AIM： To observe the therapeutic effect of corneal collagen cross-linking（CXL） in combination with liposomal amphotericin B in fungal corneal ulcers.METHODS： New Zealand rabbits were induced fungal corneal ulcers b...AIM： To observe the therapeutic effect of corneal collagen cross-linking（CXL） in combination with liposomal amphotericin B in fungal corneal ulcers.METHODS： New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B（n =5 each）. The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28 d after treatment. The corneas were examined with transmission electron microscopy（TEM） at 4wk.RESULTS： A rabbit corneal ulcer model of Fusarium was successfully established. The corneal epithelium defect areas in the two treatment groups were smaller than that in the control group on 3, 7, 14 and 21d（P 〈0.05）. The corneal epithelium defect areas of the combined group was smaller than that of the CXL group（P 〈0.05） on 7 and 14 d, but there were no statistical differences on 3, 21 and 28 d. The corneal epithelium defects of the two treatment groups have been healed by day 21. The corneal epithelium defects of the control group were healed on 28 d. The diameters of the corneal collagen fiber bundles（42.960 ±7.383 nm in the CXL group and 37.040±4.160 nm in the combined group） were thicker than that of the control group（24.900±1.868 nm）,but there was no difference between the two treatment groups. Some corneal collagen fiber bundles were distorted and with irregular arrangement, a large number of fibroblasts could be seen among them but no inflammatory cells in both treatment groups. CONCLUSION： CXL combined with liposomal amphotericin B have beneficial effects on fungal corneal ulcers. The combined therapy could alleviate corneal inflammattions, accelerate corneal repair, and shorten the course of disease.展开更多
Dear Editor,The cornea is the ocular structure most commonly affected by fungi. In general, fungal organisms infiltrate into cornea following ocular injuries, such as the vegetative trauma, leading to infectious funga...Dear Editor,The cornea is the ocular structure most commonly affected by fungi. In general, fungal organisms infiltrate into cornea following ocular injuries, such as the vegetative trauma, leading to infectious fungal keratitis, which is characterized by epithelial defects, comeal edema and ulceration, satellite lesions in the surrounding cornea, and white fluffy hypopyon. Secondary attenuation of cell defense mechanisms ailer prolonged use of topical or systemic corticosteroid or immunosuppressive agents may also result in endogenous fungal infection.展开更多
With the development and prevalence of online social networks, there is an obvious tendency that people are willing to attend and share group activities with friends or acquaintances. This motivates the study on group...With the development and prevalence of online social networks, there is an obvious tendency that people are willing to attend and share group activities with friends or acquaintances. This motivates the study on group recommendation, which aims to meet the needs of a group of users, instead of only individual users. However, how to aggregate different preferences of different group members is still a challenging problem： 1） the choice of a member in a group is influenced by various factors, e.g., personal preference, group topic, and social relationship; 2） users have different influences when in diffe- rent groups. In this paper, we propose a generative geo-social group recommendation model （GSGR） to recommend points of interest （POIs） for groups. Specifically, GSGR well models the personal preference impacted by geographical information, group topics, and social influence for recommendation. Moreover, when making recommendations, GSGR aggregates the preferences of group members with different weights to estimate the preference score of a group to a POI. Experimental results on two datasets show that GSGR is effective in group recommendation and outperforms the state-of-the-art methods.展开更多
基金Supported by Nature Science Fundamental Research Planned Projects of Shaanxi Province(No.2011JE005No.2012JM4023)Science and Technology Planned Projects of Xi'an[No.SF1207(1)]
文摘AIM： To observe the therapeutic effect of corneal collagen cross-linking（CXL） in combination with liposomal amphotericin B in fungal corneal ulcers.METHODS： New Zealand rabbits were induced fungal corneal ulcers by scratching and randomly divided into 3groups, i.e. control, treated with CXL, and combined therapy of CXL with 0.25% liposomal amphotericin B（n =5 each）. The corneal lesions were documented with slit-lamp and confocal microscopy on 3, 7, 14, 21 and 28 d after treatment. The corneas were examined with transmission electron microscopy（TEM） at 4wk.RESULTS： A rabbit corneal ulcer model of Fusarium was successfully established. The corneal epithelium defect areas in the two treatment groups were smaller than that in the control group on 3, 7, 14 and 21d（P 〈0.05）. The corneal epithelium defect areas of the combined group was smaller than that of the CXL group（P 〈0.05） on 7 and 14 d, but there were no statistical differences on 3, 21 and 28 d. The corneal epithelium defects of the two treatment groups have been healed by day 21. The corneal epithelium defects of the control group were healed on 28 d. The diameters of the corneal collagen fiber bundles（42.960 ±7.383 nm in the CXL group and 37.040±4.160 nm in the combined group） were thicker than that of the control group（24.900±1.868 nm）,but there was no difference between the two treatment groups. Some corneal collagen fiber bundles were distorted and with irregular arrangement, a large number of fibroblasts could be seen among them but no inflammatory cells in both treatment groups. CONCLUSION： CXL combined with liposomal amphotericin B have beneficial effects on fungal corneal ulcers. The combined therapy could alleviate corneal inflammattions, accelerate corneal repair, and shorten the course of disease.
基金Supported by the Shaanxi Provincial Natural Science Basic Research Program(No.2016JM8017)
文摘Dear Editor,The cornea is the ocular structure most commonly affected by fungi. In general, fungal organisms infiltrate into cornea following ocular injuries, such as the vegetative trauma, leading to infectious fungal keratitis, which is characterized by epithelial defects, comeal edema and ulceration, satellite lesions in the surrounding cornea, and white fluffy hypopyon. Secondary attenuation of cell defense mechanisms ailer prolonged use of topical or systemic corticosteroid or immunosuppressive agents may also result in endogenous fungal infection.
基金This research was partially supported by the National Natural Science Foundation of China under Grant No. 61572335 and the Natural Science Foundation of Jiangsu Province of China under Grant No. BK20151223.
文摘With the development and prevalence of online social networks, there is an obvious tendency that people are willing to attend and share group activities with friends or acquaintances. This motivates the study on group recommendation, which aims to meet the needs of a group of users, instead of only individual users. However, how to aggregate different preferences of different group members is still a challenging problem： 1） the choice of a member in a group is influenced by various factors, e.g., personal preference, group topic, and social relationship; 2） users have different influences when in diffe- rent groups. In this paper, we propose a generative geo-social group recommendation model （GSGR） to recommend points of interest （POIs） for groups. Specifically, GSGR well models the personal preference impacted by geographical information, group topics, and social influence for recommendation. Moreover, when making recommendations, GSGR aggregates the preferences of group members with different weights to estimate the preference score of a group to a POI. Experimental results on two datasets show that GSGR is effective in group recommendation and outperforms the state-of-the-art methods.
