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CNV analysis of Meishan pig by nextgeneration sequencing and effects of AHR gene CNV on pig reproductive traits 被引量:9
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作者 Xianrui Zheng Pengju Zhao +4 位作者 Kaijie Yang Chao Ning haifei wang Lei Zhou Jianfeng Liu 《Journal of Animal Science and Biotechnology》 CAS CSCD 2020年第3期667-677,共11页
Background:Reproductive performance of livestock is an economically important aspect of global food production.The Chinese Meishan pig is a prolific breed,with an average of three to five more piglets per litter than ... Background:Reproductive performance of livestock is an economically important aspect of global food production.The Chinese Meishan pig is a prolific breed,with an average of three to five more piglets per litter than European breeds;however,the genetic basis for this difference is not well understood.Results:In this study,we investigated copy number variations(CNVs)of 32 Meishan pigs and 29 Duroc pigs by nextgeneration sequencing.A genome-wide analysis of 61 pigs revealed 12,668 copy number variable regions(CNVRs)that were further divided into three categories based on copy number(CN)of the whole population,i.e.,gain(n=7,638),and loss(n=5,030)CNVRs.We then compared Meishan and Duroc pigs and identified 17.17Mb of 6,387 CNVRs that only existing in Meishan pigs CNVRs that overlapped the reproduction-related gene encoding the aryl hydrocarbon receptor(AHR)gene.We found that normal AHR CN was more frequent than CN loss in four different pig breeds.An association analysis showed that AHR CN had a positive effect on litter size(P<0.05)and that a higher CN was associated with higher total number born(P<0.05),number born alive(P<0.05),number of weaned piglets,and birth weight.Conclusions:The present study provides comprehensive CNVRs for Meishan and Duroc pigs through large-scale population resequencing.Our results provide a supplement for the high-resolution map of copy number variation in the porcine genome and valuable information for the investigation of genomic structural variation underlying traits of interest in pig.In addition,the association results provide evidence for AHR as a candidate gene associated with reproductive traits that can be used as a genetic marker in pig breeding programs. 展开更多
关键词 AHR Copy number variation MEISHAN Next-generation sequencing PIG REPRODUCTION
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Recent Progress in Large-Area Perovskite Photovoltaic Modules
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作者 haifei wang Zhixiao Qin +1 位作者 Yanfeng Miao Yixin Zhao 《Transactions of Tianjin University》 EI CAS 2022年第5期323-340,共18页
Perovskite solar cells(PSCs)have undergone a dramatic increase in laboratory-scale effi ciency to more than 25%,which is comparable to Si-based single-junction solar cell effi ciency.However,the effi ciency of PSCs dr... Perovskite solar cells(PSCs)have undergone a dramatic increase in laboratory-scale effi ciency to more than 25%,which is comparable to Si-based single-junction solar cell effi ciency.However,the effi ciency of PSCs drops from laboratory-scale to large-scale perovskite solar modules(PSMs)because of the poor quality of perovskite fi lms,and the increased resistance of large-area PSMs obstructs practical PSC applications.An in-depth understanding of the fabricating processes is vital for precisely controlling the quality of large-area perovskite fi lms,and a suitable structural design for PSMs plays an impor-tant role in minimizing energy loss.In this review,we discuss several solution-based deposition techniques for large-area perovskite fi lms and the eff ects of operating conditions on the fi lms.Furthermore,diff erent structural designs for PSMs are presented,including the processing technologies and device architectures. 展开更多
关键词 Perovskite solar cells Perovskite solar modules Large-scale perovskite fi lms Solution-based coating methods
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Mining Unknown Porcine Protein Isoforms by Tissue-based Map of Proteome Enhances Pig Genome Annotation
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作者 Pengju Zhao Xianrui Zheng +13 位作者 Ying Yu Zhuocheng Hou Chenguang Diao haifei wang Huimin Kang Chao Ning Junhui Li Wen Feng Wen wang George ELiu Bugao Li Jacqueline Smith Yangzom Chamba Jian-Feng Liu 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2021年第5期772-786,共15页
A lack of the complete pig proteome has left a gap in our knowledge of the pig genome and has restricted the feasibility of using pigs as a biomedical model.In this study,we developed a tissue-based proteome map using... A lack of the complete pig proteome has left a gap in our knowledge of the pig genome and has restricted the feasibility of using pigs as a biomedical model.In this study,we developed a tissue-based proteome map using 34 major normal pig tissues.A total of 5841 unknown protein isoforms were identified and systematically characterized,including 2225 novel protein isoforms,669 protein isoforms from 460 genes symbolized beginning with LOC,and 2947 protein isoforms without clear NCBI annotation in the current pig reference genome.These newly identified protein isoforms were functionally annotated through profiling the pig transcriptome with high-throughput RNA sequencing of the same pig tissues,further improving the genome annotation of the corresponding protein-coding genes.Combining the well-annotated genes that have parallel expression pattern and subcellular witness,we predicted the tissue-related subcellular locations and potential functions for these unknown proteins.Finally,we mined 3081 orthologous genes for 52.7% of unknown protein isoforms across multiple species,referring to 68 KEGG pathways as well as 23 disease signaling pathways.These findings provide valuable insights and a rich resource for enhancing studies of pig genomics and biology,as well as biomedical model application to human medicine. 展开更多
关键词 Expression pattern Unknown protein PIG PROTEOME Subcellular location
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