Member of Editorial Board of Rising Stars：Hai-Chao Xu

Education2002-2006 B.S. Xiamen University 2006-2010 Ph.D. Washington University in St. Louis （Supervisor： Prof. Kevin D, Moeller）Experience2011-2013 Postdoctoral Researcher, Department of Chemistry, Yale University, USA （with Prof. ]onathan A. Ellman） 2013-2014 Associate Professor, Department of Chemistry, Xiamen University 2014-present Professor, Department of Chemistry, Xiamen University

Linear paired electrolysis of furfural to furoic acid at both anode and cathode in a multiple redox mediated system

Implementing a new energy-saving electrochemical synthesis system with high commercial value is a strategy of the sustainable development for upgrading the bulk chemicals preparation technology in the future.Here,we report a multiple redox-mediated linear paired electrolysis system,combining the hydrogen peroxide mediated cathode process with the I2 mediated anode process,and realize the conversion of furfural to furoic acid in both side of the dividedflow cell simultaneously.By reasonably controlling the cathode potential,the undesired water splitting reaction and furfural reduction side reactions are avoided.Under the galvanostatic electrolysis,the two-mediated electrode processes have good compatibility,which reduce the energy consumption by about 22%while improving the electronic efficiency by about 125%.This system provides a green electrochemical synthesis route with commercial prospects.

质子交换膜燃料电池铂基催化剂研究进展

燃料电池是一种将化学能直接转化为电能的能量转换装置,具有能量密度高、利用率高、清洁安静等优点。在不同类型的燃料电池中,质子交换膜燃料电池(PEMFC)不仅能量密度高,而且具有在近常温条件下工作的特点,因此受到广泛关注。目前,商业化PEMFC仍采用铂基纳米材料作为催化剂,其中缺乏低成本、高效的阴极催化剂是限制PEMFC性能提升和成本降低的关键因素之一。本文综述PEMFC催化剂的结构可控制备及其对阴极氧还原反应和膜电极性能的影响,阐述调控催化剂结构提高PEMFC性能的方法,特别是提高贵金属催化剂的利用率,降低膜电极中贵金属用量的研究进展。

Electro.chemical Synthesis of （Aza）indolines via Dehydrogenative [3＋2] Annulatnon： Application to Total Synthesis of （±）-Hinckdentme At

An electrochemical synthesis of functionalized （aza）indolines through dehydrogenative [3＋2] annulation of arylamines with tethered alkenes has been developed. Previous reported syntheses through similar inter- and intramolecular annulation reactions required noble-metal catalysts and are mostly limited to terminal alkenes or 1,3-dienes. The electrosynthesis employs the easily available and inexpensive ferrocene as the molecular catalyst and is compatible with di-, tri- and even tetrasubstituted alkenes to construct indolines as well as the more challenging azaindolines. Employing the newly developed electrosynthesis as a key step, the total synthesis of marine alkaloid （＋）-hinckdentine A has been achieved in 12 steps （longest linear sequence） from commercially available materials.

Recent advances in organic electrosynthesis employing transition metal complexes as electrocatalysts

Organic electrosynthesis has been widely used as an environmentally conscious alternative to conventional methods for redox reactions because it utilizes electric current as a traceless redox agent instead of chemical redox agents. Indirect electrolysis employing a redox catalyst has received tremendous attention, since it provides various advantages compared to direct electrolysis. With indirect electrolysis, overpotential of electron transfer can be avoided, which is inherently milder, thus wide functional group tolerance can be achieved. Additionally, chemoselectivity, regioselectivity, and stereoselectivity can be tuned by the redox catalysts used in indirect electrolysis. Furthermore, electrode passivation can be avoided by preventing the formation of polymer films on the electrode surface. Common redox catalysts include N-oxyl radicals, hypervalent iodine species, halides, amines, benzoquinones(such as DDQ and tetrachlorobenzoquinone), and transition metals. In recent years, great progress has been made in the field of indirect organic electrosynthesis using transition metals as redox catalysts for reaction classes including C–H functionalization, radical cyclization, and cross-coupling of aryl halides-each owing to the diverse reactivity and accessible oxidation states of transition metals. Although various reviews of organic electrosynthesis are available, there is a lack of articles that focus on recent research progress in the area of indirect electrolysis using transition metals, which is the impetus for this review.

Recent Applications of Homogeneous Catalysis in Electrochemical Organic Synthesis

Although the combination of electrochemistry and homogeneous catalysis has proven to be a powerful strategy for achieving a diverse array of novel transformations,some challenges such as controlling the diffusion of catalyst-related species and the instability of catalysts at electrodes remain to be overcome.Herein,we review recent advances in electrochemical homogeneous catalysis,focusing on electrochemical noble-transition-metal catalysis,photoelectrochemical catalysis,and electrochemical enantioselective catalysis.The topics discussed include:(1)how the noblemetal catalystworks in the presence of cathodic hydrogen evolution,(2)how the photocatalyst gets enhanced redox property,and(3)how the enantioselectivity is regulated in a catalytic electrochemical reaction.

Electrochem ically Enabled Intram olecular Am inooxygenation of Alkynes v ia Am idyl Radical Cyclization

Summary of main observation and conclusion An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates-and ureas-derived amidyl radicals.The electrosynthesis relies on the dual function of 2,2,66-tetramethylpiperidin-1-y oxyl(TEMPO)as a redox mediator for amidyl radical formation and an oxygen atom donor.The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.

Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell

Dehydrogenative cyclization of thioamides is an attractive approach for the synthesis of S-heterocycles.Reported herein is an electrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis cell.The continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal-and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.

Synthesis of Acridinium Photocatalysts via Site-Selective C–H Alkylation

Acridinium dyes have been broadly used as photocatalysts,but it remains synthetically challenging to fine-tune their catalytic performance by functionalization of their structural cores.Acridinium photocatalysts are usually prepared through de novo synthesis,which involves difficult steps and requires sensitive organometallic reagents.