Objective:The transanal approach to specimen collection,combined with the prolapsing technique,is a wellestablished and minimally invasive surgery for treating rectal cancer.However,reports on outcomes for this approa...Objective:The transanal approach to specimen collection,combined with the prolapsing technique,is a wellestablished and minimally invasive surgery for treating rectal cancer.However,reports on outcomes for this approach are sparse.We compared short-and long-term outcomes of conventional laparoscopic surgery(CLS)vs.transanal natural orifice specimen extraction(NOSE)using the prolapsing technique for patients with middle-to low-rectal cancer.Methods:From January 2013 to December 2017,we enrolled consecutive patients with middle-to low-rectal cancer undergoing laparoscopic anterior resection.Totally,50 patients who underwent transanal NOSE using the prolapsing technique were matched with 50 patients who received CLS.Clinical parameters and survival outcomes between the two groups were compared.Results:Estimated blood loss(29.70±29.28 vs.52.80±45.09 mL,P=0.003),time to first flatus(2.50±0.79 vs.2.86±0.76,P=0.022),time to liquid diet(3.62±0.64 vs.4.20±0.76 d,P<0.001),and the need for analgesics(22%vs.48%,P=0.006)were significantly lower for the NOSE group compared to the CLS group.The incidences of overall complications and fecal incontinence were comparable in both groups.After a median follow-up of 44.52 months,the overall local recurrence rate(6%vs.5%,P=0.670),3-year disease-free survival(86.7%vs.88.0%,P=0.945)and 3-year overall survival(95.6%vs.96.0%,P=0.708),were not significantly different.Conclusions:For total laparoscopic rectal resection,transanal NOSE using the prolapsing technique is effective and safe,and associated with less trauma and pain,a faster recovery,and similar survival outcomes compared to CLS.展开更多
To satisfy the requirements of real-time and high quality mosaics, a bionic compound eye visual system was designed by simulating the visual mechanism of a fly compound eye. Several CCD cameras were used in this syste...To satisfy the requirements of real-time and high quality mosaics, a bionic compound eye visual system was designed by simulating the visual mechanism of a fly compound eye. Several CCD cameras were used in this system to imitate the small eyes of a compound eye. Based on the optical analysis of this system, a direct panoramic image mosaic algorithm was proposed. Several sub-images were collected by the bionic compound eye visual system, and then the system obtained the overlapping proportions of these sub-images and cut the overlap sections of the neighboring images. Thus, a panoramic image with a large field of view was directly mosaicked, which expanded the field and guaranteed the high resolution. The experimental results show that the time consumed by the direct mosaic algorithm is only 2.2% of that by the traditional image mosaic algorithm while guaranteeing mosaic quality. Furthermore, the proposed method effectively solved the problem of misalignment of the mosaic image and eliminated mosaic cracks as a result of the illumination factor and other factors. This method has better real-time properties compared to other methods.展开更多
Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyze...Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyzes the deficiencies of the state-of-the-arts algorithms and proposes a novel sub-frame-based algorithm with adaptive frame breaking policy to lower the tag identification time for EPC global C1 Gen2 UHF RFID standard.Through the observation of slot statistics in a sub-frame,the reader estimates the tag quantity and efficiently calculates an optimal frame size to fit the unread tags.Only when the expected average identification time in the calculated frame size is less than that in the previous frame size,the reader starts the new frame.Moreover,the estimation of the proposed algorithm is implemented by the look-up tables,which allows dramatically reduction in the computational complexity.Simulation results show noticeable throughput and time efficiency improvements of the proposed solution over the existing approaches.展开更多
Catalytic hydrogenation of CO_(2) using renewable hydrogen not only reduces greenhouse gas emissions,but also provides industrial chemicals.Herein,a Co-Fe bimetallic catalyst was developed by a facile reactive ball-mi...Catalytic hydrogenation of CO_(2) using renewable hydrogen not only reduces greenhouse gas emissions,but also provides industrial chemicals.Herein,a Co-Fe bimetallic catalyst was developed by a facile reactive ball-milling method for highly active and selective hydrogenation of CO_(2) to value-added hydrocarbons.When reacted at 320℃,1.0 MPa and 9600 mL h^(-1) g_(cat)^(-1),the selectivity to light olefin(C_(2)^(=)-C_(4)^(=)) and C_(5)+ species achieves 57.3% and 22.3%,respectively,at a CO_(2) co nversion of 31.4%,which is superior to previous Fe-based catalysts.The CO_(2) activation can be promoted by the CoFe phase formed by reactive ball milling of the Fe-Co_(3)O_(4) mixture,and the in-situ Co_(2)C and Fe_(5)C_(2) formed during hydrogenation are beneficial for the C-C coupling reaction.The initial C-C coupling is related to the combination of CO species with the surface carbon of Fe/Co carbides,and the sustained C-C coupling is maintained by self-recovery of defective carbides.This new strategy contributes to the development of efficient catalysts for the hydrogenation of CO_(2) to value-added hydrocarbons.展开更多
Fault detection and location are critically significant applications of a supervisory control system in a smart grid.The methods,based on random matrix theory(RMT),have been practiced using measurements to detect shor...Fault detection and location are critically significant applications of a supervisory control system in a smart grid.The methods,based on random matrix theory(RMT),have been practiced using measurements to detect short circuit faults occurring on transmission lines.However,the diagnostic accuracy is infuenced by the noise signal in the measurements.The relationship between mean eigenvalue of a random matrix and noise is detected in this paper,and the defects of the Mean Spectral Radius(MSR),as an indicator to detect faults,are theoretically determined,along with a novel indicator of the shifting degree of maximum eigenvalue and its threshold.By comparing the indicator and the threshold,the occurrence of a fault can be assessed.Finally,an augmented matrix is constructed to locate the fault area.The proposed method can effectively achieve fault detection via the RMT without any influence of noise,and also does not depend on system models.The experiment results are based on the IEEE 39-bus system.Also,actual provincial grid data is applied to validate the effectiveness of the proposed method.展开更多
Image fusion technology is the basis of computer vision task,but information is easily affected by noise during transmission.In this paper,an Improved Pigeon-Inspired Optimization(IPIO)is proposed,and used for multi-f...Image fusion technology is the basis of computer vision task,but information is easily affected by noise during transmission.In this paper,an Improved Pigeon-Inspired Optimization(IPIO)is proposed,and used for multi-focus noisy image fusion by combining with the boundary handling of the convolutional sparse representation.By two-scale image decomposition,the input image is decomposed into base layer and detail layer.For the base layer,IPIO algorithm is used to obtain the optimized weights for fusion,whose value range is gained by fusing the edge information.Besides,the global information entropy is used as the fitness index of the IPIO,which has high efficiency especially for discrete optimization problems.For the detail layer,the fusion of its coefficients is completed by performing boundary processing when solving the convolution sparse representation in the frequency domain.The sum of the above base and detail layers is as the final fused image.Experimental results show that the proposed algorithm has a better fusion effect compared with the recent algorithms.展开更多
Objective To compare the short-term efficacy indicators of laparoscopic technique and open surgery in patients with rectal cancer surgery,and to further evaluate the safety and efficacy of laparoscopic rectal cancer s...Objective To compare the short-term efficacy indicators of laparoscopic technique and open surgery in patients with rectal cancer surgery,and to further evaluate the safety and efficacy of laparoscopic rectal cancer surgery.Methods This study adopted a prospective multicenter,open-label,non-randomized concurrent control method to analyze patients who received rectal cancer surgery from 10 colorectal tumor centers across the country from January 2017 to December 2018.The two groups of patients received laparoscopic-assisted surgery and conventional open surgery respectively.All surgeons were selected according to relevant standards and participated in the two groups of operations at the same time.Comprehensive evaluation and analysis of the operation and postoperative recovery,postoperative pathological results,survival information,postoperative related functional scores and other indicators.Results In the open surgery group,the proportion of tumors with a maximum diameter of more than 5 cm was higher(χ^(2)=0.089,P=0.018),and the proportion of T4 was higher(χ^(2)=0.478,P<0.001).In the laparoscopic group,the proportion of more than 12 harvested lymph nodes was higher(χ^(2)=0.248,P<0.001).There were no significant differences in the length of postoperative hospital stay,intraoperative blood loss,time to first flatus after operation,time to first out of bed,time to first liquid diet,and preservation rate of anal sphincter between the two groups,but in the laparoscopic surgery group the operation time was shorter(t=6.750,P<0.001)and postoperative pain was less(t=0.896,0.63,0.964,and 0.989 on postoperative days 1,2,and 3,respectively,all P<0.001).The incidence of grade 2–4 adverse complication in the two groups was 12.5%and 14.6%,respectively,with no statistical difference(χ2=0.061,P=0.105),but the incidence of incision infection was lower in the laparoscopy group(χ^(2)=0.19,P<0.001).There was no significant difference in 3-year disease-free survival between the two groups(HR=1.089,95%CI=0.962–1.232,P=0.170).Multivariate analysis suggested that intraoperative blood loss,T stage,N stage,nerve invasion,and postoperative sepsis were independent prognostic factors for disease-free survival.Wexner score,IPSS score and LARS score were not statistically different between the two groups.Conclusion The pathological results and short-term outcomes of laparoscopic surgery for rectal cancer are comparable to those of conventional open surgery,and laparoscopic surgery is safe and feasible for rectal cancer patients.展开更多
Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find a...Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find alternative therapies with effective cancer prevention and treatment.Chinese herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged properties.CHMs are useful in the suppression of various types of cancers through different mechanisms of action.Non-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and development.Regulation of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and treatment.Substantial evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling pathways.Herein,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular mechanisms.This review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.展开更多
基金supported by National Key R&D Program of China(No.2017YFC0908203)Chinese Academy of Medical Sciences Initiative for Innovative Medicine(No.2017-I2M-2-003 and 2016-I2M-1-001)+2 种基金Science and Technology Project of Chaoyang District,Beijing(No.CYSF-1931)Beijing Science and Technology Program(No.D17110002617004)Beijing Gold-Bridge Funds(No.ZZ19055)。
文摘Objective:The transanal approach to specimen collection,combined with the prolapsing technique,is a wellestablished and minimally invasive surgery for treating rectal cancer.However,reports on outcomes for this approach are sparse.We compared short-and long-term outcomes of conventional laparoscopic surgery(CLS)vs.transanal natural orifice specimen extraction(NOSE)using the prolapsing technique for patients with middle-to low-rectal cancer.Methods:From January 2013 to December 2017,we enrolled consecutive patients with middle-to low-rectal cancer undergoing laparoscopic anterior resection.Totally,50 patients who underwent transanal NOSE using the prolapsing technique were matched with 50 patients who received CLS.Clinical parameters and survival outcomes between the two groups were compared.Results:Estimated blood loss(29.70±29.28 vs.52.80±45.09 mL,P=0.003),time to first flatus(2.50±0.79 vs.2.86±0.76,P=0.022),time to liquid diet(3.62±0.64 vs.4.20±0.76 d,P<0.001),and the need for analgesics(22%vs.48%,P=0.006)were significantly lower for the NOSE group compared to the CLS group.The incidences of overall complications and fecal incontinence were comparable in both groups.After a median follow-up of 44.52 months,the overall local recurrence rate(6%vs.5%,P=0.670),3-year disease-free survival(86.7%vs.88.0%,P=0.945)and 3-year overall survival(95.6%vs.96.0%,P=0.708),were not significantly different.Conclusions:For total laparoscopic rectal resection,transanal NOSE using the prolapsing technique is effective and safe,and associated with less trauma and pain,a faster recovery,and similar survival outcomes compared to CLS.
文摘To satisfy the requirements of real-time and high quality mosaics, a bionic compound eye visual system was designed by simulating the visual mechanism of a fly compound eye. Several CCD cameras were used in this system to imitate the small eyes of a compound eye. Based on the optical analysis of this system, a direct panoramic image mosaic algorithm was proposed. Several sub-images were collected by the bionic compound eye visual system, and then the system obtained the overlapping proportions of these sub-images and cut the overlap sections of the neighboring images. Thus, a panoramic image with a large field of view was directly mosaicked, which expanded the field and guaranteed the high resolution. The experimental results show that the time consumed by the direct mosaic algorithm is only 2.2% of that by the traditional image mosaic algorithm while guaranteeing mosaic quality. Furthermore, the proposed method effectively solved the problem of misalignment of the mosaic image and eliminated mosaic cracks as a result of the illumination factor and other factors. This method has better real-time properties compared to other methods.
文摘Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyzes the deficiencies of the state-of-the-arts algorithms and proposes a novel sub-frame-based algorithm with adaptive frame breaking policy to lower the tag identification time for EPC global C1 Gen2 UHF RFID standard.Through the observation of slot statistics in a sub-frame,the reader estimates the tag quantity and efficiently calculates an optimal frame size to fit the unread tags.Only when the expected average identification time in the calculated frame size is less than that in the previous frame size,the reader starts the new frame.Moreover,the estimation of the proposed algorithm is implemented by the look-up tables,which allows dramatically reduction in the computational complexity.Simulation results show noticeable throughput and time efficiency improvements of the proposed solution over the existing approaches.
基金supported by the National Natural Science Foundation of China (22008098, 21978156, 42002040)the Program for Innovative Research Team (in Science and Technology) in University of Henan Province (21IRTSTHN004)+1 种基金the Program for Science & Technology Innovation Talents in Universities of Henan Province (22HASTIT008)the Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering (2022-K34)。
文摘Catalytic hydrogenation of CO_(2) using renewable hydrogen not only reduces greenhouse gas emissions,but also provides industrial chemicals.Herein,a Co-Fe bimetallic catalyst was developed by a facile reactive ball-milling method for highly active and selective hydrogenation of CO_(2) to value-added hydrocarbons.When reacted at 320℃,1.0 MPa and 9600 mL h^(-1) g_(cat)^(-1),the selectivity to light olefin(C_(2)^(=)-C_(4)^(=)) and C_(5)+ species achieves 57.3% and 22.3%,respectively,at a CO_(2) co nversion of 31.4%,which is superior to previous Fe-based catalysts.The CO_(2) activation can be promoted by the CoFe phase formed by reactive ball milling of the Fe-Co_(3)O_(4) mixture,and the in-situ Co_(2)C and Fe_(5)C_(2) formed during hydrogenation are beneficial for the C-C coupling reaction.The initial C-C coupling is related to the combination of CO species with the surface carbon of Fe/Co carbides,and the sustained C-C coupling is maintained by self-recovery of defective carbides.This new strategy contributes to the development of efficient catalysts for the hydrogenation of CO_(2) to value-added hydrocarbons.
基金This work was supported in part by the National Natural Science Foundation of China(Key Project Number:51437003)。
文摘Fault detection and location are critically significant applications of a supervisory control system in a smart grid.The methods,based on random matrix theory(RMT),have been practiced using measurements to detect short circuit faults occurring on transmission lines.However,the diagnostic accuracy is infuenced by the noise signal in the measurements.The relationship between mean eigenvalue of a random matrix and noise is detected in this paper,and the defects of the Mean Spectral Radius(MSR),as an indicator to detect faults,are theoretically determined,along with a novel indicator of the shifting degree of maximum eigenvalue and its threshold.By comparing the indicator and the threshold,the occurrence of a fault can be assessed.Finally,an augmented matrix is constructed to locate the fault area.The proposed method can effectively achieve fault detection via the RMT without any influence of noise,and also does not depend on system models.The experiment results are based on the IEEE 39-bus system.Also,actual provincial grid data is applied to validate the effectiveness of the proposed method.
基金supported in part by National Key Research and Development Program of China(2018YFB0804202,2018YFB0804203)Regional Joint Fund of NSFC(U19A2057)+1 种基金National Natural Science Foundation of China(61876070)Jilin Province Science and Technology Development Plan Project(20190303134SF).
文摘Image fusion technology is the basis of computer vision task,but information is easily affected by noise during transmission.In this paper,an Improved Pigeon-Inspired Optimization(IPIO)is proposed,and used for multi-focus noisy image fusion by combining with the boundary handling of the convolutional sparse representation.By two-scale image decomposition,the input image is decomposed into base layer and detail layer.For the base layer,IPIO algorithm is used to obtain the optimized weights for fusion,whose value range is gained by fusing the edge information.Besides,the global information entropy is used as the fitness index of the IPIO,which has high efficiency especially for discrete optimization problems.For the detail layer,the fusion of its coefficients is completed by performing boundary processing when solving the convolution sparse representation in the frequency domain.The sum of the above base and detail layers is as the final fused image.Experimental results show that the proposed algorithm has a better fusion effect compared with the recent algorithms.
基金supported by Beijing Science and Technology Program[D17110002617004]Beijing Hope Run Special Fund of Cancer Foundation of China[LC2019B14 and LC2021A13].
文摘Objective To compare the short-term efficacy indicators of laparoscopic technique and open surgery in patients with rectal cancer surgery,and to further evaluate the safety and efficacy of laparoscopic rectal cancer surgery.Methods This study adopted a prospective multicenter,open-label,non-randomized concurrent control method to analyze patients who received rectal cancer surgery from 10 colorectal tumor centers across the country from January 2017 to December 2018.The two groups of patients received laparoscopic-assisted surgery and conventional open surgery respectively.All surgeons were selected according to relevant standards and participated in the two groups of operations at the same time.Comprehensive evaluation and analysis of the operation and postoperative recovery,postoperative pathological results,survival information,postoperative related functional scores and other indicators.Results In the open surgery group,the proportion of tumors with a maximum diameter of more than 5 cm was higher(χ^(2)=0.089,P=0.018),and the proportion of T4 was higher(χ^(2)=0.478,P<0.001).In the laparoscopic group,the proportion of more than 12 harvested lymph nodes was higher(χ^(2)=0.248,P<0.001).There were no significant differences in the length of postoperative hospital stay,intraoperative blood loss,time to first flatus after operation,time to first out of bed,time to first liquid diet,and preservation rate of anal sphincter between the two groups,but in the laparoscopic surgery group the operation time was shorter(t=6.750,P<0.001)and postoperative pain was less(t=0.896,0.63,0.964,and 0.989 on postoperative days 1,2,and 3,respectively,all P<0.001).The incidence of grade 2–4 adverse complication in the two groups was 12.5%and 14.6%,respectively,with no statistical difference(χ2=0.061,P=0.105),but the incidence of incision infection was lower in the laparoscopy group(χ^(2)=0.19,P<0.001).There was no significant difference in 3-year disease-free survival between the two groups(HR=1.089,95%CI=0.962–1.232,P=0.170).Multivariate analysis suggested that intraoperative blood loss,T stage,N stage,nerve invasion,and postoperative sepsis were independent prognostic factors for disease-free survival.Wexner score,IPSS score and LARS score were not statistically different between the two groups.Conclusion The pathological results and short-term outcomes of laparoscopic surgery for rectal cancer are comparable to those of conventional open surgery,and laparoscopic surgery is safe and feasible for rectal cancer patients.
基金the grants of National Natural Science Foundation of China(81720108033,81930114)Science and Technology Projects in Guangzhou(202201011393,202102021196)+2 种基金Project of Traditional Chinese Medicine Bureau of Guangdong Province(20211111,20231234)Key-Area Research and Development Program of Guangdong Province(2020B1111100004)Guangdong Basic and Applied Basic Reuter Foundation(2020B1515130005).
文摘Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find alternative therapies with effective cancer prevention and treatment.Chinese herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged properties.CHMs are useful in the suppression of various types of cancers through different mechanisms of action.Non-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and development.Regulation of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and treatment.Substantial evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling pathways.Herein,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular mechanisms.This review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.
