Evolutionary trend analysis and knowledge structure mapping of endothelial dysfunction in sepsis:a bibliometrics study

BACKGROUND:A pathophysiological feature of septic organ failure is endothelial dysfunction in sepsis(EDS).The physiological and pathological mechanism of sepsis is considered to be vascular leakage caused by endothelial dysfunction.These pathological changes lead to systemic organ injury.However,an analysis using bibliometric methods has not yet been conducted in the field of EDS.This study was conducted to provide an overview of knowledge structure and research trends in the fi eld of EDS.METHODS:Based on previous research,a literature search was performed in the Web of Science Core Collection(WoSCC)for publications associated with EDS published between the year 2003 and 2023.Various types of data from the publications,such as citation frequency,authorship,keywords and highly cited articles,were extracted.The"Create Citation Report"feature in the WoSCC was employed to calculate the Hirsch index(h-index)and average citations per item(ACI)of authors,institutions,and countries.To conduct bibliometric and visualization analyses,three bibliometric tools were used,including R-bibliometrix,CiteSpace(co-citation analysis of references),and VOSviewer(co-authorship analysis of institutions,co-authorship analysis of authors,co-occurrence analysis of keywords).RESULTS:After excluding invalid records,the study finaly included 4,536 publications with 135,386 citations.Most of these publications originated in the USA,China,Germany,Canada,and Japan.Harvard University emerged as the most prolifi c institution,while professor Jong-Sup Bae and his research team at Kyungpook National University emerged as authors with the greatest infl uence.The"protein C","tissue factor","thrombin","glycocalyx",“acute kidney injury”,“syndecan-1”and“biomarker”were identifi ed as prominent areas of research.Future research may focus on molecular mechanisms(such as as vascular endothelial[VE]-cadherin regulation)and therapeutic interventions to enhance endothelial repair and function.CONCLUSION:Our findings show a growing interest in EDS research.Key areas for future research include signaling pathways,molecular mechanisms,endothelial repair,and interactions between endothelial cells and other cell types in sepsis.

国际急诊预检分诊热点可视化分析

目的通过文献计量方法,定量和定性地预测预检分诊研究活动的热点话题,为急诊分诊领域研究提供借鉴。方法通过检索Web of Science数据库中2016年1月至2020年12月国际急诊分诊研究的相关文献,利用文献计量学的方法绘制可视化图谱。结果共检索得到发表文献2880篇,急诊预检分诊的研究数量总体上呈现逐年增加趋势,开展该领域研究最多的国家是美国,中介中心性为0.58,最多的研究机构是卡罗林斯卡学院,中介中心性为0.28。大血管阻塞、Manchester预检分诊系统一直都是该领域的研究热点。新型冠状病毒肺炎(COVID-19)流行是近期的研究热点。结论大血管闭塞导致的危重症疾病,如急性心肌梗死、急性脑卒中的预后一直是急诊预检分诊领域的重点与热点,利用信息技术进行COVID-19患者的预检分诊可能成为新的研究热点。