The primary objective of this investigation was to scrutinize the prepregnancy conditions and lifestyles of 2046 women residing in Liuzhou City, with the aim of delineating the determinants of delivery methods. Eviden...The primary objective of this investigation was to scrutinize the prepregnancy conditions and lifestyles of 2046 women residing in Liuzhou City, with the aim of delineating the determinants of delivery methods. Evidently, the study unearthed substantial correlations between prepregnancy body mass index, educational attainment, exposure to passive smoking, medical history, and other variables with the mode of delivery. Furthermore, a predictive nomogram model was formulated to accurately forecast the likelihood of cesarean section. These discernments equip pertinent authorities with the means to institute targeted screening and supportive measures for women contemplating pregnancy based on these identified factors. Moreover, provision of services such as prepregnancy counseling and clinical risk assessments could be instrumental in curbing the incidence of cesarean section.展开更多
Low sperm motility is one of the main causes of male infertility. Cystic fibrosis transmembrane conductance regulator (CFTR, an anion channel protein) is related to the progressive motility of sperm. CFTR disruptor CF...Low sperm motility is one of the main causes of male infertility. Cystic fibrosis transmembrane conductance regulator (CFTR, an anion channel protein) is related to the progressive motility of sperm. CFTR disruptor CFTRinh-172 or forskolin (FSK) in this study were used to treat human sperm separately, and the rates of sperm autophagy and progressive motility, mitochondrial membrane potential (MMP) and ATP concentration, and the expression levels of related factors were detected to explore their relationship. It was showed that sperms treated with CFTRinh-172 or FSK reduced the levels of cAMP, CFTR and PKA, but increased sperm autophagy rate, expression levels of AMPK and LC3B. However, reactive oxygen species content had no significant difference. It was indicated that low level of CFTR performed with cAMP and its downstream effectors such as PKA and AMPK to regulate mitochondrial structure and function, leading to increased autophagy rate and reduced vitality of sperm.展开更多
科学有效地预测水质对于水环境的可持续发展和人类健康具有重要意义,为此以固原市某黄河断面的水质监测数据为研究对象,提出了基于指标客观性的权重赋权(Criteria Importance Though Intercriteria Correlation,CRITIC)法和改进的秃鹰搜...科学有效地预测水质对于水环境的可持续发展和人类健康具有重要意义,为此以固原市某黄河断面的水质监测数据为研究对象,提出了基于指标客观性的权重赋权(Criteria Importance Though Intercriteria Correlation,CRITIC)法和改进的秃鹰搜索(Improved Bald Eagle Search,IBES)算法优化双向长短时记忆网络(Bidirectional Long Short-Term Memory Network,BiLSTM)的组合水质等级预测模型。首先,采用CRITIC法确定各水质指标的权重,加权求和获得一项综合水质指标,从而提出一种改进的水质评价指标体系,以为BiLSTM提供更丰富、更可靠的水质特征信息。其次,在训练过程中引入Logistic映射和莱维飞行策略,并设计交叉共享及准反向搜索策略优化秃鹰搜索(Bald Eagle Search,BES)算法,以提升其种群多样性,增强寻优能力。最后,通过IBES算法迭代寻找BiLSTM的最佳学习率、隐藏层节点数以及正则化系数的超参数组合,进一步提高其预测水平。结果显示:与IBES-BiLSTM、BES-BiLSTM、GA-BiLSTM、PSO-BiLSTM和BiLSTM等模型相比,CRITIC-IBES-BiLSTM模型进行水质等级预测的准确率、精准率、召回率及F_(1)均最高,且具有更好的稳定性。展开更多
With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPC),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW)...With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPC),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW),lower power and lower latency[1−3].The optical I/O leverages silicon photonic(SiPh)technology to enable high-density large-scale integrated photonics.展开更多
To mitigate the wastage of seed resources and reduce the usage of pesticides and fertilizers, seed coating agentshave gained popularity. This study employs single-factor and multi-index orthogonal experimental design ...To mitigate the wastage of seed resources and reduce the usage of pesticides and fertilizers, seed coating agentshave gained popularity. This study employs single-factor and multi-index orthogonal experimental design methodsto investigate the seed coating formula and physical properties of Tartary buckwheat. The specific effects ofeach component on Tartary buckwheat seed germination are analyzed. The findings reveal that the seed coatingagent formulated with 1.5% polyvinyl alcohol, 0.15% sodium alginate, 0.2% op-10, 0.1% polyacrylamide, 8% colorant,3% ammonium sulfate, 1% potassium dihydrogen phosphate, and 0.15% carbendazim exhibits the mosteffective coating. It demonstrates optimal physical properties and promotes seed germination efficiently. The suspensionrate of this seed coating agent reaches 91.12%, with a mere 2.13% coating shedding rate and 2.5% coatingseed rot rate. Furthermore, it achieves a germination percentage of 99.17%, which is 20.84% higher than the lowestgroup. The germination potential and index are also significantly higher than the lowest group, with anincrease of 20.84% and 26.56%, respectively. Additionally, the vitality index is 553.08, a 15.75% increase comparedto the lowest group. The application of seed coating agents helps reduce seed resource loss, increase plant numbers,and ultimately enhance agricultural yields. This finding holds practical significance in agriculturalproduction.展开更多
BACKGROUND The extraction of maxillary impacted teeth is a common procedure in oral surgery,frequently complicated by oroantral communications.For less-experienced clinicians,accurately assessing the difficulty and as...BACKGROUND The extraction of maxillary impacted teeth is a common procedure in oral surgery,frequently complicated by oroantral communications.For less-experienced clinicians,accurately assessing the difficulty and associated risks of maxillary third molar extractions remain a significant challenge.CASE SUMMARY We present a case involving disparate outcomes following bilateral extraction of maxillary third molars.Using cone-beam computed tomography and three-dimensional software,we conducted a digital assessment of the factors contributing to extraction difficulty and risk,controlling for potential confounders.Key variables analyzed included alveolar bone volume,bone quality,crown-root angulation,and maxillary sinus mucosal thickness.Additionally,we introduce the novel concept of"tegmen bone"to quantitatively evaluate the bone mass between the teeth and the maxillary sinus.This unique case,with differing outcomes on opposite sides of the same patient,provided an opportunity to minimize extraneous variables and focus on the local anatomical factors influencing the procedures,thereby improving the precision of our analysis.CONCLUSION This case highlights the potential utility of predictive analysis in guiding the management of complex tooth extractions.展开更多
文摘The primary objective of this investigation was to scrutinize the prepregnancy conditions and lifestyles of 2046 women residing in Liuzhou City, with the aim of delineating the determinants of delivery methods. Evidently, the study unearthed substantial correlations between prepregnancy body mass index, educational attainment, exposure to passive smoking, medical history, and other variables with the mode of delivery. Furthermore, a predictive nomogram model was formulated to accurately forecast the likelihood of cesarean section. These discernments equip pertinent authorities with the means to institute targeted screening and supportive measures for women contemplating pregnancy based on these identified factors. Moreover, provision of services such as prepregnancy counseling and clinical risk assessments could be instrumental in curbing the incidence of cesarean section.
文摘Low sperm motility is one of the main causes of male infertility. Cystic fibrosis transmembrane conductance regulator (CFTR, an anion channel protein) is related to the progressive motility of sperm. CFTR disruptor CFTRinh-172 or forskolin (FSK) in this study were used to treat human sperm separately, and the rates of sperm autophagy and progressive motility, mitochondrial membrane potential (MMP) and ATP concentration, and the expression levels of related factors were detected to explore their relationship. It was showed that sperms treated with CFTRinh-172 or FSK reduced the levels of cAMP, CFTR and PKA, but increased sperm autophagy rate, expression levels of AMPK and LC3B. However, reactive oxygen species content had no significant difference. It was indicated that low level of CFTR performed with cAMP and its downstream effectors such as PKA and AMPK to regulate mitochondrial structure and function, leading to increased autophagy rate and reduced vitality of sperm.
文摘科学有效地预测水质对于水环境的可持续发展和人类健康具有重要意义,为此以固原市某黄河断面的水质监测数据为研究对象,提出了基于指标客观性的权重赋权(Criteria Importance Though Intercriteria Correlation,CRITIC)法和改进的秃鹰搜索(Improved Bald Eagle Search,IBES)算法优化双向长短时记忆网络(Bidirectional Long Short-Term Memory Network,BiLSTM)的组合水质等级预测模型。首先,采用CRITIC法确定各水质指标的权重,加权求和获得一项综合水质指标,从而提出一种改进的水质评价指标体系,以为BiLSTM提供更丰富、更可靠的水质特征信息。其次,在训练过程中引入Logistic映射和莱维飞行策略,并设计交叉共享及准反向搜索策略优化秃鹰搜索(Bald Eagle Search,BES)算法,以提升其种群多样性,增强寻优能力。最后,通过IBES算法迭代寻找BiLSTM的最佳学习率、隐藏层节点数以及正则化系数的超参数组合,进一步提高其预测水平。结果显示:与IBES-BiLSTM、BES-BiLSTM、GA-BiLSTM、PSO-BiLSTM和BiLSTM等模型相比,CRITIC-IBES-BiLSTM模型进行水质等级预测的准确率、精准率、召回率及F_(1)均最高,且具有更好的稳定性。
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.61925505,92373209 and 62235017).
文摘With the explosive development of artificial intelligence(AI),machine learning(ML),and high-performance comput-ing(HPC),the ever-growing data movement is asking for high density interconnects with higher bandwidth(BW),lower power and lower latency[1−3].The optical I/O leverages silicon photonic(SiPh)technology to enable high-density large-scale integrated photonics.
基金the Sichuan Science and Technology Program(2023NSFSC0214)China Agriculture Research System(CARS-07-B-1)+1 种基金National Natural Sciences Foundation of China(Nos.3230185031771716).
文摘To mitigate the wastage of seed resources and reduce the usage of pesticides and fertilizers, seed coating agentshave gained popularity. This study employs single-factor and multi-index orthogonal experimental design methodsto investigate the seed coating formula and physical properties of Tartary buckwheat. The specific effects ofeach component on Tartary buckwheat seed germination are analyzed. The findings reveal that the seed coatingagent formulated with 1.5% polyvinyl alcohol, 0.15% sodium alginate, 0.2% op-10, 0.1% polyacrylamide, 8% colorant,3% ammonium sulfate, 1% potassium dihydrogen phosphate, and 0.15% carbendazim exhibits the mosteffective coating. It demonstrates optimal physical properties and promotes seed germination efficiently. The suspensionrate of this seed coating agent reaches 91.12%, with a mere 2.13% coating shedding rate and 2.5% coatingseed rot rate. Furthermore, it achieves a germination percentage of 99.17%, which is 20.84% higher than the lowestgroup. The germination potential and index are also significantly higher than the lowest group, with anincrease of 20.84% and 26.56%, respectively. Additionally, the vitality index is 553.08, a 15.75% increase comparedto the lowest group. The application of seed coating agents helps reduce seed resource loss, increase plant numbers,and ultimately enhance agricultural yields. This finding holds practical significance in agriculturalproduction.
文摘BACKGROUND The extraction of maxillary impacted teeth is a common procedure in oral surgery,frequently complicated by oroantral communications.For less-experienced clinicians,accurately assessing the difficulty and associated risks of maxillary third molar extractions remain a significant challenge.CASE SUMMARY We present a case involving disparate outcomes following bilateral extraction of maxillary third molars.Using cone-beam computed tomography and three-dimensional software,we conducted a digital assessment of the factors contributing to extraction difficulty and risk,controlling for potential confounders.Key variables analyzed included alveolar bone volume,bone quality,crown-root angulation,and maxillary sinus mucosal thickness.Additionally,we introduce the novel concept of"tegmen bone"to quantitatively evaluate the bone mass between the teeth and the maxillary sinus.This unique case,with differing outcomes on opposite sides of the same patient,provided an opportunity to minimize extraneous variables and focus on the local anatomical factors influencing the procedures,thereby improving the precision of our analysis.CONCLUSION This case highlights the potential utility of predictive analysis in guiding the management of complex tooth extractions.
