期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities
1
作者 Ya Gao Jian-Chao Chen +3 位作者 Xing-Rong Peng Zhong-Rong Li hai-guo su Ming-Hua Qiu 《Natural Products and Bioprospecting》 CAS 2020年第3期153-161,共9页
Ten cucurbitane-type triterpene glycosides,including five new compounds named charantosides H(1),J(2),K(3),momor-characoside A(4),goyaglycoside-l(5),and five known compounds(6-10),were isolated from the EtOAc extract ... Ten cucurbitane-type triterpene glycosides,including five new compounds named charantosides H(1),J(2),K(3),momor-characoside A(4),goyaglycoside-l(5),and five known compounds(6-10),were isolated from the EtOAc extract of Momor-dica charantia fruits.The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses.Configurations of new compounds were determined by ROESY correlations and comparison of their 13C NMR data with literature reported values.All compounds were evaluated for their inhibition againstα-glucosidase,in which compounds 2,5,7,8,9 showed moderate inhibitory activities with IC50 values ranging from 28.40 to 63.26μM comparing with the positive control(acarbose,IC5087.65±6.51μM). 展开更多
关键词 Momordica charantia Cucurbitane-type triterpene glycosides α-Glucosidase inhibitory activity
下载PDF
Applanoids A—E as the First Examples of C-15/C-20 Michael Adducts in Ganoderma Triterpenoids and Their PXR Agonistic Activity 被引量:1
2
作者 hai-guo su Hang-Fei Liang +4 位作者 Gui-Lin Hu Lin Zhou Xing-Rong Peng Hui-Chang Bi Ming-Hua Qiu 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第22期2633-2641,共9页
Ganoderma triterpenoids(GTs),a class of major active constituents of Ganoderma fungi,possess diverse structures and remarkable activities.In the present study,nine new GTs,namely applanoids A—I(1—9),were isolated fr... Ganoderma triterpenoids(GTs),a class of major active constituents of Ganoderma fungi,possess diverse structures and remarkable activities.In the present study,nine new GTs,namely applanoids A—I(1—9),were isolated from the medicinal fungus of Ganoderma applanatum.Their structures including absolute configurations were established by comprehensive spectroscopic analyses and ECD calculation.Applanoids A—E(1—5)represent the first example of GTs with 6/6/5/6/5 pentacyclic system and the formation of the ether ring between C-15 and C-20 involves Michael addition reaction.Furthermore,compounds 1—8 were evaluated for their human pregnane X receptor(hPXR)agonistic activity using dual-luciferase reporter gene assay,and the results showed that compounds 1,2 and 4 can dose-dependently activate hPXR.This investigation further illustrated the structural diversity of GTs and provided new insights for searching PXR agonists from GTs. 展开更多
关键词 Ganoderma applanatum Lanostane triterpenoids Michael adducts Structure elucidation Pregnane X receptor
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部