The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practi...The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practical interest.However,academia and industry have used a variety of interpretations,and the scientific literature lacks a unified and consistent definition of this term.The purpose of this study is to systematically examine the definitional landscape of the digital twin concept as outlined in scholarly literature,beginning with its origins in the aerospace domain and extending to its contemporary interpretations in the manufacturing industry.Notably,this investigationwill focus on the research conducted on Industry 4.0 and smartmanufacturing,elucidating the diverse applications of digital twins in fields including aerospace,intelligentmanufacturing,intelligent transportation,and intelligent cities,among others.展开更多
Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the...Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the host.Tissue temperature and tssue optical properties are important factorsin this process.In this study,a device combining interstitial photoacoustic(PA)technique andinterstitial laser photothermal interaction is proposed.Together with computational simulation,thisdevice was designed to determine temperature distributions and tissue optical properties during lasertreatment.Experiments were performed usinger-ivoFporcine liver tissue.Our results demonstratedthat interstitial PA signal amplitude was linearly dependent on tisue temperature in the tempera-ture ranges of 20-60℃,as wll as 65-80℃,with a dfferent slope,due to the change of tissue opticalproperties.Using the directly measured temperature in the tissue around the interstitial optical fiberdiffusion tip for calibration,the theoretical temperature distribution predicted by the bioheatequation was used to extract optical properties of tssue.Finally,the three-dimensional temperature distribution was simulated to guide tumor destruction and immunological stimulation,Thus,thisnovel device and method could be used for monitoring and controlling ILIT for cancer treatment.展开更多
基金This research is supported by National Natural Science Foundation of China(No.61902158).
文摘The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practical interest.However,academia and industry have used a variety of interpretations,and the scientific literature lacks a unified and consistent definition of this term.The purpose of this study is to systematically examine the definitional landscape of the digital twin concept as outlined in scholarly literature,beginning with its origins in the aerospace domain and extending to its contemporary interpretations in the manufacturing industry.Notably,this investigationwill focus on the research conducted on Industry 4.0 and smartmanufacturing,elucidating the diverse applications of digital twins in fields including aerospace,intelligentmanufacturing,intelligent transportation,and intelligent cities,among others.
基金sponsored in part by National Natural Science Foundation of China(No.61675043/81571726)Fujian Provincial Natural Science Foundation(2015J01006)by the US National Institutes of Health(R21 EB0155091).
文摘Interstitial laser immunotherapy(ILIT)is designed to use photothermal and immunological inter-actions for treatment of metastatic cancers.The photothermal ffect is crucial in inducing anti-tumorimmune responses in the host.Tissue temperature and tssue optical properties are important factorsin this process.In this study,a device combining interstitial photoacoustic(PA)technique andinterstitial laser photothermal interaction is proposed.Together with computational simulation,thisdevice was designed to determine temperature distributions and tissue optical properties during lasertreatment.Experiments were performed usinger-ivoFporcine liver tissue.Our results demonstratedthat interstitial PA signal amplitude was linearly dependent on tisue temperature in the tempera-ture ranges of 20-60℃,as wll as 65-80℃,with a dfferent slope,due to the change of tissue opticalproperties.Using the directly measured temperature in the tissue around the interstitial optical fiberdiffusion tip for calibration,the theoretical temperature distribution predicted by the bioheatequation was used to extract optical properties of tssue.Finally,the three-dimensional temperature distribution was simulated to guide tumor destruction and immunological stimulation,Thus,thisnovel device and method could be used for monitoring and controlling ILIT for cancer treatment.
