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GraphSTGAN:Situation understanding network of slow-fast high maneuvering targets for maritime monitor services of IoT data
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作者 Guanlin Wu haipeng wang +1 位作者 Yu Liu You He 《Digital Communications and Networks》 SCIE CSCD 2024年第3期620-630,共11页
With the rapid growth of the maritime Internet of Things(IoT)devices for Maritime Monitor Services(MMS),maritime traffic controllers could not handle a massive amount of data in time.For unmanned MMS,one of the key te... With the rapid growth of the maritime Internet of Things(IoT)devices for Maritime Monitor Services(MMS),maritime traffic controllers could not handle a massive amount of data in time.For unmanned MMS,one of the key technologies is situation understanding.However,the presence of slow-fast high maneuvering targets and track breakages due to radar blind zones make modeling the dynamics of marine multi-agents difficult,and pose significant challenges to maritime situation understanding.In order to comprehend the situation accurately and thus offer unmanned MMS,it is crucial to model the complex dynamics of multi-agents using IoT big data.Nevertheless,previous methods typically rely on complex assumptions,are plagued by unstructured data,and disregard the interactions between multiple agents and the spatial-temporal correlations.A deep learning model,Graph Spatial-Temporal Generative Adversarial Network(GraphSTGAN),is proposed in this paper,which uses graph neural network to model unstructured data and uses STGAN to learn the spatial-temporal dependencies and interactions.Extensive experiments show the effectiveness and robustness of the proposed method. 展开更多
关键词 Internet of things MULTI-AGENTS Graph neural network Maritime monitoring services
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A novel functional electrical stimulation-control system for restoring motor function of post-stroke hemiplegic patients 被引量:4
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作者 Zonghao Huang Zhigong wang +3 位作者 Xiaoying Lv Yuxuan Zhou haipeng wang Sihao Zong 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第23期2102-2110,共9页
Hemiparesis is one of the most common consequences of stroke. Advanced rehabilitation techniques are essential for restoring motor function in hemiplegic patients. Functional electrical stimulation applied to the affe... Hemiparesis is one of the most common consequences of stroke. Advanced rehabilitation techniques are essential for restoring motor function in hemiplegic patients. Functional electrical stimulation applied to the affected limb based on myoelectric signal from the unaffected limb is a promising therapy for hemiplegia. In this study, we developed a prototype system for evaluating this novel functional electrical stimulation-control strategy. Based on surface electromyography and a vector machine model, a self-administered, muki-movement, force-modulation functional electrical stimulation-prototype system for hemiplegia was implemented. This paper discusses the hardware design, the algorithm of the system, and key points of the self-oscillation-prone system. The experimental results demonstrate the feasibility of the prototype system for further clinical trials, which is being conducted to evaluate the efficacy of the proposed rehabilitation technique. 展开更多
关键词 nerve regeneration STROKE motor function REHABILITATION functional electrical stimulation surface electromyography stimulator circuit neural regeneration
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Synchrotron-Based Data-Constrained Modeling Analysis of Microscopic Mineral Distributions in Limestone 被引量:4
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作者 Yudan wang Yushuang Yang +4 位作者 Tiqiao Xiao Keyu Liu Ben Clennell Guoqiang Zhang haipeng wang 《International Journal of Geosciences》 2013年第2期344-351,共8页
Three dimensional (3D) microscopic distributions of dolomite and calcite in a limestone sample have been analyzed with a data-constrained modeling (DCM) technique using synchrotron radiation-based multi-energy X-ray c... Three dimensional (3D) microscopic distributions of dolomite and calcite in a limestone sample have been analyzed with a data-constrained modeling (DCM) technique using synchrotron radiation-based multi-energy X-ray computed tomography (CT) data as constraints. In order to optimize the experimental parameters, X-ray CT simulations and DCM analysis of a numerical phantom consisting of calcite (CaCO3) and dolomite (CaMg(CO3)2) have been used to investigate the effects on the predicted results in relation to noise, X-ray energy and sample-to-detector distance (SDD). The simulation results indicate that the optimal X-ray energies are 25 and 35 keVs, and the SDD is 10 mm. The high resolution 3D distributions of mineral phases of a natural limestone have been obtained. The results are useful for quantitative understanding of mineral, porosity, and physical property distributions in relation to oil and gas reservoirs hosted in carbonate rocks, which account for more than half of the world’s conventional hydrocarbon resources. The case studied is also instructive for the applicability of the DCM methods for other types of composite materials with modest atomic number contrasts between the mineral phases. 展开更多
关键词 X-Ray Computed Tomography (CT) SYNCHROTRON Radiation (SR) Data-Constrained Modeling (DCM) Microstructure LIMESTONE
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A New Understanding of the Lower Cretaceous Jiufotang Formation in Western Liaoning
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作者 Zijie Wu Longwei Qiu haipeng wang 《Open Journal of Geology》 2019年第10期658-660,共3页
The Lower Cretaceous Jiufotang Formation in western Liaoning is the most important fossil production horizon of the Jehol Biota, which is widely distributed in the Mesozoic basins of western Liaoning. Due to the influ... The Lower Cretaceous Jiufotang Formation in western Liaoning is the most important fossil production horizon of the Jehol Biota, which is widely distributed in the Mesozoic basins of western Liaoning. Due to the influence of historical data, previous scholars believed that there was no volcanic activity in the Jiufotang Formation in western Liaoning. In a field investigation in western Liaoning, the authors discovered basalt and andesite in the Hujiayingzi bed. In addition, a conformable boundary was found between the Yixian and the Jiufotang formations. It indicates that both the Jiufotang Formation and the Yixian Formation are strata containing volcanic-sedimentary rocks, only differing in strength of volcanic activity. 展开更多
关键词 Western LIAONING LOWER CRETACEOUS Jiufotang Formation VOLCANIC ROCKS NEW Discoveries
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Association between availability of glucose-lowering drugs in primary health institutions and diabetes patients’medication adherence:a cross-sectional study in Shandong Province,China
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作者 Jiansen Yao haipeng wang +4 位作者 Di Shao Jia Yin Xiaolei Guo Xiao Yin Qiang Sun 《Global Health Journal》 2021年第2期83-89,共7页
Background:Primary health care system is a critical component of diabetes care and management.This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions(PHIs)in China,and t... Background:Primary health care system is a critical component of diabetes care and management.This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions(PHIs)in China,and to explore the relationship between availability of glucose-lowering drugs and medication adherence among type 2 diabetes mellitus(T2DM)patients.Methods:This cross-sectional study conducted in Shandong Province,eastern China(hereafter referred to as Shandong),between August and December 2017.In total,2520 community-managed T2DM patients were selected from 68 PHIs in Shandong,including 62 village-level and 6 township-level PHIs.The self-developed questionnaire was used to survey the availability of glucose-lowering drugs in PHIs.Patients’medication adherence was assessed by four self-reported questions,and was classified as either adherent or non-adherent.Descriptive statistics was used to analyze the availability of glucose-lowering drugs in PHIs and the medication adherence among the T2DM patients.Multilevel logistic regression models were used to explore the relationship between the availability of glucose-lowering drugs in PHIs and patients’medication adherence.Results:A total of 1866 T2DM patients prescribed with at least one glucose-lowering drug were included in analysis.Among them,58.5%patients followed their antidiabetic treatment well.In village-level PHIs,the patient’s adherence rate was lower than in township-level PHIs(55.9%vs.61.1%,P<0.05).Among the 68 PHIs,average(2.53±0.97)glucose-lowering products(generic names)were available,which in village-level PHIs were less than in township-level PHIs(2.47 vs.3.17,P<0.05).And the number of available glucose-lowering products in PHIs was associated with the adherence of T2DM patients.Conclusion:Poor availability of glucose-lowering products was found in PHIs in Shandong.The availability of glucose-lowering products in PHIs was positively associated with patients’medication adherence,and could be enhanced to improve the control of diabetes in primary care settings. 展开更多
关键词 Diabetes mellitus Primary health institutions Medication adherence SHANDONG China
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A New Tag Index Scheme Enables Fast Peptide Retrieval for Protein Identification
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作者 Piyu Zhou Xinhang Hou haipeng wang 《Journal of Computer and Communications》 2022年第4期14-23,共10页
Sequence tag index in the field of computational proteomics can be used to facilitate faster open-search-based identification of modified peptides and in-depth analysis of mass spectrometry data. In protein-identifica... Sequence tag index in the field of computational proteomics can be used to facilitate faster open-search-based identification of modified peptides and in-depth analysis of mass spectrometry data. In protein-identification search engines, sequence tag index are playing a prominent role in recent ten years due to fast searching speed. However, in pursuit of less index space consumption, some protein search engines design excessively concise index schemes which lead to higher computational burden. We proposed a new tag index scheme named TIIP with a better balance between space and time complexity. TIIP has a unique two-level hierarchical index structure which allows rapid retrieval of all peptide sequences and their corresponding masses. Theoretically, the index space consumption of TIIP is not much higher compared to the typical tag index schemes, but the time complexity of sequence retrieval can be reduced to O(1), and practically, TIIP has about one million fold improvement in searching speed compared with brute force approach. 展开更多
关键词 PROTEOMICS Mass Spectrometry Sequence Tag Inverted Index Tag Index Open Search
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Design,modeling and experimental investigation of a novel solar sail with high area-to-mass ratios for efficient solar sailing
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作者 Zhongjing REN Chengyang LI +3 位作者 Ke WU Ziran wang haipeng wang Peng YAN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第10期234-248,共15页
Solar sailing is a promising propellant-free approach to propelling spacecraft in space.However,the propelling efficiency of conventional solar sail spacecraft is limited by their areato-mass ratios.This paper propose... Solar sailing is a promising propellant-free approach to propelling spacecraft in space.However,the propelling efficiency of conventional solar sail spacecraft is limited by their areato-mass ratios.This paper proposes a novel design of micro solar sails with area-to-mass ratios above 100 m2/kg for next-generation chip-scale spacecraft.Bilayer thin films developed by Microelectromechanical Systems(MEMS)technologies were patterned into grid microstructures,and theoretical analysis of a sail prototype was conducted.The electro-thermal and thermo-mechanical models of the solar sail in geospace were established by taking effects of Joule heating,solar radiation,and thermal re-emission into consideration,enabling rapid prediction of its threedimensional(3-D)reconfiguration from the as-released two-dimensional(2-D)microstructure.Adjustment of the ChipSail’s acceleration arising from the sail’s morphing was also analytically modeled.Fabrication and characterization of the sail prototype made of multiple Al/Ni50Ti50 bilayer beams were accomplished.In-situ SEM imaging of the sail prototype in vacuum chamber witnessed an active and continuous 3-D reconfiguration under Joule heating,and over 90deformation was detected by applying a DC voltage of 0.078 V.Theoretical and experimental work on the solar sail with at least 10 times higher area-to-mass ratios than conventional ones will lay a solid foundation for efficient solar sailing. 展开更多
关键词 Solar sails Solar sailing High area-to-mass ratios Solar radiation pressure ChipSail
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气候变化以两种不同方式驱动了丝绸之路路线的变迁
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作者 王海鹏 陈建徽 +7 位作者 仇梦晗 史志林 张盛达 董广辉 马帅 艾涛 任冠 陈发虎 《Science Bulletin》 SCIE EI CAS CSCD 2024年第8期1153-1160,共8页
Although climate change has convincingly been linked to the evolution of human civilization on different temporal scales,its role in influencing the spatial patterns of ancient civilizations has rarely been investigat... Although climate change has convincingly been linked to the evolution of human civilization on different temporal scales,its role in influencing the spatial patterns of ancient civilizations has rarely been investigated,The northward shift of the ancient Silk Road(SR)route from the Tarim Basin(TB)to the Junggar Basin during~420-850 CE provides the opportunity to investigate the relationship between climate change and the spatial evolution of human societies.Here,we use a new high-resolution chironomidbased temperature reconstruction from arid China,combined with hydroclimatic and historical datasets,to assess the possible effects of climate fluctuations on the shift of the ancient SR route,We found that a cooling/drying climate in the TB triggered the SR route shift during~420-600 CE,However,a warming/wetting climate during~600-850 CE did not inhibit this shift,but instead promoted it,because of the favorable climate-induced geopolitical conflicts between the Tubo Kingdom and the Tang Dynasty in the TB.Our findings reveal two distinct ways in which climate change drove the spatial evolution of human civilization,and they demonstrate the flexibility of societal responses to climate change. 展开更多
关键词 CHIRONOMIDS Temperature reconstruction Water resources Geopolitical conflicts
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Conversion of magnetron-sputtered sacrificial intermediate layer into a stable FeCo-LDH catalyst for oxygen evolution reaction
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作者 Zhiquan Lang Guang-Ling Song +4 位作者 Xingpeng Liao Wenzhong Huang Yixing Zhu haipeng wang Dajiang Zheng 《Nano Research》 SCIE EI CSCD 2024年第5期4307-4313,共7页
Controllable and scalable preparation of electrocatalyst materials holds significant importance for their practical application.Magnetron sputtering is a highly effective synthesis method,known for its producing unifo... Controllable and scalable preparation of electrocatalyst materials holds significant importance for their practical application.Magnetron sputtering is a highly effective synthesis method,known for its producing uniform films and allowing easy control of component compositions.In this paper,we propose an in-situ synthesis method for layered double hydroxide(LDH)electrocatalysts through sacrificing magnetron sputtered films.The resulting FeCo-LDH catalyst demonstrated a low overpotential of only 300 mV at 10 mA·cm^(-2).Furthermore,we conducted spectroscopic analysis to investigate the surface changes of the catalysts during the oxygen evolution reaction(OER)process.Our findings indicated that the formation of Co oxyhydroxides plays a beneficial role in enhancing the catalytical performance of the FeCo-LDH for OER reaction.This restructuring strategy of converting a magnetron-sputtered sacrificial film into a catalytical LDH introduces a new avenue to the synthesis of transition metal-based electrocatalysts. 展开更多
关键词 magnetron co-sputtering surface reconstruction ELECTROCATALYST oxygen evolution reaction
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Temperature variations along the Silk Road over the past 2000 years:Integration and perspectives 被引量:1
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作者 Jianhui CHEN haipeng wang +2 位作者 Yan LIU Shuai MA Wei HUANG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2023年第7期1468-1477,共10页
Reconstructing temperature changes along the Silk Road(SR)over the last two millennia can provide insights into past global changes and their impact on the rise and fall of ancient civilizations in this region.Numerou... Reconstructing temperature changes along the Silk Road(SR)over the last two millennia can provide insights into past global changes and their impact on the rise and fall of ancient civilizations in this region.Numerous high-quality single-site paleotemperature records have been produced for the eastern part of the SR(mainly for the Xinjiang region and its surrounding areas),which provide the data basis for a comprehensive synthesis.In this study,we used objective criteria to select 10 highquality ones from 30 temperature reconstructions derived from various geological archives including lacustrine sediments,ice cores,and tree rings in this region.Our aims are to summarize the pattern of temperature change over the past 2000 years,to provide a long-term viewpoint on the present warming,and to evaluate the impact of climate change on civilizations along the SR.The principal results are as follows:(1)The temperature variations over the last millennium are mutually consistent within these records.The study area experienced typical climate anomalies during the Medieval Warm Period(MWP,AD 1000-1250),the Little Ice Age(LIA,AD 1450-1850),and the Current Warm Period(CWP,AD 1850 to present);however,contrary to previous knowledge,the amplitude of climatic warming during the CWP did not exceed that during the MWP.(2)Fewer temperature records were available for the interval AD 1–1000,and there were large differences between them.For example,the reconstructed climate during both the Han Dynasty and the Sui-Tang Dynasties was either warm or cold,without prevailing consensus.(3)The warming during the MWP favored the rapid development of the SR route along the northern slopes of the Tianshan Mountains,and the cooling during the LIA contributed to the decline of the SR marked by the closure of the Jiayuguan Pass.Notably,the scarcity of temperature records and the discrepancies between them during AD 1-1000 in the eastern part of the SR have hindered our understanding of the hydroclimatic changes and their influence on the development of civilizations along the SR.Thus,it is important to obtain an increased number of high-quality reliable records spanning the past 2000 year,and to examine the occurrence of local signals of temperature changes during the period of AD 1-1000.On the other hand,the paleotemperature investigation on the western part of the SR over the last two millennia is wholly insufficient,and thus more high-quality single-site and integrated studies are needed,to facilitate more comprehensive insights into the coupled relationship between climate change and the rise and fall of civilizations along the entire length of the Silk Road. 展开更多
关键词 Silk Road Medieval Warm Period Little Ice Age Current Warm Period Rise and fall of civilizations
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Special Emergency Resources Preallocation Concerning Demand Time for Tunnel Collapse
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作者 Xia Li Yuewen Xiao +3 位作者 Jiaxuan Li haipeng wang Eryong Chuo Haili Bai 《International Journal of Disaster Risk Science》 SCIE CSCD 2023年第1期113-126,共14页
Lacking timely access to rescue resources is one of the main causes of casualties in tunnel collapse.To provide timely rescue,this study proposed a multi-objective preallocation model of special emergency resources fo... Lacking timely access to rescue resources is one of the main causes of casualties in tunnel collapse.To provide timely rescue,this study proposed a multi-objective preallocation model of special emergency resources for tunnel collapse based on demand time.Efficiency,multiple coverage,and cost-effectiveness are taken as the key objectives of the model;the demand time service range is used as a coverage decision factor considering the unique nature of tunnel collapse.The weight of potential disaster-affected points and other general factors are also considered in this model in order to thoroughly combine the distribution of disaster points and service areas.Further,we take 15 main tunnel projects under construction in China as an example.When the relative proximity to the ideal point of the selected optimal schemeε_(a)is smaller than 0.5,we will adjust the weight of three objectives and reselect the optimal scheme untilε_(a)>0.5.Compared with the not preallocated case,the number of rescue rigs needed is reduced by 8.3%,the number of covered potential disaster-affected points is increased by 36.36%,the weighted coverage times are increased from 0.853 to 1.383,and the weighted distance is significantly reduced by 99%when the rescue rigs are preallocated,verifying the feasibility and superiority of the proposed model. 展开更多
关键词 China Demand time Emergency resources preallocation Special emergency resources Tunnel collapse
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蜜蜂球囊菌的microRNA鉴定及其调控网络分析 被引量:16
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作者 郭睿 王海朋 +5 位作者 陈华枝 熊翠玲 郑燕珍 付中民 赵红霞 陈大福 《微生物学报》 CAS CSCD 北大核心 2018年第6期1077-1089,共13页
【目的】本研究利用small RNA-seq技术对球囊菌的纯培养进行测序,对球囊菌的micro RNAs miRNAs)进行预测、鉴定和分析,进而构建miRNAs-mRNAs的调控网络。【方法】利用Illumina Hiseq Xten平台对球囊菌菌丝与孢子进行测序,通过相关生物... 【目的】本研究利用small RNA-seq技术对球囊菌的纯培养进行测序,对球囊菌的micro RNAs miRNAs)进行预测、鉴定和分析,进而构建miRNAs-mRNAs的调控网络。【方法】利用Illumina Hiseq Xten平台对球囊菌菌丝与孢子进行测序,通过相关生物信息学软件对球囊菌的miRNAs进行预测和分析,通过茎环(Stem-loop)PCR对部分miRNAs进行鉴定,利用Cytoskype软件构建miRNAs-mRNAs的调控网络。【结果】本研究共获得48268696条clean reads,预测出118个球囊菌的miRNAs,它们的长度分布介于18–25 nt之间,不同长度的mi RNA的首位碱基偏好性差异明显。Stem-loop PCR验证结果显示共有10个miRNAs能够扩增出符合预期的目的片段,说明多数miRNAs可能真实存在。共预测出6529个球囊菌miRNAs的靶基因,其中5725个能够注释到Nr、Swissprot、KOG、GO和KEGG数据库。进一步分析结果显示有24个靶基因注释在MAPK信号通路。Cytoskype软件分析结果显示球囊菌的miRNAs与mRNAs之间存在复杂的调控网络,绝大多数的miRNAs处于调控网络的内部且同时结合多个mRNAs。【结论】本研究率先对球囊菌的miRNAs及miRNAs-mRNAs调控网络进行全面分析,研究结果丰富了对球囊菌miRNAs的认识,为其基础生物学信息提供了有益补充,也为阐明球囊菌致病的分子机理打下了一定基础。 展开更多
关键词 蜜蜂 球囊菌 MICRORNA 靶基因 调控网络
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中华蜜蜂幼虫肠道响应球囊菌胁迫的microRNA应答分析 被引量:14
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作者 杜宇 童新宇 +9 位作者 周丁丁 陈大福 熊翠玲 郑燕珍 徐国钧 王海朋 陈华枝 郭意龙 隆琦 郭睿 《微生物学报》 CAS CSCD 北大核心 2019年第9期1747-1764,共18页
【目的】蜜蜂球囊菌(Ascosphaera apis,简称球囊菌)是一种能够侵染中华蜜蜂(Apis cerana cerana,简称中蜂)幼虫的致死性真菌病原。微小RNA(microRNA,miRNA)可通过在转录后水平靶向抑制或降解mRNA而参与宿主与病原互作过程。本研究旨在... 【目的】蜜蜂球囊菌(Ascosphaera apis,简称球囊菌)是一种能够侵染中华蜜蜂(Apis cerana cerana,简称中蜂)幼虫的致死性真菌病原。微小RNA(microRNA,miRNA)可通过在转录后水平靶向抑制或降解mRNA而参与宿主与病原互作过程。本研究旨在对球囊菌胁迫的中蜂6日龄幼虫肠道的差异表达miRNA(DEmiRNA)及其靶基因进行深入分析,进而揭示DEmiRNA在中蜂响应球囊菌胁迫应答过程中的作用。【方法】利用Illumina MiSeq平台对正常及球囊菌胁迫的中蜂6日龄幼虫肠道(AcCK和AcT)进行测序,通过相关生物信息学软件预测DEmiRNA及其靶基因。通过Blast将靶基因注释到GO和KEGG数据库。利用Cytoscape软件构建DEmiRNA与其靶mRNA的调控网络。通过Stem-loop RT-PCR和qPCR验证测序数据的可靠性。【结果】本研究共预测出537个miRNA,其长度分布介于16–35 nt之间,且不同长度的miRNA首位碱基偏向性差异明显。通过Stem-loop RT-PCR证实了10个novel miRNA的表达。AcCK vs AcT比较组共有54个DEmiRNA,包含31个上调和23个下调miRNA,可分别靶向结合6170和8199个靶基因。GO分类结果显示上调和下调miRNA的靶基因分别涉及47和47个条目,富集基因数最多的皆为结合细胞进程和催化活性。KEGG代谢通路(pathway)富集分析结果表明上调和下调miRNA的靶基因分别富集在134和126条pathway,富集基因数最多的均为内吞作用和内质网中的蛋白质加工。调控网络分析结果表明,DEmiRNA及其靶mRNA形成十分复杂的调控关系;31个DEmiRNA可靶向结合51个与泛素介导的蛋白水解相关的mRNA,18个DEmiRNA可靶向结合14个与Jak-STAT信号通路相关的mRNA;miR-1277-x、miR-26-x、miR-27-y、miR-30-x、miR-6052-x等16个miRNA共同参与了上述两条免疫通路的调控。最后,随机挑选3个DEmiRNA进行qPCR验证,结果证明了测序数据的可靠性。【结论】本研究提供了中蜂幼虫肠道在球囊菌胁迫后期的miRNA的表达谱和差异表达信息,揭示了球囊菌与宿主之间在miRNA组学水平存在复杂的互作。miR-6052-x和miR-1277-x作为调控网络的核心可能通过影响细胞凋亡参与宿主的免疫防御,miR-26-x和miR-30-x可能通过调控Jak-STAT信号通路参与宿主的胁迫应答。本研究筛选出的关键DEmiRNA有望作为治疗白垩病的分子靶标。 展开更多
关键词 中华蜜蜂 幼虫 球囊菌 MICRORNA 靶基因 调控网络
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HMF催化合成生物基聚酯单体FDCA 被引量:3
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作者 刘雪晨 邢娟娟 +3 位作者 王海鹏 周沅逸 张玲 王文中 《化学进展》 SCIE CAS CSCD 北大核心 2020年第9期1294-1306,共13页
在石油资源日渐紧缺的背景下,充分利用自然界中可再生的生物质资源无疑是缓解当前和未来资源危机的有效手段,基于生物质平台分子的绿色化工正在逐渐替代传统石化产品的生产模式。来源于生物质的5-羟甲基糠醛(HMF)经过催化氧化可合成高... 在石油资源日渐紧缺的背景下,充分利用自然界中可再生的生物质资源无疑是缓解当前和未来资源危机的有效手段,基于生物质平台分子的绿色化工正在逐渐替代传统石化产品的生产模式。来源于生物质的5-羟甲基糠醛(HMF)经过催化氧化可合成高附加值化学品2,5-呋喃二甲酸(FDCA)。FDCA是生产绿色聚合物聚2,5-呋喃二甲酸乙二酯(PEF)的重要单体。综合近年来利用热、电、光与生物催化模式进行的HMF氧化研究成果,热催化在产率与产品纯度方面显示出明显优势,但其对高能耗与高氧压的依赖限制了在工业中的应用。以电催化和光催化为基础的催化模式能够高效利用电能和太阳能,氧化活性物种丰富可调,有广阔应用前景。此外,生物催化模式虽目前产率较低,但具有反应条件温和、选择性高的突出特点,是未来有效利用生物质资源的重要发展方向。本文对氧化途径与相应反应机理进行讨论,并全面地总结了目前由HMF催化氧化生产FDCA的研究现状,包括已取得的进展与将面临的挑战,最后对未来发展方向与前景进行了展望。 展开更多
关键词 5-羟甲基糠醛 2 5-呋喃二甲酸 热催化 电催化 光催化
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融合梯度信息和邻域点云分布的3D线特征提取与配准 被引量:2
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作者 缪永伟 戴颖婷 +2 位作者 王海鹏 刘复昌 王金荣 《中国科学:信息科学》 CSCD 北大核心 2021年第12期2069-2088,共20页
针对传统点云场景重建中由于场景区域缺乏纹理、场景物体遮挡等导致重建结果不准确的局限性,借助场景包含的几何特性和线结构信息,有效利用RGB-D数据的梯度信息和邻域点云分布信息,本文提出了一种针对点云场景的3D线特征提取、匹配和配... 针对传统点云场景重建中由于场景区域缺乏纹理、场景物体遮挡等导致重建结果不准确的局限性,借助场景包含的几何特性和线结构信息,有效利用RGB-D数据的梯度信息和邻域点云分布信息,本文提出了一种针对点云场景的3D线特征提取、匹配和配准方法.首先,通过场景RGB图的梯度信息确定梯度方向相似的3D直线段支持域.然后,借助场景深度图呈现的邻域几何特性,根据当前点与其邻近点之间的分布关系判断点云中的直线型边界线点云和直线型折边线点云并拟合得到场景3D线特征.其次,以点云场景提取的3D线特征为轴线,构造等厚度同轴圆柱区域作为3D线段支持域,并统计支持域中各层圆柱壁内点云梯度作为描述符实现3D线特征匹配.最后,利用基于线–线的迭代最近线配准算法,迭代计算得到帧间场景的旋转与平移,从而实现帧间点云场景的高效配准.实验结果表明,与已有的点云场景线特征提取及点特征配准方法比较,本文直接基于线特征的方法配准效率高、计算量小、配准精准,方法具有较强的鲁棒性. 展开更多
关键词 点云场景 3D线特征 线特征提取 线特征配准 三维重建
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侵染中华蜜蜂6日龄幼虫的蜜蜂球囊菌的微小RNA差异表达谱及调控网络 被引量:11
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作者 熊翠玲 杜宇 +12 位作者 冯睿蓉 蒋海宾 史小玉 王海朋 范小雪 王杰 祝智威 范元婵 陈华枝 周丁丁 郑燕珍 陈大福 郭睿 《微生物学报》 CAS CSCD 北大核心 2020年第5期992-1009,共18页
【目的】蜜蜂球囊菌(Ascosphaeraapis,简称球囊菌)是专性侵染蜜蜂幼虫的致死性真菌病原。MicroRNA(miRNA)作为一类重要的基因表达调控因子,能够广泛参与真菌及其宿主的相互作用过程。本研究通过比较分析球囊菌孢子(AaCK)和侵染中华蜜蜂(... 【目的】蜜蜂球囊菌(Ascosphaeraapis,简称球囊菌)是专性侵染蜜蜂幼虫的致死性真菌病原。MicroRNA(miRNA)作为一类重要的基因表达调控因子,能够广泛参与真菌及其宿主的相互作用过程。本研究通过比较分析球囊菌孢子(AaCK)和侵染中华蜜蜂(Apis cerana cerana,简称中蜂)6日龄幼虫肠道内的球囊菌(AaT)的smallRNA(sRNA)组学数据对球囊菌的差异表达miRNA(differentiallyexpressed miRNA,DEmiRNA)、靶mRNA及二者间的调控网络进行全面解析,旨在揭示miRNA介导的球囊菌对中蜂幼虫的侵染机制。【方法】对于球囊菌侵染的中蜂6日龄幼虫肠道的small RNA-seq(sRNA-seq)数据,利用BLAST工具连续比对东方蜜蜂(Apiscerana)和球囊菌的参考基因组筛滤得到AaT的sRNA组学数据。分别将AaCK和AaT的sRNA组学数据比对miRBase数据库,对球囊菌侵染宿主前后miRNA的数量和结构特征进行分析。联用RNAhybrid+svm_light、Miranda和TargetScan软件预测AaCK vs AaT比较组中DEmiRNA的靶mRNA,进而利用相关生物信息学软件对上述靶mRNA进行GO分类和KEGG代谢通路富集分析。通过Cytoscape软件对DEmiRNA-mRNA调控网络进行可视化。利用Stem-loop RT-PCR、RT-qPCR和分子克隆验证测序结果的可靠性。【结果】在AaCK和AaT中分别鉴定到380和387个miRNA。结构特征分析结果显示,AaCK和AaT的mi RNA皆集中分布在18–25 nt,且首位碱基主要偏向于U。AaCKvsAaT比较组共有270个DEmiRNA,包含155个上调miRNA和115个下调miRNA,分别靶向结合6091和6145个mRNA。GO分类结果显示,上述靶mRNA主要涉及代谢进程、细胞进程、应激反应等15个生物学进程;细胞、细胞组分、细胞器等12个细胞组分;催化活性、结合、转运子活性等11个分子功能。KEGG代谢通路富集分析结果显示,上述靶mRNA富集在123条代谢通路,参与对氨基酸代谢、碳水化合物代谢以及核苷酸代谢等物质代谢,氧化磷酸化、硫代谢、氮代谢等能量代谢,以及MAPK和Hippo等信号通路的调控。球囊菌DEmiRNA与靶mRNA之间存在复杂的调控关系,其中miR-29-x、miR-250-x、miR-4968-y、miR-11200-x、novel-m0023-5p、novel-m0130-5p和novel-m0135-5p等DEmiRNA可靶向结合与球囊菌的半胱氨酸蛋白酶、DNA甲基化转移酶以及几丁质酶相关的mRNA;此外,miR-7-x、miR-9-z、miR-319-y和miR-5951-y等同时参与调控MAPK信号通路;进一步分析发现,miR-250-x同时参与对DNA甲基化转移酶、MAPK信号通路及其他酶类合成与代谢途径的调控,并可能参与球囊菌与中蜂6日龄幼虫之间的跨界调控。通过Stem-loopRT-PCR和RT-qPCR验证了4个DEmiRNA的差异表达,并利用分子克隆和Sanger测序证实miR-7-x的序列与测序结果一致。【结论】本研究解析了侵染中蜂6日龄幼虫的球囊菌的miRNA差异表达谱及DEmiRNA的调控网络,揭示了球囊菌DEmiRNA可能通过调控病原的物质和能量代谢、增殖、毒力、信号通路及相关mRNA参与对中蜂幼虫的侵染过程。miR-7-x、miR-250-x、novel-m0023-5p等关键DEmiRNA有望作为白垩病治疗的新型分子靶点。 展开更多
关键词 蜜蜂球囊菌 中华蜜蜂 幼虫 微小RNA 调控网络 侵染机制 跨界调控
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Composition,Microstructure,Phase Constitution and Fundamental Physicochemical Properties of Low-Melting-Point Multi-Component Eutectic Alloys 被引量:5
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作者 Kaiyao Zhou Zhongyi Tang +3 位作者 Yiping Lu Tongmin wang haipeng wang Tingju Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第2期131-154,共24页
Low-melting-point alloys have an extensive applications in the fields of materials processing, phase change energy storage, electronic and electrical automatic control, continuous casting simulation, welding, etc. Spe... Low-melting-point alloys have an extensive applications in the fields of materials processing, phase change energy storage, electronic and electrical automatic control, continuous casting simulation, welding, etc. Specifically, the eutectic compositions make up a large number of low-melting-point alloys that are ex- ploited because of their desirable features like single melting peaks, excellent operational reliability, and casting fluidity. However, the fundamental physicochemical properties from the current available liter- ature on low-melting-point multi-component eutectic alloys (LMP-MCEAs) are rather rare and lowly accurate, including the exact melting temperatures and compositions, constituent phases, microstruc- tures and morphologies, melting enthalpies, specific heats, densities, and so on. This lack of information seriously limits the development and application of low-melting-point multi-component eutectic alloys. In this paper, the low-melting-point multi-component eutectic alloys composed of Bi, Cd, Sn, Pb, and In elements synthesized by high vacuum induction melting and fundamental data were investigated by scan- ning electron microscopy (SEM), energy dispersive spectrometry (EDS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and density analysis instrument. Most of the LMP-MCEAs with complex eu- tectic morphology structures and XRD diffraction patterns could be explained with the fact that they were three-phase eutectic alloys with mixed growth way. Generally, LMP-MCEAs present an extremely low melting point between 48.3 and 124 ℃ and high density between 8 and 10 g/cm3. 展开更多
关键词 Multicomponent alloys Eutectic alloy MICROSTRUCTURE Physicochemical properties
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催化转化呋喃类生物质制备芳香烃化合物的研究
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作者 曾滴 刘雪晨 +3 位作者 周沅逸 王海鹏 张玲 王文中 《化学进展》 SCIE CAS CSCD 北大核心 2022年第1期131-141,共11页
芳香烃化合物是一类与人类生产生活密切相关的重要有机化工原料。基于石油资源的日益枯竭及其生产过程中带来的环境污染问题,寻找新的合成芳香烃化合物的绿色化学路线成为有机合成领域中的研究热点。呋喃类生物质主要来源于植物系生物质... 芳香烃化合物是一类与人类生产生活密切相关的重要有机化工原料。基于石油资源的日益枯竭及其生产过程中带来的环境污染问题,寻找新的合成芳香烃化合物的绿色化学路线成为有机合成领域中的研究热点。呋喃类生物质主要来源于植物系生物质,廉价和分子多样性使其成为合成芳香烃化合物的重要候选原料。通过热催化或低温催化反应,呋喃类生物质与乙烯、丙烯等亲二烯体可进行Diels-Alder环加成和脱水等反应芳构化为芳香烃化合物。以呋喃类生物质为基础的催化反应可高效利用可再生能源,工业应用前景广阔。目前呋喃类生物质催化转化制备芳香烃化合物的研究大部分依赖高温高压的高能耗反应条件,且面临"一锅法"副反应繁杂的问题,例如水解、烷基化、异构化和低聚等。本文综述了基于不同呋喃生物质分子所取得的研究成果和面临的问题,简要介绍Diels-Alder环加成的反应机理,详细讨论催化剂组分、溶剂效应和亲二烯体对反应效率的影响,并对未来基于生物质的芳香烃化合物合成路径进行展望。 展开更多
关键词 呋喃类生物质 芳香烃化合物 催化反应 Diels-Alder环加成
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Method for denoising and reconstructing radar HRRP using modified sparse auto-encoder 被引量:2
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作者 Chen GUO haipeng wang +2 位作者 Tao JIAN Congan XU Shun SUN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2020年第3期1026-1036,共11页
A high resolution range profile(HRRP) is a summation vector of the sub-echoes of the target scattering points acquired by a wide-band radar.Generally, HRRPs obtained in a noncooperative complex electromagnetic environ... A high resolution range profile(HRRP) is a summation vector of the sub-echoes of the target scattering points acquired by a wide-band radar.Generally, HRRPs obtained in a noncooperative complex electromagnetic environment are contaminated by strong noise.Effective pre-processing of the HRRP data can greatly improve the accuracy of target recognition.In this paper, a denoising and reconstruction method for HRRP is proposed based on a Modified Sparse Auto-Encoder, which is a representative non-linear model.To better reconstruct the HRRP, a sparse constraint is added to the proposed model and the sparse coefficient is calculated based on the intrinsic dimension of HRRP.The denoising of the HRRP is performed by adding random noise to the input HRRP data during the training process and fine-tuning the weight matrix through singular-value decomposition.The results of simulations showed that the proposed method can both reconstruct the signal with fidelity and suppress noise effectively, significantly outperforming other methods, especially in low Signal-to-Noise Ratio conditions. 展开更多
关键词 High resolution range profile Intrinsic dimension Modified sparse autoencoder Signal denoise Signal sparse reconstruction
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Band structure reconstruction across nematic order in high quality FeSe single crystal as revealed by optical spectroscopy study 被引量:2
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作者 haipeng wang Zirong Ye +1 位作者 Yan Zhang Nanlin wang 《Science Bulletin》 SCIE EI CAS CSCD 2016年第14期1126-1131,共6页
We perform an in-plane optical spectroscopy measurement on high quality FeSe single crystals grown by a vapor transport technique. Below the structural transition at Ts - 90 K, the reflectivity spectrum clearly shows ... We perform an in-plane optical spectroscopy measurement on high quality FeSe single crystals grown by a vapor transport technique. Below the structural transition at Ts - 90 K, the reflectivity spectrum clearly shows a gradual suppression around 400 cm-1 and the conductivity spectrum shows a peak at higher frequency. The energy scale of this gap-like feature is comparable to the width of the band splitting observed by ARPES. The low-frequency conductivity consists of two Drude components and the overall plasma frequency is smaller than that of the FeAs based compounds, suggesting a lower cartier density or stronger correlation effect. The plasma frequency becomes even smaller below Ts which agrees with the very small Fermi energy estimated by other experiments. Similar to iron pnictides, a clear temperature-induced spectral weight transfer is observed for FeSe, being indicative of strong correlation effect. 展开更多
关键词 Iron-based superconductor OPTICALSPECTROSCOPY Nematic phase Band reconstruction
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