外,实验现象稳定、重现性好,适合本科实验教学。通过模拟“天问一号”红旗的展开,激发学生科研兴趣,培养创新思维,提高综合素质;同时让学生领略到中国航天的独特风采,增强民族自豪感。 展开更多
关键词 形状记忆聚合物 聚酰亚胺 空间可展开结构 高温驱动器
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